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The map label for this gene is thrC [H]

Identifier: 238027038

GI number: 238027038

Start: 1558816

End: 1560267

Strand: Direct

Name: thrC [H]

Synonym: bglu_1g14160

Alternate gene names: 238027038

Gene position: 1558816-1560267 (Clockwise)

Preceding gene: 238027037

Following gene: 238027039

Centisome position: 39.9

GC content: 67.84

Gene sequence:

>1452_bases
ATGAATTACATTTCGACGCGCGGCGCCGGCATCGGCGAGCACCATACGTTTTCTGACATCCTGCTCGGCGGCCTGGCGAA
GGACGGCGGGCTCTACCTGCCCGCCGAGTACCCGCGCGTGAGCGCGGCTGAGCTCGCACGCTGGCGCGCGCTGCCGTATG
CCGACCTCGCTTTCGAGGTGCTCTCGAAGTTCAGCGACGACATCCCCGCCGACGAGCTGCGCGCGCTCACGCGCCGTACC
TACCGCGCCGAGGTCTACGCCAACACGCGGCATGGCGAGAACGCGGCCGACATCACGCCGATCAAGCCGCTCGGTACCGA
GGGCGGCGCGCCGATCTCGCTGCTCGAACTGTCCAACGGGCCGACGCTCGCGTTCAAGGACATGGCGATGCAGCTGCTCG
GCAACCTGTTCGAGGCCACGCTCGCCAAGCACGGCGAGACGCTGAACATCCTCGGCGCGACTTCGGGCGACACCGGCAGC
GCGGCCGAGTATGCGATGCGCGGCAAGGTCGGCGTGCGCGTGTTCATGCTCTCGCCGCACGGCAAGATGAGCGCGTTCCA
GCGCGCGCAGATGTACAGCCTGCAGGACCCGAACATCTTCAACCTCGCCGTCGAGGGCGTGTTCGACGACGCGCAGGACA
TCGTCAAGGCGGTCTCGAACGACCACGCCTTCAAGGCGCGGCACAAGATCGGCACGGTCAACTCGATCAACTGGGCCCGC
GTGGTCGCGCAGGTCGTCTACTACTTCAAGGGCTACTTCGCGGCCACCACGAGCAACGAGCAGCGCGTCTCGTTTACGGT
GCCGTCGGGCAACTTCGGCAACGTCTGCGCCGGCCACATCGCGCGCATGATGGGCCTGCCGATCGAGAAGCTGGTGGTGG
CGACCAACGAGAACGACGTGCTCGACGAGTTCTTCCGCACCGGCCGCTACCGCGTGCGCGGCGCCGCGCAGACCTATCAC
ACGAGCAGCCCGAGCATGGACATCTCGAAGGCGTCGAACTTCGAGCGCTTCGTGTTCGACCTGCTCGGCCGCGACCCGGC
ACGCGTGCTGCAGCTGTTTCGCGACGTCGAGGAGAAGGGCGGCTTCGATCTGGCGGCGAGCGGCGACTTCGCGCGCGTGG
CCGAGTTCGGCTTCGTGTCGGGGCGCAGCACGCACGAGGACCGTCTCGCGACCATCCGCGACGTCTACCAGCGCTACGCG
ACGATGATCGACACGCACACGGCCGACGGCGTGAAGGTCGCGCGCGAACACCTGCAGCCGGGCGTGCCGATGGTCGTGCT
GGAGACGGCGCAGCCGATCAAGTTCGGCGAGACGATTCGCGAGGCGCTCGGCCGCGAGGCGGAGCGCCCGGCAGGGTTCG
AGGGCATCGAGGCGCTGCCGCAGCGCTTCGAGGTCGTGCAGGCCGACGTGCAGCAGGTGAAGGACTTCATCGTCGCGCAT
ACGGGCGGCTGA

Upstream 100 bases:

>100_bases
GAGCGCAACGTGAACGCCGCGATCGCGCGTATCGAGGCGCTCTCCACGGTGCGCTCGCAGGTCACGAAGCTGCGCATGGA
AGCGCTAAACTGAGGACGAC

Downstream 100 bases:

>100_bases
GTCCGCGCGAGCCCGTCCCGGCGCTGCGCGCCGGCCGGATCACGGCCGCGACCGGGCAGGGCTTCCGGCGCGGCCGTGCC
GTTTGCGGCCGCTGCGGCCC

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MNYISTRGAGIGEHHTFSDILLGGLAKDGGLYLPAEYPRVSAAELARWRALPYADLAFEVLSKFSDDIPADELRALTRRT
YRAEVYANTRHGENAADITPIKPLGTEGGAPISLLELSNGPTLAFKDMAMQLLGNLFEATLAKHGETLNILGATSGDTGS
AAEYAMRGKVGVRVFMLSPHGKMSAFQRAQMYSLQDPNIFNLAVEGVFDDAQDIVKAVSNDHAFKARHKIGTVNSINWAR
VVAQVVYYFKGYFAATTSNEQRVSFTVPSGNFGNVCAGHIARMMGLPIEKLVVATNENDVLDEFFRTGRYRVRGAAQTYH
TSSPSMDISKASNFERFVFDLLGRDPARVLQLFRDVEEKGGFDLAASGDFARVAEFGFVSGRSTHEDRLATIRDVYQRYA
TMIDTHTADGVKVAREHLQPGVPMVVLETAQPIKFGETIREALGREAERPAGFEGIEALPQRFEVVQADVQQVKDFIVAH
TGG

Sequences:

>Translated_483_residues
MNYISTRGAGIGEHHTFSDILLGGLAKDGGLYLPAEYPRVSAAELARWRALPYADLAFEVLSKFSDDIPADELRALTRRT
YRAEVYANTRHGENAADITPIKPLGTEGGAPISLLELSNGPTLAFKDMAMQLLGNLFEATLAKHGETLNILGATSGDTGS
AAEYAMRGKVGVRVFMLSPHGKMSAFQRAQMYSLQDPNIFNLAVEGVFDDAQDIVKAVSNDHAFKARHKIGTVNSINWAR
VVAQVVYYFKGYFAATTSNEQRVSFTVPSGNFGNVCAGHIARMMGLPIEKLVVATNENDVLDEFFRTGRYRVRGAAQTYH
TSSPSMDISKASNFERFVFDLLGRDPARVLQLFRDVEEKGGFDLAASGDFARVAEFGFVSGRSTHEDRLATIRDVYQRYA
TMIDTHTADGVKVAREHLQPGVPMVVLETAQPIKFGETIREALGREAERPAGFEGIEALPQRFEVVQADVQQVKDFIVAH
TGG
>Mature_483_residues
MNYISTRGAGIGEHHTFSDILLGGLAKDGGLYLPAEYPRVSAAELARWRALPYADLAFEVLSKFSDDIPADELRALTRRT
YRAEVYANTRHGENAADITPIKPLGTEGGAPISLLELSNGPTLAFKDMAMQLLGNLFEATLAKHGETLNILGATSGDTGS
AAEYAMRGKVGVRVFMLSPHGKMSAFQRAQMYSLQDPNIFNLAVEGVFDDAQDIVKAVSNDHAFKARHKIGTVNSINWAR
VVAQVVYYFKGYFAATTSNEQRVSFTVPSGNFGNVCAGHIARMMGLPIEKLVVATNENDVLDEFFRTGRYRVRGAAQTYH
TSSPSMDISKASNFERFVFDLLGRDPARVLQLFRDVEEKGGFDLAASGDFARVAEFGFVSGRSTHEDRLATIRDVYQRYA
TMIDTHTADGVKVAREHLQPGVPMVVLETAQPIKFGETIREALGREAERPAGFEGIEALPQRFEVVQADVQQVKDFIVAH
TGG

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=450, Percent_Identity=34, Blast_Score=210, Evalue=3e-54,
Organism=Homo sapiens, GI149193323, Length=472, Percent_Identity=30.7203389830508, Blast_Score=200, Evalue=2e-51,
Organism=Escherichia coli, GI1786185, Length=474, Percent_Identity=28.6919831223629, Blast_Score=184, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6319901, Length=472, Percent_Identity=39.1949152542373, Blast_Score=309, Evalue=8e-85,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 52925; Mature: 52925

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYISTRGAGIGEHHTFSDILLGGLAKDGGLYLPAEYPRVSAAELARWRALPYADLAFEV
CCCCCCCCCCCCCCCHHHHHHHHCCCCCCCEECCCCCCCCCHHHHHHHHCCCHHHHHHHH
LSKFSDDIPADELRALTRRTYRAEVYANTRHGENAADITPIKPLGTEGGAPISLLELSNG
HHHHCCCCCHHHHHHHHHHHHEEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEECCC
PTLAFKDMAMQLLGNLFEATLAKHGETLNILGATSGDTGSAAEYAMRGKVGVRVFMLSPH
CCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHCCCCCEEEEEECCC
GKMSAFQRAQMYSLQDPNIFNLAVEGVFDDAQDIVKAVSNDHAFKARHKIGTVNSINWAR
CHHHHHHHHHHHCCCCCCEEEEEECCHHCCHHHHHHHHCCCCHHHHHHHCCCCCCCHHHH
VVAQVVYYFKGYFAATTSNEQRVSFTVPSGNFGNVCAGHIARMMGLPIEKLVVATNENDV
HHHHHHHHHHHHEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHCCCHHHEEEECCCCHH
LDEFFRTGRYRVRGAAQTYHTSSPSMDISKASNFERFVFDLLGRDPARVLQLFRDVEEKG
HHHHHHCCCEEEEECHHHEECCCCCCCHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHC
GFDLAASGDFARVAEFGFVSGRSTHEDRLATIRDVYQRYATMIDTHTADGVKVAREHLQP
CEEEECCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCC
GVPMVVLETAQPIKFGETIREALGREAERPAGFEGIEALPQRFEVVQADVQQVKDFIVAH
CCCEEEEECCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
TGG
CCC
>Mature Secondary Structure
MNYISTRGAGIGEHHTFSDILLGGLAKDGGLYLPAEYPRVSAAELARWRALPYADLAFEV
CCCCCCCCCCCCCCCHHHHHHHHCCCCCCCEECCCCCCCCCHHHHHHHHCCCHHHHHHHH
LSKFSDDIPADELRALTRRTYRAEVYANTRHGENAADITPIKPLGTEGGAPISLLELSNG
HHHHCCCCCHHHHHHHHHHHHEEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEECCC
PTLAFKDMAMQLLGNLFEATLAKHGETLNILGATSGDTGSAAEYAMRGKVGVRVFMLSPH
CCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHCCCCCEEEEEECCC
GKMSAFQRAQMYSLQDPNIFNLAVEGVFDDAQDIVKAVSNDHAFKARHKIGTVNSINWAR
CHHHHHHHHHHHCCCCCCEEEEEECCHHCCHHHHHHHHCCCCHHHHHHHCCCCCCCHHHH
VVAQVVYYFKGYFAATTSNEQRVSFTVPSGNFGNVCAGHIARMMGLPIEKLVVATNENDV
HHHHHHHHHHHHEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHCCCHHHEEEECCCCHH
LDEFFRTGRYRVRGAAQTYHTSSPSMDISKASNFERFVFDLLGRDPARVLQLFRDVEEKG
HHHHHHCCCEEEEECHHHEECCCCCCCHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHC
GFDLAASGDFARVAEFGFVSGRSTHEDRLATIRDVYQRYATMIDTHTADGVKVAREHLQP
CEEEECCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCC
GVPMVVLETAQPIKFGETIREALGREAERPAGFEGIEALPQRFEVVQADVQQVKDFIVAH
CCCEEEEECCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
TGG
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8117070 [H]