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The map label for this gene is hom [H]

Identifier: 238027037

GI number: 238027037

Start: 1557483

End: 1558808

Strand: Direct

Name: hom [H]

Synonym: bglu_1g14150

Alternate gene names: 238027037

Gene position: 1557483-1558808 (Clockwise)

Preceding gene: 238027036

Following gene: 238027038

Centisome position: 39.87

GC content: 69.08

Gene sequence:

>1326_bases
ATGGAACCGATCAAAGTCGCCCTGTTGGGCTTCGGCACCGTCGGCGGCGGCACCTTCGAGGTGCTGCGCCGCAACCAGGA
AGAAATCAAACGGCGCGCCGGCCGGGGCATCGTGGTCACGCGCATCGCGGTCCGTAATCCGGCGAAGGTGCAGGCCGCGC
TCGGCGAGCGCGCCGGCATCGAGGTCAGCACCGATTTCCACGCGGCGGTGGACGATCCCGCGATTTCGATCGTCGCCGAG
ATGATCGGCGGCACCGGCATCGCGCGCGAGCTGGCGCTGCGCGCGATCGCCAACGGCAAGCACGTGGTGACCGCCAACAA
GGCGCTGCTCGCCGTGCATGGCAGCGAGATCTTCGCGGCCGCGCGCGAGAAGGGCGTGATGGTGGCGTTCGAGGCGGCCG
TGGCGGGCGGCATCCCGATCATCAAGGCGCTGCGCGAGGGCCTCACGGCCAACCGCATCCAGTACATCGCCGGCATCATC
AACGGCACCACCAACTACATCCTGTCCGAGATGCGCGAGCGCGGCCTCGACTTCGCGACGGCGCTGGCGGGCGCGCAGGC
GCTCGGCTACGCCGAGGCGGACCCGACCTTCGACATCGAGGGCGTGGACGCGGCGCACAAGGCCACCATCATGAGCGCGA
TCGCGTTCGGCGTGCCGGTGCAGTTCGAGCGCGCCTACGTGGAGGGCATCAGCAAGCTGGCCGCCACCGACATCCGCTAT
GCCGAGGAGCTCGGCTACCGCATCAAGCTGCTGGGCATCGCGCGCCGCGCCGAGGCCGGCATCGAACTGCGGGTGCACCC
GACGCTGGTGCCCGAGAAGCGCCTGCTCGCCAACGTCGAGGGGGCGATGAACGCGGTGGTGGTGCATGGCGACGCGGTCG
GCACGACGCTCTATTACGGCAAGGGCGCGGGCGCCGAGCCCACCGCCTCGGCCGTGGTCGCCGACCTAGTGGACGTCACG
CGCCTGCACACGGCCGACCCCGAGCACCGCGTGCCGCACCTCGCCTTCCAGCCGGAAAGTCTGTCGAACACGCCGATCCT
GCCGATCGAGGACGTCACCAGCGGCTATTACCTGCGCCTGCGGGTGGCCGACGAGACCGGCGTGATGGCCGACATCACGC
GCATCCTCGCCGAATCGGGCATCTCGATCGACGCGCTGCTGCAGAAGGAGTCGGACCAGATCGACGGTGGCGCCGACGAA
ACCGACATCATCCTGATCACGCACGTGACGGTCGAGCGCAACGTGAACGCCGCGATCGCGCGTATCGAGGCGCTCTCCAC
GGTGCGCTCGCAGGTCACGAAGCTGCGCATGGAAGCGCTAAACTGA

Upstream 100 bases:

>100_bases
GGATCGCGCGCTTCCTAGACGGCTACCGCAAGCAGCACGCGGCCTGAGCCGCCCGCCATCGCCTTCCTATCCACTCCAAA
TATTCCAGACGACACGCAGC

Downstream 100 bases:

>100_bases
GGACGACATGAATTACATTTCGACGCGCGGCGCCGGCATCGGCGAGCACCATACGTTTTCTGACATCCTGCTCGGCGGCC
TGGCGAAGGACGGCGGGCTC

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MEPIKVALLGFGTVGGGTFEVLRRNQEEIKRRAGRGIVVTRIAVRNPAKVQAALGERAGIEVSTDFHAAVDDPAISIVAE
MIGGTGIARELALRAIANGKHVVTANKALLAVHGSEIFAAAREKGVMVAFEAAVAGGIPIIKALREGLTANRIQYIAGII
NGTTNYILSEMRERGLDFATALAGAQALGYAEADPTFDIEGVDAAHKATIMSAIAFGVPVQFERAYVEGISKLAATDIRY
AEELGYRIKLLGIARRAEAGIELRVHPTLVPEKRLLANVEGAMNAVVVHGDAVGTTLYYGKGAGAEPTASAVVADLVDVT
RLHTADPEHRVPHLAFQPESLSNTPILPIEDVTSGYYLRLRVADETGVMADITRILAESGISIDALLQKESDQIDGGADE
TDIILITHVTVERNVNAAIARIEALSTVRSQVTKLRMEALN

Sequences:

>Translated_441_residues
MEPIKVALLGFGTVGGGTFEVLRRNQEEIKRRAGRGIVVTRIAVRNPAKVQAALGERAGIEVSTDFHAAVDDPAISIVAE
MIGGTGIARELALRAIANGKHVVTANKALLAVHGSEIFAAAREKGVMVAFEAAVAGGIPIIKALREGLTANRIQYIAGII
NGTTNYILSEMRERGLDFATALAGAQALGYAEADPTFDIEGVDAAHKATIMSAIAFGVPVQFERAYVEGISKLAATDIRY
AEELGYRIKLLGIARRAEAGIELRVHPTLVPEKRLLANVEGAMNAVVVHGDAVGTTLYYGKGAGAEPTASAVVADLVDVT
RLHTADPEHRVPHLAFQPESLSNTPILPIEDVTSGYYLRLRVADETGVMADITRILAESGISIDALLQKESDQIDGGADE
TDIILITHVTVERNVNAAIARIEALSTVRSQVTKLRMEALN
>Mature_441_residues
MEPIKVALLGFGTVGGGTFEVLRRNQEEIKRRAGRGIVVTRIAVRNPAKVQAALGERAGIEVSTDFHAAVDDPAISIVAE
MIGGTGIARELALRAIANGKHVVTANKALLAVHGSEIFAAAREKGVMVAFEAAVAGGIPIIKALREGLTANRIQYIAGII
NGTTNYILSEMRERGLDFATALAGAQALGYAEADPTFDIEGVDAAHKATIMSAIAFGVPVQFERAYVEGISKLAATDIRY
AEELGYRIKLLGIARRAEAGIELRVHPTLVPEKRLLANVEGAMNAVVVHGDAVGTTLYYGKGAGAEPTASAVVADLVDVT
RLHTADPEHRVPHLAFQPESLSNTPILPIEDVTSGYYLRLRVADETGVMADITRILAESGISIDALLQKESDQIDGGADE
TDIILITHVTVERNVNAAIARIEALSTVRSQVTKLRMEALN

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=252, Percent_Identity=26.984126984127, Blast_Score=62, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6322599, Length=140, Percent_Identity=32.8571428571429, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 46814; Mature: 46814

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPIKVALLGFGTVGGGTFEVLRRNQEEIKRRAGRGIVVTRIAVRNPAKVQAALGERAGI
CCCEEEEEEECCCCCCCHHHHHHCCHHHHHHHCCCCEEEEEEEECCCHHHHHHHCCCCCE
EVSTDFHAAVDDPAISIVAEMIGGTGIARELALRAIANGKHVVTANKALLAVHGSEIFAA
EEECCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEECCEEEEEECHHHHHH
AREKGVMVAFEAAVAGGIPIIKALREGLTANRIQYIAGIINGTTNYILSEMRERGLDFAT
HHHCCEEEEEECHHHCCCHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHH
ALAGAQALGYAEADPTFDIEGVDAAHKATIMSAIAFGVPVQFERAYVEGISKLAATDIRY
HHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
AEELGYRIKLLGIARRAEAGIELRVHPTLVPEKRLLANVEGAMNAVVVHGDAVGTTLYYG
HHHCCCEEEEEEEEHHHCCCCEEEECCCCCCCHHHHHHHCCCCEEEEEECCCCCCEEEEC
KGAGAEPTASAVVADLVDVTRLHTADPEHRVPHLAFQPESLSNTPILPIEDVTSGYYLRL
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCEEHHCCCCCEEEEE
RVADETGVMADITRILAESGISIDALLQKESDQIDGGADETDIILITHVTVERNVNAAIA
EEECCCCHHHHHHHHHHHCCCCEEHHHCCCCCCCCCCCCCCCEEEEEEEEEECCCHHHHH
RIEALSTVRSQVTKLRMEALN
HHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEPIKVALLGFGTVGGGTFEVLRRNQEEIKRRAGRGIVVTRIAVRNPAKVQAALGERAGI
CCCEEEEEEECCCCCCCHHHHHHCCHHHHHHHCCCCEEEEEEEECCCHHHHHHHCCCCCE
EVSTDFHAAVDDPAISIVAEMIGGTGIARELALRAIANGKHVVTANKALLAVHGSEIFAA
EEECCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEECCEEEEEECHHHHHH
AREKGVMVAFEAAVAGGIPIIKALREGLTANRIQYIAGIINGTTNYILSEMRERGLDFAT
HHHCCEEEEEECHHHCCCHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHH
ALAGAQALGYAEADPTFDIEGVDAAHKATIMSAIAFGVPVQFERAYVEGISKLAATDIRY
HHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
AEELGYRIKLLGIARRAEAGIELRVHPTLVPEKRLLANVEGAMNAVVVHGDAVGTTLYYG
HHHCCCEEEEEEEEHHHCCCCEEEECCCCCCCHHHHHHHCCCCEEEEEECCCCCCEEEEC
KGAGAEPTASAVVADLVDVTRLHTADPEHRVPHLAFQPESLSNTPILPIEDVTSGYYLRL
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCEEHHCCCCCEEEEE
RVADETGVMADITRILAESGISIDALLQKESDQIDGGADETDIILITHVTVERNVNAAIA
EEECCCCHHHHHHHHHHHCCCCEEHHHCCCCCCCCCCCCCCCEEEEEEEEEECCCHHHHH
RIEALSTVRSQVTKLRMEALN
HHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]