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The map label for this gene is ytpA [H]

Identifier: 238026547

GI number: 238026547

Start: 969355

End: 970224

Strand: Reverse

Name: ytpA [H]

Synonym: bglu_1g08910

Alternate gene names: 238026547

Gene position: 970224-969355 (Counterclockwise)

Preceding gene: 238026554

Following gene: 238026545

Centisome position: 24.84

GC content: 74.83

Gene sequence:

>870_bases
ATGCATGCCACCGCCCCCCAGGCCCGAGATCCGGGCGGCCCCGACGGTGCGGCCTGGACGCGGGTGCGCAGCGCCGACGG
CGTCGAGCTGGCCGCGTGCCGCTGGCCCGTCGCTACCCCGCCGCGCGCGACCATCGCGCTGCTGCACGGACTCGCCGAGC
ACGCGGGGCGCTACGACGCGCTGGCAGCCCGGCTCGCGGCCGCCGGCATCGAGCTGGTCGCCGTCGATCTGCGCGGCCAC
GGCCGCTCGCCGGGCTCGCGAGCCTGGGTCGAGCGCTTCGACCGCTATCTCGACGATGCCGACGCGCTGATCGGGTTCGC
CGCGCGCGACGGCGTGCCGTTGTTTCTGATGGGGCACAGCATGGGCGGCGCGATCGCGGCGCTGCATGCGATCGAGCGCG
CGCCGCGCGTGGCCGGGTTGCTGCTGTCGAGCCCGGCGCTCGCGCCCGGCCGCGACGTGCCGCGCTGGATGCTCGCGGCA
AGCCATGTGATGAGCCGCGTCTGGCCGCGCTTCCCGGCGCTGAAGATCGATGCGGCCTTGCTCTCGCGCGATCCGGCTGT
GGTGGCCGCGAACCGCGCGGACCCGCTGGTCCATCACGGTGCGGTGCCGGCGCGCACCGGCGCCGAATTGCTGGCCGCGA
TGGCACGCATCGCCCACGGCCGCGCGGCGCTGACGCTGCCCACGCTGGTCTGGCACGGCACCGCGGACCAGCTGACCGAG
CCCGACGGCAGCCGCGAGTTCGCCGCGCAGGCGGGGCCGGCCGACCTGACGCTCACGCTCTACGACGGCAATTATCACGA
GACGCTCAACGATCTCGAACGCGAGCGTGTGACCGGCGCGCTGATCGACTGGATTCGCGCCCGCACCTGA

Upstream 100 bases:

>100_bases
TCTTTCATAACCTGGAGAAATTAGAGGATCGGACCCGCGCGGCGCGCCGGCCGCGCGACTATGATCGACGGCATCCTGGA
ACCCGCCGGAGACCTTGCCG

Downstream 100 bases:

>100_bases
CCGTCCCGTTCCCACCTGAGGCAGGCGCCACCCGCGGCGCAGGAAGGATGGCGCGAGGCCGCCGCGCGCGTCAAACGCCC
GCCAGCACGCGCAGATGCGC

Product: alpha/beta fold family hydrolase

Products: NA

Alternate protein names: Bacilysocin biosynthesis protein ytpA [H]

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MHATAPQARDPGGPDGAAWTRVRSADGVELAACRWPVATPPRATIALLHGLAEHAGRYDALAARLAAAGIELVAVDLRGH
GRSPGSRAWVERFDRYLDDADALIGFAARDGVPLFLMGHSMGGAIAALHAIERAPRVAGLLLSSPALAPGRDVPRWMLAA
SHVMSRVWPRFPALKIDAALLSRDPAVVAANRADPLVHHGAVPARTGAELLAAMARIAHGRAALTLPTLVWHGTADQLTE
PDGSREFAAQAGPADLTLTLYDGNYHETLNDLERERVTGALIDWIRART

Sequences:

>Translated_289_residues
MHATAPQARDPGGPDGAAWTRVRSADGVELAACRWPVATPPRATIALLHGLAEHAGRYDALAARLAAAGIELVAVDLRGH
GRSPGSRAWVERFDRYLDDADALIGFAARDGVPLFLMGHSMGGAIAALHAIERAPRVAGLLLSSPALAPGRDVPRWMLAA
SHVMSRVWPRFPALKIDAALLSRDPAVVAANRADPLVHHGAVPARTGAELLAAMARIAHGRAALTLPTLVWHGTADQLTE
PDGSREFAAQAGPADLTLTLYDGNYHETLNDLERERVTGALIDWIRART
>Mature_289_residues
MHATAPQARDPGGPDGAAWTRVRSADGVELAACRWPVATPPRATIALLHGLAEHAGRYDALAARLAAAGIELVAVDLRGH
GRSPGSRAWVERFDRYLDDADALIGFAARDGVPLFLMGHSMGGAIAALHAIERAPRVAGLLLSSPALAPGRDVPRWMLAA
SHVMSRVWPRFPALKIDAALLSRDPAVVAANRADPLVHHGAVPARTGAELLAAMARIAHGRAALTLPTLVWHGTADQLTE
PDGSREFAAQAGPADLTLTLYDGNYHETLNDLERERVTGALIDWIRART

Specific function: Phospholipase involved in the biosynthesis of the antibiotic bacilysocin. It probably catalyzes the hydrolysis of the 2-sn-acyl moiety of phosphatidylglycerol to produce bacilysocin (lysophosphatidylglycerol). Is also able to catalyze the hydrolysis react

COG id: COG2267

COG function: function code I; Lysophospholipase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AB hydrolase superfamily [H]

Homologues:

Organism=Homo sapiens, GI51242953, Length=273, Percent_Identity=34.7985347985348, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI6005786, Length=273, Percent_Identity=34.7985347985348, Blast_Score=146, Evalue=2e-35,
Organism=Escherichia coli, GI1787678, Length=258, Percent_Identity=29.0697674418605, Blast_Score=83, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6322756, Length=300, Percent_Identity=25.3333333333333, Blast_Score=85, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR022742 [H]

Pfam domain/function: PF12146 Hydrolase_4 [H]

EC number: NA

Molecular weight: Translated: 30681; Mature: 30681

Theoretical pI: Translated: 7.47; Mature: 7.47

Prosite motif: PS00120 LIPASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHATAPQARDPGGPDGAAWTRVRSADGVELAACRWPVATPPRATIALLHGLAEHAGRYDA
CCCCCCCCCCCCCCCCHHHHEECCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCHHHH
LAARLAAAGIELVAVDLRGHGRSPGSRAWVERFDRYLDDADALIGFAARDGVPLFLMGHS
HHHHHHHCCEEEEEEEECCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEEECC
MGGAIAALHAIERAPRVAGLLLSSPALAPGRDVPRWMLAASHVMSRVWPRFPALKIDAAL
CCHHHHHHHHHHHCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEHHHH
LSRDPAVVAANRADPLVHHGAVPARTGAELLAAMARIAHGRAALTLPTLVWHGTADQLTE
HCCCCCEEEECCCCCHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEHHHHEECCCHHHCCC
PDGSREFAAQAGPADLTLTLYDGNYHETLNDLERERVTGALIDWIRART
CCCCHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MHATAPQARDPGGPDGAAWTRVRSADGVELAACRWPVATPPRATIALLHGLAEHAGRYDA
CCCCCCCCCCCCCCCCHHHHEECCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCHHHH
LAARLAAAGIELVAVDLRGHGRSPGSRAWVERFDRYLDDADALIGFAARDGVPLFLMGHS
HHHHHHHCCEEEEEEEECCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEEECC
MGGAIAALHAIERAPRVAGLLLSSPALAPGRDVPRWMLAASHVMSRVWPRFPALKIDAAL
CCHHHHHHHHHHHCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEHHHH
LSRDPAVVAANRADPLVHHGAVPARTGAELLAAMARIAHGRAALTLPTLVWHGTADQLTE
HCCCCCEEEECCCCCHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEHHHHEECCCHHHCCC
PDGSREFAAQAGPADLTLTLYDGNYHETLNDLERERVTGALIDWIRART
CCCCHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]