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The map label for this gene is adk [H]

Identifier: 238028448

GI number: 238028448

Start: 3299943

End: 3300605

Strand: Direct

Name: adk [H]

Synonym: bglu_1g29120

Alternate gene names: 238028448

Gene position: 3299943-3300605 (Clockwise)

Preceding gene: 238028447

Following gene: 238028449

Centisome position: 84.47

GC content: 65.46

Gene sequence:

>663_bases
ATGCGTTTGATCCTGTTGGGCGCTCCCGGCGCCGGCAAGGGCACCCAGGCCACGTTCATCAAGGAAAAGTTCGGCATTCC
GCAGATCTCGACGGGCGACATGCTGCGCGCGGCCGTGAAGGCCGGCACGCCGCTCGGCGTCGAGGCCAAGGGCTATATGG
ACGAGGGCAAGCTGGTGCCGGATTCGCTGATCATCGGGCTCGTCAAGGAGCGCCTGAAGGAAGCGGACTGCGCCAACGGC
TATCTGTTCGACGGCTTCCCGCGCACCATCGCGCAGGCCGACGCGATGAAGGATGCCGGCGTCGCGATCGACTACGTGCT
CGAGATCGACGTGCCGTTCTCGGCAATCATCGAGCGCATCAGCGGCCGCCGCACCCATCCGGCCTCGGGCCGCACCTACC
ACGTGACGTTCAACCCGCCGAAGGTCGAGGGCAAGGACGACGTGACGGGCGAGCCGCTGATTCAGCGCGACGACGACAAG
GAAGAGACGGTGAAGAAGCGTCTCGACGTTTACGAGGCACAAACCAAGCCGCTTATCTCGTATTACGGCGACTGGGCCGC
GCGCGGCGCCGAAAACGGCCTGCAGGCGCCCGCCTATCGCAAGATCTCGGGCCTCGGCAGCGTCGAGGAAATCCGCCAGC
GCGCGTTCGAGGCCCTGAAGTAA

Upstream 100 bases:

>100_bases
CGCCGTCAGACCGGCCGGAGCCGTGTGGAAGCCGACCGCCGGGCCGCGCGCCGATGTCATCCCCTCGCGCCACACATTCA
CGAAACTTGGAGATATCACC

Downstream 100 bases:

>100_bases
GGCCCGCGAGCCGCAACACGCCGCTCCCCGGAGCGGTTTTTTTTCGCCTCGCGCCATAAATCGCACGATCGTTCATTTTT
TGCCGTCACCGCGCGCGGTT

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 220; Mature: 220

Protein sequence:

>220_residues
MRLILLGAPGAGKGTQATFIKEKFGIPQISTGDMLRAAVKAGTPLGVEAKGYMDEGKLVPDSLIIGLVKERLKEADCANG
YLFDGFPRTIAQADAMKDAGVAIDYVLEIDVPFSAIIERISGRRTHPASGRTYHVTFNPPKVEGKDDVTGEPLIQRDDDK
EETVKKRLDVYEAQTKPLISYYGDWAARGAENGLQAPAYRKISGLGSVEEIRQRAFEALK

Sequences:

>Translated_220_residues
MRLILLGAPGAGKGTQATFIKEKFGIPQISTGDMLRAAVKAGTPLGVEAKGYMDEGKLVPDSLIIGLVKERLKEADCANG
YLFDGFPRTIAQADAMKDAGVAIDYVLEIDVPFSAIIERISGRRTHPASGRTYHVTFNPPKVEGKDDVTGEPLIQRDDDK
EETVKKRLDVYEAQTKPLISYYGDWAARGAENGLQAPAYRKISGLGSVEEIRQRAFEALK
>Mature_220_residues
MRLILLGAPGAGKGTQATFIKEKFGIPQISTGDMLRAAVKAGTPLGVEAKGYMDEGKLVPDSLIIGLVKERLKEADCANG
YLFDGFPRTIAQADAMKDAGVAIDYVLEIDVPFSAIIERISGRRTHPASGRTYHVTFNPPKVEGKDDVTGEPLIQRDDDK
EETVKKRLDVYEAQTKPLISYYGDWAARGAENGLQAPAYRKISGLGSVEEIRQRAFEALK

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI4502013, Length=201, Percent_Identity=49.2537313432836, Blast_Score=201, Evalue=3e-52,
Organism=Homo sapiens, GI7524346, Length=201, Percent_Identity=49.2537313432836, Blast_Score=201, Evalue=3e-52,
Organism=Homo sapiens, GI19923437, Length=182, Percent_Identity=50, Blast_Score=190, Evalue=8e-49,
Organism=Homo sapiens, GI310110345, Length=182, Percent_Identity=45.0549450549451, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI53832003, Length=182, Percent_Identity=45.0549450549451, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI8051579, Length=182, Percent_Identity=45.0549450549451, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI53832001, Length=182, Percent_Identity=45.0549450549451, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI22749187, Length=186, Percent_Identity=31.1827956989247, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI4502011, Length=210, Percent_Identity=28.5714285714286, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI7706497, Length=188, Percent_Identity=31.3829787234043, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI21450759, Length=139, Percent_Identity=28.0575539568345, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI28144897, Length=189, Percent_Identity=28.042328042328, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI28144899, Length=189, Percent_Identity=28.042328042328, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI237858799, Length=139, Percent_Identity=28.0575539568345, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1786680, Length=212, Percent_Identity=64.622641509434, Blast_Score=272, Evalue=1e-74,
Organism=Caenorhabditis elegans, GI17552384, Length=186, Percent_Identity=45.6989247311828, Blast_Score=178, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17537943, Length=185, Percent_Identity=38.3783783783784, Blast_Score=138, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17567503, Length=182, Percent_Identity=32.4175824175824, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17533833, Length=184, Percent_Identity=29.8913043478261, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17550688, Length=184, Percent_Identity=30.4347826086957, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6320432, Length=206, Percent_Identity=47.0873786407767, Blast_Score=196, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6321018, Length=195, Percent_Identity=45.1282051282051, Blast_Score=161, Evalue=7e-41,
Organism=Saccharomyces cerevisiae, GI6322828, Length=183, Percent_Identity=30.0546448087432, Blast_Score=84, Evalue=1e-17,
Organism=Drosophila melanogaster, GI22026816, Length=215, Percent_Identity=48.3720930232558, Blast_Score=199, Evalue=8e-52,
Organism=Drosophila melanogaster, GI17737899, Length=182, Percent_Identity=48.3516483516484, Blast_Score=174, Evalue=3e-44,
Organism=Drosophila melanogaster, GI24645822, Length=182, Percent_Identity=48.3516483516484, Blast_Score=174, Evalue=3e-44,
Organism=Drosophila melanogaster, GI24663208, Length=179, Percent_Identity=27.9329608938547, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI17647141, Length=179, Percent_Identity=27.9329608938547, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI221459597, Length=184, Percent_Identity=28.804347826087, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21356893, Length=184, Percent_Identity=28.804347826087, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 23970; Mature: 23970

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLILLGAPGAGKGTQATFIKEKFGIPQISTGDMLRAAVKAGTPLGVEAKGYMDEGKLVP
CEEEEEECCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCH
DSLIIGLVKERLKEADCANGYLFDGFPRTIAQADAMKDAGVAIDYVLEIDVPFSAIIERI
HHHHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHH
SGRRTHPASGRTYHVTFNPPKVEGKDDVTGEPLIQRDDDKEETVKKRLDVYEAQTKPLIS
HCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHH
YYGDWAARGAENGLQAPAYRKISGLGSVEEIRQRAFEALK
HHCCHHHHCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MRLILLGAPGAGKGTQATFIKEKFGIPQISTGDMLRAAVKAGTPLGVEAKGYMDEGKLVP
CEEEEEECCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCH
DSLIIGLVKERLKEADCANGYLFDGFPRTIAQADAMKDAGVAIDYVLEIDVPFSAIIERI
HHHHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHH
SGRRTHPASGRTYHVTFNPPKVEGKDDVTGEPLIQRDDDKEETVKKRLDVYEAQTKPLIS
HCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHH
YYGDWAARGAENGLQAPAYRKISGLGSVEEIRQRAFEALK
HHCCHHHHCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA