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The map label for this gene is metC [H]

Identifier: 238027209

GI number: 238027209

Start: 1744752

End: 1745933

Strand: Direct

Name: metC [H]

Synonym: bglu_1g15950

Alternate gene names: 238027209

Gene position: 1744752-1745933 (Clockwise)

Preceding gene: 238027208

Following gene: 238027212

Centisome position: 44.66

GC content: 70.81

Gene sequence:

>1182_bases
ATGACCGACACCACTCCGAAGCGCGCGCGCCAAACCCGCATCGTCCAGCCCGAAGCCGAACTGCCGCCTGGCTTCGCCTC
GTTCGTCACGCCGCTCACGCGCGCGTCCACCATCGTGTTCCCCGATCTCGCGACGATGCGCTCGCTCGACTGGCGCGAGG
ACGACCGCTGGCGCTACGGCCTGCATGCCACGCCGACCTCGCTCGAGCTCGCGCGCCAGATCGCCGTGATCGAGGGCGGC
GCGCATGCGCTGCTGCAGCCTTCGGGCCTCGCGGCGATCATGAACGTCTACTTCGGCTTCGTGAAGACGGGCGACGACGT
GCTGGTTCCGCACAACGTCTACAGCCCGAACGCCGACCTCGGCAACTGGCTCGCGCGCGACTACGGCATCTCGGTGCGCT
TCTACGATCCGCTCGTCGGCGCCGGCATCGCCGAGCTGATCCGCCCCGAAACCAAGCTGCTGTGGCTGGAGGCGCCCGGC
TCGGTCACCATGGAGGTGCCCGACGTCGCCGCGATCACGGCCGTGGCGCGCGCGCGCGGCGTGGTCACCGCGATCGACAA
CACCTACTCGGCGGGCCTCGCGTTCCAGCCGTTCGAGCATGGCGTCGACGTCTCGGTGCAGGCGCTCACGAAATACCAGT
CGGGCGGCAGCGACGTGCTGATGGGCGCGACCATCACGGCCGAGCAGGCGCTGCACGAGCGGCTCAAGCTCGCGCGGATG
CGCACCGGCATCGGCGTGTCGGCCGACGATTGCGCGCTCGTGCTGCGCGGCCTGCCGAGCCTGCGCGCGCGCTTCGAAGC
GCACAGCCGCGCCGCGCTCGGGCTAGCGAAGTGGCTGAAGGCGCGGCCCGAGATCGCGGCGGTGCTGCATCCGCAGTTGC
CCGACTGCCCGGGGCACGCGGCGTTCGTGCGCGACTTCACGGGCGCGGGCGGGCTGTTCTCGGTGGTGTTCGACGCGCGT
TACCGGCCCGGGCAGATCGACCGTTTCGTCGAGGCGCTCGAGCTGTTCGCGATCGGCTGGAGCTGGGGCGGCGCGCGCAG
TCTCGCGATGCCGTACGACGTGCCGTCGATGCGGCCGAACTGGCCGCATCGCGGCACGCTGGTGCGCTTCTACGTGGGGT
TGGAGGAAGAGGCGGACCTGCGCGCCGATATCGAGCGCGCGCTTGGCAGCACGCTAGCTTGA

Upstream 100 bases:

>100_bases
TCGACTGTATCGGGTCAAGCCGCGCGATTCGGGCTAGGCTGTGCGGATCGTTCGATTCGGCCTCGTTGCCGATTCACCCA
TCACGCACCCCGATTCCGCC

Downstream 100 bases:

>100_bases
GCGAGCCGGCGCAGCCGCGCCCGCGCGCCTGACTCGGGGCGAGGGCCGCGGCCCGTCGCCGCCCGGCGGCGTGGCGGCGC
GGCTGCGTTCATCAGCAGCA

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase; ORF5 [H]

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MTDTTPKRARQTRIVQPEAELPPGFASFVTPLTRASTIVFPDLATMRSLDWREDDRWRYGLHATPTSLELARQIAVIEGG
AHALLQPSGLAAIMNVYFGFVKTGDDVLVPHNVYSPNADLGNWLARDYGISVRFYDPLVGAGIAELIRPETKLLWLEAPG
SVTMEVPDVAAITAVARARGVVTAIDNTYSAGLAFQPFEHGVDVSVQALTKYQSGGSDVLMGATITAEQALHERLKLARM
RTGIGVSADDCALVLRGLPSLRARFEAHSRAALGLAKWLKARPEIAAVLHPQLPDCPGHAAFVRDFTGAGGLFSVVFDAR
YRPGQIDRFVEALELFAIGWSWGGARSLAMPYDVPSMRPNWPHRGTLVRFYVGLEEEADLRADIERALGSTLA

Sequences:

>Translated_393_residues
MTDTTPKRARQTRIVQPEAELPPGFASFVTPLTRASTIVFPDLATMRSLDWREDDRWRYGLHATPTSLELARQIAVIEGG
AHALLQPSGLAAIMNVYFGFVKTGDDVLVPHNVYSPNADLGNWLARDYGISVRFYDPLVGAGIAELIRPETKLLWLEAPG
SVTMEVPDVAAITAVARARGVVTAIDNTYSAGLAFQPFEHGVDVSVQALTKYQSGGSDVLMGATITAEQALHERLKLARM
RTGIGVSADDCALVLRGLPSLRARFEAHSRAALGLAKWLKARPEIAAVLHPQLPDCPGHAAFVRDFTGAGGLFSVVFDAR
YRPGQIDRFVEALELFAIGWSWGGARSLAMPYDVPSMRPNWPHRGTLVRFYVGLEEEADLRADIERALGSTLA
>Mature_392_residues
TDTTPKRARQTRIVQPEAELPPGFASFVTPLTRASTIVFPDLATMRSLDWREDDRWRYGLHATPTSLELARQIAVIEGGA
HALLQPSGLAAIMNVYFGFVKTGDDVLVPHNVYSPNADLGNWLARDYGISVRFYDPLVGAGIAELIRPETKLLWLEAPGS
VTMEVPDVAAITAVARARGVVTAIDNTYSAGLAFQPFEHGVDVSVQALTKYQSGGSDVLMGATITAEQALHERLKLARMR
TGIGVSADDCALVLRGLPSLRARFEAHSRAALGLAKWLKARPEIAAVLHPQLPDCPGHAAFVRDFTGAGGLFSVVFDARY
RPGQIDRFVEALELFAIGWSWGGARSLAMPYDVPSMRPNWPHRGTLVRFYVGLEEEADLRADIERALGSTLA

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=294, Percent_Identity=30.6122448979592, Blast_Score=158, Evalue=7e-39,
Organism=Homo sapiens, GI299473759, Length=227, Percent_Identity=32.15859030837, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI25453487, Length=293, Percent_Identity=26.962457337884, Blast_Score=116, Evalue=4e-26,
Organism=Escherichia coli, GI1789383, Length=362, Percent_Identity=36.4640883977901, Blast_Score=244, Evalue=7e-66,
Organism=Escherichia coli, GI1790375, Length=371, Percent_Identity=30.4582210242588, Blast_Score=152, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17560056, Length=343, Percent_Identity=32.3615160349854, Blast_Score=165, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI71980708, Length=391, Percent_Identity=30.1790281329923, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17538055, Length=305, Percent_Identity=32.4590163934426, Blast_Score=154, Evalue=6e-38,
Organism=Saccharomyces cerevisiae, GI6321170, Length=327, Percent_Identity=37.3088685015291, Blast_Score=222, Evalue=9e-59,
Organism=Saccharomyces cerevisiae, GI6319307, Length=350, Percent_Identity=27.4285714285714, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6323333, Length=414, Percent_Identity=25.8454106280193, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6321904, Length=345, Percent_Identity=26.6666666666667, Blast_Score=80, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6321254, Length=262, Percent_Identity=27.4809160305344, Blast_Score=73, Evalue=7e-14,
Organism=Drosophila melanogaster, GI19922554, Length=389, Percent_Identity=32.3907455012853, Blast_Score=176, Evalue=2e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 42785; Mature: 42654

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTTPKRARQTRIVQPEAELPPGFASFVTPLTRASTIVFPDLATMRSLDWREDDRWRYG
CCCCCHHHHHHCEEECCCCCCCCCHHHHHHHHHHCCEEECCCHHHHHCCCCCCCCCEEEC
LHATPTSLELARQIAVIEGGAHALLQPSGLAAIMNVYFGFVKTGDDVLVPHNVYSPNADL
CCCCCHHHHHHHHHHEEECCCCEEECCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCH
GNWLARDYGISVRFYDPLVGAGIAELIRPETKLLWLEAPGSVTMEVPDVAAITAVARARG
HHHHHHHHCCEEEEECCHHHCCHHHHHCCCCEEEEEECCCCEEEECCCHHHHHHHHHHCC
VVTAIDNTYSAGLAFQPFEHGVDVSVQALTKYQSGGSDVLMGATITAEQALHERLKLARM
EEEEECCCCCCCEEECCHHCCCCCCHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHH
RTGIGVSADDCALVLRGLPSLRARFEAHSRAALGLAKWLKARPEIAAVLHPQLPDCPGHA
HHCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCH
AFVRDFTGAGGLFSVVFDARYRPGQIDRFVEALELFAIGWSWGGARSLAMPYDVPSMRPN
HHHHHCCCCCCCEEHEECCCCCCCHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCC
WPHRGTLVRFYVGLEEEADLRADIERALGSTLA
CCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TDTTPKRARQTRIVQPEAELPPGFASFVTPLTRASTIVFPDLATMRSLDWREDDRWRYG
CCCCHHHHHHCEEECCCCCCCCCHHHHHHHHHHCCEEECCCHHHHHCCCCCCCCCEEEC
LHATPTSLELARQIAVIEGGAHALLQPSGLAAIMNVYFGFVKTGDDVLVPHNVYSPNADL
CCCCCHHHHHHHHHHEEECCCCEEECCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCH
GNWLARDYGISVRFYDPLVGAGIAELIRPETKLLWLEAPGSVTMEVPDVAAITAVARARG
HHHHHHHHCCEEEEECCHHHCCHHHHHCCCCEEEEEECCCCEEEECCCHHHHHHHHHHCC
VVTAIDNTYSAGLAFQPFEHGVDVSVQALTKYQSGGSDVLMGATITAEQALHERLKLARM
EEEEECCCCCCCEEECCHHCCCCCCHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHH
RTGIGVSADDCALVLRGLPSLRARFEAHSRAALGLAKWLKARPEIAAVLHPQLPDCPGHA
HHCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCH
AFVRDFTGAGGLFSVVFDARYRPGQIDRFVEALELFAIGWSWGGARSLAMPYDVPSMRPN
HHHHHCCCCCCCEEHEECCCCCCCHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCC
WPHRGTLVRFYVGLEEEADLRADIERALGSTLA
CCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8898392 [H]