Click here to switch to the map view.

The map label for this gene is proA [H]

Identifier: 238026218

GI number: 238026218

Start: 578888

End: 580159

Strand: Direct

Name: proA [H]

Synonym: bglu_1g05490

Alternate gene names: 238026218

Gene position: 578888-580159 (Clockwise)

Preceding gene: 238026217

Following gene: 238026219

Centisome position: 14.82

GC content: 70.28

Gene sequence:

>1272_bases
ATGGATATCGATCAGTACATGACGGACGTCGGCCGCCGCGCGCGGCAGGCCTCGCGCGCCATTGCACGGGCCGACACGGC
CGCGAAGAACGCCGCGCTCGCCGCGATCGCGACCGCGATCGAGCGCGAGGCCGGTGCGCTCAAGGCCGCCAACGCGCGCG
ACGTCGAGCGCGCGCGCGCGAAGGGCCAGGACGCCGCGTTCGTCGACCGCCTGACGCTGTCGGACAAGGCGCTGAAGACG
ATGCTGGACGGCCTGCGGCAGGTCGCGGCGCTGGCCGATCCGATCGGCGAGATCTCGAACCTGAAGTTTCGCCCGAGCGG
CATCCAGGTGGGCCAGATGCGCGTGCCGCTCGGCGTGATCGGCATCATCTACGAATCGCGGCCGAACGTGACGATCGACG
CGGCGGCGCTGTGCCTGAAGTCCGGCAACGCGACGATCCTGCGCGGCGGCTCCGAGGCGCTCGAATCGAACACCGCGCTG
GCGCGGCTGATCGGCGAGGGGCTCGCGGCGGCGGGGCTGCCGGCCGACGCCGTGCAGGTGGTCGAGACCGCCGATCGCGC
GGCCGTCGGCCGGCTGATCACCATGACCGAATACGTCGACGTGATCGTGCCGCGCGGCGGCAAGAGCCTGATCGCGAGGC
TGATCGAGGAGGCGCGCGTGCCGATGATCAAGCATCTCGACGGGATCTGCCACGTGTACGTGGACGATCGCGCCGATCTG
GCGAAGGCGCTGAGCGTCTGCGACAACGCCAAGACCCATCGCTACGGCACCTGCAACACCATGGAGACGCTGCTCGTCGC
GCGCGGCATCGCGCCCGCGGTGCTGCCGCAGCTGGGGCGCCTCTATCGCGACAAGTCGGTCGAGCTGCGCGTGGACGCGG
CCGCGAAGGCCGTGCTGGCGGCGGCCGGGGTCGGCCCGCTGGTGGACGCGACCGAGGAGGACTGGCGCACCGAGTATCTG
GCGCCGGTGCTCGCGATCAAGCTGGTGGACGGGCTCGATGCCGCGATCGAGCACATCAACGCGTATGGCTCGGCGCACAC
CGATGCGATCGTCACCGAGGACCACGACCGCGCCATGCGCTTTCTGCGCGAGGTCGATTCGGCCAGCGTGATGGTGAACG
CCTCGACGCGTTTCGCGGATGGCTTCGAATACGGCCTCGGCGCCGAGATCGGCATCTCGAACGACAAGCTGCATGCGCGC
GGGCCGGTCGGGCTCGAGGGGCTGACCTCGCTGAAGTACGTCGTGCTCGGGCACGGCGAAGGGCGGCAATGA

Upstream 100 bases:

>100_bases
ACAATCGATCACTCGCCGGCGTCCCGACCGGGCGCGGGCGGCAATGACCAACGGCATCTGGCTGCGCCACGCGGCCGCCA
TTCCGGATTCGGGTTTCACG

Downstream 100 bases:

>100_bases
ACACGCGGCGGCCGGTGCCGGCCGCCGCGGCCACGGGCCGGCGCGACCCGGCCACCGAAGGACGGGCTATTCGATGACGT
ATCTCTGGGTCAAGACCTTC

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase [H]

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MDIDQYMTDVGRRARQASRAIARADTAAKNAALAAIATAIEREAGALKAANARDVERARAKGQDAAFVDRLTLSDKALKT
MLDGLRQVAALADPIGEISNLKFRPSGIQVGQMRVPLGVIGIIYESRPNVTIDAAALCLKSGNATILRGGSEALESNTAL
ARLIGEGLAAAGLPADAVQVVETADRAAVGRLITMTEYVDVIVPRGGKSLIARLIEEARVPMIKHLDGICHVYVDDRADL
AKALSVCDNAKTHRYGTCNTMETLLVARGIAPAVLPQLGRLYRDKSVELRVDAAAKAVLAAAGVGPLVDATEEDWRTEYL
APVLAIKLVDGLDAAIEHINAYGSAHTDAIVTEDHDRAMRFLREVDSASVMVNASTRFADGFEYGLGAEIGISNDKLHAR
GPVGLEGLTSLKYVVLGHGEGRQ

Sequences:

>Translated_423_residues
MDIDQYMTDVGRRARQASRAIARADTAAKNAALAAIATAIEREAGALKAANARDVERARAKGQDAAFVDRLTLSDKALKT
MLDGLRQVAALADPIGEISNLKFRPSGIQVGQMRVPLGVIGIIYESRPNVTIDAAALCLKSGNATILRGGSEALESNTAL
ARLIGEGLAAAGLPADAVQVVETADRAAVGRLITMTEYVDVIVPRGGKSLIARLIEEARVPMIKHLDGICHVYVDDRADL
AKALSVCDNAKTHRYGTCNTMETLLVARGIAPAVLPQLGRLYRDKSVELRVDAAAKAVLAAAGVGPLVDATEEDWRTEYL
APVLAIKLVDGLDAAIEHINAYGSAHTDAIVTEDHDRAMRFLREVDSASVMVNASTRFADGFEYGLGAEIGISNDKLHAR
GPVGLEGLTSLKYVVLGHGEGRQ
>Mature_423_residues
MDIDQYMTDVGRRARQASRAIARADTAAKNAALAAIATAIEREAGALKAANARDVERARAKGQDAAFVDRLTLSDKALKT
MLDGLRQVAALADPIGEISNLKFRPSGIQVGQMRVPLGVIGIIYESRPNVTIDAAALCLKSGNATILRGGSEALESNTAL
ARLIGEGLAAAGLPADAVQVVETADRAAVGRLITMTEYVDVIVPRGGKSLIARLIEEARVPMIKHLDGICHVYVDDRADL
AKALSVCDNAKTHRYGTCNTMETLLVARGIAPAVLPQLGRLYRDKSVELRVDAAAKAVLAAAGVGPLVDATEEDWRTEYL
APVLAIKLVDGLDAAIEHINAYGSAHTDAIVTEDHDRAMRFLREVDSASVMVNASTRFADGFEYGLGAEIGISNDKLHAR
GPVGLEGLTSLKYVVLGHGEGRQ

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate [H]

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family [H]

Homologues:

Organism=Homo sapiens, GI62912457, Length=410, Percent_Identity=36.8292682926829, Blast_Score=252, Evalue=4e-67,
Organism=Homo sapiens, GI21361368, Length=410, Percent_Identity=36.8292682926829, Blast_Score=252, Evalue=4e-67,
Organism=Escherichia coli, GI1786438, Length=411, Percent_Identity=45.7420924574209, Blast_Score=355, Evalue=3e-99,
Organism=Caenorhabditis elegans, GI17569969, Length=418, Percent_Identity=33.7320574162679, Blast_Score=243, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI17569967, Length=418, Percent_Identity=33.7320574162679, Blast_Score=243, Evalue=1e-64,
Organism=Saccharomyces cerevisiae, GI6324899, Length=434, Percent_Identity=38.2488479262673, Blast_Score=286, Evalue=6e-78,
Organism=Drosophila melanogaster, GI21357643, Length=412, Percent_Identity=36.6504854368932, Blast_Score=253, Evalue=3e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.41 [H]

Molecular weight: Translated: 44846; Mature: 44846

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIDQYMTDVGRRARQASRAIARADTAAKNAALAAIATAIEREAGALKAANARDVERARA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
KGQDAAFVDRLTLSDKALKTMLDGLRQVAALADPIGEISNLKFRPSGIQVGQMRVPLGVI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCEECEEECCCEEE
GIIYESRPNVTIDAAALCLKSGNATILRGGSEALESNTALARLIGEGLAAAGLPADAVQV
EEEEECCCCEEEHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
VETADRAAVGRLITMTEYVDVIVPRGGKSLIARLIEEARVPMIKHLDGICHVYVDDRADL
HHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHCCCHHHHCCCEEEEEECCHHHH
AKALSVCDNAKTHRYGTCNTMETLLVARGIAPAVLPQLGRLYRDKSVELRVDAAAKAVLA
HHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEHHHHHHHHH
AAGVGPLVDATEEDWRTEYLAPVLAIKLVDGLDAAIEHINAYGSAHTDAIVTEDHDRAMR
HCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCHHHHHH
FLREVDSASVMVNASTRFADGFEYGLGAEIGISNDKLHARGPVGLEGLTSLKYVVLGHGE
HHHHCCCCEEEEECCCCCCCCCCCCCCCEECCCCCCEECCCCCCCCHHCCEEEEEEECCC
GRQ
CCC
>Mature Secondary Structure
MDIDQYMTDVGRRARQASRAIARADTAAKNAALAAIATAIEREAGALKAANARDVERARA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
KGQDAAFVDRLTLSDKALKTMLDGLRQVAALADPIGEISNLKFRPSGIQVGQMRVPLGVI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCEECEEECCCEEE
GIIYESRPNVTIDAAALCLKSGNATILRGGSEALESNTALARLIGEGLAAAGLPADAVQV
EEEEECCCCEEEHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
VETADRAAVGRLITMTEYVDVIVPRGGKSLIARLIEEARVPMIKHLDGICHVYVDDRADL
HHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHCCCHHHHCCCEEEEEECCHHHH
AKALSVCDNAKTHRYGTCNTMETLLVARGIAPAVLPQLGRLYRDKSVELRVDAAAKAVLA
HHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEHHHHHHHHH
AAGVGPLVDATEEDWRTEYLAPVLAIKLVDGLDAAIEHINAYGSAHTDAIVTEDHDRAMR
HCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCHHHHHH
FLREVDSASVMVNASTRFADGFEYGLGAEIGISNDKLHARGPVGLEGLTSLKYVVLGHGE
HHHHCCCCEEEEECCCCCCCCCCCCCCCEECCCCCCEECCCCCCCCHHCCEEEEEEECCC
GRQ
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA