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The map label for this gene is yuxL [H]

Identifier: 238024700

GI number: 238024700

Start: 1716586

End: 1718484

Strand: Reverse

Name: yuxL [H]

Synonym: bglu_2g13370

Alternate gene names: 238024700

Gene position: 1718484-1716586 (Counterclockwise)

Preceding gene: 238024702

Following gene: 238024698

Centisome position: 60.78

GC content: 70.04

Gene sequence:

>1899_bases
ATGGAACCCATCCCGCAGCGCGCCGCCGGTGCGGCGCCCGTCAAACGCCACGATGTCCGCGACTTCTTTCGCCGCCCCGC
ACGCACCGGCTTCCAGCTTTCGCCGGACGGCCGCCACCTGTCGTTCCTCGCGCGCCATGCCGGCCGCCTCAATCTGTTCG
TGCAGGCCATCGACGGCCAGGGCCGCGTCCATGGCGAGCCGCGCGTGCTCAGCCACGAATCGGCGCGCGACGTGTCCGGC
TACGTCTGGAAGGGCAATGACCGCGTGCTGTACGTGAAGGACTTCGGCGGCGACGAGAACTACCACGTGCTGTCGGTGCC
GATCGACGGCGGCCCGGCCGTGGACCTGACGCCTTACGACGGCGTGCGCGCCTCGATCGTCGACCGGCTGATCGACGACG
ACCGCCACGTCCTGCTGTCGCACAACCGCCGCGACGCCACCGTGTTCGACGTGCTGCGGGTGGACGTGATCACCGGCGAG
GCGAGCCTGGTCGCCGAGAACCCCGGCAACGTCCTCGGCTGGATGACCGACCACGCGGGGCGGCTGCGCGTGGCCGTCTC
GTCGGACGGCGTGAACCGGACGCTGCTCTATCGCGACGAGGAGAGCGAGCCGTTTCGCGCGCTCGTCACCACCAACTTCC
GCGAGGCGCTCGCGCCGCTCTTCTTCACGTTCGACGACCGCCGGCTCTACGTGCTGTCCAACCGCGGGCGCGACCGCGTC
GCGATCTTCGAGTTCGATCCGCAGACCGGGCTGGAAGGCACGCTGCTGTTCGAGCACGCCGAGGTGGACGTGAAGGGCAT
GAGCTTCTCGCGCGAGCGGCGCGTGCTGACCACCGCCTGGTACGAGGACGACCGGGTCCGCGCGCATCATTTCGACGCGC
GGGTGGCCGACATCTACGCCGATCTCGACGCGCGCCTGCCGGGCGGCGAATCGAGCATCGCGAGTCTCACGCGCGACGAA
TCGCGGATGCTGGTGCGCAACGCGCGCGACCTGTCGCCGGGCGCGGTCTGGTTCTACCACGCCGGCTCGCGCCAACTCAC
GCAGATCGAGGATCTCGCGCCGTGGCTCGATCCGGCCGACATGGCGCCGATGCGGCCGATCGCATACACCTCGCGCGACG
GGCTGCGCATTCACGGCTACCTGACGCTGCCGGCCGGCGTCGAGCCCGACGCGCCCGGCGCCGCGAAGCTGCCGCTGGTG
GTGAACCCGCATGGCGGGCCGTGGGCGCGCGACCACTGGGGCTTCGATCCCGAGGTGCAGCTGCTCGCCAATCGCGGCTA
TGCGGTGCTGCAGATGAACTTCCGCGGCTCGGTGGGCTATGGCCGCGCGTTCTGGGAGGCGAGCTTCGGCCAGTGGGGCC
GGGCGATGCAGAACGACATCGACGACGGCGTCGACTGGCTGGTGGGGCAGGGGCTCGTCGATCCGGCGCGCGTCGCGATC
TACGGCGCGAGCTACGGCGGCTACGCGGCGCTGGCCGGCGTCGCGTTCACGCCCGAGCGCTATGCGGCCGCCGTCGACTA
CGTCGGCGTCTCCAACCTGTTCACGCTGCTCGAATCGATGCCGCCTTACTGGAAGCCGCTGCGCGAGATGATGTACGAGC
AGATCGGCAACCCGAACACCGAGGCCGGGCGGCAGGCGCTGCACGACGCCTCGCCGCTGTTCTTCGCCGATCGCATCGTC
ACGCCGCTGTTCGTCGCGCAGGGGGCCAACGATCCGCGCGTCAAGCAGGCCGAGAGCGACCAGATCGTGGCCGCGCTGCG
CGAGCGCGGGGTGGACGTCAAGTACATGCTGAAGGCCGACGAGGGGCACGGCTTCGCCAACGAGGAGAACCAGTACGAGT
TCTACGAGGCGATGATCGCGTTTCTCGACACGCATCTCGGCACCGCGCGCGAGGGCTGA

Upstream 100 bases:

>100_bases
ACCGCGCGGCGGCGCTAGAATGGCGGGTCCGCCCGAGCCTTCAGCCGGGCGAGCCGGCTCTGGCCGGCGCGCCCTGGACA
CCAACCGAACAGGTGAGCCC

Downstream 100 bases:

>100_bases
GGGCGGCGCTGCCTGCCGGCGGGCGGCGCGCCGGCCCTGCGCGAAAGGCGCGCCGCTCAGGCCGTGCCGGTCTTGCGTGC
GGCGCGGCGTGCCGCCGGTG

Product: peptidase S9, prolyl oligopeptidase

Products: Hydrolyzed protein [C]

Alternate protein names: NA

Number of amino acids: Translated: 632; Mature: 632

Protein sequence:

>632_residues
MEPIPQRAAGAAPVKRHDVRDFFRRPARTGFQLSPDGRHLSFLARHAGRLNLFVQAIDGQGRVHGEPRVLSHESARDVSG
YVWKGNDRVLYVKDFGGDENYHVLSVPIDGGPAVDLTPYDGVRASIVDRLIDDDRHVLLSHNRRDATVFDVLRVDVITGE
ASLVAENPGNVLGWMTDHAGRLRVAVSSDGVNRTLLYRDEESEPFRALVTTNFREALAPLFFTFDDRRLYVLSNRGRDRV
AIFEFDPQTGLEGTLLFEHAEVDVKGMSFSRERRVLTTAWYEDDRVRAHHFDARVADIYADLDARLPGGESSIASLTRDE
SRMLVRNARDLSPGAVWFYHAGSRQLTQIEDLAPWLDPADMAPMRPIAYTSRDGLRIHGYLTLPAGVEPDAPGAAKLPLV
VNPHGGPWARDHWGFDPEVQLLANRGYAVLQMNFRGSVGYGRAFWEASFGQWGRAMQNDIDDGVDWLVGQGLVDPARVAI
YGASYGGYAALAGVAFTPERYAAAVDYVGVSNLFTLLESMPPYWKPLREMMYEQIGNPNTEAGRQALHDASPLFFADRIV
TPLFVAQGANDPRVKQAESDQIVAALRERGVDVKYMLKADEGHGFANEENQYEFYEAMIAFLDTHLGTAREG

Sequences:

>Translated_632_residues
MEPIPQRAAGAAPVKRHDVRDFFRRPARTGFQLSPDGRHLSFLARHAGRLNLFVQAIDGQGRVHGEPRVLSHESARDVSG
YVWKGNDRVLYVKDFGGDENYHVLSVPIDGGPAVDLTPYDGVRASIVDRLIDDDRHVLLSHNRRDATVFDVLRVDVITGE
ASLVAENPGNVLGWMTDHAGRLRVAVSSDGVNRTLLYRDEESEPFRALVTTNFREALAPLFFTFDDRRLYVLSNRGRDRV
AIFEFDPQTGLEGTLLFEHAEVDVKGMSFSRERRVLTTAWYEDDRVRAHHFDARVADIYADLDARLPGGESSIASLTRDE
SRMLVRNARDLSPGAVWFYHAGSRQLTQIEDLAPWLDPADMAPMRPIAYTSRDGLRIHGYLTLPAGVEPDAPGAAKLPLV
VNPHGGPWARDHWGFDPEVQLLANRGYAVLQMNFRGSVGYGRAFWEASFGQWGRAMQNDIDDGVDWLVGQGLVDPARVAI
YGASYGGYAALAGVAFTPERYAAAVDYVGVSNLFTLLESMPPYWKPLREMMYEQIGNPNTEAGRQALHDASPLFFADRIV
TPLFVAQGANDPRVKQAESDQIVAALRERGVDVKYMLKADEGHGFANEENQYEFYEAMIAFLDTHLGTAREG
>Mature_632_residues
MEPIPQRAAGAAPVKRHDVRDFFRRPARTGFQLSPDGRHLSFLARHAGRLNLFVQAIDGQGRVHGEPRVLSHESARDVSG
YVWKGNDRVLYVKDFGGDENYHVLSVPIDGGPAVDLTPYDGVRASIVDRLIDDDRHVLLSHNRRDATVFDVLRVDVITGE
ASLVAENPGNVLGWMTDHAGRLRVAVSSDGVNRTLLYRDEESEPFRALVTTNFREALAPLFFTFDDRRLYVLSNRGRDRV
AIFEFDPQTGLEGTLLFEHAEVDVKGMSFSRERRVLTTAWYEDDRVRAHHFDARVADIYADLDARLPGGESSIASLTRDE
SRMLVRNARDLSPGAVWFYHAGSRQLTQIEDLAPWLDPADMAPMRPIAYTSRDGLRIHGYLTLPAGVEPDAPGAAKLPLV
VNPHGGPWARDHWGFDPEVQLLANRGYAVLQMNFRGSVGYGRAFWEASFGQWGRAMQNDIDDGVDWLVGQGLVDPARVAI
YGASYGGYAALAGVAFTPERYAAAVDYVGVSNLFTLLESMPPYWKPLREMMYEQIGNPNTEAGRQALHDASPLFFADRIV
TPLFVAQGANDPRVKQAESDQIVAALRERGVDVKYMLKADEGHGFANEENQYEFYEAMIAFLDTHLGTAREG

Specific function: Cleaves Peptide Bonds On The C-Terminal Side Of Lysyl And Argininyl Residues. [C]

COG id: COG1506

COG function: function code E; Dipeptidyl aminopeptidases/acylaminoacyl-peptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9B family [H]

Homologues:

Organism=Homo sapiens, GI23510451, Length=241, Percent_Identity=28.6307053941909, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI194394146, Length=275, Percent_Identity=25.0909090909091, Blast_Score=67, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI25144537, Length=653, Percent_Identity=30.1684532924962, Blast_Score=281, Evalue=7e-76,
Organism=Caenorhabditis elegans, GI25144540, Length=443, Percent_Identity=34.7629796839729, Blast_Score=253, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI25144543, Length=561, Percent_Identity=26.7379679144385, Blast_Score=193, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI17552908, Length=230, Percent_Identity=33.4782608695652, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI25149159, Length=265, Percent_Identity=26.4150943396226, Blast_Score=84, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011042
- InterPro:   IPR011659
- InterPro:   IPR001375 [H]

Pfam domain/function: PF07676 PD40; PF00326 Peptidase_S9 [H]

EC number: 3.4.21.83 [C]

Molecular weight: Translated: 70427; Mature: 70427

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPIPQRAAGAAPVKRHDVRDFFRRPARTGFQLSPDGRHLSFLARHAGRLNLFVQAIDGQ
CCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHCCCCEEEEEEEECCC
GRVHGEPRVLSHESARDVSGYVWKGNDRVLYVKDFGGDENYHVLSVPIDGGPAVDLTPYD
CEECCCCCEECCCCCCCCCCEEEECCCEEEEEEECCCCCCEEEEEEECCCCCEEECCCCC
GVRASIVDRLIDDDRHVLLSHNRRDATVFDVLRVDVITGEASLVAENPGNVLGWMTDHAG
CHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEEEEEEECCCEEEECCCCCEEEEEECCCC
RLRVAVSSDGVNRTLLYRDEESEPFRALVTTNFREALAPLFFTFDDRRLYVLSNRGRDRV
EEEEEEECCCCCEEEEEECCCCCCEEEEEECCHHHHHHCEEEEECCCEEEEEECCCCCEE
AIFEFDPQTGLEGTLLFEHAEVDVKGMSFSRERRVLTTAWYEDDRVRAHHFDARVADIYA
EEEEECCCCCCCEEEEEEECEEEEECCCCCCCCCEEEEEEECCCCEEEEECCCHHHHHHH
DLDARLPGGESSIASLTRDESRMLVRNARDLSPGAVWFYHAGSRQLTQIEDLAPWLDPAD
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHCCCCCCCC
MAPMRPIAYTSRDGLRIHGYLTLPAGVEPDAPGAAKLPLVVNPHGGPWARDHWGFDPEVQ
CCCCCCEEECCCCCEEEEEEEEECCCCCCCCCCCEECCEEECCCCCCCCCCCCCCCCCCC
LLANRGYAVLQMNFRGSVGYGRAFWEASFGQWGRAMQNDIDDGVDWLVGQGLVDPARVAI
EEECCCEEEEEEECCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEE
YGASYGGYAALAGVAFTPERYAAAVDYVGVSNLFTLLESMPPYWKPLREMMYEQIGNPNT
EECCCCCHHHHHCEEECCHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCC
EAGRQALHDASPLFFADRIVTPLFVAQGANDPRVKQAESDQIVAALRERGVDVKYMLKAD
HHHHHHHHCCCCCEEHHHHHHHHHEECCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEEEC
EGHGFANEENQYEFYEAMIAFLDTHLGTAREG
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MEPIPQRAAGAAPVKRHDVRDFFRRPARTGFQLSPDGRHLSFLARHAGRLNLFVQAIDGQ
CCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHCCCCEEEEEEEECCC
GRVHGEPRVLSHESARDVSGYVWKGNDRVLYVKDFGGDENYHVLSVPIDGGPAVDLTPYD
CEECCCCCEECCCCCCCCCCEEEECCCEEEEEEECCCCCCEEEEEEECCCCCEEECCCCC
GVRASIVDRLIDDDRHVLLSHNRRDATVFDVLRVDVITGEASLVAENPGNVLGWMTDHAG
CHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEEEEEEECCCEEEECCCCCEEEEEECCCC
RLRVAVSSDGVNRTLLYRDEESEPFRALVTTNFREALAPLFFTFDDRRLYVLSNRGRDRV
EEEEEEECCCCCEEEEEECCCCCCEEEEEECCHHHHHHCEEEEECCCEEEEEECCCCCEE
AIFEFDPQTGLEGTLLFEHAEVDVKGMSFSRERRVLTTAWYEDDRVRAHHFDARVADIYA
EEEEECCCCCCCEEEEEEECEEEEECCCCCCCCCEEEEEEECCCCEEEEECCCHHHHHHH
DLDARLPGGESSIASLTRDESRMLVRNARDLSPGAVWFYHAGSRQLTQIEDLAPWLDPAD
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHCCCCCCCC
MAPMRPIAYTSRDGLRIHGYLTLPAGVEPDAPGAAKLPLVVNPHGGPWARDHWGFDPEVQ
CCCCCCEEECCCCCEEEEEEEEECCCCCCCCCCCEECCEEECCCCCCCCCCCCCCCCCCC
LLANRGYAVLQMNFRGSVGYGRAFWEASFGQWGRAMQNDIDDGVDWLVGQGLVDPARVAI
EEECCCEEEEEEECCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEE
YGASYGGYAALAGVAFTPERYAAAVDYVGVSNLFTLLESMPPYWKPLREMMYEQIGNPNT
EECCCCCHHHHHCEEECCHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCC
EAGRQALHDASPLFFADRIVTPLFVAQGANDPRVKQAESDQIVAALRERGVDVKYMLKAD
HHHHHHHHCCCCCEEHHHHHHHHHEECCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEEEC
EGHGFANEENQYEFYEAMIAFLDTHLGTAREG
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Ca2+ [C]

Kcat value (1/min): 11820 [C]

Specific activity: NA

Km value (mM): 0.23 {tosyl-Arg} 0.33 {N-benzyloxycarbonyl-Lys} 0.31 {N-benzyloxycarbonyl-Lys} 0.92 {benzoyl-Lys} 0.6 {N-benzoyl-Arg} 0.5 {benzoyl-Arg} 0.48 {benzoyl-Arg} 0.25 {benzoyl-Arg} 80 {acetyl-tyrosine} 0.47 {tosyl-Lys-methyl} [C]

Substrates: Protein; H2O [C]

Specific reaction: Protein + H2O = hydrolyzed protein [C]

General reaction: Peptide bond hydrolysis [C]

Inhibitor: Antipain; Aromaticamidines; Benzamidine; Co2+; DFP; Fe2+; Hg2+; L-Arginine; Leupeptin sulfhydryl agents, trypsin inhibitors, 1, 10-phenanthroline; p-Aminobenzamidine; Tosyl -Leuchloromethyl ketone; Zn2+ [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 3098560 [H]