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The map label for this gene is phbA [H]

Identifier: 238027207

GI number: 238027207

Start: 1742711

End: 1743895

Strand: Direct

Name: phbA [H]

Synonym: bglu_1g15930

Alternate gene names: 238027207

Gene position: 1742711-1743895 (Clockwise)

Preceding gene: 238027206

Following gene: 238027208

Centisome position: 44.61

GC content: 70.89

Gene sequence:

>1185_bases
ATGCAACGCGAAGTGGTGGTGGTCAGCGGAGTACGCACCGCGATCGGCGATTTCGGCGGCAGCCTGAAGGATTTCGCGCC
GACCGAGCTTGGCGCGCGCGTGGTGCGCGAGGCGATGGCGCGCGCGGGCGTGGCGGGCGACGAGGTCGGGCACGTGGTGT
TCGGCAACGTGGTCCATACGGAGCCGAAGGACATGTATCTGGCGCGCGTGGCGGCGATCGACGGCGGCGTCTCGCAGCAC
GCGCCGGCGCTGACGGTGAACCGGCTGTGCGGCTCGGGGCTGCAGGCGATCGTCTCGGCGGCGCAGAGCGTGCTGCTCGG
CGACGCCGAGATCGCGGTGGCGGGCGGCGCGGAAAGCATGAGCCGCGCGCCGTACACGCTGCCGGCGGCGCGCTTCGGGC
AGCGCATGGGCGATGCGCGGGCGGTCGACATGATGCTCGGCGCCCTCAACGATCCGTTCCAGGCGATCCACATGGGCATG
ACGGCCGAGAACGTGGCGGCGAAGTACGGCATCACGCGCGAGGCGCAGGACGCGCTCGCGCTCGAATCGCACCGGCGCGC
CTCGCACGCGACCAAGGCCGGCTACTTCAAGACCCAGATCCTGCCGATCGAGATCGGCTCGAAGCGCGGCACCGTCAGCT
TCGACACCGACGAGCACGTGCGCCACGACGCGGCGGCGGAGGATTTCGCCAAGCTGCGCCCGGTGTTCGCGAAGGAGAAC
GGCACGGTCACGGCCGGCAATGCGTCGGGCATCAACGACGCGGCGGCGGCCGTGACGCTGATGGAGCGGCGCGTGGCCGA
GGCGCGCGGCCTGAAGCCGCTGGCGCGGCTGGTGGCCTACGCGCACGCGGGCGTCGATCCGGCCTACATGGGCATCGGCC
CGGTGCCGGCCTCGAAGAAGGCGCTCGAGCGCGCCGGCATCGGCGTGGCCGATCTCGACGTGATCGAGGCGAACGAGGCG
TTCGCGGCGCAGGCCTGCGCGGTGGCCAACGAGCTGGGCTTCGATCCCGAGAAGGTGAATCCGAACGGCTCGGGCATCTC
GCTCGGCCATCCGATCGGTGCGACGGGCGCGCTGATCACCGTCAAGGCGCTCTACGAACTGCATCGGATCTCGGGCCGCT
ATGCGCTGGTGACGATGTGCATCGGCGGCGGCCAGGGCATTGCCGCCGTGTTCGAACGTATCTGA

Upstream 100 bases:

>100_bases
GGCGGCGGGCCCGGCCCGGTGGAAGGATTCTTCGGTTGCCGCCGGGCGCTTCCGTATTACTCTGCGGGTCATTCGACACA
ACTTGAGGCAGGGAGGCACG

Downstream 100 bases:

>100_bases
CGACATCCGGGCGGCCGCTTCGGGCCGCCCACGCAACCCAAGGAGTGACAAGACGTGGCAGCCAGCCGAACCCGAATCCG
CATCCGAGTCGCGACGGCGC

Product: beta-ketothiolase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MQREVVVVSGVRTAIGDFGGSLKDFAPTELGARVVREAMARAGVAGDEVGHVVFGNVVHTEPKDMYLARVAAIDGGVSQH
APALTVNRLCGSGLQAIVSAAQSVLLGDAEIAVAGGAESMSRAPYTLPAARFGQRMGDARAVDMMLGALNDPFQAIHMGM
TAENVAAKYGITREAQDALALESHRRASHATKAGYFKTQILPIEIGSKRGTVSFDTDEHVRHDAAAEDFAKLRPVFAKEN
GTVTAGNASGINDAAAAVTLMERRVAEARGLKPLARLVAYAHAGVDPAYMGIGPVPASKKALERAGIGVADLDVIEANEA
FAAQACAVANELGFDPEKVNPNGSGISLGHPIGATGALITVKALYELHRISGRYALVTMCIGGGQGIAAVFERI

Sequences:

>Translated_394_residues
MQREVVVVSGVRTAIGDFGGSLKDFAPTELGARVVREAMARAGVAGDEVGHVVFGNVVHTEPKDMYLARVAAIDGGVSQH
APALTVNRLCGSGLQAIVSAAQSVLLGDAEIAVAGGAESMSRAPYTLPAARFGQRMGDARAVDMMLGALNDPFQAIHMGM
TAENVAAKYGITREAQDALALESHRRASHATKAGYFKTQILPIEIGSKRGTVSFDTDEHVRHDAAAEDFAKLRPVFAKEN
GTVTAGNASGINDAAAAVTLMERRVAEARGLKPLARLVAYAHAGVDPAYMGIGPVPASKKALERAGIGVADLDVIEANEA
FAAQACAVANELGFDPEKVNPNGSGISLGHPIGATGALITVKALYELHRISGRYALVTMCIGGGQGIAAVFERI
>Mature_394_residues
MQREVVVVSGVRTAIGDFGGSLKDFAPTELGARVVREAMARAGVAGDEVGHVVFGNVVHTEPKDMYLARVAAIDGGVSQH
APALTVNRLCGSGLQAIVSAAQSVLLGDAEIAVAGGAESMSRAPYTLPAARFGQRMGDARAVDMMLGALNDPFQAIHMGM
TAENVAAKYGITREAQDALALESHRRASHATKAGYFKTQILPIEIGSKRGTVSFDTDEHVRHDAAAEDFAKLRPVFAKEN
GTVTAGNASGINDAAAAVTLMERRVAEARGLKPLARLVAYAHAGVDPAYMGIGPVPASKKALERAGIGVADLDVIEANEA
FAAQACAVANELGFDPEKVNPNGSGISLGHPIGATGALITVKALYELHRISGRYALVTMCIGGGQGIAAVFERI

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=393, Percent_Identity=44.2748091603053, Blast_Score=342, Evalue=3e-94,
Organism=Homo sapiens, GI148539872, Length=391, Percent_Identity=44.7570332480818, Blast_Score=338, Evalue=6e-93,
Organism=Homo sapiens, GI4501853, Length=397, Percent_Identity=41.3098236775819, Blast_Score=263, Evalue=2e-70,
Organism=Homo sapiens, GI4557237, Length=398, Percent_Identity=39.1959798994975, Blast_Score=257, Evalue=1e-68,
Organism=Homo sapiens, GI4504327, Length=425, Percent_Identity=33.8823529411765, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI194353979, Length=391, Percent_Identity=30.9462915601023, Blast_Score=153, Evalue=3e-37,
Organism=Escherichia coli, GI1788554, Length=398, Percent_Identity=50, Blast_Score=347, Evalue=6e-97,
Organism=Escherichia coli, GI87082165, Length=392, Percent_Identity=47.1938775510204, Blast_Score=335, Evalue=4e-93,
Organism=Escherichia coli, GI1787663, Length=404, Percent_Identity=43.5643564356436, Blast_Score=310, Evalue=2e-85,
Organism=Escherichia coli, GI48994986, Length=398, Percent_Identity=40.4522613065327, Blast_Score=263, Evalue=1e-71,
Organism=Escherichia coli, GI1788683, Length=409, Percent_Identity=34.718826405868, Blast_Score=204, Evalue=8e-54,
Organism=Caenorhabditis elegans, GI133906874, Length=391, Percent_Identity=46.8030690537084, Blast_Score=354, Evalue=4e-98,
Organism=Caenorhabditis elegans, GI25147385, Length=394, Percent_Identity=34.010152284264, Blast_Score=228, Evalue=3e-60,
Organism=Caenorhabditis elegans, GI17535921, Length=398, Percent_Identity=33.1658291457286, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI17551802, Length=425, Percent_Identity=30.5882352941176, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17535917, Length=396, Percent_Identity=27.020202020202, Blast_Score=145, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6325229, Length=403, Percent_Identity=39.454094292804, Blast_Score=260, Evalue=3e-70,
Organism=Saccharomyces cerevisiae, GI6322031, Length=403, Percent_Identity=36.4764267990074, Blast_Score=221, Evalue=1e-58,
Organism=Drosophila melanogaster, GI24655093, Length=392, Percent_Identity=45.9183673469388, Blast_Score=343, Evalue=9e-95,
Organism=Drosophila melanogaster, GI17648125, Length=394, Percent_Identity=43.1472081218274, Blast_Score=311, Evalue=5e-85,
Organism=Drosophila melanogaster, GI24640423, Length=397, Percent_Identity=40.3022670025189, Blast_Score=263, Evalue=1e-70,
Organism=Drosophila melanogaster, GI17137578, Length=426, Percent_Identity=31.924882629108, Blast_Score=176, Evalue=2e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40874; Mature: 40874

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS00098 THIOLASE_1 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQREVVVVSGVRTAIGDFGGSLKDFAPTELGARVVREAMARAGVAGDEVGHVVFGNVVHT
CCCCEEEECCHHHHHHHCCCCCHHCCHHHHHHHHHHHHHHHCCCCCCCCCCEEECCEEEC
EPKDMYLARVAAIDGGVSQHAPALTVNRLCGSGLQAIVSAAQSVLLGDAEIAVAGGAESM
CCHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEECCHHHH
SRAPYTLPAARFGQRMGDARAVDMMLGALNDPFQAIHMGMTAENVAAKYGITREAQDALA
CCCCCCCCHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHCCCHHHHHHHH
LESHRRASHATKAGYFKTQILPIEIGSKRGTVSFDTDEHVRHDAAAEDFAKLRPVFAKEN
HHHHHHHHHHHHCCCEEEEEEEEEECCCCCCEEECCHHHHHHHHHHHHHHHHCCCEECCC
GTVTAGNASGINDAAAAVTLMERRVAEARGLKPLARLVAYAHAGVDPAYMGIGPVPASKK
CEEEECCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHCCCCCCCCHHH
ALERAGIGVADLDVIEANEAFAAQACAVANELGFDPEKVNPNGSGISLGHPIGATGALIT
HHHHHCCCEEEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCCCCCHHHHH
VKALYELHRISGRYALVTMCIGGGQGIAAVFERI
HHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHCC
>Mature Secondary Structure
MQREVVVVSGVRTAIGDFGGSLKDFAPTELGARVVREAMARAGVAGDEVGHVVFGNVVHT
CCCCEEEECCHHHHHHHCCCCCHHCCHHHHHHHHHHHHHHHCCCCCCCCCCEEECCEEEC
EPKDMYLARVAAIDGGVSQHAPALTVNRLCGSGLQAIVSAAQSVLLGDAEIAVAGGAESM
CCHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEECCHHHH
SRAPYTLPAARFGQRMGDARAVDMMLGALNDPFQAIHMGMTAENVAAKYGITREAQDALA
CCCCCCCCHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHCCCHHHHHHHH
LESHRRASHATKAGYFKTQILPIEIGSKRGTVSFDTDEHVRHDAAAEDFAKLRPVFAKEN
HHHHHHHHHHHHCCCEEEEEEEEEECCCCCCEEECCHHHHHHHHHHHHHHHHCCCEECCC
GTVTAGNASGINDAAAAVTLMERRVAEARGLKPLARLVAYAHAGVDPAYMGIGPVPASKK
CEEEECCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHCCCCCCCCHHH
ALERAGIGVADLDVIEANEAFAAQACAVANELGFDPEKVNPNGSGISLGHPIGATGALIT
HHHHHCCCEEEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCCCCCHHHHH
VKALYELHRISGRYALVTMCIGGGQGIAAVFERI
HHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1396692 [H]