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The map label for this gene is norM [H]

Identifier: 238026579

GI number: 238026579

Start: 1000416

End: 1001798

Strand: Reverse

Name: norM [H]

Synonym: bglu_1g09230

Alternate gene names: 238026579

Gene position: 1001798-1000416 (Counterclockwise)

Preceding gene: 238026580

Following gene: 238026578

Centisome position: 25.64

GC content: 71.29

Gene sequence:

>1383_bases
ATGCCGCGTCACGATTTCTCGCGCGCCGCTCTCGCGCCGCCCTCCTTTTCCCGCCACGCAGCCGACACCGCCCGTCTGGC
CGCGCCGCTTGCGATCGCACAGCTCTCGCAGATGGCGATGAGCGTCACCGACACGGTACTGCTCGGCTCGCTCGGTCCCG
ATGCGCTCGCCGCCGGCGGCCTCGGCGCCACGCTGTTCTTCGTCGCCGTCACGGTGTTGCAGGGCGTGCTGAGCTCGGTC
AGCGTCAGTGTCGCCCACGCGCGCGGTGCCCGCGACGACAGCCAGATTCCCCACATCTACTGGACCGGCGTGGTGCTCGC
GCTGCTGCTGTCGGTGCCGGCGATCGCGGTGCTGCTCTACACCGAGCCGCTGCTGCTGATGTTCCACGAGCCGCCGATGC
TGGCCCACCACATCGGCGAATACACGCGCGTGCTGAGTCTGGCCGCGCCCGGCAGCCTGATCGGCGTCGGCCTGATGCGC
TCGTTCCTGCCGGCGATCGGCGCGGCGCGACGCCTGCTGTGGGTGTCGATCGCGAGCGTCGGCGTCAACGCGGTGCTGAA
CTACGGGCTGATCCACGGTGCGTTCGGGTTGCCGCGGCTTGGCTTCCTCGGCTCGGCGGCGGCCACCACCCTCACCATCT
GGCTCACCGCGATCTCGCTCATGCTGCTGCTGCATGGCCGGCCGGCCTACCGCCAGTTCGTCGCGGCCTCGCGCCCGAAG
CTGCCGCTGATGGGCGAGCTGGTCGGCATCGGCTGGCCGGTGGCGATCACCTACGGGGTCGAGTCGACCCTGTTCCTCGC
CACCGGCCTCACGATCGGCGTGCTCGGCGAGACCTCGCTCGCCGCGCACCAAATCGCCCTCAACATCGCCTCGGTCACCT
TCATGGTGCCGCTCGCGATCGGCCAGGCCGCCAACGTGCGCGTGAGCTACTGGGTCGGCGCCGGCGCGCCGCTCGCCGCT
CGCCACGCGGGCTTCGTCGCGATCGGGCTCGGCGCCGCGTTCATGTTGCTGTCCGGGCTCGTGATGATCGTCGCGCCGCA
CGCGATCGTCGGGCTCTATCTGCGTCTCGACGACCCGGCCAACGCGCGCACCATCGCGCTGGCGGCCTCGCTGCTCGGCA
TCGCCGCGCTGTTCCAGATCGTCGACGGCGTGCAGACAGTGGGCTCGGGCTGCCTGCGCGGCCTCAAGGACACGCGCGTG
CCGATGCTGGCCGCCACGATCGGCTACTGGGGCATCGGCTTCCCGGTGGGCTACTGGTTCGCGTTCCATGTCGGGCTGGG
CGCGCGCGGGCTCTGGTGGGGCCTCGCGGCCGGCCTCGCCAGCGTCGCGGTGCTGATGACGTGGCGCTTCCACCGCAAGA
CCTCAATGCTGGCCGGCCGCTGA

Upstream 100 bases:

>100_bases
GGCCCCTGCGCGGCGCGATTCGACAGCGGGAAGCGAAACCCGTAAGCTTGCCGTCCCAGTACAACAACGCCGCGCGGGCT
CGCACTCGCGCGCACCGCTC

Downstream 100 bases:

>100_bases
CCGCCTGCGCCGCGAGCCGACGTGAAATCGGCCGCGGCGCTATGCTGGTCGCCTCCGGACGCCGTCGCCAGAACGGTGCC
CGTCCCCACTTGCGCTTTCA

Product: multidrug resistance protein NorM

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 460; Mature: 459

Protein sequence:

>460_residues
MPRHDFSRAALAPPSFSRHAADTARLAAPLAIAQLSQMAMSVTDTVLLGSLGPDALAAGGLGATLFFVAVTVLQGVLSSV
SVSVAHARGARDDSQIPHIYWTGVVLALLLSVPAIAVLLYTEPLLLMFHEPPMLAHHIGEYTRVLSLAAPGSLIGVGLMR
SFLPAIGAARRLLWVSIASVGVNAVLNYGLIHGAFGLPRLGFLGSAAATTLTIWLTAISLMLLLHGRPAYRQFVAASRPK
LPLMGELVGIGWPVAITYGVESTLFLATGLTIGVLGETSLAAHQIALNIASVTFMVPLAIGQAANVRVSYWVGAGAPLAA
RHAGFVAIGLGAAFMLLSGLVMIVAPHAIVGLYLRLDDPANARTIALAASLLGIAALFQIVDGVQTVGSGCLRGLKDTRV
PMLAATIGYWGIGFPVGYWFAFHVGLGARGLWWGLAAGLASVAVLMTWRFHRKTSMLAGR

Sequences:

>Translated_460_residues
MPRHDFSRAALAPPSFSRHAADTARLAAPLAIAQLSQMAMSVTDTVLLGSLGPDALAAGGLGATLFFVAVTVLQGVLSSV
SVSVAHARGARDDSQIPHIYWTGVVLALLLSVPAIAVLLYTEPLLLMFHEPPMLAHHIGEYTRVLSLAAPGSLIGVGLMR
SFLPAIGAARRLLWVSIASVGVNAVLNYGLIHGAFGLPRLGFLGSAAATTLTIWLTAISLMLLLHGRPAYRQFVAASRPK
LPLMGELVGIGWPVAITYGVESTLFLATGLTIGVLGETSLAAHQIALNIASVTFMVPLAIGQAANVRVSYWVGAGAPLAA
RHAGFVAIGLGAAFMLLSGLVMIVAPHAIVGLYLRLDDPANARTIALAASLLGIAALFQIVDGVQTVGSGCLRGLKDTRV
PMLAATIGYWGIGFPVGYWFAFHVGLGARGLWWGLAAGLASVAVLMTWRFHRKTSMLAGR
>Mature_459_residues
PRHDFSRAALAPPSFSRHAADTARLAAPLAIAQLSQMAMSVTDTVLLGSLGPDALAAGGLGATLFFVAVTVLQGVLSSVS
VSVAHARGARDDSQIPHIYWTGVVLALLLSVPAIAVLLYTEPLLLMFHEPPMLAHHIGEYTRVLSLAAPGSLIGVGLMRS
FLPAIGAARRLLWVSIASVGVNAVLNYGLIHGAFGLPRLGFLGSAAATTLTIWLTAISLMLLLHGRPAYRQFVAASRPKL
PLMGELVGIGWPVAITYGVESTLFLATGLTIGVLGETSLAAHQIALNIASVTFMVPLAIGQAANVRVSYWVGAGAPLAAR
HAGFVAIGLGAAFMLLSGLVMIVAPHAIVGLYLRLDDPANARTIALAASLLGIAALFQIVDGVQTVGSGCLRGLKDTRVP
MLAATIGYWGIGFPVGYWFAFHVGLGARGLWWGLAAGLASVAVLMTWRFHRKTSMLAGR

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI22907060, Length=413, Percent_Identity=26.3922518159806, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI153792564, Length=433, Percent_Identity=24.2494226327945, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI38261960, Length=464, Percent_Identity=22.4137931034483, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI48994890, Length=435, Percent_Identity=31.0344827586207, Blast_Score=165, Evalue=5e-42,
Organism=Escherichia coli, GI226510954, Length=453, Percent_Identity=26.4900662251656, Blast_Score=89, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6320545, Length=436, Percent_Identity=23.394495412844, Blast_Score=81, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 47958; Mature: 47827

Theoretical pI: Translated: 10.59; Mature: 10.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRHDFSRAALAPPSFSRHAADTARLAAPLAIAQLSQMAMSVTDTVLLGSLGPDALAAGG
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCC
LGATLFFVAVTVLQGVLSSVSVSVAHARGARDDSQIPHIYWTGVVLALLLSVPAIAVLLY
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHH
TEPLLLMFHEPPMLAHHIGEYTRVLSLAAPGSLIGVGLMRSFLPAIGAARRLLWVSIASV
HCCEEEEECCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVNAVLNYGLIHGAFGLPRLGFLGSAAATTLTIWLTAISLMLLLHGRPAYRQFVAASRPK
HHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCC
LPLMGELVGIGWPVAITYGVESTLFLATGLTIGVLGETSLAAHQIALNIASVTFMVPLAI
CCHHHHHHCCCCCEEEEECCCHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHC
GQAANVRVSYWVGAGAPLAARHAGFVAIGLGAAFMLLSGLVMIVAPHAIVGLYLRLDDPA
CCCCCEEEEEEECCCCCHHHHCCCEEEEHHHHHHHHHHHHHHHHCCHHHEEEEEEECCCC
NARTIALAASLLGIAALFQIVDGVQTVGSGCLRGLKDTRVPMLAATIGYWGIGFPVGYWF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCHHHHHHHH
AFHVGLGARGLWWGLAAGLASVAVLMTWRFHRKTSMLAGR
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PRHDFSRAALAPPSFSRHAADTARLAAPLAIAQLSQMAMSVTDTVLLGSLGPDALAAGG
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCC
LGATLFFVAVTVLQGVLSSVSVSVAHARGARDDSQIPHIYWTGVVLALLLSVPAIAVLLY
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHH
TEPLLLMFHEPPMLAHHIGEYTRVLSLAAPGSLIGVGLMRSFLPAIGAARRLLWVSIASV
HCCEEEEECCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVNAVLNYGLIHGAFGLPRLGFLGSAAATTLTIWLTAISLMLLLHGRPAYRQFVAASRPK
HHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCC
LPLMGELVGIGWPVAITYGVESTLFLATGLTIGVLGETSLAAHQIALNIASVTFMVPLAI
CCHHHHHHCCCCCEEEEECCCHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHC
GQAANVRVSYWVGAGAPLAARHAGFVAIGLGAAFMLLSGLVMIVAPHAIVGLYLRLDDPA
CCCCCEEEEEEECCCCCHHHHCCCEEEEHHHHHHHHHHHHHHHHCCHHHEEEEEEECCCC
NARTIALAASLLGIAALFQIVDGVQTVGSGCLRGLKDTRVPMLAATIGYWGIGFPVGYWF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCHHHHHHHH
AFHVGLGARGLWWGLAAGLASVAVLMTWRFHRKTSMLAGR
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA