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The map label for this gene is zwf [H]

Identifier: 238026462

GI number: 238026462

Start: 867945

End: 869414

Strand: Reverse

Name: zwf [H]

Synonym: bglu_1g08060

Alternate gene names: 238026462

Gene position: 869414-867945 (Counterclockwise)

Preceding gene: 238026467

Following gene: 238026461

Centisome position: 22.26

GC content: 67.35

Gene sequence:

>1470_bases
ATGCAAACCGATTCCAGCTTTACCTTCGTTCTGTTCGGCGGCACCGGCGACCTGTCGATGCGCAAGATCCTACCCGCGCT
GTTCGAGGCGCACCGCGCCAACATGCTCGCCGAGGCGGGACGCATTGTCGCGGTCGCGCGCCACGAGTCGGATCGCGCCG
CCTATCACCGCTGGGTCGAGGAACACGTGAAGCCGCATGCGAGGAAGGCGTCGGGCAGCGCGTTCCAGGAGGCCGACTGG
CAGCGCTTCCTCGCGCGCATCGACTATGTCCATCTCGACCTCGGCCGCCCGGCGGATTACGAGGTGCTGCGCGATGCGAT
CGGCACGCTGCCCGGCACGCGCGTGTTCTACCTGGCCACCGGCCCCTCGCTGTTCGAGCCGATCTGCAAGGCGCTGGCCG
GCGTGGGCCTGAGCGAAGGCGCGCGCATCGTGCTCGAGAAGCCGCTCGGCTACGACCTCGCCTCGTCCAACGAAATCAAC
GACGCGGTGGGCGAGATCTTCGCCGAGGACCAGATCTACCGGATCGACCACTATCTCGGCAAGGAGCCGGTACAAAACCT
GCTGGCGCTGCGCTTCGGCAATGCGCTGTTCGAGCCGCTGTGGCGCCGCGAGTGGGTGGAGAGCATCCAGATCACGATCG
CCGAGGAACTCGGCGTGGAAGCGCGCGGCGATTTCTACGACAACACCGGCGCGCTGCGCGACATGGTGCAGAACCACCTG
CTGCAGCTGCTGTCGATCGTGGCGATGGAGCCGCCGCATTCGATGGATTCGGATTCGGTGCGCGACGAAAAGCTGCGCGT
GCTGCGCGCGCTCAAGCCGGTCGACCCGCGCGACATCAGCAAGGTGGCCGTGCGCGGCCAGTACCACAGCGGCACCATCA
AGGGCACCCAGGTGCCCGCCTATGCCACCGAGCCGGGCGTGAAGCCCGACAGCACGACCGAGACCTACGTCGCGCTGAAG
GTCGAGATCGAGAACTGGCGCTGGGCCGGCGTGCCGTTCTTCCTGCGTACCGGCAAGCGGCTCGCCGATCGCGTCGCCGA
GATCGTGGTCAACTTCCGCGCCGTGCCGCATTCGGCGCTCGGTGCCTCCGCGCTGCGCGCCGGCGCGAACCGGCTGGTGA
TCCGGCTGCAGCCGAACGAGTCGATCCGCCTCTACTGCCTCGCCAAGCAACCCGGCGAGGGCATGAACCTGGCGAGCGTG
CACCTCGACCTCGCGTTCGACCAGTTTTTCAAGGAAGGCCAGATGGAGGCCTACCAGCGCCTGCTGCTCGACGTGATCAA
CGGACGCCTCGCGCTGTTCGTGCGGCGCGACGAGCAGGAAGCCGCCTGGCGCTGGGTCGAGCCGATCCAGAACGAATGGC
AGAAATCGCTGAAGCCGCCGAAGCCCTACGCATCGGGCACCTGGGGGCCGGCCGCCGCGAGCGCGATGCTCGCCCAGCAC
GGCACCTGCTGGCTGGAAGAAGAAAACTGA

Upstream 100 bases:

>100_bases
ATTTTTATCGCACTACGGTTCCGATTCGTACCCGCCGCGCCCGCCGGATCGAGGTCGCAGGCATGCCGTGGTGGGGGCAC
TTCCAACCGGGCGGAGACAC

Downstream 100 bases:

>100_bases
GCGAAACCGCGATGCGGCGGCTCGCGGCCGGTCGGCCACGCCGCGGCATCGGCAATCCATGATGTCCGAAATCAATAAGA
GCAGCCTGGAGGAGAAGTGA

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 489; Mature: 489

Protein sequence:

>489_residues
MQTDSSFTFVLFGGTGDLSMRKILPALFEAHRANMLAEAGRIVAVARHESDRAAYHRWVEEHVKPHARKASGSAFQEADW
QRFLARIDYVHLDLGRPADYEVLRDAIGTLPGTRVFYLATGPSLFEPICKALAGVGLSEGARIVLEKPLGYDLASSNEIN
DAVGEIFAEDQIYRIDHYLGKEPVQNLLALRFGNALFEPLWRREWVESIQITIAEELGVEARGDFYDNTGALRDMVQNHL
LQLLSIVAMEPPHSMDSDSVRDEKLRVLRALKPVDPRDISKVAVRGQYHSGTIKGTQVPAYATEPGVKPDSTTETYVALK
VEIENWRWAGVPFFLRTGKRLADRVAEIVVNFRAVPHSALGASALRAGANRLVIRLQPNESIRLYCLAKQPGEGMNLASV
HLDLAFDQFFKEGQMEAYQRLLLDVINGRLALFVRRDEQEAAWRWVEPIQNEWQKSLKPPKPYASGTWGPAAASAMLAQH
GTCWLEEEN

Sequences:

>Translated_489_residues
MQTDSSFTFVLFGGTGDLSMRKILPALFEAHRANMLAEAGRIVAVARHESDRAAYHRWVEEHVKPHARKASGSAFQEADW
QRFLARIDYVHLDLGRPADYEVLRDAIGTLPGTRVFYLATGPSLFEPICKALAGVGLSEGARIVLEKPLGYDLASSNEIN
DAVGEIFAEDQIYRIDHYLGKEPVQNLLALRFGNALFEPLWRREWVESIQITIAEELGVEARGDFYDNTGALRDMVQNHL
LQLLSIVAMEPPHSMDSDSVRDEKLRVLRALKPVDPRDISKVAVRGQYHSGTIKGTQVPAYATEPGVKPDSTTETYVALK
VEIENWRWAGVPFFLRTGKRLADRVAEIVVNFRAVPHSALGASALRAGANRLVIRLQPNESIRLYCLAKQPGEGMNLASV
HLDLAFDQFFKEGQMEAYQRLLLDVINGRLALFVRRDEQEAAWRWVEPIQNEWQKSLKPPKPYASGTWGPAAASAMLAQH
GTCWLEEEN
>Mature_489_residues
MQTDSSFTFVLFGGTGDLSMRKILPALFEAHRANMLAEAGRIVAVARHESDRAAYHRWVEEHVKPHARKASGSAFQEADW
QRFLARIDYVHLDLGRPADYEVLRDAIGTLPGTRVFYLATGPSLFEPICKALAGVGLSEGARIVLEKPLGYDLASSNEIN
DAVGEIFAEDQIYRIDHYLGKEPVQNLLALRFGNALFEPLWRREWVESIQITIAEELGVEARGDFYDNTGALRDMVQNHL
LQLLSIVAMEPPHSMDSDSVRDEKLRVLRALKPVDPRDISKVAVRGQYHSGTIKGTQVPAYATEPGVKPDSTTETYVALK
VEIENWRWAGVPFFLRTGKRLADRVAEIVVNFRAVPHSALGASALRAGANRLVIRLQPNESIRLYCLAKQPGEGMNLASV
HLDLAFDQFFKEGQMEAYQRLLLDVINGRLALFVRRDEQEAAWRWVEPIQNEWQKSLKPPKPYASGTWGPAAASAMLAQH
GTCWLEEEN

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=488, Percent_Identity=37.2950819672131, Blast_Score=313, Evalue=2e-85,
Organism=Homo sapiens, GI109389365, Length=488, Percent_Identity=37.2950819672131, Blast_Score=313, Evalue=2e-85,
Organism=Homo sapiens, GI52145310, Length=364, Percent_Identity=32.1428571428571, Blast_Score=165, Evalue=9e-41,
Organism=Escherichia coli, GI1788158, Length=491, Percent_Identity=44.3991853360489, Blast_Score=434, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI17538218, Length=499, Percent_Identity=35.6713426853707, Blast_Score=323, Evalue=9e-89,
Organism=Saccharomyces cerevisiae, GI6324088, Length=488, Percent_Identity=34.2213114754098, Blast_Score=290, Evalue=3e-79,
Organism=Drosophila melanogaster, GI24643350, Length=478, Percent_Identity=37.6569037656904, Blast_Score=310, Evalue=1e-84,
Organism=Drosophila melanogaster, GI24643352, Length=478, Percent_Identity=37.6569037656904, Blast_Score=310, Evalue=2e-84,
Organism=Drosophila melanogaster, GI221513548, Length=483, Percent_Identity=27.9503105590062, Blast_Score=202, Evalue=4e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 54795; Mature: 54795

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTDSSFTFVLFGGTGDLSMRKILPALFEAHRANMLAEAGRIVAVARHESDRAAYHRWVE
CCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHH
EHVKPHARKASGSAFQEADWQRFLARIDYVHLDLGRPADYEVLRDAIGTLPGTRVFYLAT
HHCCCHHHCCCCCHHHHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHCCCCCEEEEEEC
GPSLFEPICKALAGVGLSEGARIVLEKPLGYDLASSNEINDAVGEIFAEDQIYRIDHYLG
CCHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHCCCEEEHHHHCC
KEPVQNLLALRFGNALFEPLWRREWVESIQITIAEELGVEARGDFYDNTGALRDMVQNHL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHCCCCCCCCCCCCCHHHHHHHHHHH
LQLLSIVAMEPPHSMDSDSVRDEKLRVLRALKPVDPRDISKVAVRGQYHSGTIKGTQVPA
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCCCC
YATEPGVKPDSTTETYVALKVEIENWRWAGVPFFLRTGKRLADRVAEIVVNFRAVPHSAL
CCCCCCCCCCCCCCEEEEEEEEECCEEECCCHHHHHCCHHHHHHHHHHHHHHHCCCCHHH
GASALRAGANRLVIRLQPNESIRLYCLAKQPGEGMNLASVHLDLAFDQFFKEGQMEAYQR
HHHHHHCCCCEEEEEECCCCCEEEEEEECCCCCCCCEEEEEEHHHHHHHHHCCHHHHHHH
LLLDVINGRLALFVRRDEQEAAWRWVEPIQNEWQKSLKPPKPYASGTWGPAAASAMLAQH
HHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHC
GTCWLEEEN
CCEEEECCC
>Mature Secondary Structure
MQTDSSFTFVLFGGTGDLSMRKILPALFEAHRANMLAEAGRIVAVARHESDRAAYHRWVE
CCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHH
EHVKPHARKASGSAFQEADWQRFLARIDYVHLDLGRPADYEVLRDAIGTLPGTRVFYLAT
HHCCCHHHCCCCCHHHHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHCCCCCEEEEEEC
GPSLFEPICKALAGVGLSEGARIVLEKPLGYDLASSNEINDAVGEIFAEDQIYRIDHYLG
CCHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHCCCEEEHHHHCC
KEPVQNLLALRFGNALFEPLWRREWVESIQITIAEELGVEARGDFYDNTGALRDMVQNHL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHCCCCCCCCCCCCCHHHHHHHHHHH
LQLLSIVAMEPPHSMDSDSVRDEKLRVLRALKPVDPRDISKVAVRGQYHSGTIKGTQVPA
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCCCC
YATEPGVKPDSTTETYVALKVEIENWRWAGVPFFLRTGKRLADRVAEIVVNFRAVPHSAL
CCCCCCCCCCCCCCEEEEEEEEECCEEECCCHHHHHCCHHHHHHHHHHHHHHHCCCCHHH
GASALRAGANRLVIRLQPNESIRLYCLAKQPGEGMNLASVHLDLAFDQFFKEGQMEAYQR
HHHHHHCCCCEEEEEECCCCCEEEEEEECCCCCCCCEEEEEEHHHHHHHHHCCHHHHHHH
LLLDVINGRLALFVRRDEQEAAWRWVEPIQNEWQKSLKPPKPYASGTWGPAAASAMLAQH
HHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHC
GTCWLEEEN
CCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10400573; 11481430 [H]