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The map label for this gene is iclR [H]

Identifier: 238027446

GI number: 238027446

Start: 2024130

End: 2024897

Strand: Direct

Name: iclR [H]

Synonym: bglu_1g18490

Alternate gene names: 238027446

Gene position: 2024130-2024897 (Clockwise)

Preceding gene: 238027444

Following gene: 238027451

Centisome position: 51.81

GC content: 72.01

Gene sequence:

>768_bases
ATGCCCGATCAAGCCGCCCAGCCCGACAAAGTCCATGACGTGCCCGCGATCGGCCGCGTCCACGACATCCTCGAGGCCTT
GAAGTCCACCCGCCGCCCGACCTCGGCGCGCGACCTGCTGGCGCTCACCGGCATGCCGCGCAGCACGCTCTACCTGACGC
TCGACGCGCTGGAACGCCGGCAGTGGATCGAGAAGATCGGCGACGGCTATGCGATCGGCGTCGCGCTGTTCGAGATCGGC
AGCACCTATCTGCTCGCCGACTTCACGCTCGACGCGTTCCGCCGCGAGGCGGCCTGGTTCGTGGCGAAGCACAACGAGGC
CGTGCAGATGGCGGTGCTCGACCGCGCCGAGGTGGTCTACCTCGCACGCGAGGACCCGTCGCGCGCGGTGCGGCTCGTCT
CCGACATCGGCTCGCGGCTGCCCGCGCATTGCTCGGCGCTCGGCAAGGCGCTGCTCGCGAGCCTGGCCGACGAAACCGTG
CAGATGCTGCTGCCGGCGCGGCTGCCTGCGCTGACCGAGCGCTCGGTGACGCGCCGCGCCGAGCTGATCGAGGCGCTGGC
CGGCGTGCGCGCGAGCGGCTACGCGATCGAGCGCGAGGAAGCCTGCACCGGGCTCGCGTGCCTGGCGGTGATGGTGGGCG
TGTCCTCGGTGGGCAAGCGGATCGCCGTGAGCACCAGCGTGCCGGTGGACCGGCTCGACGCGAAGCGCGAGACGCGGCTG
CTCGTCGATCTGACCACGCTCGCGCAGCGCGTGGCGCGCGGGCTGTGA

Upstream 100 bases:

>100_bases
GCGCGTCGTGCCGCCGTCCTGCCGGTTCGTGCCGACAGTTCGTGCTGACTCGTTGTCCCGCCGCCGTCGGCCTGCCCCGT
TCCTTCCACGAGCCGTCCCG

Downstream 100 bases:

>100_bases
GCGCCGCGCCGCGAGGCAGGAAGCCCAGGCGGGAGCACGGGCTTGCCGCCGCCGGGCAGCAGCGCCGCCCACCGCCTGCA
AGCCGGAATCATGAGCAGGC

Product: IclR-family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 255; Mature: 254

Protein sequence:

>255_residues
MPDQAAQPDKVHDVPAIGRVHDILEALKSTRRPTSARDLLALTGMPRSTLYLTLDALERRQWIEKIGDGYAIGVALFEIG
STYLLADFTLDAFRREAAWFVAKHNEAVQMAVLDRAEVVYLAREDPSRAVRLVSDIGSRLPAHCSALGKALLASLADETV
QMLLPARLPALTERSVTRRAELIEALAGVRASGYAIEREEACTGLACLAVMVGVSSVGKRIAVSTSVPVDRLDAKRETRL
LVDLTTLAQRVARGL

Sequences:

>Translated_255_residues
MPDQAAQPDKVHDVPAIGRVHDILEALKSTRRPTSARDLLALTGMPRSTLYLTLDALERRQWIEKIGDGYAIGVALFEIG
STYLLADFTLDAFRREAAWFVAKHNEAVQMAVLDRAEVVYLAREDPSRAVRLVSDIGSRLPAHCSALGKALLASLADETV
QMLLPARLPALTERSVTRRAELIEALAGVRASGYAIEREEACTGLACLAVMVGVSSVGKRIAVSTSVPVDRLDAKRETRL
LVDLTTLAQRVARGL
>Mature_254_residues
PDQAAQPDKVHDVPAIGRVHDILEALKSTRRPTSARDLLALTGMPRSTLYLTLDALERRQWIEKIGDGYAIGVALFEIGS
TYLLADFTLDAFRREAAWFVAKHNEAVQMAVLDRAEVVYLAREDPSRAVRLVSDIGSRLPAHCSALGKALLASLADETVQ
MLLPARLPALTERSVTRRAELIEALAGVRASGYAIEREEACTGLACLAVMVGVSSVGKRIAVSTSVPVDRLDAKRETRLL
VDLTTLAQRVARGL

Specific function: Regulation of the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase as well as isocitrate dehydrogenase kinase/phosphorylase. Glyoxylate disrupts the interaction with the promoter by favoring the inactive dimeric form. Pyr

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI87082359, Length=251, Percent_Identity=29.4820717131474, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1788131, Length=260, Percent_Identity=30.7692307692308, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1786715, Length=240, Percent_Identity=28.3333333333333, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1786468, Length=226, Percent_Identity=27.4336283185841, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1790752, Length=227, Percent_Identity=26.8722466960352, Blast_Score=64, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 27723; Mature: 27592

Theoretical pI: Translated: 8.07; Mature: 8.07

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDQAAQPDKVHDVPAIGRVHDILEALKSTRRPTSARDLLALTGMPRSTLYLTLDALERR
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCEEEEHHHHHHH
QWIEKIGDGYAIGVALFEIGSTYLLADFTLDAFRREAAWFVAKHNEAVQMAVLDRAEVVY
HHHHHHCCCHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHEEECCCHHHHHHHCCCEEEE
LAREDPSRAVRLVSDIGSRLPAHCSALGKALLASLADETVQMLLPARLPALTERSVTRRA
EECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
ELIEALAGVRASGYAIEREEACTGLACLAVMVGVSSVGKRIAVSTSVPVDRLDAKRETRL
HHHHHHHCCCCCCCEECHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHCCHHHHHH
LVDLTTLAQRVARGL
HHHHHHHHHHHHHCC
>Mature Secondary Structure 
PDQAAQPDKVHDVPAIGRVHDILEALKSTRRPTSARDLLALTGMPRSTLYLTLDALERR
CCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCEEEEHHHHHHH
QWIEKIGDGYAIGVALFEIGSTYLLADFTLDAFRREAAWFVAKHNEAVQMAVLDRAEVVY
HHHHHHCCCHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHEEECCCHHHHHHHCCCEEEE
LAREDPSRAVRLVSDIGSRLPAHCSALGKALLASLADETVQMLLPARLPALTERSVTRRA
EECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
ELIEALAGVRASGYAIEREEACTGLACLAVMVGVSSVGKRIAVSTSVPVDRLDAKRETRL
HHHHHHHCCCCCCCEECHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHCCHHHHHH
LVDLTTLAQRVARGL
HHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2185227; 1995431; 8265357; 9278503; 1995429 [H]