Click here to switch to the map view.

The map label for this gene is mltA [H]

Identifier: 238026115

GI number: 238026115

Start: 462174

End: 463406

Strand: Direct

Name: mltA [H]

Synonym: bglu_1g04450

Alternate gene names: 238026115

Gene position: 462174-463406 (Clockwise)

Preceding gene: 238026114

Following gene: 238026120

Centisome position: 11.83

GC content: 70.72

Gene sequence:

>1233_bases
ATGAAAATCAGCAGGCCGAGCGCCAGCAGTGATTCCAGCGCGAAGATCAGCATCGGGTATTCGTCGAACAGATCAGACAT
GGCGGTTTCCATCAAGAACGTTCATTGTAGGTGGTTCGGGCCGCGGCTAGCCGGATGGGCAGCCGCGATCGCGACGGCGG
CGCTGCTGGCCGCCTGCGGCGGGGCGCCGGTGCGCCCGCCGGTGGCAAGGGCGCCCGGCGGCGCGCCGTTCGTGCCCGGC
CAGGTGGCCGCCGAGCGGCTCACGCCGGTGGCCTGGCAGCAGGTGCCGGGCTGGCAGGACGACACGCTGATCGGCGCGAC
CATCGCGCTGCGCGAGAACTGCACGCGCCTCGCGCGCGTCCCCAACTGGCGCCGGGCCTGCGAGGCGGCCGGCCGGCTCG
ACGATCTCGACATCACCGGCGCGCGCAGCTTCTTCGAAACCTACTTCACCCCGTACCAGTTCGCCAACACCGACGGCACG
CTCGACGGCCTCGTGACCGGCTACTACGAGCCGCTGCTGCGCGGCTCGCGCGTGCGCCGCGGGCCTTACCAGACCGCGCT
CTACCGCTGGCCGGCCGGCTATCGCGCCGGCGCCGTGCTGCCGACGCGCGCGCAGCTCGAACGCTCGGGCGTGCTGAACG
GCAACGAACTGGTGTGGGTCGATGATCCGGTCGACGCGTTTTTCCTGCAAGTGCAGGGCTCCGGGCGCGTGGTGCTCGAC
GACGGCACCGTGATGCGGGTCGGCTACGGCGGCACCAACAACCAGCCGTACCGGTCGATCGGCAAATGGCTGCTCGACCA
CGGCGAACTCACGCCCGGACAGGCGACCATGCAGGGCATCAAGGCCTGGGCGCGCGCCAACCCGACGCGGCTCGACGCGC
TACTCGACACCAATCCGCGCTTCGTGTTCTTCCGCGAGATGCCCTCGCAGGAAGGCGTGCCGCAAGGCGGTGCGGACGGC
CCGATCGGCGCGCTCGGGGTGCCGCTGACCGCCGAGCGCTCGATCGCCGTCGATCCGTCGGCGATTCCGCTCGGCACGCC
GGTGTTCCTGCAGACCACGCGGCCGCTCACCAATACGCCGATGAGCCGGCTCGTGTTCGCGCAGGACACCGGCTCCGCGA
TCAAGGGCGGCGTGCGCGCCGATTATTTCTGGGGGCTCGGCGACGACGCGGGCGATCTGGCCGGCCGCATGAAGCAGGTC
GGCCGGATGTGGCTGCTGCTGCCGAACTCCTGA

Upstream 100 bases:

>100_bases
CGCACGCTGCACTGAGGGCGCGGGGCCTTAGCTTCGGTTGCGCGGATCGTCGGCTTGCTGCCGGCGCTGCTGTTTCTTGC
CGGACGCGGTCCAGGCGACG

Downstream 100 bases:

>100_bases
GGCGCGGCCGCCGCGGCGGGGCGCCTGCGGGGTGAGCCGGCGGCGGCCTTCAGCGGCGCCGGTCGATCACGCGGCGTGCC
TTGCCGACCGAGCGCTCGAT

Product: MltA domain-containing protein

Products: Muramic Acid Residue [C]

Alternate protein names: Murein hydrolase A [H]

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MKISRPSASSDSSAKISIGYSSNRSDMAVSIKNVHCRWFGPRLAGWAAAIATAALLAACGGAPVRPPVARAPGGAPFVPG
QVAAERLTPVAWQQVPGWQDDTLIGATIALRENCTRLARVPNWRRACEAAGRLDDLDITGARSFFETYFTPYQFANTDGT
LDGLVTGYYEPLLRGSRVRRGPYQTALYRWPAGYRAGAVLPTRAQLERSGVLNGNELVWVDDPVDAFFLQVQGSGRVVLD
DGTVMRVGYGGTNNQPYRSIGKWLLDHGELTPGQATMQGIKAWARANPTRLDALLDTNPRFVFFREMPSQEGVPQGGADG
PIGALGVPLTAERSIAVDPSAIPLGTPVFLQTTRPLTNTPMSRLVFAQDTGSAIKGGVRADYFWGLGDDAGDLAGRMKQV
GRMWLLLPNS

Sequences:

>Translated_410_residues
MKISRPSASSDSSAKISIGYSSNRSDMAVSIKNVHCRWFGPRLAGWAAAIATAALLAACGGAPVRPPVARAPGGAPFVPG
QVAAERLTPVAWQQVPGWQDDTLIGATIALRENCTRLARVPNWRRACEAAGRLDDLDITGARSFFETYFTPYQFANTDGT
LDGLVTGYYEPLLRGSRVRRGPYQTALYRWPAGYRAGAVLPTRAQLERSGVLNGNELVWVDDPVDAFFLQVQGSGRVVLD
DGTVMRVGYGGTNNQPYRSIGKWLLDHGELTPGQATMQGIKAWARANPTRLDALLDTNPRFVFFREMPSQEGVPQGGADG
PIGALGVPLTAERSIAVDPSAIPLGTPVFLQTTRPLTNTPMSRLVFAQDTGSAIKGGVRADYFWGLGDDAGDLAGRMKQV
GRMWLLLPNS
>Mature_410_residues
MKISRPSASSDSSAKISIGYSSNRSDMAVSIKNVHCRWFGPRLAGWAAAIATAALLAACGGAPVRPPVARAPGGAPFVPG
QVAAERLTPVAWQQVPGWQDDTLIGATIALRENCTRLARVPNWRRACEAAGRLDDLDITGARSFFETYFTPYQFANTDGT
LDGLVTGYYEPLLRGSRVRRGPYQTALYRWPAGYRAGAVLPTRAQLERSGVLNGNELVWVDDPVDAFFLQVQGSGRVVLD
DGTVMRVGYGGTNNQPYRSIGKWLLDHGELTPGQATMQGIKAWARANPTRLDALLDTNPRFVFFREMPSQEGVPQGGADG
PIGALGVPLTAERSIAVDPSAIPLGTPVFLQTTRPLTNTPMSRLVFAQDTGSAIKGGVRADYFWGLGDDAGDLAGRMKQV
GRMWLLLPNS

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division [H]

COG id: COG2821

COG function: function code M; Membrane-bound lytic murein transglycosylase

Gene ontology:

Cell location: Note=In closely related bacteria this protein is attached to the outer membrane by a lipid anchor. This is apparently not the case here [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789179, Length=263, Percent_Identity=34.2205323193916, Blast_Score=130, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010611
- InterPro:   IPR014733
- InterPro:   IPR005300 [H]

Pfam domain/function: PF06725 3D; PF03562 MltA [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 44104; Mature: 44104

Theoretical pI: Translated: 9.48; Mature: 9.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKISRPSASSDSSAKISIGYSSNRSDMAVSIKNVHCRWFGPRLAGWAAAIATAALLAACG
CCCCCCCCCCCCCCEEEEEECCCCCCEEEEEEEEEEEEECCHHHHHHHHHHHHHHHHHCC
GAPVRPPVARAPGGAPFVPGQVAAERLTPVAWQQVPGWQDDTLIGATIALRENCTRLARV
CCCCCCCCCCCCCCCCCCCHHHHHHHCCCHHHHHCCCCCCCCEEEEEEHHHHHHHHHHHC
PNWRRACEAAGRLDDLDITGARSFFETYFTPYQFANTDGTLDGLVTGYYEPLLRGSRVRR
CCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHCCCCCCC
GPYQTALYRWPAGYRAGAVLPTRAQLERSGVLNGNELVWVDDPVDAFFLQVQGSGRVVLD
CCCHHHEEECCCCCCCCCCCCCHHHHHHCCCCCCCEEEEEECCCCEEEEEECCCCEEEEE
DGTVMRVGYGGTNNQPYRSIGKWLLDHGELTPGQATMQGIKAWARANPTRLDALLDTNPR
CCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHEECCCCC
FVFFREMPSQEGVPQGGADGPIGALGVPLTAERSIAVDPSAIPLGTPVFLQTTRPLTNTP
EEEEECCCCCCCCCCCCCCCCCCEECCCCCCCCCEEECCCCCCCCCCEEEEECCCCCCCC
MSRLVFAQDTGSAIKGGVRADYFWGLGDDAGDLAGRMKQVGRMWLLLPNS
HHHEEEECCCCHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCEEEEECCC
>Mature Secondary Structure
MKISRPSASSDSSAKISIGYSSNRSDMAVSIKNVHCRWFGPRLAGWAAAIATAALLAACG
CCCCCCCCCCCCCCEEEEEECCCCCCEEEEEEEEEEEEECCHHHHHHHHHHHHHHHHHCC
GAPVRPPVARAPGGAPFVPGQVAAERLTPVAWQQVPGWQDDTLIGATIALRENCTRLARV
CCCCCCCCCCCCCCCCCCCHHHHHHHCCCHHHHHCCCCCCCCEEEEEEHHHHHHHHHHHC
PNWRRACEAAGRLDDLDITGARSFFETYFTPYQFANTDGTLDGLVTGYYEPLLRGSRVRR
CCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHCCCCCCC
GPYQTALYRWPAGYRAGAVLPTRAQLERSGVLNGNELVWVDDPVDAFFLQVQGSGRVVLD
CCCHHHEEECCCCCCCCCCCCCHHHHHHCCCCCCCEEEEEECCCCEEEEEECCCCEEEEE
DGTVMRVGYGGTNNQPYRSIGKWLLDHGELTPGQATMQGIKAWARANPTRLDALLDTNPR
CCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHEECCCCC
FVFFREMPSQEGVPQGGADGPIGALGVPLTAERSIAVDPSAIPLGTPVFLQTTRPLTNTP
EEEEECCCCCCCCCCCCCCCCCCEECCCCCCCCCEEECCCCCCCCCCEEEEECCCCCCCC
MSRLVFAQDTGSAIKGGVRADYFWGLGDDAGDLAGRMKQVGRMWLLLPNS
HHHEEEECCCCHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic [C]

General reaction: Cleavage Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12089438 [H]