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The map label for this gene is pepP [H]

Identifier: 238026252

GI number: 238026252

Start: 614119

End: 615546

Strand: Reverse

Name: pepP [H]

Synonym: bglu_1g05850

Alternate gene names: 238026252

Gene position: 615546-614119 (Counterclockwise)

Preceding gene: 238026254

Following gene: 238026251

Centisome position: 15.76

GC content: 73.18

Gene sequence:

>1428_bases
ATGAACGCGCCGACCGATACCTGCCTCGTCCCCGACGTCTACCGCCAGCGCCGCGCGCGCGTGCTCGCCGCCTTGCGCGC
GACGGGCGGCGGCGTCGCGATCGTCCCCACCGCGCCCCAGGCGCTGCGCAACCGCGATGCCGATTATCCGTATCGGCACG
ACAGCTACTTCTATTACCTGACCGGCTTCAGCGAGCCCGACGCGCTGCTCGTGCTCGATGCGAACGCCGCCGACGGCGCG
CCGCAATCGATCCTGTTCTGTCGTGCGAAGCATCCCGAGCGCGAGATCTGGGAAGGCTTCCACTATGGGCCGGACGGCGC
GCGCGACGCGTTCGGCTTCGATGCCGCGTTCGCCAGCGACGCGCTCGACACCGAGATGCCGCGGCTCCTCGCCGATGCCG
GCGCGCTTCATTACCGCTTCGGCGCGTCGGCCGAGTTCGAGCGCCGGCTCGCGGGCTGGCTCGAGGCGGTGCGCGCGAAG
AGCCGGGCCGGCGTCGCCGCGCCGGCCTCCGCGCACGATCTCACGCCGCTGCTCGACGAGATGCGCATCGTCAAGGACGC
CCACGAGCAGGCGATCATGCGCCGCGCCGCCGTGATCTCCGCGAGCGCGCACCGGCGCGCGATGGCGGTGACGCGGCCGG
GCATCCGCGAATACGAGATCGAGGCCGAACTGCTCCACGAATTCCGCCGCCACGGCGCGGCCGGCCCCGCCTACGGCTCG
ATCGTCGCGGCCGGCGCGAACGCCTGCGTGCTGCACTATCCGGCCGGCAACGCGGTGGCGCGCGACGGCGATCTGATCCT
GATCGACGCGGCCTGCGAACTGGAAGGCTACGCCTCCGACATCACGCGCACGTTTCCCGCCAACGGCCGCTTCTCCGGCC
CGCAGCGTGCGCTCTACGACATCGTGCTCGCCGCGCAGGCCGCGGCTGCGGCCGCCACGCGGCCCGGCGCGGCATTCGAG
GCGCCGCACGAGGCCGCCGTGCGCGTGCTCGCGCAAGGGCTGCTCGACACCGGCATCGTGCCGAAGTCGCGCTTCGCGAG
CGTCGACGACGTCGTGGCCGAGCGCGCCTACGCGCGCTTCTACATGCACCGCACCGGCCACTGGCTCGGCATGGACGTCC
ACGACTGCGGCGACTACCGCGAGCGCGGCGCCGCGCGCGACGCGCAGGGCGCGCTGCCATGGCGCACGCTGCGCGAGGGC
ATGGCGCTGACGATCGAGCCGGGCCTCTACGTGCGCGCGGCCGACGACGTGCCGGCCCGATTCCACGATATCGGCATCCG
CATCGAGGACGACGCATTCGTCACCGCCGCCGGCTGCGAACTGATCACGCGCGACGTGCCGGTGGACGCCGACGAGATCG
AGGCGCTGATGCGCGACGCGCACGGCACCTCGGGCCCGTCCGGCACTACGCCGCCGGCGCGGCCGTGA

Upstream 100 bases:

>100_bases
TCCGCGCCGCGGCGCGCCGCCGTCCGCCCGCCCGCCCGCCCGCCCGCCCGGCGCATGGTGCCGAAGCGCAGCGCGCGCGC
CACAGCGCTACAATCGCCCC

Downstream 100 bases:

>100_bases
CCGGCGCGCCGGCGTGCCGCCTCCCCCGAACCCGCTCCCCCGCTTTCGCCCGATGACCACCTCCGCTCCGCTTGCGCCCG
CCGCCGCACCGTTCGACGCC

Product: peptidase M24B

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 475; Mature: 475

Protein sequence:

>475_residues
MNAPTDTCLVPDVYRQRRARVLAALRATGGGVAIVPTAPQALRNRDADYPYRHDSYFYYLTGFSEPDALLVLDANAADGA
PQSILFCRAKHPEREIWEGFHYGPDGARDAFGFDAAFASDALDTEMPRLLADAGALHYRFGASAEFERRLAGWLEAVRAK
SRAGVAAPASAHDLTPLLDEMRIVKDAHEQAIMRRAAVISASAHRRAMAVTRPGIREYEIEAELLHEFRRHGAAGPAYGS
IVAAGANACVLHYPAGNAVARDGDLILIDAACELEGYASDITRTFPANGRFSGPQRALYDIVLAAQAAAAAATRPGAAFE
APHEAAVRVLAQGLLDTGIVPKSRFASVDDVVAERAYARFYMHRTGHWLGMDVHDCGDYRERGAARDAQGALPWRTLREG
MALTIEPGLYVRAADDVPARFHDIGIRIEDDAFVTAAGCELITRDVPVDADEIEALMRDAHGTSGPSGTTPPARP

Sequences:

>Translated_475_residues
MNAPTDTCLVPDVYRQRRARVLAALRATGGGVAIVPTAPQALRNRDADYPYRHDSYFYYLTGFSEPDALLVLDANAADGA
PQSILFCRAKHPEREIWEGFHYGPDGARDAFGFDAAFASDALDTEMPRLLADAGALHYRFGASAEFERRLAGWLEAVRAK
SRAGVAAPASAHDLTPLLDEMRIVKDAHEQAIMRRAAVISASAHRRAMAVTRPGIREYEIEAELLHEFRRHGAAGPAYGS
IVAAGANACVLHYPAGNAVARDGDLILIDAACELEGYASDITRTFPANGRFSGPQRALYDIVLAAQAAAAAATRPGAAFE
APHEAAVRVLAQGLLDTGIVPKSRFASVDDVVAERAYARFYMHRTGHWLGMDVHDCGDYRERGAARDAQGALPWRTLREG
MALTIEPGLYVRAADDVPARFHDIGIRIEDDAFVTAAGCELITRDVPVDADEIEALMRDAHGTSGPSGTTPPARP
>Mature_475_residues
MNAPTDTCLVPDVYRQRRARVLAALRATGGGVAIVPTAPQALRNRDADYPYRHDSYFYYLTGFSEPDALLVLDANAADGA
PQSILFCRAKHPEREIWEGFHYGPDGARDAFGFDAAFASDALDTEMPRLLADAGALHYRFGASAEFERRLAGWLEAVRAK
SRAGVAAPASAHDLTPLLDEMRIVKDAHEQAIMRRAAVISASAHRRAMAVTRPGIREYEIEAELLHEFRRHGAAGPAYGS
IVAAGANACVLHYPAGNAVARDGDLILIDAACELEGYASDITRTFPANGRFSGPQRALYDIVLAAQAAAAAATRPGAAFE
APHEAAVRVLAQGLLDTGIVPKSRFASVDDVVAERAYARFYMHRTGHWLGMDVHDCGDYRERGAARDAQGALPWRTLREG
MALTIEPGLYVRAADDVPARFHDIGIRIEDDAFVTAAGCELITRDVPVDADEIEALMRDAHGTSGPSGTTPPARP

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=458, Percent_Identity=31.2227074235808, Blast_Score=235, Evalue=7e-62,
Organism=Homo sapiens, GI149589008, Length=489, Percent_Identity=30.0613496932515, Blast_Score=179, Evalue=6e-45,
Organism=Homo sapiens, GI260593665, Length=309, Percent_Identity=37.2168284789644, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI260593663, Length=363, Percent_Identity=31.6804407713499, Blast_Score=142, Evalue=5e-34,
Organism=Escherichia coli, GI1789275, Length=442, Percent_Identity=42.3076923076923, Blast_Score=348, Evalue=3e-97,
Organism=Escherichia coli, GI1788728, Length=329, Percent_Identity=30.0911854103343, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1790282, Length=294, Percent_Identity=29.9319727891156, Blast_Score=91, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17508215, Length=491, Percent_Identity=31.5682281059063, Blast_Score=202, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI71989583, Length=300, Percent_Identity=32, Blast_Score=122, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6320922, Length=424, Percent_Identity=27.122641509434, Blast_Score=179, Evalue=7e-46,
Organism=Saccharomyces cerevisiae, GI6321118, Length=435, Percent_Identity=29.1954022988506, Blast_Score=161, Evalue=2e-40,
Organism=Drosophila melanogaster, GI19920384, Length=483, Percent_Identity=33.5403726708075, Blast_Score=215, Evalue=5e-56,
Organism=Drosophila melanogaster, GI21357079, Length=494, Percent_Identity=30.9716599190283, Blast_Score=201, Evalue=1e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 51240; Mature: 51240

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAPTDTCLVPDVYRQRRARVLAALRATGGGVAIVPTAPQALRNRDADYPYRHDSYFYYL
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHCCCCCCCCCCCCEEEEE
TGFSEPDALLVLDANAADGAPQSILFCRAKHPEREIWEGFHYGPDGARDAFGFDAAFASD
ECCCCCCEEEEEECCCCCCCCCEEEEEECCCCCHHHHCCCCCCCCCCCCCCCCHHHHHHH
ALDTEMPRLLADAGALHYRFGASAEFERRLAGWLEAVRAKSRAGVAAPASAHDLTPLLDE
HHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
MRIVKDAHEQAIMRRAAVISASAHRRAMAVTRPGIREYEIEAELLHEFRRHGAAGPAYGS
HHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCEEEHHHHHHHHHHHCCCCCCCCCC
IVAAGANACVLHYPAGNAVARDGDLILIDAACELEGYASDITRTFPANGRFSGPQRALYD
EEECCCCEEEEECCCCCCEECCCCEEEEEECCCCCCHHHHHHHHCCCCCCCCCHHHHHHH
IVLAAQAAAAAATRPGAAFEAPHEAAVRVLAQGLLDTGIVPKSRFASVDDVVAERAYARF
HHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHHHHH
YMHRTGHWLGMDVHDCGDYRERGAARDAQGALPWRTLREGMALTIEPGLYVRAADDVPAR
HHHHCCCEEECCHHHCCCHHHHCCCCCCCCCCCHHHHHCCCEEEECCCEEEEECCCCCCC
FHDIGIRIEDDAFVTAAGCELITRDVPVDADEIEALMRDAHGTSGPSGTTPPARP
HHHCCCEECCCCEEEECCCCEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNAPTDTCLVPDVYRQRRARVLAALRATGGGVAIVPTAPQALRNRDADYPYRHDSYFYYL
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHCCCCCCCCCCCCEEEEE
TGFSEPDALLVLDANAADGAPQSILFCRAKHPEREIWEGFHYGPDGARDAFGFDAAFASD
ECCCCCCEEEEEECCCCCCCCCEEEEEECCCCCHHHHCCCCCCCCCCCCCCCCHHHHHHH
ALDTEMPRLLADAGALHYRFGASAEFERRLAGWLEAVRAKSRAGVAAPASAHDLTPLLDE
HHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
MRIVKDAHEQAIMRRAAVISASAHRRAMAVTRPGIREYEIEAELLHEFRRHGAAGPAYGS
HHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCEEEHHHHHHHHHHHCCCCCCCCCC
IVAAGANACVLHYPAGNAVARDGDLILIDAACELEGYASDITRTFPANGRFSGPQRALYD
EEECCCCEEEEECCCCCCEECCCCEEEEEECCCCCCHHHHHHHHCCCCCCCCCHHHHHHH
IVLAAQAAAAAATRPGAAFEAPHEAAVRVLAQGLLDTGIVPKSRFASVDDVVAERAYARF
HHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHHHHH
YMHRTGHWLGMDVHDCGDYRERGAARDAQGALPWRTLREGMALTIEPGLYVRAADDVPAR
HHHHCCCEEECCHHHCCCHHHHCCCCCCCCCCCHHHHHCCCEEEECCCEEEEECCCCCCC
FHDIGIRIEDDAFVTAAGCELITRDVPVDADEIEALMRDAHGTSGPSGTTPPARP
HHHCCCEECCCCEEEECCCCEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659585; 1339425; 9278503; 9520390 [H]