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The map label for this gene is fdh [H]

Identifier: 238027104

GI number: 238027104

Start: 1637443

End: 1638657

Strand: Direct

Name: fdh [H]

Synonym: bglu_1g14840

Alternate gene names: 238027104

Gene position: 1637443-1638657 (Clockwise)

Preceding gene: 238027103

Following gene: 238027105

Centisome position: 41.92

GC content: 70.53

Gene sequence:

>1215_bases
ATGAAGGCAATCGTATTTCACGGCATCGGCGACATCCGGCTCGATACCGTTCCCGACCCCGGCATCCGGCAGCCCACCGA
CGCGATCGTGCGGATCACCGCCAGCGCGATCTGCGGCACAGACCTGCACATGGTGCGCGGCACCCTGGGCGGCATGCGCG
AGGGGACCATTCTCGGCCACGAAGCGGTGGGCGTGGTCGAGGCGGTCGGCAGCGACGTGCGCAACTTCCGCGCGGGCGAC
CGCGTGCTGGTGCCCTCGACGATCTCGTGCGGCGCCTGCGCCTACTGCCGCGCGGGCTACACCGCCCAGTGCGACACGGC
CCATCCCGGCGGCATGCGCGCCGGCACGGCGTTCTTCGGCGGGCCGAAAGCCGCCGGCAGCTTCGACGGCCTGCAGGCCG
ATTACGCACGCATCCCGCACGCCAACGCCAGCCTGATCCGGCTGCCCGATGCGATCGACGACGATCGCGCCATCCTGCTC
TCGGATATCTTCCCGACCGCCTGGTTCGGCGCGCAACTCGCCGAGATACGCAATGGCGACACGGTGGCCGTGCTCGGCGC
CGGGCCGGTCGGCCAGTTCGCGATCGCGAGCGCGCGCCTGCAGGGCGCCGGGCGCGTGATCGCGATCGACCGCATCGCCT
CGCGGCTCGACATGGCGCGCGCGCAGGGCGCGGAAAGCATCGATTTCGATCGCGACGATCCGGTGGAGACGGTGCTCAGA
CTCACGGGCGGCATCGGCGTGGACCGCGTGATCGACGCGGTGGGGGTGGATGCGATGCGCTATCCGGCCGCTGCCGCGGA
CCCCGCGCTAGCCGGCGCATTCGACGCGGAGCTCGAGGTCGTGGCTCCCGAGCGCCGTCCCGACGGCGCCAACTGGATCC
CGGGCAACGGGCCGTCGCAGGCCCTGGCGGCGGCGACTCGAATGGTCGCGAAGGCGGGCACGATCGGCATCATCGGCGTG
TATCCGCCGCAGTTGCGCGTGTTCCCGATCGGCGAGGCGATGAACCGGAACCTCACGCTCAAGATGGGCAATTGCAATCA
CCGCACGATCGCGCCGCGGCTCGTCGAACTGGTGGCGGGCGGCACCTTCGATCCGCTGTCGGTGCTGACGCAGCGCGAAC
CGCTGATGAGCGCGATCGATGCCTATCGGATGTTCGATACGCGCGAGCCCGGCTGGATCAAGGTGAAACTGGAGCCCGCG
GCCGGGCCGCGCTGA

Upstream 100 bases:

>100_bases
CGGGACGCCGTGTTCTGCCCAGCTGGAACGACGCTTGCCTGATGCTGGCGAAGGCGCCCGGCATGACGCGCCTATTTTCG
ACCAGCGAAAGGGAGAGAGC

Downstream 100 bases:

>100_bases
GCCGGTCGCGCTGAGTCGGTCGCCCCGTGCGCTGGTATGGGCCTTGCGACGGCAAGGGCAGCGATCACGCCACCCCCGAC
AGGAGCAAAGATGACGCCAT

Product: Threonine dehydrogenase-like Zn-dependent dehydrogenase

Products: NA

Alternate protein names: Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH [H]

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MKAIVFHGIGDIRLDTVPDPGIRQPTDAIVRITASAICGTDLHMVRGTLGGMREGTILGHEAVGVVEAVGSDVRNFRAGD
RVLVPSTISCGACAYCRAGYTAQCDTAHPGGMRAGTAFFGGPKAAGSFDGLQADYARIPHANASLIRLPDAIDDDRAILL
SDIFPTAWFGAQLAEIRNGDTVAVLGAGPVGQFAIASARLQGAGRVIAIDRIASRLDMARAQGAESIDFDRDDPVETVLR
LTGGIGVDRVIDAVGVDAMRYPAAAADPALAGAFDAELEVVAPERRPDGANWIPGNGPSQALAAATRMVAKAGTIGIIGV
YPPQLRVFPIGEAMNRNLTLKMGNCNHRTIAPRLVELVAGGTFDPLSVLTQREPLMSAIDAYRMFDTREPGWIKVKLEPA
AGPR

Sequences:

>Translated_404_residues
MKAIVFHGIGDIRLDTVPDPGIRQPTDAIVRITASAICGTDLHMVRGTLGGMREGTILGHEAVGVVEAVGSDVRNFRAGD
RVLVPSTISCGACAYCRAGYTAQCDTAHPGGMRAGTAFFGGPKAAGSFDGLQADYARIPHANASLIRLPDAIDDDRAILL
SDIFPTAWFGAQLAEIRNGDTVAVLGAGPVGQFAIASARLQGAGRVIAIDRIASRLDMARAQGAESIDFDRDDPVETVLR
LTGGIGVDRVIDAVGVDAMRYPAAAADPALAGAFDAELEVVAPERRPDGANWIPGNGPSQALAAATRMVAKAGTIGIIGV
YPPQLRVFPIGEAMNRNLTLKMGNCNHRTIAPRLVELVAGGTFDPLSVLTQREPLMSAIDAYRMFDTREPGWIKVKLEPA
AGPR
>Mature_404_residues
MKAIVFHGIGDIRLDTVPDPGIRQPTDAIVRITASAICGTDLHMVRGTLGGMREGTILGHEAVGVVEAVGSDVRNFRAGD
RVLVPSTISCGACAYCRAGYTAQCDTAHPGGMRAGTAFFGGPKAAGSFDGLQADYARIPHANASLIRLPDAIDDDRAILL
SDIFPTAWFGAQLAEIRNGDTVAVLGAGPVGQFAIASARLQGAGRVIAIDRIASRLDMARAQGAESIDFDRDDPVETVLR
LTGGIGVDRVIDAVGVDAMRYPAAAADPALAGAFDAELEVVAPERRPDGANWIPGNGPSQALAAATRMVAKAGTIGIIGV
YPPQLRVFPIGEAMNRNLTLKMGNCNHRTIAPRLVELVAGGTFDPLSVLTQREPLMSAIDAYRMFDTREPGWIKVKLEPA
AGPR

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=406, Percent_Identity=23.8916256157635, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI4501929, Length=239, Percent_Identity=31.7991631799163, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI4501933, Length=239, Percent_Identity=30.5439330543933, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI34577061, Length=239, Percent_Identity=31.3807531380753, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI71565152, Length=258, Percent_Identity=30.6201550387597, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI71743840, Length=235, Percent_Identity=28.936170212766, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI262073058, Length=235, Percent_Identity=28.936170212766, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI4501939, Length=237, Percent_Identity=28.2700421940928, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI156523966, Length=237, Percent_Identity=28.2700421940928, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI71565154, Length=241, Percent_Identity=31.1203319502075, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1786825, Length=412, Percent_Identity=37.378640776699, Blast_Score=261, Evalue=4e-71,
Organism=Escherichia coli, GI87082125, Length=263, Percent_Identity=32.6996197718631, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1790045, Length=215, Percent_Identity=33.953488372093, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1787863, Length=225, Percent_Identity=31.1111111111111, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1788073, Length=248, Percent_Identity=27.0161290322581, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1788075, Length=270, Percent_Identity=27.7777777777778, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1786552, Length=247, Percent_Identity=32.3886639676113, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87081918, Length=220, Percent_Identity=31.3636363636364, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1788407, Length=224, Percent_Identity=30.3571428571429, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI226510992, Length=276, Percent_Identity=28.2608695652174, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1790718, Length=208, Percent_Identity=26.4423076923077, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562878, Length=227, Percent_Identity=31.7180616740088, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17562876, Length=388, Percent_Identity=25.2577319587629, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17565904, Length=259, Percent_Identity=29.3436293436293, Blast_Score=82, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI25146526, Length=252, Percent_Identity=29.3650793650794, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71997431, Length=251, Percent_Identity=29.0836653386454, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71988145, Length=220, Percent_Identity=30, Blast_Score=74, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6320033, Length=240, Percent_Identity=33.3333333333333, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6319955, Length=265, Percent_Identity=30.188679245283, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6322619, Length=265, Percent_Identity=30.188679245283, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6319257, Length=332, Percent_Identity=24.3975903614458, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319258, Length=246, Percent_Identity=26.4227642276423, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6319621, Length=251, Percent_Identity=29.8804780876494, Blast_Score=73, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323961, Length=250, Percent_Identity=28, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324486, Length=251, Percent_Identity=29.0836653386454, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323729, Length=232, Percent_Identity=25.8620689655172, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17137530, Length=261, Percent_Identity=29.5019157088123, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI17737897, Length=261, Percent_Identity=29.1187739463602, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI17737895, Length=248, Percent_Identity=30.241935483871, Blast_Score=85, Evalue=7e-17,
Organism=Drosophila melanogaster, GI45551930, Length=210, Percent_Identity=29.0476190476191, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45550770, Length=210, Percent_Identity=29.0476190476191, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221457811, Length=210, Percent_Identity=29.0476190476191, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284 [H]

Molecular weight: Translated: 42395; Mature: 42395

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAIVFHGIGDIRLDTVPDPGIRQPTDAIVRITASAICGTDLHMVRGTLGGMREGTILGH
CCEEEEECCCCEEECCCCCCCCCCCCHHHEEEEHHHHCCCHHHHHHHHHCCCCCCEEECH
EAVGVVEAVGSDVRNFRAGDRVLVPSTISCGACAYCRAGYTAQCDTAHPGGMRAGTAFFG
HHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHHCCCCEECCCCCCCCCCCCCEECC
GPKAAGSFDGLQADYARIPHANASLIRLPDAIDDDRAILLSDIFPTAWFGAQLAEIRNGD
CCCCCCCCCCCCHHHHHCCCCCCCEEECCCCCCCCCEEEEHHHCCHHHHHHHHHHHCCCC
TVAVLGAGPVGQFAIASARLQGAGRVIAIDRIASRLDMARAQGAESIDFDRDDPVETVLR
EEEEEECCCCCHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
LTGGIGVDRVIDAVGVDAMRYPAAAADPALAGAFDAELEVVAPERRPDGANWIPGNGPSQ
HHCCCCHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCHHH
ALAAATRMVAKAGTIGIIGVYPPQLRVFPIGEAMNRNLTLKMGNCNHRTIAPRLVELVAG
HHHHHHHHHHHCCCEEEEEECCCCEEEEECCHHHCCEEEEEECCCCCCHHHHHHHHHHHC
GTFDPLSVLTQREPLMSAIDAYRMFDTREPGWIKVKLEPAAGPR
CCCCHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCC
>Mature Secondary Structure
MKAIVFHGIGDIRLDTVPDPGIRQPTDAIVRITASAICGTDLHMVRGTLGGMREGTILGH
CCEEEEECCCCEEECCCCCCCCCCCCHHHEEEEHHHHCCCHHHHHHHHHCCCCCCEEECH
EAVGVVEAVGSDVRNFRAGDRVLVPSTISCGACAYCRAGYTAQCDTAHPGGMRAGTAFFG
HHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHHCCCCEECCCCCCCCCCCCCEECC
GPKAAGSFDGLQADYARIPHANASLIRLPDAIDDDRAILLSDIFPTAWFGAQLAEIRNGD
CCCCCCCCCCCCHHHHHCCCCCCCEEECCCCCCCCCEEEEHHHCCHHHHHHHHHHHCCCC
TVAVLGAGPVGQFAIASARLQGAGRVIAIDRIASRLDMARAQGAESIDFDRDDPVETVLR
EEEEEECCCCCHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
LTGGIGVDRVIDAVGVDAMRYPAAAADPALAGAFDAELEVVAPERRPDGANWIPGNGPSQ
HHCCCCHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCHHH
ALAAATRMVAKAGTIGIIGVYPPQLRVFPIGEAMNRNLTLKMGNCNHRTIAPRLVELVAG
HHHHHHHHHHHCCCEEEEEECCCCEEEEECCHHHCCEEEEEECCCCCCHHHHHHHHHHHC
GTFDPLSVLTQREPLMSAIDAYRMFDTREPGWIKVKLEPAAGPR
CCCCHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7926692 [H]