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The map label for this gene is trpE [H]

Identifier: 238026111

GI number: 238026111

Start: 458285

End: 459778

Strand: Reverse

Name: trpE [H]

Synonym: bglu_1g04400

Alternate gene names: 238026111

Gene position: 459778-458285 (Counterclockwise)

Preceding gene: 238026112

Following gene: 238026110

Centisome position: 11.77

GC content: 67.74

Gene sequence:

>1494_bases
ATGACTGAACTCGAATTCCAATCGCTCGCGAACGCCGGCTACAACCGCATCCCGCTGATCGCGGAGGCGCTGGCCGACCT
CGAAACCCCGCTGTCGCTGTACCTGAAGCTCGCGCAGCCCGAGCGCGGCGGCGCCAATTCGTTCCTGCTCGAATCGGTGG
TGGGCGGCGAGCGCTTCGGGCGCTACTCGTTCATCGGGCTGCCGGCCCGCACGCTGGTGCGCACCCGCAACGGCGTCTGC
GAGATCGTCACCGACGGCCAGGTGGTGGAAACCCACGAAGGCGATCCGTTCGCCTTCATCGAGGCCTTCCAGGCGCGCTT
CAAGGTGGCCCAGCGTCCCGGCCTGCCACGCTTCTGCGGCGGCCTGGCCGGCTACTTCGGCTACGACGCGGTGCGCTACA
TCGAGAAGAAGCTCGCCGACTCGACGCCGCCCGACGATCTGAACCTGCCGGACATCCAGCTGCTGCTGACCGAGGAAGTC
GCCGTGATCGACAACCTCGCCGGCAAGCTCTATCTGATCGTCTACGCCGATCCGGGCCGGCCGGAAGCCTACGCGAAGGC
GAAGCAGCGGCTGCGCGAACTGAAGCAGCGGCTGCATGCGACGGTGCAGCCGCCCGTCACGTCGGCGAGCGTGCGCACCG
AGACGTTCCGCGAGTTCAAGAAGGACGACTATCTGGCGGCGGTGCGCCAGGCCAAGGAATACATCGCGGCCGGCGAGCTG
ATGCAGGTGCAGGTCGGCCAGCGCCTGACCAAGCCGTTTCGCGACAATCCGCTGTCGCTGTACCGGGCGCTGCGATCCCT
GAACCCGTCGCCGTACATGTACTACTACAACTTCGGCGAATTCCACGTGGTGGGCGCCTCGCCCGAGATCCTGGTGCGCC
AGGAAAAGCGCGGCGAGGACCAGGTCGTCACGATCCGCCCGCTGGCCGGCACGCGCCCGCGCGGCAACACGCCGGAACGC
GACGCGGCGCTCGCCACCGAACTGCTCAACGATCCGAAGGAGATCGCCGAGCACGTGATGCTGATCGACCTCGCGCGCAA
CGACGTGGGCCGCATCGCGACCACCGGCTCGGTAGCCGTCACCGACCGGATGGTGATCGAGAAGTACTCGCACGTGCAGC
ACATCGTCAGCTCGGTCGAGGGCACGCTCAAGCCCGGCATGACGAACTACGACGTGCTGCGCGCGACGTTCCCGGCCGGC
ACGCTGTCCGGCGCGCCGAAGGTGCGCGCGATGGAATTGATCGACGAGCTCGAGCCGGTCAAGCGCGGCCTCTACGGCGG
CGCGGTCGGCTATCTGTCGTTCTCGGGCGAGATGGACCTCGCGATCGCGATCCGCACCGGCCTGATCCACAACGGCAACC
TCTACGTGCAGGCGGCCGCCGGCGTGGTGGCCGACTCGGTGCCCGAATCGGAATGGCAGGAAACGGAGAACAAGGCGCGC
GCGGTGCTGCGCGCGGCCGAACAGGTTCAGGACGGCCTCGACGGCGACTTCTGA

Upstream 100 bases:

>100_bases
AAGCCGGTCAGGCTTACGACCGTCCCGCCCCCCCGGCCCGCCGCGCAGCGCCCGCGATTCTCCCGGCACCTTTTGCCGCT
CGTCCAGACAGGACCGGAAC

Downstream 100 bases:

>100_bases
ACGACGGCTCGCGGCGCCGGACGCGGCTGCCTGCCGTCGGCGCCGCCAGTTGCGGCAGGCCGCGCGCGACTTCGGGCGCC
GCCGCGTGCCGCCACCAGGC

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 497; Mature: 496

Protein sequence:

>497_residues
MTELEFQSLANAGYNRIPLIAEALADLETPLSLYLKLAQPERGGANSFLLESVVGGERFGRYSFIGLPARTLVRTRNGVC
EIVTDGQVVETHEGDPFAFIEAFQARFKVAQRPGLPRFCGGLAGYFGYDAVRYIEKKLADSTPPDDLNLPDIQLLLTEEV
AVIDNLAGKLYLIVYADPGRPEAYAKAKQRLRELKQRLHATVQPPVTSASVRTETFREFKKDDYLAAVRQAKEYIAAGEL
MQVQVGQRLTKPFRDNPLSLYRALRSLNPSPYMYYYNFGEFHVVGASPEILVRQEKRGEDQVVTIRPLAGTRPRGNTPER
DAALATELLNDPKEIAEHVMLIDLARNDVGRIATTGSVAVTDRMVIEKYSHVQHIVSSVEGTLKPGMTNYDVLRATFPAG
TLSGAPKVRAMELIDELEPVKRGLYGGAVGYLSFSGEMDLAIAIRTGLIHNGNLYVQAAAGVVADSVPESEWQETENKAR
AVLRAAEQVQDGLDGDF

Sequences:

>Translated_497_residues
MTELEFQSLANAGYNRIPLIAEALADLETPLSLYLKLAQPERGGANSFLLESVVGGERFGRYSFIGLPARTLVRTRNGVC
EIVTDGQVVETHEGDPFAFIEAFQARFKVAQRPGLPRFCGGLAGYFGYDAVRYIEKKLADSTPPDDLNLPDIQLLLTEEV
AVIDNLAGKLYLIVYADPGRPEAYAKAKQRLRELKQRLHATVQPPVTSASVRTETFREFKKDDYLAAVRQAKEYIAAGEL
MQVQVGQRLTKPFRDNPLSLYRALRSLNPSPYMYYYNFGEFHVVGASPEILVRQEKRGEDQVVTIRPLAGTRPRGNTPER
DAALATELLNDPKEIAEHVMLIDLARNDVGRIATTGSVAVTDRMVIEKYSHVQHIVSSVEGTLKPGMTNYDVLRATFPAG
TLSGAPKVRAMELIDELEPVKRGLYGGAVGYLSFSGEMDLAIAIRTGLIHNGNLYVQAAAGVVADSVPESEWQETENKAR
AVLRAAEQVQDGLDGDF
>Mature_496_residues
TELEFQSLANAGYNRIPLIAEALADLETPLSLYLKLAQPERGGANSFLLESVVGGERFGRYSFIGLPARTLVRTRNGVCE
IVTDGQVVETHEGDPFAFIEAFQARFKVAQRPGLPRFCGGLAGYFGYDAVRYIEKKLADSTPPDDLNLPDIQLLLTEEVA
VIDNLAGKLYLIVYADPGRPEAYAKAKQRLRELKQRLHATVQPPVTSASVRTETFREFKKDDYLAAVRQAKEYIAAGELM
QVQVGQRLTKPFRDNPLSLYRALRSLNPSPYMYYYNFGEFHVVGASPEILVRQEKRGEDQVVTIRPLAGTRPRGNTPERD
AALATELLNDPKEIAEHVMLIDLARNDVGRIATTGSVAVTDRMVIEKYSHVQHIVSSVEGTLKPGMTNYDVLRATFPAGT
LSGAPKVRAMELIDELEPVKRGLYGGAVGYLSFSGEMDLAIAIRTGLIHNGNLYVQAAAGVVADSVPESEWQETENKARA
VLRAAEQVQDGLDGDF

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=376, Percent_Identity=41.4893617021277, Blast_Score=245, Evalue=5e-66,
Organism=Escherichia coli, GI1788114, Length=447, Percent_Identity=31.0961968680089, Blast_Score=227, Evalue=1e-60,
Organism=Escherichia coli, GI87082077, Length=274, Percent_Identity=28.8321167883212, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1786809, Length=225, Percent_Identity=26.6666666666667, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6320935, Length=465, Percent_Identity=41.0752688172043, Blast_Score=314, Evalue=2e-86,
Organism=Saccharomyces cerevisiae, GI6324361, Length=501, Percent_Identity=25.748502994012, Blast_Score=128, Evalue=2e-30,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 54791; Mature: 54660

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTELEFQSLANAGYNRIPLIAEALADLETPLSLYLKLAQPERGGANSFLLESVVGGERFG
CCCCCHHHHHHCCCCCCHHHHHHHHHHCCCHHHHEEECCCCCCCCHHHHHHHHHCCHHCC
RYSFIGLPARTLVRTRNGVCEIVTDGQVVETHEGDPFAFIEAFQARFKVAQRPGLPRFCG
CEEEECCCHHHHHHHCCCEEEEEECCEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHHH
GLAGYFGYDAVRYIEKKLADSTPPDDLNLPDIQLLLTEEVAVIDNLAGKLYLIVYADPGR
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEHHHHHHHHHCCCEEEEEEEECCCC
PEAYAKAKQRLRELKQRLHATVQPPVTSASVRTETFREFKKDDYLAAVRQAKEYIAAGEL
CHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCH
MQVQVGQRLTKPFRDNPLSLYRALRSLNPSPYMYYYNFGEFHVVGASPEILVRQEKRGED
HHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEEEECCEEEEECCCCCEEEECCCCCCC
QVVTIRPLAGTRPRGNTPERDAALATELLNDPKEIAEHVMLIDLARNDVGRIATTGSVAV
CEEEEEECCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEECCCEEH
TDRMVIEKYSHVQHIVSSVEGTLKPGMTNYDVLRATFPAGTLSGAPKVRAMELIDELEPV
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHEEECCCCCCCCCCCHHHHHHHHHHHHH
KRGLYGGAVGYLSFSGEMDLAIAIRTGLIHNGNLYVQAAAGVVADSVPESEWQETENKAR
HHHHCCCEEEEEEECCCCEEEEEEEECEEECCCEEEEECCCHHHCCCCCHHHHHHHHHHH
AVLRAAEQVQDGLDGDF
HHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TELEFQSLANAGYNRIPLIAEALADLETPLSLYLKLAQPERGGANSFLLESVVGGERFG
CCCCHHHHHHCCCCCCHHHHHHHHHHCCCHHHHEEECCCCCCCCHHHHHHHHHCCHHCC
RYSFIGLPARTLVRTRNGVCEIVTDGQVVETHEGDPFAFIEAFQARFKVAQRPGLPRFCG
CEEEECCCHHHHHHHCCCEEEEEECCEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHHH
GLAGYFGYDAVRYIEKKLADSTPPDDLNLPDIQLLLTEEVAVIDNLAGKLYLIVYADPGR
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEHHHHHHHHHCCCEEEEEEEECCCC
PEAYAKAKQRLRELKQRLHATVQPPVTSASVRTETFREFKKDDYLAAVRQAKEYIAAGEL
CHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCH
MQVQVGQRLTKPFRDNPLSLYRALRSLNPSPYMYYYNFGEFHVVGASPEILVRQEKRGED
HHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEEEECCEEEEECCCCCEEEECCCCCCC
QVVTIRPLAGTRPRGNTPERDAALATELLNDPKEIAEHVMLIDLARNDVGRIATTGSVAV
CEEEEEECCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEECCCEEH
TDRMVIEKYSHVQHIVSSVEGTLKPGMTNYDVLRATFPAGTLSGAPKVRAMELIDELEPV
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHEEECCCCCCCCCCCHHHHHHHHHHHHH
KRGLYGGAVGYLSFSGEMDLAIAIRTGLIHNGNLYVQAAAGVVADSVPESEWQETENKAR
HHHHCCCEEEEEEECCCCEEEEEEEECEEECCCEEEEECCCHHHCCCCCHHHHHHHHHHH
AVLRAAEQVQDGLDGDF
HHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10417653 [H]