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The map label for this gene is acsA [H]

Identifier: 238028085

GI number: 238028085

Start: 2895066

End: 2897048

Strand: Reverse

Name: acsA [H]

Synonym: bglu_1g25360

Alternate gene names: 238028085

Gene position: 2897048-2895066 (Counterclockwise)

Preceding gene: 238028095

Following gene: 238028084

Centisome position: 74.16

GC content: 68.58

Gene sequence:

>1983_bases
ATGTCTGCGATTGAATCGGTTCTGCACGAACGCCGTCAGTTTGCTCCGCCCGCCAGCGTCGAACAGGCGGCCAATATTTC
CGGCATGGACGCGTACCGCGCGCTGGTGGACGAGGCCGGCCGCGATTACGAAGGCTTCTGGGCGCGTCTCGCGCGCGAGT
CGCTCGATTGGCACAAGCCGTTCTCGAGCGTGCTCGACGAGTCGAACGCGCCGTTCTACAAGTGGTTCGAGGACGGCGAG
CTGAACGCCTCCTACAACTGCCTCGACCGCCACGTGGCCGCCGGCCGCGGCGAGCGTGTCGCCGTGATCTTCGAGGCCGA
CGACGGCACCGTCACGCGCGTCACCTATGCCGAACTGCTGGCGCGCGTGTGCCGCCTCGCCAACGCGCTGAAGGCGCGCG
GCATCGGCCGTGGCGACCGCGTCATCATCTACATCCCGATGTCGATCGAGGGCATCGTCGCGATGCAGGCCTGCGCGCGG
ATCGGCGCGACGCACTCGGTGGTGTTCGGCGGCTTCTCGGCGAAGTCGCTCAACGAGCGGCTGGTGGACGTGGGCGCCTG
CGCGCTGATCACGGCCGACGAGCAGGTGCGCGGCGGCAAGACCCTGCCGATCAAGAGCATCGCCGACGACGCGATCGCGA
TGGGCGGCTGCGAGGCCGTGAAGAGCGTGATCGTCTACCGCCGCACCGGCGGCGAGGTCGCCTGGCACGAGGGCCGCGAC
CTGTGGCTCGACGAGATCACGGCGAACCAGCCCGATACCTGCGAGCCCGAATGGGTCGGCGCCGAGCATCCGCTCTTCAT
CCTCTACACCTCGGGTTCGACCGGCAAGCCGAAGGGATTGCAGCACAGCACCGGCGGTTACCTGCTGTGGGCCGCGCTGA
CGATGGACTGGACCTTCGACCGCAAGCCCGACGACGTGTTCTGGTGTACCGCCGACATCGGCTGGATCACGGGCCACACC
TACATCACCTACGGGCCGCTCGCGACCTGCTCGACGCAGGTGGTGTTCGAGGGCGTGCCGACCTATCCGAACGCGGGCCG
CTTCTGGAAGATGGTGGCCGACCACAAGGTCACCGTGTTCTACACGGCGCCCACCGCGATCCGCTCGCTGATCAAGGCAT
CGGGCGCCGACGAGGCGGCCCATCCGTCGCGCTACGACCTGTCGAGCCTGCGCATCATCGGCACGGTCGGCGAGCCGATC
AATCCGGAATCGTGGATGTGGTACCACAAGAACGTCGGCGGCGAACGCTGCCCGATCGTCGATACCTGGTTCCAGACCGA
GACGGGCGGCCACATGATCACGCCGCTGCCGGGCGCCACGCCGACCGTGCCCGGCTCCTGCACGCTCGGGCTGCCGGGCA
TCATGGCGGCGGTGGTCGACGAGACCGGCCAGGACGTGCCGAACGGGCAGGGCGGCATCCTCGTGATCAAGCGGCCGTGG
CCGGCGATGGCCCGCACCATCTGGGGCGATCCCGACCGGTTCCGCAAGAGCTACTTCCCCGACGAGCTGGGCGGGCGGCT
CTACCTGGCCGGCGACGGCACGGTGCGTGACAAGGACACCGGCTACTTCACCATCATGGGCCGCATCGACGACGTGCTGA
ACGTGTCGGGGCACCGGCTCGGCACGATGGAGATCGAGTCGGCGCTGGTCTCGCACGAGCTGGTGGCCGAGGCGGCCGTG
GTGGGCCGCCCCGACGACATGACGGGCGAGGCGGTGGTGGCGTTCGTGGTGCTCAAGCGCACCCGCCCGGAAGGCGAGGA
GGCGCAGCAGATCGCGAAGATGCTGCGCGACTGGGTGGGCAAGGAGATCGGCCCGATCGCCAAGCCGAAGGACATCCGCT
TCGGCGACAACCTGCCCAAGACGCGCTCCGGCAAGATCATGCGGCGCCTGCTGCGCTCGTTGGCCAAGGGCGAGGCGGTC
ACGCAGGATACCTCGACGCTGGAGAATCCCGCGATCCTCGAGCAGCTCGCCGAAGCGCGCTGA

Upstream 100 bases:

>100_bases
GGTTTCAGGAGGCACGGCGCGCGAGCTTCGTCGCGCCGTGTGCGGTGCGCGGTGCGCGCGCCGTCATGCAGTGGGTTTCA
CCTTCATCAAGGGGTAGTCG

Downstream 100 bases:

>100_bases
GCGGGCGGCGCGGCCCGCCCGGCAAGCGCCCCTGCGCGGCAATCCCGATTGCCCGCGCGGGGGCATTTTTGTTAGATAAG
CGAATGCCCGCCCCCACACG

Product: acetate--CoA ligase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 660; Mature: 659

Protein sequence:

>660_residues
MSAIESVLHERRQFAPPASVEQAANISGMDAYRALVDEAGRDYEGFWARLARESLDWHKPFSSVLDESNAPFYKWFEDGE
LNASYNCLDRHVAAGRGERVAVIFEADDGTVTRVTYAELLARVCRLANALKARGIGRGDRVIIYIPMSIEGIVAMQACAR
IGATHSVVFGGFSAKSLNERLVDVGACALITADEQVRGGKTLPIKSIADDAIAMGGCEAVKSVIVYRRTGGEVAWHEGRD
LWLDEITANQPDTCEPEWVGAEHPLFILYTSGSTGKPKGLQHSTGGYLLWAALTMDWTFDRKPDDVFWCTADIGWITGHT
YITYGPLATCSTQVVFEGVPTYPNAGRFWKMVADHKVTVFYTAPTAIRSLIKASGADEAAHPSRYDLSSLRIIGTVGEPI
NPESWMWYHKNVGGERCPIVDTWFQTETGGHMITPLPGATPTVPGSCTLGLPGIMAAVVDETGQDVPNGQGGILVIKRPW
PAMARTIWGDPDRFRKSYFPDELGGRLYLAGDGTVRDKDTGYFTIMGRIDDVLNVSGHRLGTMEIESALVSHELVAEAAV
VGRPDDMTGEAVVAFVVLKRTRPEGEEAQQIAKMLRDWVGKEIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRSLAKGEAV
TQDTSTLENPAILEQLAEAR

Sequences:

>Translated_660_residues
MSAIESVLHERRQFAPPASVEQAANISGMDAYRALVDEAGRDYEGFWARLARESLDWHKPFSSVLDESNAPFYKWFEDGE
LNASYNCLDRHVAAGRGERVAVIFEADDGTVTRVTYAELLARVCRLANALKARGIGRGDRVIIYIPMSIEGIVAMQACAR
IGATHSVVFGGFSAKSLNERLVDVGACALITADEQVRGGKTLPIKSIADDAIAMGGCEAVKSVIVYRRTGGEVAWHEGRD
LWLDEITANQPDTCEPEWVGAEHPLFILYTSGSTGKPKGLQHSTGGYLLWAALTMDWTFDRKPDDVFWCTADIGWITGHT
YITYGPLATCSTQVVFEGVPTYPNAGRFWKMVADHKVTVFYTAPTAIRSLIKASGADEAAHPSRYDLSSLRIIGTVGEPI
NPESWMWYHKNVGGERCPIVDTWFQTETGGHMITPLPGATPTVPGSCTLGLPGIMAAVVDETGQDVPNGQGGILVIKRPW
PAMARTIWGDPDRFRKSYFPDELGGRLYLAGDGTVRDKDTGYFTIMGRIDDVLNVSGHRLGTMEIESALVSHELVAEAAV
VGRPDDMTGEAVVAFVVLKRTRPEGEEAQQIAKMLRDWVGKEIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRSLAKGEAV
TQDTSTLENPAILEQLAEAR
>Mature_659_residues
SAIESVLHERRQFAPPASVEQAANISGMDAYRALVDEAGRDYEGFWARLARESLDWHKPFSSVLDESNAPFYKWFEDGEL
NASYNCLDRHVAAGRGERVAVIFEADDGTVTRVTYAELLARVCRLANALKARGIGRGDRVIIYIPMSIEGIVAMQACARI
GATHSVVFGGFSAKSLNERLVDVGACALITADEQVRGGKTLPIKSIADDAIAMGGCEAVKSVIVYRRTGGEVAWHEGRDL
WLDEITANQPDTCEPEWVGAEHPLFILYTSGSTGKPKGLQHSTGGYLLWAALTMDWTFDRKPDDVFWCTADIGWITGHTY
ITYGPLATCSTQVVFEGVPTYPNAGRFWKMVADHKVTVFYTAPTAIRSLIKASGADEAAHPSRYDLSSLRIIGTVGEPIN
PESWMWYHKNVGGERCPIVDTWFQTETGGHMITPLPGATPTVPGSCTLGLPGIMAAVVDETGQDVPNGQGGILVIKRPWP
AMARTIWGDPDRFRKSYFPDELGGRLYLAGDGTVRDKDTGYFTIMGRIDDVLNVSGHRLGTMEIESALVSHELVAEAAVV
GRPDDMTGEAVVAFVVLKRTRPEGEEAQQIAKMLRDWVGKEIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRSLAKGEAVT
QDTSTLENPAILEQLAEAR

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI8923896, Length=684, Percent_Identity=46.0526315789474, Blast_Score=592, Evalue=1e-169,
Organism=Homo sapiens, GI253970489, Length=697, Percent_Identity=45.19368723099, Blast_Score=587, Evalue=1e-167,
Organism=Homo sapiens, GI28416953, Length=633, Percent_Identity=46.9194312796209, Blast_Score=540, Evalue=1e-153,
Organism=Homo sapiens, GI13375727, Length=635, Percent_Identity=36.3779527559055, Blast_Score=394, Evalue=1e-109,
Organism=Homo sapiens, GI42544132, Length=551, Percent_Identity=29.4010889292196, Blast_Score=180, Evalue=3e-45,
Organism=Homo sapiens, GI31982927, Length=651, Percent_Identity=26.2672811059908, Blast_Score=173, Evalue=5e-43,
Organism=Homo sapiens, GI122937307, Length=581, Percent_Identity=28.0550774526678, Blast_Score=173, Evalue=6e-43,
Organism=Homo sapiens, GI38505220, Length=546, Percent_Identity=28.9377289377289, Blast_Score=170, Evalue=5e-42,
Organism=Homo sapiens, GI58082049, Length=528, Percent_Identity=28.7878787878788, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI115511026, Length=598, Percent_Identity=27.0903010033445, Blast_Score=148, Evalue=2e-35,
Organism=Homo sapiens, GI157311624, Length=530, Percent_Identity=28.1132075471698, Blast_Score=147, Evalue=4e-35,
Organism=Homo sapiens, GI157311622, Length=530, Percent_Identity=28.1132075471698, Blast_Score=147, Evalue=4e-35,
Organism=Homo sapiens, GI187761345, Length=399, Percent_Identity=25.31328320802, Blast_Score=89, Evalue=2e-17,
Organism=Homo sapiens, GI187761343, Length=399, Percent_Identity=25.31328320802, Blast_Score=89, Evalue=2e-17,
Organism=Homo sapiens, GI42544134, Length=318, Percent_Identity=26.1006289308176, Blast_Score=84, Evalue=4e-16,
Organism=Escherichia coli, GI1790505, Length=635, Percent_Identity=50.3937007874016, Blast_Score=625, Evalue=1e-180,
Organism=Escherichia coli, GI1786529, Length=625, Percent_Identity=38.4, Blast_Score=389, Evalue=1e-109,
Organism=Escherichia coli, GI221142682, Length=556, Percent_Identity=24.1007194244604, Blast_Score=110, Evalue=3e-25,
Organism=Escherichia coli, GI1788107, Length=563, Percent_Identity=24.866785079929, Blast_Score=99, Evalue=1e-21,
Organism=Escherichia coli, GI145693145, Length=550, Percent_Identity=23.8181818181818, Blast_Score=90, Evalue=5e-19,
Organism=Escherichia coli, GI1786810, Length=559, Percent_Identity=22.7191413237925, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71982997, Length=671, Percent_Identity=44.1132637853949, Blast_Score=494, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI71983001, Length=667, Percent_Identity=44.2278860569715, Blast_Score=494, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI17569507, Length=671, Percent_Identity=24.2921013412817, Blast_Score=157, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17558820, Length=540, Percent_Identity=23.5185185185185, Blast_Score=93, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI71985884, Length=402, Percent_Identity=25.1243781094527, Blast_Score=86, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI71994690, Length=575, Percent_Identity=23.6521739130435, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71994694, Length=575, Percent_Identity=23.6521739130435, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71994703, Length=575, Percent_Identity=23.6521739130435, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17559526, Length=564, Percent_Identity=23.758865248227, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17538037, Length=142, Percent_Identity=31.6901408450704, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17557194, Length=152, Percent_Identity=31.5789473684211, Blast_Score=66, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6323182, Length=649, Percent_Identity=47.3035439137134, Blast_Score=566, Evalue=1e-162,
Organism=Saccharomyces cerevisiae, GI6319264, Length=666, Percent_Identity=46.3963963963964, Blast_Score=551, Evalue=1e-157,
Organism=Saccharomyces cerevisiae, GI6319699, Length=555, Percent_Identity=23.4234234234234, Blast_Score=100, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24667955, Length=675, Percent_Identity=45.1851851851852, Blast_Score=568, Evalue=1e-162,
Organism=Drosophila melanogaster, GI62472339, Length=562, Percent_Identity=48.7544483985765, Blast_Score=525, Evalue=1e-149,
Organism=Drosophila melanogaster, GI24667959, Length=531, Percent_Identity=48.0225988700565, Blast_Score=485, Evalue=1e-137,
Organism=Drosophila melanogaster, GI21355225, Length=653, Percent_Identity=33.9969372128637, Blast_Score=349, Evalue=4e-96,
Organism=Drosophila melanogaster, GI21355181, Length=527, Percent_Identity=24.2884250474383, Blast_Score=103, Evalue=5e-22,
Organism=Drosophila melanogaster, GI19922652, Length=545, Percent_Identity=23.8532110091743, Blast_Score=77, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24581924, Length=206, Percent_Identity=33.0097087378641, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 72190; Mature: 72059

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAIESVLHERRQFAPPASVEQAANISGMDAYRALVDEAGRDYEGFWARLARESLDWHKP
CHHHHHHHHHHHHCCCCCCHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCHHCCC
FSSVLDESNAPFYKWFEDGELNASYNCLDRHVAAGRGERVAVIFEADDGTVTRVTYAELL
HHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCEEEEEHHHHH
ARVCRLANALKARGIGRGDRVIIYIPMSIEGIVAMQACARIGATHSVVFGGFSAKSLNER
HHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHH
LVDVGACALITADEQVRGGKTLPIKSIADDAIAMGGCEAVKSVIVYRRTGGEVAWHEGRD
HHHHCCEEEEECCHHHCCCCCCCHHHHCCHHHHHCCHHHHHHHEEEEECCCEEEEECCCC
LWLDEITANQPDTCEPEWVGAEHPLFILYTSGSTGKPKGLQHSTGGYLLWAALTMDWTFD
CCHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEEEEEECEECC
RKPDDVFWCTADIGWITGHTYITYGPLATCSTQVVFEGVPTYPNAGRFWKMVADHKVTVF
CCCCCEEEEECCCCEEECCCEEEECCCCCCCCEEEEECCCCCCCCCHHEEEECCCEEEEE
YTAPTAIRSLIKASGADEAAHPSRYDLSSLRIIGTVGEPINPESWMWYHKNVGGERCPIV
EECHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCCCEE
DTWFQTETGGHMITPLPGATPTVPGSCTLGLPGIMAAVVDETGQDVPNGQGGILVIKRPW
EECEECCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEECCC
PAMARTIWGDPDRFRKSYFPDELGGRLYLAGDGTVRDKDTGYFTIMGRIDDVLNVSGHRL
HHHHHHHCCCHHHHHHHCCCHHHCCEEEEECCCCCCCCCCCEEEEEECHHHHHCCCCCEE
GTMEIESALVSHELVAEAAVVGRPDDMTGEAVVAFVVLKRTRPEGEEAQQIAKMLRDWVG
EHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHC
KEIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRSLAKGEAVTQDTSTLENPAILEQLAEAR
CHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHCCCHHHHHHHHHCC
>Mature Secondary Structure 
SAIESVLHERRQFAPPASVEQAANISGMDAYRALVDEAGRDYEGFWARLARESLDWHKP
HHHHHHHHHHHHCCCCCCHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCHHCCC
FSSVLDESNAPFYKWFEDGELNASYNCLDRHVAAGRGERVAVIFEADDGTVTRVTYAELL
HHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCEEEEEHHHHH
ARVCRLANALKARGIGRGDRVIIYIPMSIEGIVAMQACARIGATHSVVFGGFSAKSLNER
HHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHH
LVDVGACALITADEQVRGGKTLPIKSIADDAIAMGGCEAVKSVIVYRRTGGEVAWHEGRD
HHHHCCEEEEECCHHHCCCCCCCHHHHCCHHHHHCCHHHHHHHEEEEECCCEEEEECCCC
LWLDEITANQPDTCEPEWVGAEHPLFILYTSGSTGKPKGLQHSTGGYLLWAALTMDWTFD
CCHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEEEEEECEECC
RKPDDVFWCTADIGWITGHTYITYGPLATCSTQVVFEGVPTYPNAGRFWKMVADHKVTVF
CCCCCEEEEECCCCEEECCCEEEECCCCCCCCEEEEECCCCCCCCCHHEEEECCCEEEEE
YTAPTAIRSLIKASGADEAAHPSRYDLSSLRIIGTVGEPINPESWMWYHKNVGGERCPIV
EECHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCCCEE
DTWFQTETGGHMITPLPGATPTVPGSCTLGLPGIMAAVVDETGQDVPNGQGGILVIKRPW
EECEECCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEECCC
PAMARTIWGDPDRFRKSYFPDELGGRLYLAGDGTVRDKDTGYFTIMGRIDDVLNVSGHRL
HHHHHHHCCCHHHHHHHCCCHHHCCEEEEECCCCCCCCCCCEEEEEECHHHHHCCCCCEE
GTMEIESALVSHELVAEAAVVGRPDDMTGEAVVAFVVLKRTRPEGEEAQQIAKMLRDWVG
EHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHC
KEIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRSLAKGEAVTQDTSTLENPAILEQLAEAR
CHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA