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The map label for this gene is mdtG [H]

Identifier: 238026110

GI number: 238026110

Start: 456748

End: 457998

Strand: Reverse

Name: mdtG [H]

Synonym: bglu_1g04390

Alternate gene names: 238026110

Gene position: 457998-456748 (Counterclockwise)

Preceding gene: 238026111

Following gene: 238026109

Centisome position: 11.72

GC content: 70.42

Gene sequence:

>1251_bases
ATGACCACTTCCCCTCCGGCTCCCGGCGCGTCGAACGCCGCGTGGCAGCGCAATCTCGCCGTCTGTTTCTGCGGCTCGTT
CGTCAACATCGTCGCCATGACGCTGCTGCTGCCGTTCCTGCCGCTCTACATCGAGCAGCTCGGCGTGCACGGGCACGCGG
CCATCGTGCAGTGGTCCGGCATCGCCTACGGCGCGACGTTCCTTTCCGCGGCGCTGGTGGCGCCGCTCTGGGGGCGGCTG
GCCGATCGCTACGGCTGCAAGCTGAACCTGGTGCGAGCCAGCTTCGGCATGGTGGTGGCGATGTCGCTGATCGGGCTGTC
GCAGAACGTCTGGCAACTCGTCGCGCTGCGCCTGCTGGTCGGGCTCGCCGGCGGCTACACGTCCGGCTCGTACGTGATCG
TCGCCGCCCAGACGCCGAAGGAACGCTCGGCCTGGGCGCTCGGCATGCTGTCCTCCGGGATCATGGCGGGCAACCTGCTG
GGGCCGCTCCTGGGCGGAATCCTGCCGCAGTACGTCGGGATCCGCATGACCTTCTTCCTCGCGAGCGGCTTCATCCTGCT
CAACTTCGTCGCCACCGCCACCCTGATCCGCGAGGATCGCGACGCGATCGCGGCCCGCCGCCAGCAGGGCGCCGGCAGCG
GCGCCGCGCTCGCCGCCGGCACCCGCGGGCTGGTGCTGACCATGCTCGCCACCGCGATGCTGCTGATGTTCGCCAACATG
TCGATCGAGCCGATCATCACGGTCTACATGCAGCAGTTGCTCGGCGATGCCGGCAACGTGACGTTCTACGCCGGCCTCGC
GATGTCGGCGGCCGCACTGGGCAGCATCACCTCGGCCTCGCGGCTGGGGAAGATCGCCGACCGGATCGGCGCGCTGAAGG
TGGTGATCGCCTGCCTCGCCGTGTCGGGGCTGCTGCTGATTCCGCAGGCCTTCGTCACGCACGCCTGGCAGCTCATCGCG
CTGCGCTTCCTGATGGGCCTGTCGCTCGGCGGCCTGCTGCCGTGCCTGACCTCGATCATCCGCCACAACGTGCAGGACGG
CTCGGTGGGCCGCGTGCTCGGCTATTCCACCTCGGCGCAGTATTCCGGGCAGGTGCTGGGGCCGGTGGCGGGCGGCTTTG
TCGGCGGCCACCTGGGGATGCGCTACGTGTTCCTGACGACCTGCGTGCTGCTGCTCGCCAGCGCGCTCAGCAACGCGGTG
CTGGGCCGCGCGCCGGCGCGGCGCGCGCGCGGCCGGTCCACCACCGCCTGA

Upstream 100 bases:

>100_bases
AAGCCGATTCCTGCTCACCGCCCGCCGTCGTGGCGAGCGGACGCGGTCGCGTCCTCGATCCCGTCCGCCGCGGCCGCCTG
AGCGCCCAACCGCACCGTCC

Downstream 100 bases:

>100_bases
AACCGCCCGGCCGGCGGGACGGCTGCCGCCCGGCGCCCGGCTGGCGTGCCGCGTCCAAGCGGCGCGCCTCGCCAGCTGCG
GCGCGAGGGTCGCGATCCGG

Product: multi-drug resistance efflux protein

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MTTSPPAPGASNAAWQRNLAVCFCGSFVNIVAMTLLLPFLPLYIEQLGVHGHAAIVQWSGIAYGATFLSAALVAPLWGRL
ADRYGCKLNLVRASFGMVVAMSLIGLSQNVWQLVALRLLVGLAGGYTSGSYVIVAAQTPKERSAWALGMLSSGIMAGNLL
GPLLGGILPQYVGIRMTFFLASGFILLNFVATATLIREDRDAIAARRQQGAGSGAALAAGTRGLVLTMLATAMLLMFANM
SIEPIITVYMQQLLGDAGNVTFYAGLAMSAAALGSITSASRLGKIADRIGALKVVIACLAVSGLLLIPQAFVTHAWQLIA
LRFLMGLSLGGLLPCLTSIIRHNVQDGSVGRVLGYSTSAQYSGQVLGPVAGGFVGGHLGMRYVFLTTCVLLLASALSNAV
LGRAPARRARGRSTTA

Sequences:

>Translated_416_residues
MTTSPPAPGASNAAWQRNLAVCFCGSFVNIVAMTLLLPFLPLYIEQLGVHGHAAIVQWSGIAYGATFLSAALVAPLWGRL
ADRYGCKLNLVRASFGMVVAMSLIGLSQNVWQLVALRLLVGLAGGYTSGSYVIVAAQTPKERSAWALGMLSSGIMAGNLL
GPLLGGILPQYVGIRMTFFLASGFILLNFVATATLIREDRDAIAARRQQGAGSGAALAAGTRGLVLTMLATAMLLMFANM
SIEPIITVYMQQLLGDAGNVTFYAGLAMSAAALGSITSASRLGKIADRIGALKVVIACLAVSGLLLIPQAFVTHAWQLIA
LRFLMGLSLGGLLPCLTSIIRHNVQDGSVGRVLGYSTSAQYSGQVLGPVAGGFVGGHLGMRYVFLTTCVLLLASALSNAV
LGRAPARRARGRSTTA
>Mature_415_residues
TTSPPAPGASNAAWQRNLAVCFCGSFVNIVAMTLLLPFLPLYIEQLGVHGHAAIVQWSGIAYGATFLSAALVAPLWGRLA
DRYGCKLNLVRASFGMVVAMSLIGLSQNVWQLVALRLLVGLAGGYTSGSYVIVAAQTPKERSAWALGMLSSGIMAGNLLG
PLLGGILPQYVGIRMTFFLASGFILLNFVATATLIREDRDAIAARRQQGAGSGAALAAGTRGLVLTMLATAMLLMFANMS
IEPIITVYMQQLLGDAGNVTFYAGLAMSAAALGSITSASRLGKIADRIGALKVVIACLAVSGLLLIPQAFVTHAWQLIAL
RFLMGLSLGGLLPCLTSIIRHNVQDGSVGRVLGYSTSAQYSGQVLGPVAGGFVGGHLGMRYVFLTTCVLLLASALSNAVL
GRAPARRARGRSTTA

Specific function: Confers resistance to fosfomycin and deoxycholate [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. DHA1 family. MdtG (TC 2.A.1.2.20) subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787291, Length=405, Percent_Identity=40, Blast_Score=283, Evalue=2e-77,
Organism=Escherichia coli, GI87082404, Length=321, Percent_Identity=25.2336448598131, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43302; Mature: 43171

Theoretical pI: Translated: 10.58; Mature: 10.58

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTSPPAPGASNAAWQRNLAVCFCGSFVNIVAMTLLLPFLPLYIEQLGVHGHAAIVQWSG
CCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECC
IAYGATFLSAALVAPLWGRLADRYGCKLNLVRASFGMVVAMSLIGLSQNVWQLVALRLLV
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
GLAGGYTSGSYVIVAAQTPKERSAWALGMLSSGIMAGNLLGPLLGGILPQYVGIRMTFFL
HHCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASGFILLNFVATATLIREDRDAIAARRQQGAGSGAALAAGTRGLVLTMLATAMLLMFANM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHCC
SIEPIITVYMQQLLGDAGNVTFYAGLAMSAAALGSITSASRLGKIADRIGALKVVIACLA
CHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSGLLLIPQAFVTHAWQLIALRFLMGLSLGGLLPCLTSIIRHNVQDGSVGRVLGYSTSAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCEEECCCCCC
YSGQVLGPVAGGFVGGHLGMRYVFLTTCVLLLASALSNAVLGRAPARRARGRSTTA
CCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCC
>Mature Secondary Structure 
TTSPPAPGASNAAWQRNLAVCFCGSFVNIVAMTLLLPFLPLYIEQLGVHGHAAIVQWSG
CCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECC
IAYGATFLSAALVAPLWGRLADRYGCKLNLVRASFGMVVAMSLIGLSQNVWQLVALRLLV
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
GLAGGYTSGSYVIVAAQTPKERSAWALGMLSSGIMAGNLLGPLLGGILPQYVGIRMTFFL
HHCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASGFILLNFVATATLIREDRDAIAARRQQGAGSGAALAAGTRGLVLTMLATAMLLMFANM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHCC
SIEPIITVYMQQLLGDAGNVTFYAGLAMSAAALGSITSASRLGKIADRIGALKVVIACLA
CHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSGLLLIPQAFVTHAWQLIALRFLMGLSLGGLLPCLTSIIRHNVQDGSVGRVLGYSTSAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCEEECCCCCC
YSGQVLGPVAGGFVGGHLGMRYVFLTTCVLLLASALSNAVLGRAPARRARGRSTTA
CCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA