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The map label for this gene is phhA [H]

Identifier: 238025731

GI number: 238025731

Start: 54796

End: 55701

Strand: Reverse

Name: phhA [H]

Synonym: bglu_1g00530

Alternate gene names: 238025731

Gene position: 55701-54796 (Counterclockwise)

Preceding gene: 238025733

Following gene: 238025730

Centisome position: 1.43

GC content: 69.09

Gene sequence:

>906_bases
ATGTCCAACGTCGTCACCGCGATGCTTCAGGAGCAGTTCGACGCGGGTCTCGAGACCCGCCAGGATTTCACCATCGATCA
GCCGCTCGAGCGCTACACGCGCGTCGATCACGCAGTCTGGTCGCAGCTCTACGCGCGGCAGACGGCGCTGCTCGAGGGCC
GCGCGGCCGACGCATTCGTGGCCGGCATGAAACGCCTCACGCTGCCGGCCGACCGCGTGCCGTCGTTCGAGGACGTGAAC
CGGCAGCTGCAGCCGGCCACCGGCTGGGAAATCGTCGCGGTGCCGGGGCTCGTGCCGGCCGACGTATTCTTCGCACACCT
TGCGAGCCGCCGCTTTCCCGTCACTTGGTGGATGCGCCGCCCGGACCAGCTCGACTACCTGCAGGAGCCGGACTGCTTCC
ACGACCTGTTCGGCCACGTGCCGCTGCTGATCGATCCGGTGTTCGCCGACTACATGCATGCCTACGGCCAGGCCGCGCTC
GCCGTCTCCGACGACCCGTTCGCGCTGTCGCTGCTGGGCCGGCTCTACTGGTACACGGTGGAATTCGGCCTGATCCGCAG
CCGGCACGATCGCGACCAGCTGCGCATCTATGGCGCCGGCATCGTGTCGAGCCGCGGCGAATCGGTCTACAGCCTCGAAA
GCGCCGCGCCGAACCGGATCGGCTTCGATCTCGACCGCGTGATGCGCACCGCCTATCGCATCGACACGTTCCAGAAGACC
TACTTCGTGATCGACGATTTCGAGCAGTTGTTCGCGCTCGCGAAGGTGGACGCGCGCGCGCTGGCCAGGCGGCTCGCCGG
GCTCGCCGAGCACCCGGCCGGCGCCGTGCTGGCCGGCGACCGGGTCCTGCATCGCGGCACCGGCGAAGGCTGGGCCGGTG
ACGACGACGCCACCGGCCGCGCCTGA

Upstream 100 bases:

>100_bases
ATCGCATTAAAAGTTCCACAAGCGTCGAAATTGCGCCCTTCCCGCGCGTTACCCGCTCTACACTGGCATCCATCGTCACC
GCAGCCGTGCCCAGCCAGCC

Downstream 100 bases:

>100_bases
ATCAACGTCGTCTGGCCGCAAATATGGAAGAATGTCCCGATGGCGCGCCGACGCTTCGCGCGGCTCGCGCGACGGCGGCC
AGGCGCGCGTCACTGCACAC

Product: phenylalanine 4-monooxygenase

Products: NA

Alternate protein names: PAH; Phe-4-monooxygenase [H]

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MSNVVTAMLQEQFDAGLETRQDFTIDQPLERYTRVDHAVWSQLYARQTALLEGRAADAFVAGMKRLTLPADRVPSFEDVN
RQLQPATGWEIVAVPGLVPADVFFAHLASRRFPVTWWMRRPDQLDYLQEPDCFHDLFGHVPLLIDPVFADYMHAYGQAAL
AVSDDPFALSLLGRLYWYTVEFGLIRSRHDRDQLRIYGAGIVSSRGESVYSLESAAPNRIGFDLDRVMRTAYRIDTFQKT
YFVIDDFEQLFALAKVDARALARRLAGLAEHPAGAVLAGDRVLHRGTGEGWAGDDDATGRA

Sequences:

>Translated_301_residues
MSNVVTAMLQEQFDAGLETRQDFTIDQPLERYTRVDHAVWSQLYARQTALLEGRAADAFVAGMKRLTLPADRVPSFEDVN
RQLQPATGWEIVAVPGLVPADVFFAHLASRRFPVTWWMRRPDQLDYLQEPDCFHDLFGHVPLLIDPVFADYMHAYGQAAL
AVSDDPFALSLLGRLYWYTVEFGLIRSRHDRDQLRIYGAGIVSSRGESVYSLESAAPNRIGFDLDRVMRTAYRIDTFQKT
YFVIDDFEQLFALAKVDARALARRLAGLAEHPAGAVLAGDRVLHRGTGEGWAGDDDATGRA
>Mature_300_residues
SNVVTAMLQEQFDAGLETRQDFTIDQPLERYTRVDHAVWSQLYARQTALLEGRAADAFVAGMKRLTLPADRVPSFEDVNR
QLQPATGWEIVAVPGLVPADVFFAHLASRRFPVTWWMRRPDQLDYLQEPDCFHDLFGHVPLLIDPVFADYMHAYGQAALA
VSDDPFALSLLGRLYWYTVEFGLIRSRHDRDQLRIYGAGIVSSRGESVYSLESAAPNRIGFDLDRVMRTAYRIDTFQKTY
FVIDDFEQLFALAKVDARALARRLAGLAEHPAGAVLAGDRVLHRGTGEGWAGDDDATGRA

Specific function: Unknown

COG id: COG3186

COG function: function code E; Phenylalanine-4-hydroxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family [H]

Homologues:

Organism=Homo sapiens, GI88900503, Length=242, Percent_Identity=35.1239669421488, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI88900501, Length=242, Percent_Identity=35.1239669421488, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI88900505, Length=242, Percent_Identity=35.1239669421488, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI31795563, Length=246, Percent_Identity=34.1463414634146, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI4557819, Length=252, Percent_Identity=31.7460317460317, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI4759248, Length=252, Percent_Identity=31.3492063492063, Blast_Score=118, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI71980736, Length=277, Percent_Identity=32.4909747292419, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17531391, Length=224, Percent_Identity=34.8214285714286, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI115533973, Length=238, Percent_Identity=32.7731092436975, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI115532103, Length=238, Percent_Identity=32.7731092436975, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI71980731, Length=178, Percent_Identity=33.1460674157303, Blast_Score=94, Evalue=9e-20,
Organism=Drosophila melanogaster, GI62472054, Length=221, Percent_Identity=34.841628959276, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24660393, Length=221, Percent_Identity=34.841628959276, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI17136774, Length=225, Percent_Identity=30.6666666666667, Blast_Score=114, Evalue=7e-26,
Organism=Drosophila melanogaster, GI17136776, Length=225, Percent_Identity=30.6666666666667, Blast_Score=114, Evalue=8e-26,
Organism=Drosophila melanogaster, GI24654994, Length=196, Percent_Identity=34.6938775510204, Blast_Score=109, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001273
- InterPro:   IPR018301
- InterPro:   IPR019774
- InterPro:   IPR005960 [H]

Pfam domain/function: PF00351 Biopterin_H [H]

EC number: =1.14.16.1 [H]

Molecular weight: Translated: 33854; Mature: 33722

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00367 BIOPTERIN_HYDROXYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNVVTAMLQEQFDAGLETRQDFTIDQPLERYTRVDHAVWSQLYARQTALLEGRAADAFV
CCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
AGMKRLTLPADRVPSFEDVNRQLQPATGWEIVAVPGLVPADVFFAHLASRRFPVTWWMRR
HHHHHHCCCHHCCCCHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCEEEECCC
PDQLDYLQEPDCFHDLFGHVPLLIDPVFADYMHAYGQAALAVSDDPFALSLLGRLYWYTV
CCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHH
EFGLIRSRHDRDQLRIYGAGIVSSRGESVYSLESAAPNRIGFDLDRVMRTAYRIDTFQKT
HHHHHHCCCCCCCEEEEECCCCCCCCCCEEEHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
YFVIDDFEQLFALAKVDARALARRLAGLAEHPAGAVLAGDRVLHRGTGEGWAGDDDATGR
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCHHEECCCCCCCCCCCCCCCC
A
C
>Mature Secondary Structure 
SNVVTAMLQEQFDAGLETRQDFTIDQPLERYTRVDHAVWSQLYARQTALLEGRAADAFV
CHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
AGMKRLTLPADRVPSFEDVNRQLQPATGWEIVAVPGLVPADVFFAHLASRRFPVTWWMRR
HHHHHHCCCHHCCCCHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCEEEECCC
PDQLDYLQEPDCFHDLFGHVPLLIDPVFADYMHAYGQAALAVSDDPFALSLLGRLYWYTV
CCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHH
EFGLIRSRHDRDQLRIYGAGIVSSRGESVYSLESAAPNRIGFDLDRVMRTAYRIDTFQKT
HHHHHHCCCCCCCEEEEECCCCCCCCCCEEEHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
YFVIDDFEQLFALAKVDARALARRLAGLAEHPAGAVLAGDRVLHRGTGEGWAGDDDATGR
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCHHEECCCCCCCCCCCCCCCC
A
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]