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The map label for this gene is ethA [H]

Identifier: 238025071

GI number: 238025071

Start: 2164782

End: 2166431

Strand: Direct

Name: ethA [H]

Synonym: bglu_2g17270

Alternate gene names: 238025071

Gene position: 2164782-2166431 (Clockwise)

Preceding gene: 238025070

Following gene: 339717978

Centisome position: 76.57

GC content: 71.88

Gene sequence:

>1650_bases
ATGAGCACCACTCACCTGCCGCGCGAGGCGGCCCACCGCGCCGCGTCGCGCCCGCACGGGCGCGACGCCGATCCCGCCGA
GCGCGCGAGCGGCACCGAACCGGCCGAGGCGGCAACCGATTTCGACGTGCTGATCGTGGGGGCGGGCCTGTCCGGCATCG
GCGCGGCGCACCATCTGCGCCAGCGCTGCCCGTGGGCCAGCTTCGCGATCCTCGAAAGCCGCGCGACGCTGGGCGGCACC
TGGGATCTGTTCCGCTATCCCGGGGTGCGCTCCGACTCCGACATGTTCACGCTCGGCTACAGCTTCCGGCCCTGGCACAG
CGACCAAGCGATCGCCGAAGGCGGGACGATCCTCGACTACATTCGCGACACCGCGCGCGAGGCGGACATCGAGCGCACCA
TCCGTTTCCACCATCGCGTGACGGCCGCGAACTGGGACTCGGCCACGGCACGCTGGCAGGTCGAGGTGCTGCGCGGCGAC
GGCACCGACGGCCAGCCGCGGCAGGCGCTGCGCTTCACCTGCCGCTTCCTCTACATGTGCAGCGGCTACTACGACTACGA
GCAAGGCCACGCGCCTAGCTGGCCGGGCATGGAAAGCTTTCGCGGCCGCATCGTGCATCCGCAGCACTGGCCGCGCGATC
TCGACTATGCCGGCAAGCGCGTGGTCGTGATCGGCAGCGGCGCGACGGCGGTCACGCTGGTGCCGTCGATGGCGCGCGAG
GCCGCCCATGTCACGATGCTGCAGCGCTCGCCGACCTACATCGTCTCGATGCCGGCGCGCGACAAGCTGGCGGCGCGGCT
GCGCCGCTGGCTGCCGGCCGGCCTCGCGCACCGGCTGGTGCGGGTCCGCAACGTGCTGCTGACGATGTCCGTGTACCGGT
TCGCGCGGCGCCGCCCCGAGGCGGCCAAGCGTTTCATCCTGCGCGCCGCGAGCCGCCAGCTCGGGCCGGAGTTCGACGTC
GCGAAGCATCTGACGCCGCGCTACGCGCCCTGGGACCAGCGGCTGTGCCTGGTGCCCAACGGCGACCTGTTCAAGGCGAT
CCGCGCCGGCGACGCGTCGATCGCCACCGACGAGATCGAGCGCTTCACGCCGGAGGGCCTGCTGCTGAAAAGCGGCCGCA
CGCTCGAGGCGGACCTGGTCGTCAGCGCCACCGGGCTCAAGGTGCGCATGCTGGGCGGCGCCACGCTGAGCGTGGACGGG
TGCCCCGTCGAGTTCGGCGAGGCCGTGTCGTACAAGGGCATGATGGCAAGCGGCGTGCCGAACCTCGCGACCTCGTTCGG
CTACATCAACGCCTCGTGGACCCTGAAGGCCGAGCTGATCGCGCTGTACGTCTGCCGGCTGCTCAACCACATGCGCGCGC
ACGGCTACGACAGCTGCACGCCCACCCTCGACGACGCCGCCATGCCGCTCGCGCCGGCCGTCGAGCTCAGCTCCGGCTAC
ATCCAGCGCGCGGCCGCGCTGCTGCCGAAGCAGGGCCCGCGCAATCCGTGGAAATCGCACCAGAATTACGCACGCGACCT
CGCGCTGCTGCGCTTCGGCTCGCTCGTCGACGGCGCGATGCGCTTCGCGCGGCGGCCGGCGCAAGCCGGCCAGGCCGCCG
CGCCGGCCGAGCGTCACGCCGCTTCCGAACCCGCCTACGAGAGAAGGTGA

Upstream 100 bases:

>100_bases
TGTTCGTGCTGCGCTTCGTGCGCAGCTCGCGCGAACGCAACCTGCGGCGGCACGGCGCCGGCGCCGCCGCGAACCACTCC
GCCGAGACGAGGGACGCGGC

Downstream 100 bases:

>100_bases
ACATCATGATCGTCCAACTGATCGCCGTCGTGCTTGCCCTCTATGCCGTGCTGTTCGCGTTTACGCTGTTCACCGCCCAT
CAGGTGCGCCGCCGCTTTCC

Product: Arylesterase/monooxygenase

Products: NA

Alternate protein names: Baeyer-Villiger monooxygenase; BVMO [H]

Number of amino acids: Translated: 549; Mature: 548

Protein sequence:

>549_residues
MSTTHLPREAAHRAASRPHGRDADPAERASGTEPAEAATDFDVLIVGAGLSGIGAAHHLRQRCPWASFAILESRATLGGT
WDLFRYPGVRSDSDMFTLGYSFRPWHSDQAIAEGGTILDYIRDTAREADIERTIRFHHRVTAANWDSATARWQVEVLRGD
GTDGQPRQALRFTCRFLYMCSGYYDYEQGHAPSWPGMESFRGRIVHPQHWPRDLDYAGKRVVVIGSGATAVTLVPSMARE
AAHVTMLQRSPTYIVSMPARDKLAARLRRWLPAGLAHRLVRVRNVLLTMSVYRFARRRPEAAKRFILRAASRQLGPEFDV
AKHLTPRYAPWDQRLCLVPNGDLFKAIRAGDASIATDEIERFTPEGLLLKSGRTLEADLVVSATGLKVRMLGGATLSVDG
CPVEFGEAVSYKGMMASGVPNLATSFGYINASWTLKAELIALYVCRLLNHMRAHGYDSCTPTLDDAAMPLAPAVELSSGY
IQRAAALLPKQGPRNPWKSHQNYARDLALLRFGSLVDGAMRFARRPAQAGQAAAPAERHAASEPAYERR

Sequences:

>Translated_549_residues
MSTTHLPREAAHRAASRPHGRDADPAERASGTEPAEAATDFDVLIVGAGLSGIGAAHHLRQRCPWASFAILESRATLGGT
WDLFRYPGVRSDSDMFTLGYSFRPWHSDQAIAEGGTILDYIRDTAREADIERTIRFHHRVTAANWDSATARWQVEVLRGD
GTDGQPRQALRFTCRFLYMCSGYYDYEQGHAPSWPGMESFRGRIVHPQHWPRDLDYAGKRVVVIGSGATAVTLVPSMARE
AAHVTMLQRSPTYIVSMPARDKLAARLRRWLPAGLAHRLVRVRNVLLTMSVYRFARRRPEAAKRFILRAASRQLGPEFDV
AKHLTPRYAPWDQRLCLVPNGDLFKAIRAGDASIATDEIERFTPEGLLLKSGRTLEADLVVSATGLKVRMLGGATLSVDG
CPVEFGEAVSYKGMMASGVPNLATSFGYINASWTLKAELIALYVCRLLNHMRAHGYDSCTPTLDDAAMPLAPAVELSSGY
IQRAAALLPKQGPRNPWKSHQNYARDLALLRFGSLVDGAMRFARRPAQAGQAAAPAERHAASEPAYERR
>Mature_548_residues
STTHLPREAAHRAASRPHGRDADPAERASGTEPAEAATDFDVLIVGAGLSGIGAAHHLRQRCPWASFAILESRATLGGTW
DLFRYPGVRSDSDMFTLGYSFRPWHSDQAIAEGGTILDYIRDTAREADIERTIRFHHRVTAANWDSATARWQVEVLRGDG
TDGQPRQALRFTCRFLYMCSGYYDYEQGHAPSWPGMESFRGRIVHPQHWPRDLDYAGKRVVVIGSGATAVTLVPSMAREA
AHVTMLQRSPTYIVSMPARDKLAARLRRWLPAGLAHRLVRVRNVLLTMSVYRFARRRPEAAKRFILRAASRQLGPEFDVA
KHLTPRYAPWDQRLCLVPNGDLFKAIRAGDASIATDEIERFTPEGLLLKSGRTLEADLVVSATGLKVRMLGGATLSVDGC
PVEFGEAVSYKGMMASGVPNLATSFGYINASWTLKAELIALYVCRLLNHMRAHGYDSCTPTLDDAAMPLAPAVELSSGYI
QRAAALLPKQGPRNPWKSHQNYARDLALLRFGSLVDGAMRFARRPAQAGQAAAPAERHAASEPAYERR

Specific function: Catalyzes the activation of thiocarbamide-containing drugs such as ethionamide (ETH), isoxyl (ISO) and thiacetazone (TAC) into reactive species [H]

COG id: COG2072

COG function: function code P; Predicted flavoprotein involved in K+ transport

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-binding monooxygenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006076
- InterPro:   IPR020946 [H]

Pfam domain/function: PF01266 DAO; PF00743 FMO-like [H]

EC number: NA

Molecular weight: Translated: 60641; Mature: 60509

Theoretical pI: Translated: 9.82; Mature: 9.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTHLPREAAHRAASRPHGRDADPAERASGTEPAEAATDFDVLIVGAGLSGIGAAHHLR
CCCCCCCHHHHHHHHCCCCCCCCCHHHHCCCCCCHHHHCCCEEEEEECCCCHHHHHHHHH
QRCPWASFAILESRATLGGTWDLFRYPGVRSDSDMFTLGYSFRPWHSDQAIAEGGTILDY
HHCCCHHHHHHHCCCCCCCCCHHHCCCCCCCCCCEEEECCCCCCCCCCCHHHCCCHHHHH
IRDTAREADIERTIRFHHRVTAANWDSATARWQVEVLRGDGTDGQPRQALRFTCRFLYMC
HHHHHHHHHHHHHHHHHHEEEECCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHH
SGYYDYEQGHAPSWPGMESFRGRIVHPQHWPRDLDYAGKRVVVIGSGATAVTLVPSMARE
CCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEECHHHHHH
AAHVTMLQRSPTYIVSMPARDKLAARLRRWLPAGLAHRLVRVRNVLLTMSVYRFARRRPE
HHHHHEEECCCCEEEECCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHH
AAKRFILRAASRQLGPEFDVAKHLTPRYAPWDQRLCLVPNGDLFKAIRAGDASIATDEIE
HHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCEEECCCCHHHHHHHCCCCHHHHHHHH
RFTPEGLLLKSGRTLEADLVVSATGLKVRMLGGATLSVDGCPVEFGEAVSYKGMMASGVP
HCCCCCEEEECCCCEEEEEEEEECCEEEEEECCCEEEECCCCCCCCCHHCCCCHHHCCCC
NLATSFGYINASWTLKAELIALYVCRLLNHMRAHGYDSCTPTLDDAAMPLAPAVELSSGY
HHHHHCCEEECEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHH
IQRAAALLPKQGPRNPWKSHQNYARDLALLRFGSLVDGAMRFARRPAQAGQAAAPAERHA
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCHHHHC
ASEPAYERR
CCCCCCCCC
>Mature Secondary Structure 
STTHLPREAAHRAASRPHGRDADPAERASGTEPAEAATDFDVLIVGAGLSGIGAAHHLR
CCCCCCHHHHHHHHCCCCCCCCCHHHHCCCCCCHHHHCCCEEEEEECCCCHHHHHHHHH
QRCPWASFAILESRATLGGTWDLFRYPGVRSDSDMFTLGYSFRPWHSDQAIAEGGTILDY
HHCCCHHHHHHHCCCCCCCCCHHHCCCCCCCCCCEEEECCCCCCCCCCCHHHCCCHHHHH
IRDTAREADIERTIRFHHRVTAANWDSATARWQVEVLRGDGTDGQPRQALRFTCRFLYMC
HHHHHHHHHHHHHHHHHHEEEECCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHH
SGYYDYEQGHAPSWPGMESFRGRIVHPQHWPRDLDYAGKRVVVIGSGATAVTLVPSMARE
CCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEECHHHHHH
AAHVTMLQRSPTYIVSMPARDKLAARLRRWLPAGLAHRLVRVRNVLLTMSVYRFARRRPE
HHHHHEEECCCCEEEECCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHH
AAKRFILRAASRQLGPEFDVAKHLTPRYAPWDQRLCLVPNGDLFKAIRAGDASIATDEIE
HHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCEEECCCCHHHHHHHCCCCHHHHHHHH
RFTPEGLLLKSGRTLEADLVVSATGLKVRMLGGATLSVDGCPVEFGEAVSYKGMMASGVP
HCCCCCEEEECCCCEEEEEEEEECCEEEEEECCCEEEECCCCCCCCCHHCCCCHHHCCCC
NLATSFGYINASWTLKAELIALYVCRLLNHMRAHGYDSCTPTLDDAAMPLAPAVELSSGY
HHHHHCCEEECEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHH
IQRAAALLPKQGPRNPWKSHQNYARDLALLRFGSLVDGAMRFARRPAQAGQAAAPAERHA
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCHHHHC
ASEPAYERR
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]