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The map label for this gene is emrA [H]

Identifier: 238028638

GI number: 238028638

Start: 3527263

End: 3528471

Strand: Reverse

Name: emrA [H]

Synonym: bglu_1g31020

Alternate gene names: 238028638

Gene position: 3528471-3527263 (Counterclockwise)

Preceding gene: 238028639

Following gene: 238028637

Centisome position: 90.32

GC content: 70.64

Gene sequence:

>1209_bases
ATGAGCGACCCCCAGCAGCAAGCCGCGGCACCCGCCGCGCGCAACGACGGCAAACGCAAGTGGCTGATGACCTTGCTCGT
CGTGATCATCGTGCTCGCCGCGATCGCCTACGGCATCTATTACTTCCTGGTCGCGCGGTTCCACGAGGACACCGACGACG
CCTACGTCAACGGCAACGTGGTCCAGATCACGCCGCAGGTGACGGGCACGGTGATCGCGGTCAATGCCGACGACACGCAG
TCGATCCGCGAAGGCGAGCCGCTCGTGCAGCTCGACCCCGCCGACGCGCGGATCGCGCTGCAATCGGCCGAGGCGAAGCT
GGCCCAGACGGTGCGCCGCGTGCGCGGCCTCTACGCCGCCGACGACCAGTACCGGGCGCAGGTGGCCCAGCGCGAATCGG
ATCTGTCGAAGGCGCAGGACGACCTGCGCCGGCGCCTGGCCGTGGCGCAGACGGGCGCGGTCTCCCAGGAGGAGATCTCG
CATGCGCGCGACGCGGTGAAGGCCGCGCAGGCCACGCTCGACGCGGCCAGGCAGCAGCTTGCCGCGAACCTGGCGCTGAC
CGCGAACACCACCGTCAGCCACCATCCCGACGTGCTGGCCGCGGTCGCGACGGTGCGCGACGCCTACCTGGCCAACGCGC
GCAACACGCTGCCCGCGCCCGTCACCGGCTACGTGGCCAAGCGCACGGTGCAGGTGGGCCAGCGCGTGTCGCCTGGCACG
CCGCTGATGTCGGTGGTGCCGCTCGGCCAGATCTGGGTGGACGCGAACTTCAAGGAAGTGCAGCTCGACCACATGCGCAT
CGGCCAGCCGGTCGAGCTGACGGCCGACATCTACGGCTCGTCGGTCACGTATCACGGCAAGGTGGCGGGCTTCTCGGCCG
GCACCGGCTCGGCGTTCTCGCTGCTGCCGGCGCAGAACGCCACCGGCAACTGGATCAAGGTGGTGCAGCGCCTGCCGGTG
CGCATCGCGCTCGATCCGCGCGAGCTCGAACGTCACCCGCTGCGCATCGGCCTGTCGATGCAGGCCGACGTCAGCATCAA
GGACGAGAGCGGCAGCCAGCTCGGCAGCGTCAGCAACACCGTCTATCAGACCGAGGTGTTCGCGAAGTACGGCGATGCGG
CCAACGCCGAGATCGCGCGGATCATCGCCGAGAACGCCGGCGGCCCGGTCCGGGCCGCCCAGCCGGCGCCTCGCGCGCCG
CGGGCCTGA

Upstream 100 bases:

>100_bases
TCGAACGCCACCCCGGGCTGAGCCGCCCGCCACCTTCTCGAATCGACAGACCCAGTGCGCCGCGCTCCGAACGCGGCGGA
CGAAGACGGAGAACCTCGCG

Downstream 100 bases:

>100_bases
GGCAAGCGGAACCGCTCCATGGCTGCTTCGATGCCCCTGCGCCCGCTCTCGGGCGCCCAGCTCGCGCTCGGCACCCTGGC
GGTGTCGCTCGCGATGTTCA

Product: efflux pump membrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 402; Mature: 401

Protein sequence:

>402_residues
MSDPQQQAAAPAARNDGKRKWLMTLLVVIIVLAAIAYGIYYFLVARFHEDTDDAYVNGNVVQITPQVTGTVIAVNADDTQ
SIREGEPLVQLDPADARIALQSAEAKLAQTVRRVRGLYAADDQYRAQVAQRESDLSKAQDDLRRRLAVAQTGAVSQEEIS
HARDAVKAAQATLDAARQQLAANLALTANTTVSHHPDVLAAVATVRDAYLANARNTLPAPVTGYVAKRTVQVGQRVSPGT
PLMSVVPLGQIWVDANFKEVQLDHMRIGQPVELTADIYGSSVTYHGKVAGFSAGTGSAFSLLPAQNATGNWIKVVQRLPV
RIALDPRELERHPLRIGLSMQADVSIKDESGSQLGSVSNTVYQTEVFAKYGDAANAEIARIIAENAGGPVRAAQPAPRAP
RA

Sequences:

>Translated_402_residues
MSDPQQQAAAPAARNDGKRKWLMTLLVVIIVLAAIAYGIYYFLVARFHEDTDDAYVNGNVVQITPQVTGTVIAVNADDTQ
SIREGEPLVQLDPADARIALQSAEAKLAQTVRRVRGLYAADDQYRAQVAQRESDLSKAQDDLRRRLAVAQTGAVSQEEIS
HARDAVKAAQATLDAARQQLAANLALTANTTVSHHPDVLAAVATVRDAYLANARNTLPAPVTGYVAKRTVQVGQRVSPGT
PLMSVVPLGQIWVDANFKEVQLDHMRIGQPVELTADIYGSSVTYHGKVAGFSAGTGSAFSLLPAQNATGNWIKVVQRLPV
RIALDPRELERHPLRIGLSMQADVSIKDESGSQLGSVSNTVYQTEVFAKYGDAANAEIARIIAENAGGPVRAAQPAPRAP
RA
>Mature_401_residues
SDPQQQAAAPAARNDGKRKWLMTLLVVIIVLAAIAYGIYYFLVARFHEDTDDAYVNGNVVQITPQVTGTVIAVNADDTQS
IREGEPLVQLDPADARIALQSAEAKLAQTVRRVRGLYAADDQYRAQVAQRESDLSKAQDDLRRRLAVAQTGAVSQEEISH
ARDAVKAAQATLDAARQQLAANLALTANTTVSHHPDVLAAVATVRDAYLANARNTLPAPVTGYVAKRTVQVGQRVSPGTP
LMSVVPLGQIWVDANFKEVQLDHMRIGQPVELTADIYGSSVTYHGKVAGFSAGTGSAFSLLPAQNATGNWIKVVQRLPVR
IALDPRELERHPLRIGLSMQADVSIKDESGSQLGSVSNTVYQTEVFAKYGDAANAEIARIIAENAGGPVRAAQPAPRAPR
A

Specific function: The emr locus confers resistance to substances of high hydrophobicity. EmrA probably participate in a transport system to extrude toxins and drugs from the cell [H]

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789041, Length=343, Percent_Identity=51.8950437317784, Blast_Score=343, Evalue=9e-96,
Organism=Escherichia coli, GI1788711, Length=377, Percent_Identity=44.5623342175066, Blast_Score=330, Evalue=7e-92,
Organism=Escherichia coli, GI1790519, Length=310, Percent_Identity=30.9677419354839, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI87081951, Length=311, Percent_Identity=27.9742765273312, Blast_Score=115, Evalue=7e-27,
Organism=Escherichia coli, GI1789637, Length=317, Percent_Identity=27.1293375394322, Blast_Score=83, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 43093; Mature: 42962

Theoretical pI: Translated: 7.91; Mature: 7.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDPQQQAAAPAARNDGKRKWLMTLLVVIIVLAAIAYGIYYFLVARFHEDTDDAYVNGNV
CCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCE
VQITPQVTGTVIAVNADDTQSIREGEPLVQLDPADARIALQSAEAKLAQTVRRVRGLYAA
EEEECCCCEEEEEEECCCCHHHHCCCCEEEECCCCCEEEHHHHHHHHHHHHHHHHCCCCC
DDQYRAQVAQRESDLSKAQDDLRRRLAVAQTGAVSQEEISHARDAVKAAQATLDAARQQL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AANLALTANTTVSHHPDVLAAVATVRDAYLANARNTLPAPVTGYVAKRTVQVGQRVSPGT
HHHEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCC
PLMSVVPLGQIWVDANFKEVQLDHMRIGQPVELTADIYGSSVTYHGKVAGFSAGTGSAFS
CCHHHCCCCEEEECCCHHEEEEHHHHCCCCCEEEHHHCCCEEEEECEEEECCCCCCCCEE
LLPAQNATGNWIKVVQRLPVRIALDPRELERHPLRIGLSMQADVSIKDESGSQLGSVSNT
EECCCCCCCHHHHHHHHCCCEEEECHHHHCCCCEEEEEEEEECEEEECCCCCHHCCHHHH
VYQTEVFAKYGDAANAEIARIIAENAGGPVRAAQPAPRAPRA
HHHHHHHHHCCCCCCHHHHHHHHHCCCCCEECCCCCCCCCCC
>Mature Secondary Structure 
SDPQQQAAAPAARNDGKRKWLMTLLVVIIVLAAIAYGIYYFLVARFHEDTDDAYVNGNV
CCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCE
VQITPQVTGTVIAVNADDTQSIREGEPLVQLDPADARIALQSAEAKLAQTVRRVRGLYAA
EEEECCCCEEEEEEECCCCHHHHCCCCEEEECCCCCEEEHHHHHHHHHHHHHHHHCCCCC
DDQYRAQVAQRESDLSKAQDDLRRRLAVAQTGAVSQEEISHARDAVKAAQATLDAARQQL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AANLALTANTTVSHHPDVLAAVATVRDAYLANARNTLPAPVTGYVAKRTVQVGQRVSPGT
HHHEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCC
PLMSVVPLGQIWVDANFKEVQLDHMRIGQPVELTADIYGSSVTYHGKVAGFSAGTGSAFS
CCHHHCCCCEEEECCCHHEEEEHHHHCCCCCEEEHHHCCCEEEEECEEEECCCCCCCCEE
LLPAQNATGNWIKVVQRLPVRIALDPRELERHPLRIGLSMQADVSIKDESGSQLGSVSNT
EECCCCCCCHHHHHHHHCCCEEEECHHHHCCCCEEEEEEEEECEEEECCCCCHHCCHHHH
VYQTEVFAKYGDAANAEIARIIAENAGGPVRAAQPAPRAPRA
HHHHHHHHHCCCCCCHHHHHHHHHCCCCCEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1409590; 9205837; 9278503; 8203018 [H]