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The map label for this gene is clcA [H]

Identifier: 238026479

GI number: 238026479

Start: 887329

End: 888960

Strand: Reverse

Name: clcA [H]

Synonym: bglu_1g08230

Alternate gene names: 238026479

Gene position: 888960-887329 (Counterclockwise)

Preceding gene: 238026480

Following gene: 238026468

Centisome position: 22.76

GC content: 70.77

Gene sequence:

>1632_bases
ATGCAACGGTTGACCGATTTCCTCCCGACGCTGACGCGCCGTTCGCTACGGCTCTGGCGCCTGTACGGCGTGTTCTGGCT
GGGCGCGATCGTGGTCGGCATCACCGCGGTACTCTACGCGCGCCTGATCGACTGGGGCTACGAGACGTTCCGCTCGCTGC
AGCAGAGCCACGCGTGGCTGCCGCTGATCCTGACCCCGGCGATCGCCTCGGCCTCGGTCTGGCTCACGCGCCGCTTCTTT
CGCGGCGCCGAGGGCAGCGGCATCCCGCAGGTGATCGCGACGCTGCAGGCCAGCCCCAGCGCGTTCGGCGCGCGGCTGCT
GACGTTGCGCATCCTCTGCGGCAAGATCCTGATCTCGCTGCTCGGCATTCTCGGCGGCTTCACGATCGGCCGCGAGGGGC
CGACGGTCCAGATCGGCGCCGCGCTGATGTTCAACCTGCGGCGCTTCTATCCGCGCTCGAACGCGCTGATCGAGCGCCAG
CTCGTGCTGGCCGGTGCAGCGGCCGGCCTGTCGGCGGCCTTCAACACGCCGCTGGCCGGGATCGTGTTCGCGATCGAGGA
ACTCACGCGCAGCTTCTCCGAGCGCGCGAGCGGCGTGCTGATCACGGCGATCATCATCGCCGGGGTGATCGCGCTCGGCA
TGAATGGCAACTACACCTACTTCGGCACCATCGACGTCGGCCCGCACTTTCCGCGGCTGATGGCAGTGGCGGTGCTGGCC
GCCGCAATCACCACCGGCATCGCGGGCGGCCTGTTCTCCTGGCTGCTGCTCAATACCAACCGCTGGCTGCCCGCGCGGCT
GCTGACGATGTACCGCGGCCGGCCGGTCGCGTTCGCGGCCCTCTGCGGGCTCGTGATCGCGGTGGTCGGCATGGTGTCGG
GCGGCACCACGTTCGGCAGCGGCTATGCCGAGGCGCGCGGCCTGCTGGGCGGCCATTCGCAGTTGTCGATGCTGTATCCG
TTCGAGAAGATGGTCTCGATGGTCGCGTCGTACCTGCCCGGGATTCCAGGCGGAATCTTCGCGCCCTCGCTGTCGATCGG
TGCCGGCTTCGGCAACCTGCTGCACCTGGCGTTCACCCATGTGCCGCTGACGATGCTGATCGCGCTGGCGATGGTCGGCT
ATCTGGCCGCGGTCACGCAAGCGCCGATCACCTCGTTCGTGATCGTGATGGAAATGATCAACGGGCATGCGCTCGTGATC
TCGCTGATGGCCACCGCACTGATCTCCAGCCGCGTGTCACGCTTCTTCGTGACGCCGCTCTACGAGGCGCTCGCGCACCG
CTACCTGCATCCGCCCGCGCCGCCCGCTACCGCGACGGCAACCGCCACGACAGCCGCGGCGGCGAGCGACGACGGACTGA
CGACGCCGGCCGACGCCACCGCCTCGCCGGCCGATCCGCTGCGCACGCTGACGCGCGGGGCGGTCGGCGAAGCCGATCCC
GCCACCGGCAGCGAGACGGCTGCGCGCCAGCCCGATGCCGCCGCCGGCCACCAGGCCGGCGCGCGCGACGCCGCCCAACA
GGCCGACTCCGTCACGTCGGCCCGGCCCGACGCCATCGGCCCCGCCGGCACCGCGCACCAAGCCGCGAGCCCGCCCGCGC
CGCACGACGCGAACGACCCGCCGGCGCGCTGA

Upstream 100 bases:

>100_bases
GCGGCCTCGGCCCGCCCCCATCGACGGGCACGATCGCGTGCTCTCGGGCCGGATCTCCGTATAATTCCCTTTTGTCCGCG
CCGCCTGCCACCATGCCGCC

Downstream 100 bases:

>100_bases
GCGCGCCGCCACCTCGCCTCAATACACGACGACGCGCGCCGGACGGTAGTACACCGGCCGCGCCGGCACGACCACGCAGC
CGGCCAGCACGACGGCGGCG

Product: Cl- channel, voltage-gated family protein

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 543; Mature: 543

Protein sequence:

>543_residues
MQRLTDFLPTLTRRSLRLWRLYGVFWLGAIVVGITAVLYARLIDWGYETFRSLQQSHAWLPLILTPAIASASVWLTRRFF
RGAEGSGIPQVIATLQASPSAFGARLLTLRILCGKILISLLGILGGFTIGREGPTVQIGAALMFNLRRFYPRSNALIERQ
LVLAGAAAGLSAAFNTPLAGIVFAIEELTRSFSERASGVLITAIIIAGVIALGMNGNYTYFGTIDVGPHFPRLMAVAVLA
AAITTGIAGGLFSWLLLNTNRWLPARLLTMYRGRPVAFAALCGLVIAVVGMVSGGTTFGSGYAEARGLLGGHSQLSMLYP
FEKMVSMVASYLPGIPGGIFAPSLSIGAGFGNLLHLAFTHVPLTMLIALAMVGYLAAVTQAPITSFVIVMEMINGHALVI
SLMATALISSRVSRFFVTPLYEALAHRYLHPPAPPATATATATTAAAASDDGLTTPADATASPADPLRTLTRGAVGEADP
ATGSETAARQPDAAAGHQAGARDAAQQADSVTSARPDAIGPAGTAHQAASPPAPHDANDPPAR

Sequences:

>Translated_543_residues
MQRLTDFLPTLTRRSLRLWRLYGVFWLGAIVVGITAVLYARLIDWGYETFRSLQQSHAWLPLILTPAIASASVWLTRRFF
RGAEGSGIPQVIATLQASPSAFGARLLTLRILCGKILISLLGILGGFTIGREGPTVQIGAALMFNLRRFYPRSNALIERQ
LVLAGAAAGLSAAFNTPLAGIVFAIEELTRSFSERASGVLITAIIIAGVIALGMNGNYTYFGTIDVGPHFPRLMAVAVLA
AAITTGIAGGLFSWLLLNTNRWLPARLLTMYRGRPVAFAALCGLVIAVVGMVSGGTTFGSGYAEARGLLGGHSQLSMLYP
FEKMVSMVASYLPGIPGGIFAPSLSIGAGFGNLLHLAFTHVPLTMLIALAMVGYLAAVTQAPITSFVIVMEMINGHALVI
SLMATALISSRVSRFFVTPLYEALAHRYLHPPAPPATATATATTAAAASDDGLTTPADATASPADPLRTLTRGAVGEADP
ATGSETAARQPDAAAGHQAGARDAAQQADSVTSARPDAIGPAGTAHQAASPPAPHDANDPPAR
>Mature_543_residues
MQRLTDFLPTLTRRSLRLWRLYGVFWLGAIVVGITAVLYARLIDWGYETFRSLQQSHAWLPLILTPAIASASVWLTRRFF
RGAEGSGIPQVIATLQASPSAFGARLLTLRILCGKILISLLGILGGFTIGREGPTVQIGAALMFNLRRFYPRSNALIERQ
LVLAGAAAGLSAAFNTPLAGIVFAIEELTRSFSERASGVLITAIIIAGVIALGMNGNYTYFGTIDVGPHFPRLMAVAVLA
AAITTGIAGGLFSWLLLNTNRWLPARLLTMYRGRPVAFAALCGLVIAVVGMVSGGTTFGSGYAEARGLLGGHSQLSMLYP
FEKMVSMVASYLPGIPGGIFAPSLSIGAGFGNLLHLAFTHVPLTMLIALAMVGYLAAVTQAPITSFVIVMEMINGHALVI
SLMATALISSRVSRFFVTPLYEALAHRYLHPPAPPATATATATTAAAASDDGLTTPADATASPADPLRTLTRGAVGEADP
ATGSETAARQPDAAAGHQAGARDAAQQADSVTSARPDAIGPAGTAHQAASPPAPHDANDPPAR

Specific function: Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786350, Length=454, Percent_Identity=29.5154185022026, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI87081943, Length=309, Percent_Identity=29.7734627831715, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 56777; Mature: 56777

Theoretical pI: Translated: 10.00; Mature: 10.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRLTDFLPTLTRRSLRLWRLYGVFWLGAIVVGITAVLYARLIDWGYETFRSLQQSHAWL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PLILTPAIASASVWLTRRFFRGAEGSGIPQVIATLQASPSAFGARLLTLRILCGKILISL
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
LGILGGFTIGREGPTVQIGAALMFNLRRFYPRSNALIERQLVLAGAAAGLSAAFNTPLAG
HHHHCCCCCCCCCCCEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHH
IVFAIEELTRSFSERASGVLITAIIIAGVIALGMNGNYTYFGTIDVGPHFPRLMAVAVLA
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHH
AAITTGIAGGLFSWLLLNTNRWLPARLLTMYRGRPVAFAALCGLVIAVVGMVSGGTTFGS
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
GYAEARGLLGGHSQLSMLYPFEKMVSMVASYLPGIPGGIFAPSLSIGAGFGNLLHLAFTH
CHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHCCCCCCCHHCCCCHHCCCHHHHHHHHHHH
VPLTMLIALAMVGYLAAVTQAPITSFVIVMEMINGHALVISLMATALISSRVSRFFVTPL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
YEALAHRYLHPPAPPATATATATTAAAASDDGLTTPADATASPADPLRTLTRGAVGEADP
HHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCC
ATGSETAARQPDAAAGHQAGARDAAQQADSVTSARPDAIGPAGTAHQAASPPAPHDANDP
CCCCCHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PAR
CCC
>Mature Secondary Structure
MQRLTDFLPTLTRRSLRLWRLYGVFWLGAIVVGITAVLYARLIDWGYETFRSLQQSHAWL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PLILTPAIASASVWLTRRFFRGAEGSGIPQVIATLQASPSAFGARLLTLRILCGKILISL
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
LGILGGFTIGREGPTVQIGAALMFNLRRFYPRSNALIERQLVLAGAAAGLSAAFNTPLAG
HHHHCCCCCCCCCCCEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHH
IVFAIEELTRSFSERASGVLITAIIIAGVIALGMNGNYTYFGTIDVGPHFPRLMAVAVLA
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHH
AAITTGIAGGLFSWLLLNTNRWLPARLLTMYRGRPVAFAALCGLVIAVVGMVSGGTTFGS
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
GYAEARGLLGGHSQLSMLYPFEKMVSMVASYLPGIPGGIFAPSLSIGAGFGNLLHLAFTH
CHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHCCCCCCCHHCCCCHHCCCHHHHHHHHHHH
VPLTMLIALAMVGYLAAVTQAPITSFVIVMEMINGHALVISLMATALISSRVSRFFVTPL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
YEALAHRYLHPPAPPATATATATTAAAASDDGLTTPADATASPADPLRTLTRGAVGEADP
HHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCC
ATGSETAARQPDAAAGHQAGARDAAQQADSVTSARPDAIGPAGTAHQAASPPAPHDANDP
CCCCCHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PAR
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA