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The map label for this gene is tyrS [H]

Identifier: 238026240

GI number: 238026240

Start: 602112

End: 603353

Strand: Direct

Name: tyrS [H]

Synonym: bglu_1g05730

Alternate gene names: 238026240

Gene position: 602112-603353 (Clockwise)

Preceding gene: 238026238

Following gene: 238026241

Centisome position: 15.41

GC content: 66.1

Gene sequence:

>1242_bases
ATGAGCCACGATCCCCAAACGAAGCCCGCGCTCCCGATCACCGATGCCGTGCGCGAGGCGCTCGCGATCACCAAGCGCGG
CGTCGACGAACTGCTGATCGAGGACGAGTTCGCGCAGAAGCTGGCGCGCAGCGAGGCGACCGGCACGCCGCTGCGGATCA
AGCTGGGGCTCGATCCGACCGCGCCCGACATCCATATCGGCCACACGGTGGTGCTCAACAAGATGCGCCAGCTGCAGGAT
CTCGGCCACACGGTGATTTTCCTGATCGGCGACTTCACCTCGCTGATCGGCGATCCGTCGGGCCGCAACGCCACGCGCCC
GCCGCTCACGCGCGAGCAGATCGAGGCCAACGCGAAGACCTATTTCGAGCAGGCCGCGCTGGTGCTCGACCGCGACAAGA
CCGAGATCCGCTACAACAGCGAATGGTCGATGCCGCTCGGCGCCGACGGCATGATCAAGCTCGCCTCGCGCTACACGGTG
GCGCGCATCCTCGAGCGCGAGGATTTCACGAAGCGCTTCCAGGGCGGCGTGCCGATCTCGATCCACGAATTCCTCTACCC
GCTGATGCAGGGCTACGATTCGGTCGCGCTGAACGCCGACCTCGAACTCGGCGGCACCGACCAGAAGTTCAACCTGCTGG
TGGGCCGCGAGCTGCAGAAGCAGTACGGCCAGGAGCCGCAGTGCATCCTGACCATGCCGCTGCTGGAAGGCCTCGACGGC
GTCGAGAAGATGTCGAAGTCGAAGGGCAACTACGTCGGCATCAGCGAGAAGCCGGCCGAGATGTTCGGCAAGCTGATGAG
CATCTCGGACGTGCTGATGTGGCGTTACTTCGAACTGCTGTCGTTCCGGCCGATGCGCGAGATCGAGAAGTTCAAGGCCG
AGATCGAGGCGGGCCGCAACCCGCGCGACTTCAAGGTGCTGCTCGCCCAGGAAATCGTCGCACGTTTTCACTCGCAGGCC
GACGCCGAGCAGGCGCTCGAGGACTTCAACCACCGCGCGCGCGGCGGCGTGCCCGACGACATCCCGTCGGTGTCGCTCGG
CGGCGCGCCGCTCGCGATCGGCCAGTTGCTCAAGCAGGCTGGCCTGGTGCCTTCGACCAGCGAGGCGCTGCGCAACATCG
AGCAGGGCGGCGTGAAGATCGACGGCACCACCGTTTCCGACAAGGGCCTCAAGGTCGAGGCGGGCGAGTACGTGGTTCAA
GTCGGCAAGCGGCGCTTCGCGCGCGTGACGGTCGGCGCATGA

Upstream 100 bases:

>100_bases
GTGGTCCGATTATCCGCGCAAGCGGCGGCGCCGTTAAGCGATGCGCGCGGAAGTTATGGGAAAATCACCGCTTTTCCGAC
TTTCCTCCTTTTCCGCACCG

Downstream 100 bases:

>100_bases
TCGCGCTGATCCAGCGCGTGCGGCGCGCCGACGTGCGCGTCGGCGAGCGCGTGACCGGGCAGATCGGCGCGGGCCTGCTC
GCGCTCGTCTGCGCCGAGCG

Product: tyrosyl-tRNA synthetase

Products: NA

Alternate protein names: Tyrosine--tRNA ligase; TyrRS [H]

Number of amino acids: Translated: 413; Mature: 412

Protein sequence:

>413_residues
MSHDPQTKPALPITDAVREALAITKRGVDELLIEDEFAQKLARSEATGTPLRIKLGLDPTAPDIHIGHTVVLNKMRQLQD
LGHTVIFLIGDFTSLIGDPSGRNATRPPLTREQIEANAKTYFEQAALVLDRDKTEIRYNSEWSMPLGADGMIKLASRYTV
ARILEREDFTKRFQGGVPISIHEFLYPLMQGYDSVALNADLELGGTDQKFNLLVGRELQKQYGQEPQCILTMPLLEGLDG
VEKMSKSKGNYVGISEKPAEMFGKLMSISDVLMWRYFELLSFRPMREIEKFKAEIEAGRNPRDFKVLLAQEIVARFHSQA
DAEQALEDFNHRARGGVPDDIPSVSLGGAPLAIGQLLKQAGLVPSTSEALRNIEQGGVKIDGTTVSDKGLKVEAGEYVVQ
VGKRRFARVTVGA

Sequences:

>Translated_413_residues
MSHDPQTKPALPITDAVREALAITKRGVDELLIEDEFAQKLARSEATGTPLRIKLGLDPTAPDIHIGHTVVLNKMRQLQD
LGHTVIFLIGDFTSLIGDPSGRNATRPPLTREQIEANAKTYFEQAALVLDRDKTEIRYNSEWSMPLGADGMIKLASRYTV
ARILEREDFTKRFQGGVPISIHEFLYPLMQGYDSVALNADLELGGTDQKFNLLVGRELQKQYGQEPQCILTMPLLEGLDG
VEKMSKSKGNYVGISEKPAEMFGKLMSISDVLMWRYFELLSFRPMREIEKFKAEIEAGRNPRDFKVLLAQEIVARFHSQA
DAEQALEDFNHRARGGVPDDIPSVSLGGAPLAIGQLLKQAGLVPSTSEALRNIEQGGVKIDGTTVSDKGLKVEAGEYVVQ
VGKRRFARVTVGA
>Mature_412_residues
SHDPQTKPALPITDAVREALAITKRGVDELLIEDEFAQKLARSEATGTPLRIKLGLDPTAPDIHIGHTVVLNKMRQLQDL
GHTVIFLIGDFTSLIGDPSGRNATRPPLTREQIEANAKTYFEQAALVLDRDKTEIRYNSEWSMPLGADGMIKLASRYTVA
RILEREDFTKRFQGGVPISIHEFLYPLMQGYDSVALNADLELGGTDQKFNLLVGRELQKQYGQEPQCILTMPLLEGLDGV
EKMSKSKGNYVGISEKPAEMFGKLMSISDVLMWRYFELLSFRPMREIEKFKAEIEAGRNPRDFKVLLAQEIVARFHSQAD
AEQALEDFNHRARGGVPDDIPSVSLGGAPLAIGQLLKQAGLVPSTSEALRNIEQGGVKIDGTTVSDKGLKVEAGEYVVQV
GKRRFARVTVGA

Specific function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) [H]

COG id: COG0162

COG function: function code J; Tyrosyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S4 RNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI94681057, Length=404, Percent_Identity=26.7326732673267, Blast_Score=106, Evalue=3e-23,
Organism=Escherichia coli, GI1787925, Length=424, Percent_Identity=28.3018867924528, Blast_Score=131, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI25145802, Length=210, Percent_Identity=29.0476190476191, Blast_Score=82, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6325160, Length=318, Percent_Identity=25.1572327044025, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI20130383, Length=450, Percent_Identity=25.3333333333333, Blast_Score=128, Evalue=9e-30,

Paralogues:

None

Copy number: 892 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002942
- InterPro:   IPR002307 [H]

Pfam domain/function: PF01479 S4; PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.1 [H]

Molecular weight: Translated: 45687; Mature: 45556

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS50889 S4 ; PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHDPQTKPALPITDAVREALAITKRGVDELLIEDEFAQKLARSEATGTPLRIKLGLDPT
CCCCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCC
APDIHIGHTVVLNKMRQLQDLGHTVIFLIGDFTSLIGDPSGRNATRPPLTREQIEANAKT
CCCCCCCHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHH
YFEQAALVLDRDKTEIRYNSEWSMPLGADGMIKLASRYTVARILEREDFTKRFQGGVPIS
HHHHHHHHEECCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
IHEFLYPLMQGYDSVALNADLELGGTDQKFNLLVGRELQKQYGQEPQCILTMPLLEGLDG
HHHHHHHHHCCCCCEEEECCEEECCCCCHHHHHHHHHHHHHCCCCCCEEEECHHHHCCHH
VEKMSKSKGNYVGISEKPAEMFGKLMSISDVLMWRYFELLSFRPMREIEKFKAEIEAGRN
HHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCC
PRDFKVLLAQEIVARFHSQADAEQALEDFNHRARGGVPDDIPSVSLGGAPLAIGQLLKQA
CHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHC
GLVPSTSEALRNIEQGGVKIDGTTVSDKGLKVEAGEYVVQVGKRRFARVTVGA
CCCCCHHHHHHHHHHCCEEECCEEECCCCCEEEHHHHHHHHHHHHHHEEECCC
>Mature Secondary Structure 
SHDPQTKPALPITDAVREALAITKRGVDELLIEDEFAQKLARSEATGTPLRIKLGLDPT
CCCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCC
APDIHIGHTVVLNKMRQLQDLGHTVIFLIGDFTSLIGDPSGRNATRPPLTREQIEANAKT
CCCCCCCHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHH
YFEQAALVLDRDKTEIRYNSEWSMPLGADGMIKLASRYTVARILEREDFTKRFQGGVPIS
HHHHHHHHEECCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
IHEFLYPLMQGYDSVALNADLELGGTDQKFNLLVGRELQKQYGQEPQCILTMPLLEGLDG
HHHHHHHHHCCCCCEEEECCEEECCCCCHHHHHHHHHHHHHCCCCCCEEEECHHHHCCHH
VEKMSKSKGNYVGISEKPAEMFGKLMSISDVLMWRYFELLSFRPMREIEKFKAEIEAGRN
HHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCC
PRDFKVLLAQEIVARFHSQADAEQALEDFNHRARGGVPDDIPSVSLGGAPLAIGQLLKQA
CHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHC
GLVPSTSEALRNIEQGGVKIDGTTVSDKGLKVEAGEYVVQVGKRRFARVTVGA
CCCCCHHHHHHHHHHCCEEECCEEECCCCCEEEHHHHHHHHHHHHHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA