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The map label for this gene is mdtD [H]

Identifier: 238028438

GI number: 238028438

Start: 3289255

End: 3290688

Strand: Direct

Name: mdtD [H]

Synonym: bglu_1g29020

Alternate gene names: 238028438

Gene position: 3289255-3290688 (Clockwise)

Preceding gene: 238028437

Following gene: 238028439

Centisome position: 84.2

GC content: 67.64

Gene sequence:

>1434_bases
ATGTCCCGTCCTGCCGCCCCCACCCCGAGCGAATCGTCCCTGACCGTGATGCTGTGGGTCGTCGCGACCGGCTTCTTCAT
GCAGACGCTCGATGCGACCATCGTCAACACGGCGTTGCCGTCGATGGCCGCGAGCCTCGGCGAATCGCCGCTGCGCATGC
AGTCGGTGGTGATCGCCTACTCGCTGACGATGGCGGTGATGATCCCCGTCTCGGGCTGGCTGGCCGATACCTTGGGCACG
CGGCGCGTGTTCTTCAGCGCGATCCTCATCTTCTCGGCCAGCTCCCTGCTCTGCGCGAGCTCGCACACGCTGCCGCAGCT
GGTGGCCTCGCGCGTGGCACAGGGCGTGGGCGGCGCGATGCTGCTGCCGGTCGGACGGCTGGCCGTGCTGCGCACGTTCC
CGGCCGAACGCTACCTGCCGGCGCTGTCGTTCGTAGCGATACCGGGCCTGATCGGCCCGCTGATCGGGCCGACGCTCGGC
GGCTGGCTCGTCAAGATCGCGTCGTGGCACTGGATCTTCCTGATCAACGTGCCGGTGGGCGTGGCGGGCTGCCTCGCCAC
GTTCTACTCGATGCCCGATTCGCGCAACCCGGCAGCCGGCCGCTTCGACCTGAAAGGCTACCTGCTGCTGACGGTCGGCA
TGGTCGCGGTGTCGCTGTCGCTCGACGGCCTCGCCGACCTCGGCATGGACCACGCCGCCGTGCTGGTGCTGATGATCCTC
GGCCTCGCCTCGTTCGTCGCGTACGGGCTCTACGCGGTGCGCGCGCCGAGCCCGATCTTTTCGCTCGAACTGTTCCGCAT
CCACACCTTCAGTGTCGGCCTGCTCGGCAACCTGTTCGCGCGCATCGGCAGCGGCGCGATGCCTTACCTGGTTCCGCTGC
TGCTGCAGGTGAGCCTCGGCTATTCGGCATTCGAGGCCGGCCTGATGATGCTGCCGGTGGCGGTGGTGGGGATGTTCTCG
AAACGGCTCATCACGCATCTGATCCAGCGTCACGGCTATCGCCAGGTGCTGCTCGTCAACACCGTGATGGTCGGGCTGCT
GATGGCGAGCTTCGCGCTGATGCGCGACAACGTGCCGGTGTGGGTGCAGGTGCTGCAGCTGGCCGTGTTCGGCGGCTTCA
ATTCGATGCAGTTCACGGCGATGAACACGCTCACGCTGAAGGACCTCGGCACCGGCGGCGCGAGCAGCGGCAACAGCCTG
TTCTCGCTGGTGCAGATGCTGTCGATGAGCCTCGGCGTGACGGTGGCGGGCGCGCTGCTCACCACCTTCACCGGCGTGAT
CCGCAGCGTGACGCCCACCCACACGCTGCCGGCGTTCCACGCGACCTTCTTCTGCGTCGGCATCATCACGGCCGGCTCGG
CGTGGATCTTCGCGCAGCTCGCGCCGGACGTGCGCGCCAGCACGAAAAAGACCGATCCGTCCGAGCGCACCTAG

Upstream 100 bases:

>100_bases
CGCGCGGGCTGATCCCGCGCACTCCTCCGTGCCCACCTGTCCTGCGCGCGCCGCCTGATTTTCTTACAATGTCGGCTGTT
TCGCGCCCACGCCCCCGCCC

Downstream 100 bases:

>100_bases
CGCGCAGGCGGCACGGGGCGGCGGCAACGACGCGCCGCCGCCGGCGCACCGGCGTGTGCGCCGGGCGCACCAACGCGGTG
CGCGACTCGGCCCCGGTCCG

Product: EmrB/QacA subfamily drug resistance transporter

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 477; Mature: 476

Protein sequence:

>477_residues
MSRPAAPTPSESSLTVMLWVVATGFFMQTLDATIVNTALPSMAASLGESPLRMQSVVIAYSLTMAVMIPVSGWLADTLGT
RRVFFSAILIFSASSLLCASSHTLPQLVASRVAQGVGGAMLLPVGRLAVLRTFPAERYLPALSFVAIPGLIGPLIGPTLG
GWLVKIASWHWIFLINVPVGVAGCLATFYSMPDSRNPAAGRFDLKGYLLLTVGMVAVSLSLDGLADLGMDHAAVLVLMIL
GLASFVAYGLYAVRAPSPIFSLELFRIHTFSVGLLGNLFARIGSGAMPYLVPLLLQVSLGYSAFEAGLMMLPVAVVGMFS
KRLITHLIQRHGYRQVLLVNTVMVGLLMASFALMRDNVPVWVQVLQLAVFGGFNSMQFTAMNTLTLKDLGTGGASSGNSL
FSLVQMLSMSLGVTVAGALLTTFTGVIRSVTPTHTLPAFHATFFCVGIITAGSAWIFAQLAPDVRASTKKTDPSERT

Sequences:

>Translated_477_residues
MSRPAAPTPSESSLTVMLWVVATGFFMQTLDATIVNTALPSMAASLGESPLRMQSVVIAYSLTMAVMIPVSGWLADTLGT
RRVFFSAILIFSASSLLCASSHTLPQLVASRVAQGVGGAMLLPVGRLAVLRTFPAERYLPALSFVAIPGLIGPLIGPTLG
GWLVKIASWHWIFLINVPVGVAGCLATFYSMPDSRNPAAGRFDLKGYLLLTVGMVAVSLSLDGLADLGMDHAAVLVLMIL
GLASFVAYGLYAVRAPSPIFSLELFRIHTFSVGLLGNLFARIGSGAMPYLVPLLLQVSLGYSAFEAGLMMLPVAVVGMFS
KRLITHLIQRHGYRQVLLVNTVMVGLLMASFALMRDNVPVWVQVLQLAVFGGFNSMQFTAMNTLTLKDLGTGGASSGNSL
FSLVQMLSMSLGVTVAGALLTTFTGVIRSVTPTHTLPAFHATFFCVGIITAGSAWIFAQLAPDVRASTKKTDPSERT
>Mature_476_residues
SRPAAPTPSESSLTVMLWVVATGFFMQTLDATIVNTALPSMAASLGESPLRMQSVVIAYSLTMAVMIPVSGWLADTLGTR
RVFFSAILIFSASSLLCASSHTLPQLVASRVAQGVGGAMLLPVGRLAVLRTFPAERYLPALSFVAIPGLIGPLIGPTLGG
WLVKIASWHWIFLINVPVGVAGCLATFYSMPDSRNPAAGRFDLKGYLLLTVGMVAVSLSLDGLADLGMDHAAVLVLMILG
LASFVAYGLYAVRAPSPIFSLELFRIHTFSVGLLGNLFARIGSGAMPYLVPLLLQVSLGYSAFEAGLMMLPVAVVGMFSK
RLITHLIQRHGYRQVLLVNTVMVGLLMASFALMRDNVPVWVQVLQLAVFGGFNSMQFTAMNTLTLKDLGTGGASSGNSLF
SLVQMLSMSLGVTVAGALLTTFTGVIRSVTPTHTLPAFHATFFCVGIITAGSAWIFAQLAPDVRASTKKTDPSERT

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=474, Percent_Identity=46.2025316455696, Blast_Score=414, Evalue=1e-117,
Organism=Escherichia coli, GI1788392, Length=452, Percent_Identity=49.5575221238938, Blast_Score=385, Evalue=1e-108,
Organism=Escherichia coli, GI1788710, Length=325, Percent_Identity=32.6153846153846, Blast_Score=155, Evalue=8e-39,
Organism=Escherichia coli, GI1789042, Length=418, Percent_Identity=27.0334928229665, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI87081983, Length=318, Percent_Identity=31.4465408805031, Blast_Score=128, Evalue=8e-31,
Organism=Escherichia coli, GI1788509, Length=165, Percent_Identity=29.0909090909091, Blast_Score=62, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6322958, Length=180, Percent_Identity=30, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6325455, Length=125, Percent_Identity=29.6, Blast_Score=64, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 50554; Mature: 50423

Theoretical pI: Translated: 10.04; Mature: 10.04

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRPAAPTPSESSLTVMLWVVATGFFMQTLDATIVNTALPSMAASLGESPLRMQSVVIAY
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
SLTMAVMIPVSGWLADTLGTRRVFFSAILIFSASSLLCASSHTLPQLVASRVAQGVGGAM
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEE
LLPVGRLAVLRTFPAERYLPALSFVAIPGLIGPLIGPTLGGWLVKIASWHWIFLINVPVG
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEECCHH
VAGCLATFYSMPDSRNPAAGRFDLKGYLLLTVGMVAVSLSLDGLADLGMDHAAVLVLMIL
HHHHHHHHHCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHCHHHHCCCHHHHHHHHHHH
GLASFVAYGLYAVRAPSPIFSLELFRIHTFSVGLLGNLFARIGSGAMPYLVPLLLQVSLG
HHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCC
YSAFEAGLMMLPVAVVGMFSKRLITHLIQRHGYRQVLLVNTVMVGLLMASFALMRDNVPV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHH
WVQVLQLAVFGGFNSMQFTAMNTLTLKDLGTGGASSGNSLFSLVQMLSMSLGVTVAGALL
HHHHHHHHHHCCCCCEEEEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
TTFTGVIRSVTPTHTLPAFHATFFCVGIITAGSAWIFAQLAPDVRASTKKTDPSERT
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCHHCCCCCCCCCCCC
>Mature Secondary Structure 
SRPAAPTPSESSLTVMLWVVATGFFMQTLDATIVNTALPSMAASLGESPLRMQSVVIAY
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
SLTMAVMIPVSGWLADTLGTRRVFFSAILIFSASSLLCASSHTLPQLVASRVAQGVGGAM
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEE
LLPVGRLAVLRTFPAERYLPALSFVAIPGLIGPLIGPTLGGWLVKIASWHWIFLINVPVG
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEECCHH
VAGCLATFYSMPDSRNPAAGRFDLKGYLLLTVGMVAVSLSLDGLADLGMDHAAVLVLMIL
HHHHHHHHHCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHCHHHHCCCHHHHHHHHHHH
GLASFVAYGLYAVRAPSPIFSLELFRIHTFSVGLLGNLFARIGSGAMPYLVPLLLQVSLG
HHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCC
YSAFEAGLMMLPVAVVGMFSKRLITHLIQRHGYRQVLLVNTVMVGLLMASFALMRDNVPV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHH
WVQVLQLAVFGGFNSMQFTAMNTLTLKDLGTGGASSGNSLFSLVQMLSMSLGVTVAGALL
HHHHHHHHHHCCCCCEEEEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
TTFTGVIRSVTPTHTLPAFHATFFCVGIITAGSAWIFAQLAPDVRASTKKTDPSERT
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA