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The map label for this gene is holA [H]

Identifier: 238026217

GI number: 238026217

Start: 577626

End: 578765

Strand: Direct

Name: holA [H]

Synonym: bglu_1g05480

Alternate gene names: 238026217

Gene position: 577626-578765 (Clockwise)

Preceding gene: 238026216

Following gene: 238026218

Centisome position: 14.79

GC content: 73.51

Gene sequence:

>1140_bases
ATGCAATTGCGACTTGACGCGCTGGAGGCGCACCTCGCGAAGACGCTCGCGGGCCTCTACACCGTGTACGGCGACGAGCC
GCTGCTGGTGCAGGAGGCCTGCGACCGGATTCGCGCCGCCGCGCGCGCGGGCGGCTTCACCGAGCGTTCGGTGTTTACCG
TCGAGCGCAGCTTCGACTGGAGTTCGCTGCTCGGCGCGAGCCAGGCCATGTCGCTGTTCGGCGAGCGCCAGCTGATCGAG
CTGCGGATTCCGTCGGGCAAGCCCGGCAAGGAAGGTGCCGATGCGCTGAAGACGCTCGCCGGCGCAGGCAACCCCGACGT
GCTGATGCTCGTGACGCTGCCGCGGCTCGATGCGGCCACGCAGAAATCGGCCTGGTTCACGGCGCTCGGCAACGGCGGGG
TGGCGCTGAAGATCGATCCCGTCGATCGCGCCCAGCTGCCGAACTGGATCGGCCAGCGGCTCGCCGCGCAGGGCCAGCGC
GTGGCCGCCGGCGAGGACGGCCGGCGCGCGCTGCAGTTCATCGCCGAGCGCGTGGAGGGCAACCTGCTGGCCGCCCATCA
GGAGATCCAGAAGCTCGGGCTGCTCTATCCGTCCGGCACGCTCGCGCTCGATCAGGTGCAGGACGCCGTGCTGAACGTGG
CGCGCTACGACGTGTTCAAGCTCAACGAGGCGATGCTGGCGGGCGACGCGGGCCGGCTCGCGCGCATGATCGACGGCCTG
AAGGGCGAGGGCGAGGCGCTCGTGCTGGTGCTGTGGGCCGTGGTCGAGGAACTGCGCACGCTGCTGCGGATCAAGCGCGG
CGTCGCGGCCGGCAAGCCGCTCGCGGTGCTGGTCCGCGAGAATCGCGTCTGGGGGCCGCGCGAGCGGCTGATCGGGCCGG
CGCTGTCGCGCGTCTCGGAAGCGGTGCTCGAGGCGGCGCTCGCGCTGGCCGCCAGGCTCGACCGCCAGGTGAAGGGGCTG
TCCGGCATGGCGCCGGGGCTGCCGCGCGTCGACGAGCCGCCGCCGGACCCGTGGGACGGGCTGTTCCAGCTCGCCATGAC
GGTGGCCGGTGCGCAGGGCTCGCCGGCGGCCGGCTCCGGCACGCGCGGCGCCGCCGGCGCACGTGCCGCGGCTTTCGCCG
CGCCGCGGCGCCCGGCCTGA

Upstream 100 bases:

>100_bases
TGGCGCCGGGCGTCGCGCCGCGCGCGCCGCTGCCGCCGCCGCCGCTGTGAGCGCGCGGTTCCGGGCGTGGTTTCCTTTCG
ACTGCTGAGCATGCCAACCG

Downstream 100 bases:

>100_bases
GCGGCCACGGCACGGCGCGCTTACAATCGATCACTCGCCGGCGTCCCGACCGGGCGCGGGCGGCAATGACCAACGGCATC
TGGCTGCGCCACGCGGCCGC

Product: DNA polymerase III subunit delta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MQLRLDALEAHLAKTLAGLYTVYGDEPLLVQEACDRIRAAARAGGFTERSVFTVERSFDWSSLLGASQAMSLFGERQLIE
LRIPSGKPGKEGADALKTLAGAGNPDVLMLVTLPRLDAATQKSAWFTALGNGGVALKIDPVDRAQLPNWIGQRLAAQGQR
VAAGEDGRRALQFIAERVEGNLLAAHQEIQKLGLLYPSGTLALDQVQDAVLNVARYDVFKLNEAMLAGDAGRLARMIDGL
KGEGEALVLVLWAVVEELRTLLRIKRGVAAGKPLAVLVRENRVWGPRERLIGPALSRVSEAVLEAALALAARLDRQVKGL
SGMAPGLPRVDEPPPDPWDGLFQLAMTVAGAQGSPAAGSGTRGAAGARAAAFAAPRRPA

Sequences:

>Translated_379_residues
MQLRLDALEAHLAKTLAGLYTVYGDEPLLVQEACDRIRAAARAGGFTERSVFTVERSFDWSSLLGASQAMSLFGERQLIE
LRIPSGKPGKEGADALKTLAGAGNPDVLMLVTLPRLDAATQKSAWFTALGNGGVALKIDPVDRAQLPNWIGQRLAAQGQR
VAAGEDGRRALQFIAERVEGNLLAAHQEIQKLGLLYPSGTLALDQVQDAVLNVARYDVFKLNEAMLAGDAGRLARMIDGL
KGEGEALVLVLWAVVEELRTLLRIKRGVAAGKPLAVLVRENRVWGPRERLIGPALSRVSEAVLEAALALAARLDRQVKGL
SGMAPGLPRVDEPPPDPWDGLFQLAMTVAGAQGSPAAGSGTRGAAGARAAAFAAPRRPA
>Mature_379_residues
MQLRLDALEAHLAKTLAGLYTVYGDEPLLVQEACDRIRAAARAGGFTERSVFTVERSFDWSSLLGASQAMSLFGERQLIE
LRIPSGKPGKEGADALKTLAGAGNPDVLMLVTLPRLDAATQKSAWFTALGNGGVALKIDPVDRAQLPNWIGQRLAAQGQR
VAAGEDGRRALQFIAERVEGNLLAAHQEIQKLGLLYPSGTLALDQVQDAVLNVARYDVFKLNEAMLAGDAGRLARMIDGL
KGEGEALVLVLWAVVEELRTLLRIKRGVAAGKPLAVLVRENRVWGPRERLIGPALSRVSEAVLEAALALAARLDRQVKGL
SGMAPGLPRVDEPPPDPWDGLFQLAMTVAGAQGSPAAGSGTRGAAGARAAAFAAPRRPA

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The delta subunit seems to interact with the gamma subunit to transfer the b

COG id: COG1466

COG function: function code L; DNA polymerase III, delta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786859, Length=319, Percent_Identity=34.7962382445141, Blast_Score=165, Evalue=5e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008921
- InterPro:   IPR010372
- InterPro:   IPR005790 [H]

Pfam domain/function: PF06144 DNA_pol3_delta [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 40159; Mature: 40159

Theoretical pI: Translated: 9.72; Mature: 9.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLRLDALEAHLAKTLAGLYTVYGDEPLLVQEACDRIRAAARAGGFTERSVFTVERSFDW
CCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCH
SSLLGASQAMSLFGERQLIELRIPSGKPGKEGADALKTLAGAGNPDVLMLVTLPRLDAAT
HHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCHH
QKSAWFTALGNGGVALKIDPVDRAQLPNWIGQRLAAQGQRVAAGEDGRRALQFIAERVEG
CCCCEEEEECCCCEEEEECCCCHHHCCHHHHHHHHHCCCEECCCCCHHHHHHHHHHHHCC
NLLAAHQEIQKLGLLYPSGTLALDQVQDAVLNVARYDVFKLNEAMLAGDAGRLARMIDGL
CHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCC
KGEGEALVLVLWAVVEELRTLLRIKRGVAAGKPLAVLVRENRVWGPRERLIGPALSRVSE
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHH
AVLEAALALAARLDRQVKGLSGMAPGLPRVDEPPPDPWDGLFQLAMTVAGAQGSPAAGSG
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCC
TRGAAGARAAAFAAPRRPA
CCCCCCCHHHHHCCCCCCC
>Mature Secondary Structure
MQLRLDALEAHLAKTLAGLYTVYGDEPLLVQEACDRIRAAARAGGFTERSVFTVERSFDW
CCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCH
SSLLGASQAMSLFGERQLIELRIPSGKPGKEGADALKTLAGAGNPDVLMLVTLPRLDAAT
HHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCHH
QKSAWFTALGNGGVALKIDPVDRAQLPNWIGQRLAAQGQRVAAGEDGRRALQFIAERVEG
CCCCEEEEECCCCEEEEECCCCHHHCCHHHHHHHHHCCCEECCCCCHHHHHHHHHHHHCC
NLLAAHQEIQKLGLLYPSGTLALDQVQDAVLNVARYDVFKLNEAMLAGDAGRLARMIDGL
CHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCC
KGEGEALVLVLWAVVEELRTLLRIKRGVAAGKPLAVLVRENRVWGPRERLIGPALSRVSE
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHH
AVLEAALALAARLDRQVKGLSGMAPGLPRVDEPPPDPWDGLFQLAMTVAGAQGSPAAGSG
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCC
TRGAAGARAAAFAAPRRPA
CCCCCCCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8505303; 1400251; 8905232; 9278503; 3316191; 8505304; 1575709 [H]