Click here to switch to the map view.

The map label for this gene is iclR [H]

Identifier: 238026671

GI number: 238026671

Start: 1109994

End: 1110821

Strand: Reverse

Name: iclR [H]

Synonym: bglu_1g10250

Alternate gene names: 238026671

Gene position: 1110821-1109994 (Counterclockwise)

Preceding gene: 238026672

Following gene: 238026670

Centisome position: 28.44

GC content: 69.44

Gene sequence:

>828_bases
GTGCCGAAACTGAATAAAGCAGCGACCGCTTCACGAGATCGAGAATCGTCCACGGATGAGATTTCGGCACTCGCCAGAGG
GCTCGCGGTACTGCGCCGGATCGCGGCGGCGGACGCGCCGGTGAGCAACCGCGAGCTGACAGAATTGACAGGCATCCCCA
AACCGACCGTCTCGCGCATCACCGCGACGCTGGTCAGCGCTGGTTTCCTGCTTCGGCTGCCCGACAGCGAGCGCTTCGTA
CTGACCGCCTCGGTGCTCGAACTGAGCAAAGGCTTCCTGCGCAACTTCGACATCCGCGCCCGCTCGCGGCCGTTCCTGAG
CGAGTTGGCGGAGCGCACCTCGCTGTCGGTCCATCTCGCCGTGCGCGACCGGCTCGACATGGTCGCGATCGACGTGGTCC
GGCCGCGCTCGGCCGTGCTCGTCACCCGGCTCGAGATCGGCTCGCGGATGGACATGGCGCGCACCGCCGTCGGCCGCGCC
TACCTGGCGGCGCTCGACGAGGACGAGCGCGGCGAACTGCTCGCCGCGCTGCAGGCGGCCCACGGCGACGACTGGCCGCT
CGTGGTGGCACGACTCAGCCCCGCCCTGGAGGATACGCTGCGCAACGGTTACGCGCTCGCCATCGGCGAATGGCGCGACG
GGCTCAACGCGATCGCGGCCGGCTTCGTGGGCCCGTCGGGCCAGCGCTATGCCGTCAATTGCGGCGGCGCCGCCCAGCAG
TATCCGGCCGAATGGCTGCTCGAGACTGCCGTGCCCGCCATCCAGGCCTGCATCGCCGACATCACGCGCGAGATCGGCGG
CGAGATTCCGCCACGCCAAGCGAGCTGA

Upstream 100 bases:

>100_bases
TCATTGCATGCAAAGTTTTCCTTAAAGCATGCACGAACCGCCATTTGTCGTATTATTTAAGAGAATCTGAGATTTTGTTT
CATAAAATAGAGAGAGTCCC

Downstream 100 bases:

>100_bases
GCGGGCCAGCCAGCCGCGCCCGGCCGGGCATCGCGCGACGGCGGCCCGGCCGGCAACACGGCGCGGCGGCAGCCGCTTGA
GCACGCCGCATGCCCGGCCC

Product: IclR family regulatory protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 275; Mature: 274

Protein sequence:

>275_residues
MPKLNKAATASRDRESSTDEISALARGLAVLRRIAAADAPVSNRELTELTGIPKPTVSRITATLVSAGFLLRLPDSERFV
LTASVLELSKGFLRNFDIRARSRPFLSELAERTSLSVHLAVRDRLDMVAIDVVRPRSAVLVTRLEIGSRMDMARTAVGRA
YLAALDEDERGELLAALQAAHGDDWPLVVARLSPALEDTLRNGYALAIGEWRDGLNAIAAGFVGPSGQRYAVNCGGAAQQ
YPAEWLLETAVPAIQACIADITREIGGEIPPRQAS

Sequences:

>Translated_275_residues
MPKLNKAATASRDRESSTDEISALARGLAVLRRIAAADAPVSNRELTELTGIPKPTVSRITATLVSAGFLLRLPDSERFV
LTASVLELSKGFLRNFDIRARSRPFLSELAERTSLSVHLAVRDRLDMVAIDVVRPRSAVLVTRLEIGSRMDMARTAVGRA
YLAALDEDERGELLAALQAAHGDDWPLVVARLSPALEDTLRNGYALAIGEWRDGLNAIAAGFVGPSGQRYAVNCGGAAQQ
YPAEWLLETAVPAIQACIADITREIGGEIPPRQAS
>Mature_274_residues
PKLNKAATASRDRESSTDEISALARGLAVLRRIAAADAPVSNRELTELTGIPKPTVSRITATLVSAGFLLRLPDSERFVL
TASVLELSKGFLRNFDIRARSRPFLSELAERTSLSVHLAVRDRLDMVAIDVVRPRSAVLVTRLEIGSRMDMARTAVGRAY
LAALDEDERGELLAALQAAHGDDWPLVVARLSPALEDTLRNGYALAIGEWRDGLNAIAAGFVGPSGQRYAVNCGGAAQQY
PAEWLLETAVPAIQACIADITREIGGEIPPRQAS

Specific function: Regulation of the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase as well as isocitrate dehydrogenase kinase/phosphorylase. Glyoxylate disrupts the interaction with the promoter by favoring the inactive dimeric form. Pyr

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI87082359, Length=208, Percent_Identity=27.8846153846154, Blast_Score=78, Evalue=5e-16,
Organism=Escherichia coli, GI145693096, Length=254, Percent_Identity=27.5590551181102, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1786468, Length=203, Percent_Identity=27.0935960591133, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788131, Length=268, Percent_Identity=23.8805970149254, Blast_Score=69, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 29607; Mature: 29476

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKLNKAATASRDRESSTDEISALARGLAVLRRIAAADAPVSNRELTELTGIPKPTVSRI
CCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCHHHHHH
TATLVSAGFLLRLPDSERFVLTASVLELSKGFLRNFDIRARSRPFLSELAERTSLSVHLA
HHHHHHCCEEEECCCCCCEEEHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCEEEEE
VRDRLDMVAIDVVRPRSAVLVTRLEIGSRMDMARTAVGRAYLAALDEDERGELLAALQAA
ECCCCCEEEEEEECCCCCEEEEEHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
HGDDWPLVVARLSPALEDTLRNGYALAIGEWRDGLNAIAAGFVGPSGQRYAVNCGGAAQQ
CCCCCCCHHHHHCHHHHHHHCCCEEEEEHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHH
YPAEWLLETAVPAIQACIADITREIGGEIPPRQAS
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
PKLNKAATASRDRESSTDEISALARGLAVLRRIAAADAPVSNRELTELTGIPKPTVSRI
CCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCHHHHHH
TATLVSAGFLLRLPDSERFVLTASVLELSKGFLRNFDIRARSRPFLSELAERTSLSVHLA
HHHHHHCCEEEECCCCCCEEEHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCEEEEE
VRDRLDMVAIDVVRPRSAVLVTRLEIGSRMDMARTAVGRAYLAALDEDERGELLAALQAA
ECCCCCEEEEEEECCCCCEEEEEHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
HGDDWPLVVARLSPALEDTLRNGYALAIGEWRDGLNAIAAGFVGPSGQRYAVNCGGAAQQ
CCCCCCCHHHHHCHHHHHHHCCCEEEEEHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHH
YPAEWLLETAVPAIQACIADITREIGGEIPPRQAS
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2185227; 1995431; 8265357; 9278503; 1995429 [H]