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The map label for this gene is cusS [H]

Identifier: 238027105

GI number: 238027105

Start: 1639713

End: 1640870

Strand: Direct

Name: cusS [H]

Synonym: bglu_1g14850

Alternate gene names: 238027105

Gene position: 1639713-1640870 (Clockwise)

Preceding gene: 238027104

Following gene: 238027110

Centisome position: 41.97

GC content: 68.65

Gene sequence:

>1158_bases
ATGAGCCTGTCAGCTTTCATAGAAACGCACATCGAAGCATTGATCGACGACTGGGCGCGGCATGCGGCCAGTCTCCACCA
GGGTCGTAGCCGTCTTTCGTTCACCGAATTGCGCGATTCGGCCCGGCGAATCCTGATCGAGGTCGCGGCGAACATGCGAA
AGGCGCAGACCGCCGCTCAACAGGAAGACAAGGCACGCGGCGCCAAGCGCGAGCTCGACCAGGCGCTCGATGCGGTCTCG
GTGCTGCATGCCGACGACCGCCTCGCGCAGGGCTTCGACCTCAACGAAGTGATCGCCGAATATCGCGCGCTGCGCGCGAG
CGTGCTGCGCCGCTGGGAGCCGGGGCCCCTGGCGGGGCCGCAGGCGTTGCAGGAGATGATCCGCTTCAACGAGGCGATCG
ATCAGGGCATCACCGAGTCGGTGCGCCAGTTCTCGCGGCGTTCCGAGCGGATGCGCGACCTGTTCGCCGGCGCGCTCGCG
CATGACCTGCGTTCGCCGCTCGGGGTTGTGCTCATTTCGGCCGAGATCCTGCTGCGTGACGACACGCTCGTGCCCTCGAG
CCGCCATGCGGCGGTGTACGCGCAGCGCAGCGGCTTGCGCATCAAGCGGATGATCGACGATCTGCTGATCTTCACCCGCA
CGCGGCTCGGCGACGCGATGCCGATCGACGTCTCGCCGCAGGACATGGGGCGCCTGTGCCGCGACGCGTGTGACGAAATC
CGCCAGCTGTTTTCCGAGGCGGTGATCGACCTGAATTGCACGGGGCAACTGGGCGGAACCTGGGATGGCGGGCGCCTCGG
GCAGCTGCTGTTCAATCTGCTGTCCAATGCCGCCCGCTACGGCACCGGCGAGATCGGCGTCGAGGTACGCGGCAGCGATG
GCTGGGTGACGCTGACGGTGTCGAATCCCGGCCAACCGATCCCGGCGCAGGCGCTGCCCACGCTGTTCGATCCGCTCACG
CGTGCCGATTCCGTGCCGCGCCGCGCCGGCATCGCTGCGGGCATCGGGCTCGGGCTGTATATCTGCCGCTGCATTTCGAC
GGCGCACGGCGGGACGGTCGAGGTGGCCTCGGATGCGCGCGGCACGCGCTTCACGGTACGCCTGCCGCGCGATGCCAGCT
CGGCCGCGGCCGAGCCGCCCGGCGGCGCGGCCGGATGA

Upstream 100 bases:

>100_bases
CACGCCGGTTCGACCCAGCGCGGCCACGCCCGCGCACCGGGCCGGGACTTCAGCGCGGGCCGGACGCCCGTTTCGAACCT
GCTTGCACCGAGAGAGCGGT

Downstream 100 bases:

>100_bases
GCCGCGCGTGCCTTCAGCGGTGGATCGCCGCGCGCAGCGCCTGAACCTCGCGCGTGGCGACCGGCGCGGCGCGATTCCCC
CATGCCCCGCGCACGAAGCT

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 385; Mature: 384

Protein sequence:

>385_residues
MSLSAFIETHIEALIDDWARHAASLHQGRSRLSFTELRDSARRILIEVAANMRKAQTAAQQEDKARGAKRELDQALDAVS
VLHADDRLAQGFDLNEVIAEYRALRASVLRRWEPGPLAGPQALQEMIRFNEAIDQGITESVRQFSRRSERMRDLFAGALA
HDLRSPLGVVLISAEILLRDDTLVPSSRHAAVYAQRSGLRIKRMIDDLLIFTRTRLGDAMPIDVSPQDMGRLCRDACDEI
RQLFSEAVIDLNCTGQLGGTWDGGRLGQLLFNLLSNAARYGTGEIGVEVRGSDGWVTLTVSNPGQPIPAQALPTLFDPLT
RADSVPRRAGIAAGIGLGLYICRCISTAHGGTVEVASDARGTRFTVRLPRDASSAAAEPPGGAAG

Sequences:

>Translated_385_residues
MSLSAFIETHIEALIDDWARHAASLHQGRSRLSFTELRDSARRILIEVAANMRKAQTAAQQEDKARGAKRELDQALDAVS
VLHADDRLAQGFDLNEVIAEYRALRASVLRRWEPGPLAGPQALQEMIRFNEAIDQGITESVRQFSRRSERMRDLFAGALA
HDLRSPLGVVLISAEILLRDDTLVPSSRHAAVYAQRSGLRIKRMIDDLLIFTRTRLGDAMPIDVSPQDMGRLCRDACDEI
RQLFSEAVIDLNCTGQLGGTWDGGRLGQLLFNLLSNAARYGTGEIGVEVRGSDGWVTLTVSNPGQPIPAQALPTLFDPLT
RADSVPRRAGIAAGIGLGLYICRCISTAHGGTVEVASDARGTRFTVRLPRDASSAAAEPPGGAAG
>Mature_384_residues
SLSAFIETHIEALIDDWARHAASLHQGRSRLSFTELRDSARRILIEVAANMRKAQTAAQQEDKARGAKRELDQALDAVSV
LHADDRLAQGFDLNEVIAEYRALRASVLRRWEPGPLAGPQALQEMIRFNEAIDQGITESVRQFSRRSERMRDLFAGALAH
DLRSPLGVVLISAEILLRDDTLVPSSRHAAVYAQRSGLRIKRMIDDLLIFTRTRLGDAMPIDVSPQDMGRLCRDACDEIR
QLFSEAVIDLNCTGQLGGTWDGGRLGQLLFNLLSNAARYGTGEIGVEVRGSDGWVTLTVSNPGQPIPAQALPTLFDPLTR
ADSVPRRAGIAAGIGLGLYICRCISTAHGGTVEVASDARGTRFTVRLPRDASSAAAEPPGGAAG

Specific function: Member of the two-component regulatory system CusS/CusR. Copper ion sensor. Could also be a silver ion sensor. Probably activates CusR by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=268, Percent_Identity=33.5820895522388, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI145693157, Length=243, Percent_Identity=27.9835390946502, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788393, Length=228, Percent_Identity=28.0701754385965, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI87082128, Length=236, Percent_Identity=26.271186440678, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR006290
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 41809; Mature: 41678

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLSAFIETHIEALIDDWARHAASLHQGRSRLSFTELRDSARRILIEVAANMRKAQTAAQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QEDKARGAKRELDQALDAVSVLHADDRLAQGFDLNEVIAEYRALRASVLRRWEPGPLAGP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCH
QALQEMIRFNEAIDQGITESVRQFSRRSERMRDLFAGALAHDLRSPLGVVLISAEILLRD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEHHHHHHHEEC
DTLVPSSRHAAVYAQRSGLRIKRMIDDLLIFTRTRLGDAMPIDVSPQDMGRLCRDACDEI
CCCCCCCCCCEEEEHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
RQLFSEAVIDLNCTGQLGGTWDGGRLGQLLFNLLSNAARYGTGEIGVEVRGSDGWVTLTV
HHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEE
SNPGQPIPAQALPTLFDPLTRADSVPRRAGIAAGIGLGLYICRCISTAHGGTVEVASDAR
CCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
GTRFTVRLPRDASSAAAEPPGGAAG
CCEEEEECCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SLSAFIETHIEALIDDWARHAASLHQGRSRLSFTELRDSARRILIEVAANMRKAQTAAQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QEDKARGAKRELDQALDAVSVLHADDRLAQGFDLNEVIAEYRALRASVLRRWEPGPLAGP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCH
QALQEMIRFNEAIDQGITESVRQFSRRSERMRDLFAGALAHDLRSPLGVVLISAEILLRD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEHHHHHHHEEC
DTLVPSSRHAAVYAQRSGLRIKRMIDDLLIFTRTRLGDAMPIDVSPQDMGRLCRDACDEI
CCCCCCCCCCEEEEHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
RQLFSEAVIDLNCTGQLGGTWDGGRLGQLLFNLLSNAARYGTGEIGVEVRGSDGWVTLTV
HHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEE
SNPGQPIPAQALPTLFDPLTRADSVPRRAGIAAGIGLGLYICRCISTAHGGTVEVASDAR
CCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
GTRFTVRLPRDASSAAAEPPGGAAG
CCEEEEECCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]