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The map label for this gene is folD [H]

Identifier: 238028034

GI number: 238028034

Start: 2822978

End: 2823838

Strand: Direct

Name: folD [H]

Synonym: bglu_1g24840

Alternate gene names: 238028034

Gene position: 2822978-2823838 (Clockwise)

Preceding gene: 238028033

Following gene: 238028035

Centisome position: 72.26

GC content: 69.34

Gene sequence:

>861_bases
ATGACAGCCACCCTGATCGACGGCAACGCCCTTTCGAAGACCCTGCGCGCGCAAGCCGCCGAACGCGCCGCGGCGCTCAC
CGCGCGCGGCCATCGTCCCGGCCTCGCGGTCGTGCTGGTCGGCGACAACGCGGCCAGCGAGGTCTACGTGCGCAACAAGA
TCAAGGCCTGCGAGGACCACGGCTTCTTCTCGCTCAAGGACGCCTACCCGGCGACGCTGTCGGAGGCCGATCTGCTCGCG
CGCATCGGCGAACTGAACCGCGACCCGCGGATCCACGGCATCCTCGTGCAACTGCCGCTGCCGCCGCACATCGACAGCCA
CAAGGTGATCGAGGCGATCGCTCCCGAGAAGGACGTGGACGGCTTTCACGTCGCGAACGCCGGCGCGCTGATGACGGGCA
AGCCGCTGTTCCGCCCCTGCACGCCCTACGGCGTGATGAAGATGTTCGAGGCGCACGGTATCGAGCTGGCCGGCGCGAAC
GCGGTGGTGATCGGCCGCTCGAACATCGTCGGCAAGCCGATGGCGATGCTGCTGCTCGAGGCCGGCGCGACGGTCACGAT
CTGCCATAGCAGGACGCGCGATCTGGCCGCCCACACGCGCAACGCCGACGTGGTGGTGGCCGCGGTCGGCAAGCGCAACG
TGCTGACGGCCGAGATGGTCAAGCCCGGCGCGACCGTGATCGACGTCGGCATGAACCGCAACGACGAAGGCAAGCTGTGC
GGCGACATCGATTTCGACGCGATCCGCGAGGTGGCCGGCTTCGTCACGCCGGTGCCGGGCGGCGTCGGCCCGATGACGAT
CACGATGCTGCTGATCAACACCATCGAGGCCGCCGAGCGCGCGGCCGGCGCGGCGGCCTGA

Upstream 100 bases:

>100_bases
GTCGGATGCCGACAAGCGATGGGTATAATTCCGTGCTTTGTTGCGGCGGTGTTCCGCCCACCGCCCGCGCCGGCCTCCCC
CATTCGGATCGAATCCCACC

Downstream 100 bases:

>100_bases
GCCCGGCCGCGCGGGCCCGGTCGCGGCCTCGCCGCGCCAGGCGCGCCCGGCCCGCGCCGGCTTCCCCGCTCGGTCCCCCT
ACCGTTTTTCCATCCCGCCA

Product: bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase

Products: NA

Alternate protein names: Methylenetetrahydrofolate dehydrogenase; Methenyltetrahydrofolate cyclohydrolase [H]

Number of amino acids: Translated: 286; Mature: 285

Protein sequence:

>286_residues
MTATLIDGNALSKTLRAQAAERAAALTARGHRPGLAVVLVGDNAASEVYVRNKIKACEDHGFFSLKDAYPATLSEADLLA
RIGELNRDPRIHGILVQLPLPPHIDSHKVIEAIAPEKDVDGFHVANAGALMTGKPLFRPCTPYGVMKMFEAHGIELAGAN
AVVIGRSNIVGKPMAMLLLEAGATVTICHSRTRDLAAHTRNADVVVAAVGKRNVLTAEMVKPGATVIDVGMNRNDEGKLC
GDIDFDAIREVAGFVTPVPGGVGPMTITMLLINTIEAAERAAGAAA

Sequences:

>Translated_286_residues
MTATLIDGNALSKTLRAQAAERAAALTARGHRPGLAVVLVGDNAASEVYVRNKIKACEDHGFFSLKDAYPATLSEADLLA
RIGELNRDPRIHGILVQLPLPPHIDSHKVIEAIAPEKDVDGFHVANAGALMTGKPLFRPCTPYGVMKMFEAHGIELAGAN
AVVIGRSNIVGKPMAMLLLEAGATVTICHSRTRDLAAHTRNADVVVAAVGKRNVLTAEMVKPGATVIDVGMNRNDEGKLC
GDIDFDAIREVAGFVTPVPGGVGPMTITMLLINTIEAAERAAGAAA
>Mature_285_residues
TATLIDGNALSKTLRAQAAERAAALTARGHRPGLAVVLVGDNAASEVYVRNKIKACEDHGFFSLKDAYPATLSEADLLAR
IGELNRDPRIHGILVQLPLPPHIDSHKVIEAIAPEKDVDGFHVANAGALMTGKPLFRPCTPYGVMKMFEAHGIELAGANA
VVIGRSNIVGKPMAMLLLEAGATVTICHSRTRDLAAHTRNADVVVAAVGKRNVLTAEMVKPGATVIDVGMNRNDEGKLCG
DIDFDAIREVAGFVTPVPGGVGPMTITMLLINTIEAAERAAGAAA

Specific function: Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate [H]

COG id: COG0190

COG function: function code H; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family [H]

Homologues:

Organism=Homo sapiens, GI222418558, Length=294, Percent_Identity=44.8979591836735, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI94721354, Length=294, Percent_Identity=45.578231292517, Blast_Score=230, Evalue=1e-60,
Organism=Homo sapiens, GI222136639, Length=290, Percent_Identity=42.0689655172414, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI36796743, Length=199, Percent_Identity=28.1407035175879, Blast_Score=83, Evalue=2e-16,
Organism=Escherichia coli, GI1786741, Length=279, Percent_Identity=51.2544802867383, Blast_Score=275, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI17568735, Length=295, Percent_Identity=41.3559322033898, Blast_Score=205, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6319558, Length=286, Percent_Identity=44.7552447552448, Blast_Score=256, Evalue=2e-69,
Organism=Saccharomyces cerevisiae, GI6321643, Length=300, Percent_Identity=39.6666666666667, Blast_Score=217, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6322933, Length=295, Percent_Identity=26.4406779661017, Blast_Score=79, Evalue=7e-16,
Organism=Drosophila melanogaster, GI17136818, Length=294, Percent_Identity=47.2789115646259, Blast_Score=252, Evalue=2e-67,
Organism=Drosophila melanogaster, GI17136816, Length=294, Percent_Identity=47.2789115646259, Blast_Score=252, Evalue=3e-67,
Organism=Drosophila melanogaster, GI62472483, Length=289, Percent_Identity=45.3287197231834, Blast_Score=251, Evalue=4e-67,
Organism=Drosophila melanogaster, GI45551871, Length=289, Percent_Identity=45.3287197231834, Blast_Score=251, Evalue=4e-67,
Organism=Drosophila melanogaster, GI24645718, Length=289, Percent_Identity=45.3287197231834, Blast_Score=251, Evalue=5e-67,
Organism=Drosophila melanogaster, GI17137370, Length=289, Percent_Identity=45.3287197231834, Blast_Score=251, Evalue=5e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR000672
- InterPro:   IPR020630
- InterPro:   IPR020867
- InterPro:   IPR020631 [H]

Pfam domain/function: PF00763 THF_DHG_CYH; PF02882 THF_DHG_CYH_C [H]

EC number: =1.5.1.5; =3.5.4.9 [H]

Molecular weight: Translated: 30004; Mature: 29873

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: PS00766 THF_DHG_CYH_1 ; PS00767 THF_DHG_CYH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATLIDGNALSKTLRAQAAERAAALTARGHRPGLAVVLVGDNAASEVYVRNKIKACEDH
CEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEEHHHHHHHHCC
GFFSLKDAYPATLSEADLLARIGELNRDPRIHGILVQLPLPPHIDSHKVIEAIAPEKDVD
CCEEECCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCHHHHHHHCCCCCCC
GFHVANAGALMTGKPLFRPCTPYGVMKMFEAHGIELAGANAVVIGRSNIVGKPMAMLLLE
CEEEECCCEEEECCCCCCCCCCHHHHHHHHHCCEEEECCCEEEEECCCCCCCHHHHHHHH
AGATVTICHSRTRDLAAHTRNADVVVAAVGKRNVLTAEMVKPGATVIDVGMNRNDEGKLC
CCCEEEEECCCCHHHHHHCCCCCEEEEECCCCCEEEHHHCCCCCEEEEECCCCCCCCCEE
GDIDFDAIREVAGFVTPVPGGVGPMTITMLLINTIEAAERAAGAAA
CCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TATLIDGNALSKTLRAQAAERAAALTARGHRPGLAVVLVGDNAASEVYVRNKIKACEDH
EEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEEHHHHHHHHCC
GFFSLKDAYPATLSEADLLARIGELNRDPRIHGILVQLPLPPHIDSHKVIEAIAPEKDVD
CCEEECCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCHHHHHHHCCCCCCC
GFHVANAGALMTGKPLFRPCTPYGVMKMFEAHGIELAGANAVVIGRSNIVGKPMAMLLLE
CEEEECCCEEEECCCCCCCCCCHHHHHHHHHCCEEEECCCEEEEECCCCCCCHHHHHHHH
AGATVTICHSRTRDLAAHTRNADVVVAAVGKRNVLTAEMVKPGATVIDVGMNRNDEGKLC
CCCEEEEECCCCHHHHHHCCCCCEEEEECCCCCEEEHHHCCCCCEEEEECCCCCCCCCEE
GDIDFDAIREVAGFVTPVPGGVGPMTITMLLINTIEAAERAAGAAA
CCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA