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The map label for this gene is adiC [H]

Identifier: 238026522

GI number: 238026522

Start: 941603

End: 942907

Strand: Reverse

Name: adiC [H]

Synonym: bglu_1g08660

Alternate gene names: 238026522

Gene position: 942907-941603 (Counterclockwise)

Preceding gene: 238026524

Following gene: 238026521

Centisome position: 24.14

GC content: 65.21

Gene sequence:

>1305_bases
ATGTCGACCAAAAAGATGGGACTCGTTGCGCTGACGCTCGTCACCGCCTCGAACATGATGGGCTCCGGGGTGTTCCTCCT
GCCCACCAACCTCGCCAACGTCGGCTACATCTCGGTGTGGGGGTGGGCACTGACGATCGTCGGCGTGATGGCGCTGGCGC
TGGTGTTCGCCAAGACCAACCTGGTTCAGCAGCGCGCAGGCGGCATCGTCGCCTATGCCGGCGACGCGTTCGGGCCGTTC
ATCGGTTTCCAGTCCACGTTCTGCTACTGGATCAGCGCCTGGGTCGGCAACGTGGCGCTGCTGGTGGCGGGGGTCGGCTA
CCTGAGCTATTTCTTTCCGCAGATGAAGAACCCGATGATCGGCAGCCTGACGGCCATCGGCATTCTGTGGGCGTTCATCG
GCCTGTCCTGCTTCGGCGCCAAGGTGGCCGGGCGGGCGCAGTCGTTTACCGCCTCCTGCATGCTGATCGTCGTGCTCGGC
GTCGGGCTCGGCGGCTGGGGATGGTTCAACCCCCATACCTTCACGGAGGTGTACAACGGCACGCCCCACGGTAGCGGCGC
GGCGATCGTCACGGCAGCCTCGATCGCGCTCTGGGGGTTTCTCGGCGTCGAATCGGCCGTGGTGTCGACCGGCCAGGTCG
AACGCCCCGAATATACGGTTCCGCGCGCCACCGTCATCGGCCTGCTGATCGCGGCGTTCTGCTACGTGGCGAGCTGCACG
GTCATCATGGGTATCGTCCCGCATGCAGTGCTGATCAAGTCGGCCGCGCCGTTCGCCGATTCGGCACGCTACATGTTCGG
TCCGCGCGCCGGCGAAATCGTCTCCGCGCTCAGCGTCATCGCCTGCCTCGGCTCGATTTCGGGCTGGCTGATCCTGCAGA
GCGAATCGGCCCGCTCGGGGGCCGAACGGGGCCTGTTTCCGCGCTTCTTCGCCGACACCAACCGCAACGACGTGACGGTC
AAGGGGCTCGTCGTCACCGGCGTGCTGATGTCGGGCGTGCTGCTGCTGACGGCTTCGCCCGATCTGGCCGCCCAGTTCCA
GGTGATCATCCTGATGTCGGTGTTCGCCTCGCTGCTGCCCTACATGTACGCGGTGATGGCGCTGCCCATCATCATGGCCT
CGAAGAAGATGAACATCGGCCCGACCTTCAAGCTCTACGCCGTGCTGGCCCTGATCGGCGTGGTCTACAGCATCTTCGCG
CTGCTCGGATCGGGTTCCCGGTCGATCTTCTGGGGCACCGCGCTGATCATGGTGACGATTCCGCTGTACTCGCTCGTGGT
CCGCAACCAAGCGGCCCGCACCTGA

Upstream 100 bases:

>100_bases
CAATCCCCCACCGCCTTGCTCCTTTGACTTGTCTATACAAGCTTTATAGTGAAGCGCGTCCTTCACTTTCATGGAGCGGA
AAATGGGAAATGCACAGGTC

Downstream 100 bases:

>100_bases
GGCATCACATGCAGGCATGCATGCCCGCATCCGGATTCATTTTATAAGGAATACGAACCAGCCCGGCGAGGCCGCGGCAG
GTTACTTCGGAGCAATTTCA

Product: putative cationic amino acid permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MSTKKMGLVALTLVTASNMMGSGVFLLPTNLANVGYISVWGWALTIVGVMALALVFAKTNLVQQRAGGIVAYAGDAFGPF
IGFQSTFCYWISAWVGNVALLVAGVGYLSYFFPQMKNPMIGSLTAIGILWAFIGLSCFGAKVAGRAQSFTASCMLIVVLG
VGLGGWGWFNPHTFTEVYNGTPHGSGAAIVTAASIALWGFLGVESAVVSTGQVERPEYTVPRATVIGLLIAAFCYVASCT
VIMGIVPHAVLIKSAAPFADSARYMFGPRAGEIVSALSVIACLGSISGWLILQSESARSGAERGLFPRFFADTNRNDVTV
KGLVVTGVLMSGVLLLTASPDLAAQFQVIILMSVFASLLPYMYAVMALPIIMASKKMNIGPTFKLYAVLALIGVVYSIFA
LLGSGSRSIFWGTALIMVTIPLYSLVVRNQAART

Sequences:

>Translated_434_residues
MSTKKMGLVALTLVTASNMMGSGVFLLPTNLANVGYISVWGWALTIVGVMALALVFAKTNLVQQRAGGIVAYAGDAFGPF
IGFQSTFCYWISAWVGNVALLVAGVGYLSYFFPQMKNPMIGSLTAIGILWAFIGLSCFGAKVAGRAQSFTASCMLIVVLG
VGLGGWGWFNPHTFTEVYNGTPHGSGAAIVTAASIALWGFLGVESAVVSTGQVERPEYTVPRATVIGLLIAAFCYVASCT
VIMGIVPHAVLIKSAAPFADSARYMFGPRAGEIVSALSVIACLGSISGWLILQSESARSGAERGLFPRFFADTNRNDVTV
KGLVVTGVLMSGVLLLTASPDLAAQFQVIILMSVFASLLPYMYAVMALPIIMASKKMNIGPTFKLYAVLALIGVVYSIFA
LLGSGSRSIFWGTALIMVTIPLYSLVVRNQAART
>Mature_433_residues
STKKMGLVALTLVTASNMMGSGVFLLPTNLANVGYISVWGWALTIVGVMALALVFAKTNLVQQRAGGIVAYAGDAFGPFI
GFQSTFCYWISAWVGNVALLVAGVGYLSYFFPQMKNPMIGSLTAIGILWAFIGLSCFGAKVAGRAQSFTASCMLIVVLGV
GLGGWGWFNPHTFTEVYNGTPHGSGAAIVTAASIALWGFLGVESAVVSTGQVERPEYTVPRATVIGLLIAAFCYVASCTV
IMGIVPHAVLIKSAAPFADSARYMFGPRAGEIVSALSVIACLGSISGWLILQSESARSGAERGLFPRFFADTNRNDVTVK
GLVVTGVLMSGVLLLTASPDLAAQFQVIILMSVFASLLPYMYAVMALPIIMASKKMNIGPTFKLYAVLALIGVVYSIFAL
LGSGSRSIFWGTALIMVTIPLYSLVVRNQAART

Specific function: Major component of the acid-resistance (AR) system allowing enteric pathogens to survive the acidic environment in the stomach. Exchanges extracellular arginine for its intracellular decarboxylation product agmatine (Agm) thereby expelling intracellular p

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Escherichia coli, GI2367353, Length=424, Percent_Identity=40.8018867924528, Blast_Score=338, Evalue=4e-94,
Organism=Escherichia coli, GI1786908, Length=428, Percent_Identity=37.1495327102804, Blast_Score=271, Evalue=7e-74,
Organism=Escherichia coli, GI1790575, Length=410, Percent_Identity=35.8536585365854, Blast_Score=229, Evalue=3e-61,
Organism=Escherichia coli, GI1787890, Length=351, Percent_Identity=29.9145299145299, Blast_Score=104, Evalue=9e-24,
Organism=Escherichia coli, GI1790653, Length=296, Percent_Identity=23.9864864864865, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI87082250, Length=337, Percent_Identity=24.6290801186944, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1790584, Length=287, Percent_Identity=26.4808362369338, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 45722; Mature: 45591

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHCCC
>Mature Secondary Structure 
STKKMGLVALTLVTASNMMGSGVFLLPTNLANVGYISVWGWALTIVGVMALALVFAKTN
CCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LVQQRAGGIVAYAGDAFGPFIGFQSTFCYWISAWVGNVALLVAGVGYLSYFFPQMKNPMI
HHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
GSLTAIGILWAFIGLSCFGAKVAGRAQSFTASCMLIVVLGVGLGGWGWFNPHTFTEVYNG
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCC
TPHGSGAAIVTAASIALWGFLGVESAVVSTGQVERPEYTVPRATVIGLLIAAFCYVASCT
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
VIMGIVPHAVLIKSAAPFADSARYMFGPRAGEIVSALSVIACLGSISGWLILQSESARSG
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCC
AERGLFPRFFADTNRNDVTVKGLVVTGVLMSGVLLLTASPDLAAQFQVIILMSVFASLLP
HHCCCCCHHHCCCCCCCEEEHHHHHHHHHHHCEEEEECCCCHHHHHHHHHHHHHHHHHHH
YMYAVMALPIIMASKKMNIGPTFKLYAVLALIGVVYSIFALLGSGSRSIFWGTALIMVTI
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
PLYSLVVRNQAART
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]