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The map label for this gene is pcaK [H]

Identifier: 238026358

GI number: 238026358

Start: 744172

End: 745527

Strand: Direct

Name: pcaK [H]

Synonym: bglu_1g06920

Alternate gene names: 238026358

Gene position: 744172-745527 (Clockwise)

Preceding gene: 238026356

Following gene: 238026363

Centisome position: 19.05

GC content: 72.79

Gene sequence:

>1356_bases
ATGAGCGCGCCGCAGGCGGGGCCGCGCACGCTCGAGATCGAGCGCGTGATCGACGAGACGCACCGGCCGGGCTTCCAGGC
CGCGCTGTTCGCGTTGTGCGGCGCATGCCTCGTGATCGACGGCTTCGACGCGCAGGCGATGGGCTACGTCGCGCCGAGCG
TGATCGCCGAGTGGGGCGTCGCGAAGGCCGCGCTCGGACCGGTGTTCAGCGCGAGCCTGTTCGGCATGCTGATCGGCGCG
CTGGGGCTGTCGGTGCTGGCCGACCGGATCGGCCGCCGCCCGGTGCTAATCGGCGCGACGCTGTTCTTCGCGCTGGCGAT
GCTCGCCACGCCGCTGGCCGCCTCGATCACGTCATTGATCGCGCTGCGCTTCGTGACCGGGCTTGGCCTTGGCTGCATCA
TGCCGAACGCGATGGCGCTGGTCGGCGAGTTCAGCCCGGCCGTGCATCGCGTCAAGCGCATGATGTTCGTGTCGTGCGGC
TTCACGCTGGGCGCCGCGCTCGGCGGGTTCGTCAGCGCCGCGCTGATCCCGGCCCTCGGCTGGCGCGCGGTGTTCGTGGC
GGGCGGGGCGGTGCCGCTCGCGCTGGCGCTGGCGATGCTTGCCTGGCTGCCGGAATCGCTGCAGTTCCTGGTGCTGAAGG
CACGCATGGCGCGCGCCCGCGCCTGGCTCGCGGCGTTCGCGCCGGCGCTTGAGATCGACGCGCGGACGCGGCTCGTGGTG
CGCGAGCCGGCCGCTGGCGCCGCGCCCGTCGCCGAGCTGTTCCGCGCGGGCCGGCTGCCCGTCACGCTGCTGCTCTGGGC
GATCAGCTTTCTGAACCTGATCGATTTGTATTTCCTGTCGAACTGGCTGCCCACCGTGATGCGCGACGCCGGCCATTCGT
CGCAGGCGGCCGTGATCGTCGGCACCGCGCTGCAGACGGGCGGCGTGGCCGGCACGCTGCTGCTGGGCGGGTTCATCGAG
CGCCATGGTTTCGTGCGCGTGCTGTCCGCCTGCTTCGTCTGCGCCGCCTTGTCGGTGGCGGCGATCGGCGCGGTGGCGGG
CTCGCTGCCGTGGCTGCTGGTGGCGGTGTTCGCCGGCGGCTTCTGCGTGGTGGGCGGGCAGCCGGCTGTCAACGCGCTGG
CCGGCCACTATTATCCGACCGCGCTGCGCTCGACCGGAATCGGCTGGAGCCTTGGGGTGGGCCGCATCGGCTCGGTGCTC
GGGCCGCTCGTGGGCGGCCAGCTGATCGCGCTCGGCTGGTCGAACGGCGCGCTGTTTCTCGCCGCCGCGCTGCCGGTGCT
GGCCTCGGCATTGTTCGTGCTGAGCCTCGGCCTGGCCACGCGGCCGGCCGATGGCCAGGCGCGGCGCACGGTGTGA

Upstream 100 bases:

>100_bases
TGCGCCAGCCGACGCCTCGCGACGCCGTGGCCGGCCGCCGTGACGGCCCGCCTCGATGCCGGCGCCGCCGCGCCCGCCCC
GTGCCCGCCGGGAGCGCGCG

Downstream 100 bases:

>100_bases
GATGCGAATCGGGCTCGAACGGCGACGCGGCCGGTGATTGGCGCCCGCTTCAGACCTCGCGTGCGGCCGCCGCCGGCAGG
CGCCGGCGTTCCCACCACGC

Product: major facilitator superfamily protein

Products: Proton [Cytoplasm]; 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 451; Mature: 450

Protein sequence:

>451_residues
MSAPQAGPRTLEIERVIDETHRPGFQAALFALCGACLVIDGFDAQAMGYVAPSVIAEWGVAKAALGPVFSASLFGMLIGA
LGLSVLADRIGRRPVLIGATLFFALAMLATPLAASITSLIALRFVTGLGLGCIMPNAMALVGEFSPAVHRVKRMMFVSCG
FTLGAALGGFVSAALIPALGWRAVFVAGGAVPLALALAMLAWLPESLQFLVLKARMARARAWLAAFAPALEIDARTRLVV
REPAAGAAPVAELFRAGRLPVTLLLWAISFLNLIDLYFLSNWLPTVMRDAGHSSQAAVIVGTALQTGGVAGTLLLGGFIE
RHGFVRVLSACFVCAALSVAAIGAVAGSLPWLLVAVFAGGFCVVGGQPAVNALAGHYYPTALRSTGIGWSLGVGRIGSVL
GPLVGGQLIALGWSNGALFLAAALPVLASALFVLSLGLATRPADGQARRTV

Sequences:

>Translated_451_residues
MSAPQAGPRTLEIERVIDETHRPGFQAALFALCGACLVIDGFDAQAMGYVAPSVIAEWGVAKAALGPVFSASLFGMLIGA
LGLSVLADRIGRRPVLIGATLFFALAMLATPLAASITSLIALRFVTGLGLGCIMPNAMALVGEFSPAVHRVKRMMFVSCG
FTLGAALGGFVSAALIPALGWRAVFVAGGAVPLALALAMLAWLPESLQFLVLKARMARARAWLAAFAPALEIDARTRLVV
REPAAGAAPVAELFRAGRLPVTLLLWAISFLNLIDLYFLSNWLPTVMRDAGHSSQAAVIVGTALQTGGVAGTLLLGGFIE
RHGFVRVLSACFVCAALSVAAIGAVAGSLPWLLVAVFAGGFCVVGGQPAVNALAGHYYPTALRSTGIGWSLGVGRIGSVL
GPLVGGQLIALGWSNGALFLAAALPVLASALFVLSLGLATRPADGQARRTV
>Mature_450_residues
SAPQAGPRTLEIERVIDETHRPGFQAALFALCGACLVIDGFDAQAMGYVAPSVIAEWGVAKAALGPVFSASLFGMLIGAL
GLSVLADRIGRRPVLIGATLFFALAMLATPLAASITSLIALRFVTGLGLGCIMPNAMALVGEFSPAVHRVKRMMFVSCGF
TLGAALGGFVSAALIPALGWRAVFVAGGAVPLALALAMLAWLPESLQFLVLKARMARARAWLAAFAPALEIDARTRLVVR
EPAAGAAPVAELFRAGRLPVTLLLWAISFLNLIDLYFLSNWLPTVMRDAGHSSQAAVIVGTALQTGGVAGTLLLGGFIER
HGFVRVLSACFVCAALSVAAIGAVAGSLPWLLVAVFAGGFCVVGGQPAVNALAGHYYPTALRSTGIGWSLGVGRIGSVLG
PLVGGQLIALGWSNGALFLAAALPVLASALFVLSLGLATRPADGQARRTV

Specific function: Transporter for 4-hydroxybenzoate. Also required for chemotaxis to aromatic acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI24308167, Length=422, Percent_Identity=24.6445497630332, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI8923870, Length=375, Percent_Identity=29.0666666666667, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI213021148, Length=493, Percent_Identity=23.1237322515213, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI166064021, Length=405, Percent_Identity=26.9135802469136, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI87081723, Length=408, Percent_Identity=34.5588235294118, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI87082231, Length=397, Percent_Identity=25.9445843828715, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1788068, Length=436, Percent_Identity=23.8532110091743, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1786229, Length=337, Percent_Identity=22.2551928783383, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87082404, Length=378, Percent_Identity=21.6931216931217, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI87082159, Length=388, Percent_Identity=25.2577319587629, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI32564663, Length=417, Percent_Identity=22.5419664268585, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI19922874, Length=413, Percent_Identity=23.4866828087167, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24640198, Length=470, Percent_Identity=22.7659574468085, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24640196, Length=470, Percent_Identity=22.7659574468085, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24640200, Length=470, Percent_Identity=22.7659574468085, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI161077756, Length=483, Percent_Identity=22.5672877846791, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI28573099, Length=229, Percent_Identity=27.9475982532751, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24649618, Length=375, Percent_Identity=23.4666666666667, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28573101, Length=229, Percent_Identity=27.9475982532751, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004746
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 46331; Mature: 46199

Theoretical pI: Translated: 10.25; Mature: 10.25

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1 ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPQAGPRTLEIERVIDETHRPGFQAALFALCGACLVIDGFDAQAMGYVAPSVIAEWGV
CCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHH
AKAALGPVFSASLFGMLIGALGLSVLADRIGRRPVLIGATLFFALAMLATPLAASITSLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHH
ALRFVTGLGLGCIMPNAMALVGEFSPAVHRVKRMMFVSCGFTLGAALGGFVSAALIPALG
HHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHC
WRAVFVAGGAVPLALALAMLAWLPESLQFLVLKARMARARAWLAAFAPALEIDARTRLVV
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEE
REPAAGAAPVAELFRAGRLPVTLLLWAISFLNLIDLYFLSNWLPTVMRDAGHSSQAAVIV
ECCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
GTALQTGGVAGTLLLGGFIERHGFVRVLSACFVCAALSVAAIGAVAGSLPWLLVAVFAGG
ECCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
FCVVGGQPAVNALAGHYYPTALRSTGIGWSLGVGRIGSVLGPLVGGQLIALGWSNGALFL
EEEECCCHHHHHHHCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHCCEEEEEECCCCHHHH
AAALPVLASALFVLSLGLATRPADGQARRTV
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SAPQAGPRTLEIERVIDETHRPGFQAALFALCGACLVIDGFDAQAMGYVAPSVIAEWGV
CCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHH
AKAALGPVFSASLFGMLIGALGLSVLADRIGRRPVLIGATLFFALAMLATPLAASITSLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHH
ALRFVTGLGLGCIMPNAMALVGEFSPAVHRVKRMMFVSCGFTLGAALGGFVSAALIPALG
HHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHC
WRAVFVAGGAVPLALALAMLAWLPESLQFLVLKARMARARAWLAAFAPALEIDARTRLVV
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEE
REPAAGAAPVAELFRAGRLPVTLLLWAISFLNLIDLYFLSNWLPTVMRDAGHSSQAAVIV
ECCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
GTALQTGGVAGTLLLGGFIERHGFVRVLSACFVCAALSVAAIGAVAGSLPWLLVAVFAGG
ECCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
FCVVGGQPAVNALAGHYYPTALRSTGIGWSLGVGRIGSVLGPLVGGQLIALGWSNGALFL
EEEECCCHHHHHHHCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHCCEEEEEECCCCHHHH
AAALPVLASALFVLSLGLATRPADGQARRTV
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 3-(3-hydroxyphenyl)propionate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 3-(3-hydroxyphenyl)propionate [Periplasm] = Proton [Cytoplasm] + 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7961399 [H]