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The map label for this gene is bioA [C]

Identifier: 238028059

GI number: 238028059

Start: 2854739

End: 2856166

Strand: Reverse

Name: bioA [C]

Synonym: bglu_1g25100

Alternate gene names: 238028059

Gene position: 2856166-2854739 (Counterclockwise)

Preceding gene: 238028060

Following gene: 238028058

Centisome position: 73.11

GC content: 69.89

Gene sequence:

>1428_bases
ATGACGCAACGAATCGGCGAATCGGCCTACGTCCAGCCGGTGCGCGCACCGGCTGCGGCCGAGGCGCGCTCCACGGCCGA
GTATCGCGCGCTCGACGCCGCGCATCACCTGCACCCGTTCTCGGACATGGGCGCGCTCAATCGCGCCGGCAGCCGCGTGA
TCACCAGCGCGCACGGCGTCCATCTGCGCGATTCGGACGGCAACCGCATCATCGACGGGATGGCCGGGCTTTGGTGCGTG
AACGTCGGCTACGGCCGCGAGGAACTGATCGAGGCCGGCGCGCGGCAGCTGCGCGAGCTGCCGTTCTACAACACCTTCTT
CAAGACCACGCATCCGCCCGTGATCGAGCTGTCGGCGCTGCTCGCCGAGATCGCGCCGCCCGCCTTCAACCGCTTCTTCT
ATTGCAACAGCGGCTCGGAAGGCAACGACACGGTGCTGCGCGTCGTCTACCAGTACTGGCGCACGCAGGGGCAGCCGCAG
CGCAGGTACGTGATTTCGCGCCGCAACGGCTATCACGGCTCGACCATCGCGGGCGGCACGCTCGGCGGGATGGACTACAT
GCACGAGCAGATGCCGTCGAAGGTCGAGCACGTCGTGCATATCGACCAGCCGTACTTCTTCGGCGAGGCGCCCGCCGGCC
AGACGCCCGAGGCGTTCGCGCTCGAACGCGCGCGGCAGCTGGAGGCGAAGATCCTCGAACTCGGCGCCGACAACGTGGCC
GCGTTCATCGGCGAGCCGTTCCAGGGCGCGGGCGGCGTGATCTTTCCCGACGCGGCCTACTGGCCCGAGATCGAGCGGAT
CTGCCGCAAGTACGACGTGCTGCTGGTGGCCGACGAGGTGATCGGCGGCTTCGGCCGCACGGGCGAATGGTTCTCGCACC
AGCACTTCGGCTTCACGCCCGACCTGATGACGCTGGCCAAGGGGCTCACCAGCGGCTATGTGCCGATGGGCGCCGTGGCG
CTGTCCGATCGCATCGCCGACGCGCTGATCGCGCACGGCGAGTTCAACCACGGCATGACGTATTCGGGGCACCCGGTGGC
GGCGGCCGTCGCGGTGGCGAACCTCCGGGTGCTGCGCGAGGGCGGCGTGGTCGAGCGCGTGAAGCGCGAGATCGGGCCGT
ATTTCCAGCGGCGCCTGCGCGAGGCGCTGGCGGGCAGCCCGATCGTCGGCGAGGTGGCGGGCGCCGGGCTCGTGGCCGGC
ATCCAGCTCGCCCAGGATCCGGCCGCGCGGCGCCGCTTTGCCAACGGCGGCGAGGTCGGCACGATCTGCCGCGACTACTG
TTTCAACGGCAACCTCATCATGCGCGCCACCGGCGACCGCATGCTGCTGTCGCCGCCGCTCGTGGTGACGCAGCAGGACG
TCGACGAGATCGTCGACAAGGCGGCCCGGGCGATCGCCTCGACCGCGCGACAGATCGACGCCGCATGA

Upstream 100 bases:

>100_bases
TCTTCCGCGTGATCAGCTCGTGGGAGCGGCGCCATCTGCTGCTGCACGTGTGACGAAACCCGAACCCGCGGCGCTCGCGC
CGCCCCACGGAGGACTCATC

Downstream 100 bases:

>100_bases
GGTGGCGCTGCACGGCGCGCGGTCGAGCGCGCTCTTGATCGCGCACCGCGCGGCGCGGCCAGGCGCTCGGCCGGGCCGCG
GGCTAGGGTGCCGGCCTTCC

Product: putative aminotransferase

Products: S-Adenosyl-4-methylthio-2-oxobutanoate; 7,8-Diaminononanoate [C]

Alternate protein names: NA

Number of amino acids: Translated: 475; Mature: 474

Protein sequence:

>475_residues
MTQRIGESAYVQPVRAPAAAEARSTAEYRALDAAHHLHPFSDMGALNRAGSRVITSAHGVHLRDSDGNRIIDGMAGLWCV
NVGYGREELIEAGARQLRELPFYNTFFKTTHPPVIELSALLAEIAPPAFNRFFYCNSGSEGNDTVLRVVYQYWRTQGQPQ
RRYVISRRNGYHGSTIAGGTLGGMDYMHEQMPSKVEHVVHIDQPYFFGEAPAGQTPEAFALERARQLEAKILELGADNVA
AFIGEPFQGAGGVIFPDAAYWPEIERICRKYDVLLVADEVIGGFGRTGEWFSHQHFGFTPDLMTLAKGLTSGYVPMGAVA
LSDRIADALIAHGEFNHGMTYSGHPVAAAVAVANLRVLREGGVVERVKREIGPYFQRRLREALAGSPIVGEVAGAGLVAG
IQLAQDPAARRRFANGGEVGTICRDYCFNGNLIMRATGDRMLLSPPLVVTQQDVDEIVDKAARAIASTARQIDAA

Sequences:

>Translated_475_residues
MTQRIGESAYVQPVRAPAAAEARSTAEYRALDAAHHLHPFSDMGALNRAGSRVITSAHGVHLRDSDGNRIIDGMAGLWCV
NVGYGREELIEAGARQLRELPFYNTFFKTTHPPVIELSALLAEIAPPAFNRFFYCNSGSEGNDTVLRVVYQYWRTQGQPQ
RRYVISRRNGYHGSTIAGGTLGGMDYMHEQMPSKVEHVVHIDQPYFFGEAPAGQTPEAFALERARQLEAKILELGADNVA
AFIGEPFQGAGGVIFPDAAYWPEIERICRKYDVLLVADEVIGGFGRTGEWFSHQHFGFTPDLMTLAKGLTSGYVPMGAVA
LSDRIADALIAHGEFNHGMTYSGHPVAAAVAVANLRVLREGGVVERVKREIGPYFQRRLREALAGSPIVGEVAGAGLVAG
IQLAQDPAARRRFANGGEVGTICRDYCFNGNLIMRATGDRMLLSPPLVVTQQDVDEIVDKAARAIASTARQIDAA
>Mature_474_residues
TQRIGESAYVQPVRAPAAAEARSTAEYRALDAAHHLHPFSDMGALNRAGSRVITSAHGVHLRDSDGNRIIDGMAGLWCVN
VGYGREELIEAGARQLRELPFYNTFFKTTHPPVIELSALLAEIAPPAFNRFFYCNSGSEGNDTVLRVVYQYWRTQGQPQR
RYVISRRNGYHGSTIAGGTLGGMDYMHEQMPSKVEHVVHIDQPYFFGEAPAGQTPEAFALERARQLEAKILELGADNVAA
FIGEPFQGAGGVIFPDAAYWPEIERICRKYDVLLVADEVIGGFGRTGEWFSHQHFGFTPDLMTLAKGLTSGYVPMGAVAL
SDRIADALIAHGEFNHGMTYSGHPVAAAVAVANLRVLREGGVVERVKREIGPYFQRRLREALAGSPIVGEVAGAGLVAGI
QLAQDPAARRRFANGGEVGTICRDYCFNGNLIMRATGDRMLLSPPLVVTQQDVDEIVDKAARAIASTARQIDAA

Specific function: Biotin biosynthesis. [C]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI13994255, Length=426, Percent_Identity=27.2300469483568, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI4557809, Length=467, Percent_Identity=25.9100642398287, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI37574042, Length=448, Percent_Identity=26.7857142857143, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI226442705, Length=445, Percent_Identity=26.9662921348315, Blast_Score=129, Evalue=8e-30,
Organism=Homo sapiens, GI226442709, Length=401, Percent_Identity=27.1820448877805, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI24119277, Length=360, Percent_Identity=28.3333333333333, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI284507298, Length=248, Percent_Identity=32.6612903225806, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI188536080, Length=286, Percent_Identity=25.1748251748252, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI38679950, Length=286, Percent_Identity=25.1748251748252, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI38679946, Length=286, Percent_Identity=25.1748251748252, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1786991, Length=451, Percent_Identity=29.0465631929047, Blast_Score=158, Evalue=9e-40,
Organism=Escherichia coli, GI1788044, Length=409, Percent_Identity=28.6063569682152, Blast_Score=151, Evalue=7e-38,
Organism=Escherichia coli, GI145693181, Length=418, Percent_Identity=25.5980861244019, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1789759, Length=415, Percent_Identity=27.2289156626506, Blast_Score=139, Evalue=5e-34,
Organism=Escherichia coli, GI1787560, Length=362, Percent_Identity=29.8342541436464, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1789016, Length=355, Percent_Identity=24.5070422535211, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1786349, Length=346, Percent_Identity=25.7225433526012, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI32564660, Length=444, Percent_Identity=30.4054054054054, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI25144271, Length=425, Percent_Identity=26.1176470588235, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI25144274, Length=234, Percent_Identity=33.7606837606838, Blast_Score=134, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI71992977, Length=442, Percent_Identity=26.6968325791855, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17541228, Length=508, Percent_Identity=22.6377952755905, Blast_Score=87, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323470, Length=455, Percent_Identity=28.1318681318681, Blast_Score=158, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6324386, Length=475, Percent_Identity=27.7894736842105, Blast_Score=154, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6324432, Length=410, Percent_Identity=24.6341463414634, Blast_Score=120, Evalue=3e-28,
Organism=Drosophila melanogaster, GI28574759, Length=438, Percent_Identity=28.9954337899543, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI161085790, Length=425, Percent_Identity=28.7058823529412, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI21357415, Length=461, Percent_Identity=26.8980477223427, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI21356575, Length=371, Percent_Identity=29.3800539083558, Blast_Score=131, Evalue=8e-31,
Organism=Drosophila melanogaster, GI281366494, Length=296, Percent_Identity=22.972972972973, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24667139, Length=296, Percent_Identity=22.972972972973, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24667143, Length=296, Percent_Identity=22.972972972973, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: 2.6.1.62 [C]

Molecular weight: Translated: 51695; Mature: 51564

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQRIGESAYVQPVRAPAAAEARSTAEYRALDAAHHLHPFSDMGALNRAGSRVITSAHGV
CCCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEECCCCE
HLRDSDGNRIIDGMAGLWCVNVGYGREELIEAGARQLRELPFYNTFFKTTHPPVIELSAL
EEECCCCCEEHHCCCCEEEEECCCCHHHHHHHHHHHHHHCCCHHHHHCCCCCCHHHHHHH
LAEIAPPAFNRFFYCNSGSEGNDTVLRVVYQYWRTQGQPQRRYVISRRNGYHGSTIAGGT
HHHHCCCHHCCEEEECCCCCCCHHHHHHHHHHHHCCCCCHHHEEEECCCCCCCCCCCCCC
LGGMDYMHEQMPSKVEHVVHIDQPYFFGEAPAGQTPEAFALERARQLEAKILELGADNVA
CCHHHHHHHHHHHHHHHHEECCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHH
AFIGEPFQGAGGVIFPDAAYWPEIERICRKYDVLLVADEVIGGFGRTGEWFSHQHFGFTP
HHHCCCCCCCCCEECCCCCCCHHHHHHHHHHCEEEEEHHHHCCCCCCCCCCCCCCCCCCH
DLMTLAKGLTSGYVPMGAVALSDRIADALIAHGEFNHGMTYSGHPVAAAVAVANLRVLRE
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHC
GGVVERVKREIGPYFQRRLREALAGSPIVGEVAGAGLVAGIQLAQDPAARRRFANGGEVG
CCHHHHHHHHHCHHHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHCCHHHHHHCCCCCCHH
TICRDYCFNGNLIMRATGDRMLLSPPLVVTQQDVDEIVDKAARAIASTARQIDAA
HHHHHHHCCCCEEEEECCCEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TQRIGESAYVQPVRAPAAAEARSTAEYRALDAAHHLHPFSDMGALNRAGSRVITSAHGV
CCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEECCCCE
HLRDSDGNRIIDGMAGLWCVNVGYGREELIEAGARQLRELPFYNTFFKTTHPPVIELSAL
EEECCCCCEEHHCCCCEEEEECCCCHHHHHHHHHHHHHHCCCHHHHHCCCCCCHHHHHHH
LAEIAPPAFNRFFYCNSGSEGNDTVLRVVYQYWRTQGQPQRRYVISRRNGYHGSTIAGGT
HHHHCCCHHCCEEEECCCCCCCHHHHHHHHHHHHCCCCCHHHEEEECCCCCCCCCCCCCC
LGGMDYMHEQMPSKVEHVVHIDQPYFFGEAPAGQTPEAFALERARQLEAKILELGADNVA
CCHHHHHHHHHHHHHHHHEECCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHH
AFIGEPFQGAGGVIFPDAAYWPEIERICRKYDVLLVADEVIGGFGRTGEWFSHQHFGFTP
HHHCCCCCCCCCEECCCCCCCHHHHHHHHHHCEEEEEHHHHCCCCCCCCCCCCCCCCCCH
DLMTLAKGLTSGYVPMGAVALSDRIADALIAHGEFNHGMTYSGHPVAAAVAVANLRVLRE
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHC
GGVVERVKREIGPYFQRRLREALAGSPIVGEVAGAGLVAGIQLAQDPAARRRFANGGEVG
CCHHHHHHHHHCHHHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHCCHHHHHHCCCCCCHH
TICRDYCFNGNLIMRATGDRMLLSPPLVVTQQDVDEIVDKAARAIASTARQIDAA
HHHHHHHCCCCEEEEECCCEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Pyridoxal Phosphate. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 8-Amino-7-oxononanoate; S-Adenosyl-L-methionine [C]

Specific reaction: 8-Amino-7-oxononanoate + S-Adenosyl-L-methionine <==> S-Adenosyl-4-methylthio-2-oxobutanoate + 7,8-Diaminononanoate [C]

General reaction: Amino group transfer [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8796346; 9163424 [H]