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The map label for this gene is bioA [C]

Identifier: 238024698

GI number: 238024698

Start: 1714027

End: 1715424

Strand: Reverse

Name: bioA [C]

Synonym: bglu_2g13350

Alternate gene names: 238024698

Gene position: 1715424-1714027 (Counterclockwise)

Preceding gene: 238024700

Following gene: 238024697

Centisome position: 60.67

GC content: 70.24

Gene sequence:

>1398_bases
ATGCGCAACACACCGAACCACGAGGAGCGCGCCGCGCCTGCCGACATGACCGAACTGACCGCCCCCCCGCAAGCGGACGC
GATCCGCACCGACGCCGCCTGGCTCGACGCCCACTGGATGCCGTTTACCGGCAATCGCCAGTTCAAGCAGGACCCGCGCA
TCATCGTGGAGGGCAAGGGCGCCTATTACACCGATGCGGCCGGCCGCAAGATCTTCGACGGCCTGTCGGGCCTCTGGTGC
TGCGGCCTCGGCCACGGCCGCAGCGAGATCACCGAGGCGGTCAGCCGCCAGATCGCGAAGCTCGACTACGCGCCGGGCTT
CCAGTTCGGCCATCCGCAGTCGTTCGAGCTGGCGAACCGGATCAAGGCGCTGACGCCGGCCGGCCTCGACCACGTGTTCT
TCACGAGTTCGGGCTCGGAGGCCGCCGATACCTCGCTGAAGATGGCCCGCGCCTATTGGCGCGCCAAGGGCAAGGGCACC
AAGACGCGCCTGATCGGCCGCGAGAAGGGCTACCACGGCGTGAACTTCGGCGGCATCTCGGTGGGCGGGATCGGCGCGAA
CCGCAAGCTGTTCGGCCAGGGCGTGGACGCCGATTTCCTGCCGCACACGCAGCTCGCGCAGAACCGCTTCTCGCGCGGCC
TGCCCGAGCACGGCGTCGAGCTGGCCGACCGGCTGCTCGACCTGATCGCGCTGCACGACGCGTCGAACATCGCCGCGGTG
ATCGTCGAGCCGTTCTCGGGCTCGGCCGGCGTGGTGGTGCCGCCCAAGGGCTACCTGAAGCGGCTGCGCGAGATCTGCAC
CGCGCACGACATCCTGCTGATCTTCGACGAGGTGATCACGGGCTTCGGCCGTGCCGGCGCGCTGACGGGCGCCGACGCGT
TCGGCGTGATGCCGGACCTGCTCAACTTCGCCAAGCAGGTCACCAACGGCACGCAGCCGCTCGGCGGCGTGGTGGCGACG
CGGGAGATCCACGACACGTTCATGGCCGCGGGCGGCCCGGAATATCTGGTCGAGTTCCCGCACGGCTATACCTACTCGGC
GCATCCGGTGGCCTGCGCGGCCGGCAACGCGGCGCTGGAACTGCTGCGCCGCGAGGACGGGGTGGGCCGCGTGCGTGCGC
TCGCGCCGCATTTCGAGAACGCCGTCCACGGCCTGAAAGGCTTGCGCCACGTGGCCGACATCCGCAACTTCGGCCTCGCC
GCCGGCATCTCGATCGATCCGCTGCCGGGCGAGCCGGCGCGGCGTCCGTTCGAGATCGCGATGCGCTGCTGGGAGAAGGG
CTTCTATGTGCGCTACGGCGGCGACACGATCCAGCTCGCGCCGCCGTTCATCGCCGAGCCGCGCGAGATCGACAGCCTGG
TGGGCGCGCTGGCCGAGGCGCTGAACGCCACGGCCTGA

Upstream 100 bases:

>100_bases
CTGGCCGAGCAGCGCGCGATGCTTGGAAGTTCTTACTTGCATGAATGCTCAAGTAAACATTGATATTGCGATATTCAAAA
GACTATCCGGCGCCCCAACA

Downstream 100 bases:

>100_bases
GCGAGCGCCGACGCTGATTGCCTGGCCCGGCGCTCCGCTCGAGCCGGGGCGCGATGGGCGGCGAGAACGCCGGCTTGCCG
ATCCGCTCGCACAAGCAGCC

Product: beta alanine--pyruvate transaminase

Products: NA

Alternate protein names: Omega-APT; Beta-alanine--pyruvate aminotransferase [H]

Number of amino acids: Translated: 465; Mature: 465

Protein sequence:

>465_residues
MRNTPNHEERAAPADMTELTAPPQADAIRTDAAWLDAHWMPFTGNRQFKQDPRIIVEGKGAYYTDAAGRKIFDGLSGLWC
CGLGHGRSEITEAVSRQIAKLDYAPGFQFGHPQSFELANRIKALTPAGLDHVFFTSSGSEAADTSLKMARAYWRAKGKGT
KTRLIGREKGYHGVNFGGISVGGIGANRKLFGQGVDADFLPHTQLAQNRFSRGLPEHGVELADRLLDLIALHDASNIAAV
IVEPFSGSAGVVVPPKGYLKRLREICTAHDILLIFDEVITGFGRAGALTGADAFGVMPDLLNFAKQVTNGTQPLGGVVAT
REIHDTFMAAGGPEYLVEFPHGYTYSAHPVACAAGNAALELLRREDGVGRVRALAPHFENAVHGLKGLRHVADIRNFGLA
AGISIDPLPGEPARRPFEIAMRCWEKGFYVRYGGDTIQLAPPFIAEPREIDSLVGALAEALNATA

Sequences:

>Translated_465_residues
MRNTPNHEERAAPADMTELTAPPQADAIRTDAAWLDAHWMPFTGNRQFKQDPRIIVEGKGAYYTDAAGRKIFDGLSGLWC
CGLGHGRSEITEAVSRQIAKLDYAPGFQFGHPQSFELANRIKALTPAGLDHVFFTSSGSEAADTSLKMARAYWRAKGKGT
KTRLIGREKGYHGVNFGGISVGGIGANRKLFGQGVDADFLPHTQLAQNRFSRGLPEHGVELADRLLDLIALHDASNIAAV
IVEPFSGSAGVVVPPKGYLKRLREICTAHDILLIFDEVITGFGRAGALTGADAFGVMPDLLNFAKQVTNGTQPLGGVVAT
REIHDTFMAAGGPEYLVEFPHGYTYSAHPVACAAGNAALELLRREDGVGRVRALAPHFENAVHGLKGLRHVADIRNFGLA
AGISIDPLPGEPARRPFEIAMRCWEKGFYVRYGGDTIQLAPPFIAEPREIDSLVGALAEALNATA
>Mature_465_residues
MRNTPNHEERAAPADMTELTAPPQADAIRTDAAWLDAHWMPFTGNRQFKQDPRIIVEGKGAYYTDAAGRKIFDGLSGLWC
CGLGHGRSEITEAVSRQIAKLDYAPGFQFGHPQSFELANRIKALTPAGLDHVFFTSSGSEAADTSLKMARAYWRAKGKGT
KTRLIGREKGYHGVNFGGISVGGIGANRKLFGQGVDADFLPHTQLAQNRFSRGLPEHGVELADRLLDLIALHDASNIAAV
IVEPFSGSAGVVVPPKGYLKRLREICTAHDILLIFDEVITGFGRAGALTGADAFGVMPDLLNFAKQVTNGTQPLGGVVAT
REIHDTFMAAGGPEYLVEFPHGYTYSAHPVACAAGNAALELLRREDGVGRVRALAPHFENAVHGLKGLRHVADIRNFGLA
AGISIDPLPGEPARRPFEIAMRCWEKGFYVRYGGDTIQLAPPFIAEPREIDSLVGALAEALNATA

Specific function: Catalyzes transamination between a variety of omega- amino acids, mono and diamines, and pyruvate. Plays a pivotal role in the metabolism of the omega amino acids [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI13994255, Length=445, Percent_Identity=26.2921348314607, Blast_Score=135, Evalue=9e-32,
Organism=Homo sapiens, GI4557809, Length=410, Percent_Identity=28.780487804878, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI37574042, Length=442, Percent_Identity=27.8280542986425, Blast_Score=129, Evalue=8e-30,
Organism=Homo sapiens, GI226442705, Length=442, Percent_Identity=27.8280542986425, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI226442709, Length=407, Percent_Identity=28.009828009828, Blast_Score=118, Evalue=9e-27,
Organism=Homo sapiens, GI284507298, Length=318, Percent_Identity=28.9308176100629, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI24119277, Length=404, Percent_Identity=25.990099009901, Blast_Score=104, Evalue=1e-22,
Organism=Escherichia coli, GI1786991, Length=428, Percent_Identity=31.3084112149533, Blast_Score=171, Evalue=1e-43,
Organism=Escherichia coli, GI145693181, Length=303, Percent_Identity=31.6831683168317, Blast_Score=144, Evalue=2e-35,
Organism=Escherichia coli, GI1788044, Length=406, Percent_Identity=29.8029556650246, Blast_Score=142, Evalue=5e-35,
Organism=Escherichia coli, GI1789759, Length=432, Percent_Identity=28.4722222222222, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI1789016, Length=402, Percent_Identity=27.363184079602, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1787560, Length=416, Percent_Identity=27.8846153846154, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1786349, Length=319, Percent_Identity=30.7210031347962, Blast_Score=98, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI32564660, Length=447, Percent_Identity=26.6219239373602, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI25144271, Length=416, Percent_Identity=27.1634615384615, Blast_Score=121, Evalue=8e-28,
Organism=Caenorhabditis elegans, GI71992977, Length=442, Percent_Identity=27.3755656108597, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI25144274, Length=229, Percent_Identity=30.5676855895196, Blast_Score=101, Evalue=9e-22,
Organism=Saccharomyces cerevisiae, GI6323470, Length=421, Percent_Identity=26.8408551068884, Blast_Score=150, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6324386, Length=432, Percent_Identity=25, Blast_Score=126, Evalue=9e-30,
Organism=Saccharomyces cerevisiae, GI6324432, Length=423, Percent_Identity=25.0591016548463, Blast_Score=118, Evalue=2e-27,
Organism=Drosophila melanogaster, GI21357415, Length=402, Percent_Identity=28.3582089552239, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI161085790, Length=448, Percent_Identity=26.7857142857143, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI28574759, Length=453, Percent_Identity=27.3730684326711, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI21356575, Length=434, Percent_Identity=25.5760368663594, Blast_Score=119, Evalue=5e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.18 [H]

Molecular weight: Translated: 50041; Mature: 50041

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNTPNHEERAAPADMTELTAPPQADAIRTDAAWLDAHWMPFTGNRQFKQDPRIIVEGKG
CCCCCCCHHHCCCCCHHHCCCCCCCCCEECCCHHHCCCCCCCCCCCCCCCCCEEEEECCC
AYYTDAAGRKIFDGLSGLWCCGLGHGRSEITEAVSRQIAKLDYAPGFQFGHPQSFELANR
CEEECCCCHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
IKALTPAGLDHVFFTSSGSEAADTSLKMARAYWRAKGKGTKTRLIGREKGYHGVNFGGIS
HHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCEE
VGGIGANRKLFGQGVDADFLPHTQLAQNRFSRGLPEHGVELADRLLDLIALHDASNIAAV
ECCCCCCCHHHCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEE
IVEPFSGSAGVVVPPKGYLKRLREICTAHDILLIFDEVITGFGRAGALTGADAFGVMPDL
EEECCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
LNFAKQVTNGTQPLGGVVATREIHDTFMAAGGPEYLVEFPHGYTYSAHPVACAAGNAALE
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCEEECCHHHHH
LLRREDGVGRVRALAPHFENAVHGLKGLRHVADIRNFGLAAGISIDPLPGEPARRPFEIA
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCEECCCCCCCCCCHHHHH
MRCWEKGFYVRYGGDTIQLAPPFIAEPREIDSLVGALAEALNATA
HHHHHCCCEEEECCCEEEECCCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRNTPNHEERAAPADMTELTAPPQADAIRTDAAWLDAHWMPFTGNRQFKQDPRIIVEGKG
CCCCCCCHHHCCCCCHHHCCCCCCCCCEECCCHHHCCCCCCCCCCCCCCCCCEEEEECCC
AYYTDAAGRKIFDGLSGLWCCGLGHGRSEITEAVSRQIAKLDYAPGFQFGHPQSFELANR
CEEECCCCHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
IKALTPAGLDHVFFTSSGSEAADTSLKMARAYWRAKGKGTKTRLIGREKGYHGVNFGGIS
HHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCEE
VGGIGANRKLFGQGVDADFLPHTQLAQNRFSRGLPEHGVELADRLLDLIALHDASNIAAV
ECCCCCCCHHHCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEE
IVEPFSGSAGVVVPPKGYLKRLREICTAHDILLIFDEVITGFGRAGALTGADAFGVMPDL
EEECCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
LNFAKQVTNGTQPLGGVVATREIHDTFMAAGGPEYLVEFPHGYTYSAHPVACAAGNAALE
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCEEECCHHHHH
LLRREDGVGRVRALAPHFENAVHGLKGLRHVADIRNFGLAAGISIDPLPGEPARRPFEIA
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCEECCCCCCCCCCHHHHH
MRCWEKGFYVRYGGDTIQLAPPFIAEPREIDSLVGALAEALNATA
HHHHHCCCEEEECCCEEEECCCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1618757; 6822556; 2500426 [H]