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The map label for this gene is hbaA [H]

Identifier: 238024540

GI number: 238024540

Start: 1457304

End: 1458932

Strand: Reverse

Name: hbaA [H]

Synonym: bglu_2g11460

Alternate gene names: 238024540

Gene position: 1458932-1457304 (Counterclockwise)

Preceding gene: 238024541

Following gene: 238024539

Centisome position: 51.6

GC content: 71.45

Gene sequence:

>1629_bases
ATGAGCGACGTCAATCTCGCTGCCGCGCTGCTGTTCAACAAGCGCCACCTCGACAAGCCGGCCTACATCGGCCCCGACTT
CGCGCTCAGCTATGCCGAACTCGATCGCGCGGTACGGCGCCAGGCCGCCTGGATGACGATGCAGGAAGTCGCGCCCGGCG
AGCGCATCGTGATCGCGCTCGACGACGGCCCGGACCTCGCGGTGATCTTCTTCGCCTCGCTCGCGGTGGGCGCGCTGCCC
GTGGTGGTGAGTTCGAAGCTCGACACGGCGCCGCTGCGTCACATCCTCGGCGATGCCGAGCCGCTGATGGTGTATGGCAA
GGCGGTGCAGGCCGACACGATTCGCGCCGCGATCGACGGCCTGGCCACGCGCCCGCAGGCGTTTCTGCTGGAGGCCGGCT
GGTATCGCACGCTGCTCGCACGGCGCGTCGGGGCGCCGCGTGCGCCGGCCGCGGCCCTCGCCGGCGACGCGTTCGACGAG
TCGTCCGACGAGGCATTGGAGGAGGCCGCGGAGCAGGAATGGGACGCCGCGGTCCTGCGTGATCGCCACGCGCCGGCGCT
GATCCAGTACACCTCGGGCACCACCGGGCTCGCGAAGGGCGTGACGCACAGTGCCGCGTCGGTGCTGGCCTGCTGCGCCG
CCGTGACGGGCCAGCTGGGCCTGAGCGCCGACGACGTGCTCTATTCGGTGCCGAAGTCGTTCTTCGGCTTCGGCATGGGC
AACAGCCTGTTCTTCCCGCTCCATCTCGGCGCGAGCGCCGTGCTCGACGCGGCCTGGCCGAACGCCGCGCAGGTGGAGGC
GAACCTGCGACGCTTCCGGCCCACGGTGCTGTTCGCCGTGCCGACCCTGTACCGGATGCTGCTCGACAACGGCTTCGGCC
CCGACGATTCCCCGCTGCGGCTGGCGTTCTCGGCCGGCGCGCCGCTTGCCGGCAACACCGGCGCGCGCTGGCGCGAGCGC
TTCGGTTTCGATCTGCACGACGGCATCGGTGCGACCGAACTCTGCCACGTGTTCGCGACCAGCTACCCGGATTCGCTGCG
CCGGGGCAGCCTCGGCCGGCTGCTGGCGGGCTGCGAGGCGCGCATCGTCGACGAGGCCGGGCACGAGGTCCGGCCCGGCG
AGACCGGCGTGCTGGTGGTGAAGTCGCCGGCCGTCTCGCCCGGCTACTGGCGACGCCCGCAGGACGACGCGGCGCGCTTT
CACGGCGGCTGGTACCGCACCGGCGACCTGTTCAGCCGCGACGCGGACGGCTTCCTCTATTTCCACGGCCGCGAGGACGA
TCGCTTCAAGGTGTTCGGGCGCTGGGTGGTGCCGGCCGAGATCGAGGCGCTGCTGGTGGCGCATGCGCCGCAACTCGGCG
ACTGCTTCGTGGTGCCGGGCCGCGAGCCGAATGGCGAGGACCGCCCGGTGCTGTGCCTGCATGGTCAACACGGCGGGCAC
GCGGCACGGCAGGTGCTGGCCGTGCTGCACCGGCTCGACGGCTACAAGCGGCCGGTCAGGCTGCTGCCGGTCGACGAACT
GCCGCTCACGCCGAACGGCAAGCCCAACCGCCGCGCGCTCGCCCAGCTGGCGAGCCGCGCGCTGCAAGACGGGACGGGCA
TCAATCTAGTGGAGGAATCAACATGTTGA

Upstream 100 bases:

>100_bases
ATCGCCTGTCGCGCAGCCACGGCGAGCGCGCCGAAGCCGGTGCCGGCGCGGCCGAGGCGGCCGACGAGGAAGCCGACCGC
TACGACCTGGAGCGCAGCGT

Downstream 100 bases:

>100_bases
GCCAGGATGAGTTTACGCGGTACGGCGAGGCGGGGTTCAACCTCGTGCCGCTCTGGAAGGTGCTGCCGCTGCCCGAGCGG
CTCGATCCGCTGGACGTCTA

Product: putative coenzyme A ligase

Products: NA

Alternate protein names: 4-hydroxybenzoyl-CoA synthetase [H]

Number of amino acids: Translated: 542; Mature: 541

Protein sequence:

>542_residues
MSDVNLAAALLFNKRHLDKPAYIGPDFALSYAELDRAVRRQAAWMTMQEVAPGERIVIALDDGPDLAVIFFASLAVGALP
VVVSSKLDTAPLRHILGDAEPLMVYGKAVQADTIRAAIDGLATRPQAFLLEAGWYRTLLARRVGAPRAPAAALAGDAFDE
SSDEALEEAAEQEWDAAVLRDRHAPALIQYTSGTTGLAKGVTHSAASVLACCAAVTGQLGLSADDVLYSVPKSFFGFGMG
NSLFFPLHLGASAVLDAAWPNAAQVEANLRRFRPTVLFAVPTLYRMLLDNGFGPDDSPLRLAFSAGAPLAGNTGARWRER
FGFDLHDGIGATELCHVFATSYPDSLRRGSLGRLLAGCEARIVDEAGHEVRPGETGVLVVKSPAVSPGYWRRPQDDAARF
HGGWYRTGDLFSRDADGFLYFHGREDDRFKVFGRWVVPAEIEALLVAHAPQLGDCFVVPGREPNGEDRPVLCLHGQHGGH
AARQVLAVLHRLDGYKRPVRLLPVDELPLTPNGKPNRRALAQLASRALQDGTGINLVEESTC

Sequences:

>Translated_542_residues
MSDVNLAAALLFNKRHLDKPAYIGPDFALSYAELDRAVRRQAAWMTMQEVAPGERIVIALDDGPDLAVIFFASLAVGALP
VVVSSKLDTAPLRHILGDAEPLMVYGKAVQADTIRAAIDGLATRPQAFLLEAGWYRTLLARRVGAPRAPAAALAGDAFDE
SSDEALEEAAEQEWDAAVLRDRHAPALIQYTSGTTGLAKGVTHSAASVLACCAAVTGQLGLSADDVLYSVPKSFFGFGMG
NSLFFPLHLGASAVLDAAWPNAAQVEANLRRFRPTVLFAVPTLYRMLLDNGFGPDDSPLRLAFSAGAPLAGNTGARWRER
FGFDLHDGIGATELCHVFATSYPDSLRRGSLGRLLAGCEARIVDEAGHEVRPGETGVLVVKSPAVSPGYWRRPQDDAARF
HGGWYRTGDLFSRDADGFLYFHGREDDRFKVFGRWVVPAEIEALLVAHAPQLGDCFVVPGREPNGEDRPVLCLHGQHGGH
AARQVLAVLHRLDGYKRPVRLLPVDELPLTPNGKPNRRALAQLASRALQDGTGINLVEESTC
>Mature_541_residues
SDVNLAAALLFNKRHLDKPAYIGPDFALSYAELDRAVRRQAAWMTMQEVAPGERIVIALDDGPDLAVIFFASLAVGALPV
VVSSKLDTAPLRHILGDAEPLMVYGKAVQADTIRAAIDGLATRPQAFLLEAGWYRTLLARRVGAPRAPAAALAGDAFDES
SDEALEEAAEQEWDAAVLRDRHAPALIQYTSGTTGLAKGVTHSAASVLACCAAVTGQLGLSADDVLYSVPKSFFGFGMGN
SLFFPLHLGASAVLDAAWPNAAQVEANLRRFRPTVLFAVPTLYRMLLDNGFGPDDSPLRLAFSAGAPLAGNTGARWRERF
GFDLHDGIGATELCHVFATSYPDSLRRGSLGRLLAGCEARIVDEAGHEVRPGETGVLVVKSPAVSPGYWRRPQDDAARFH
GGWYRTGDLFSRDADGFLYFHGREDDRFKVFGRWVVPAEIEALLVAHAPQLGDCFVVPGREPNGEDRPVLCLHGQHGGHA
ARQVLAVLHRLDGYKRPVRLLPVDELPLTPNGKPNRRALAQLASRALQDGTGINLVEESTC

Specific function: Catalyzes the ligation of 4-hydroxybenzoate, benzoate or cyclohex-1,4-dienecarboxylate and CoA at the expense of ATP. The enzyme shows low activity towards cyclo-2,5-dienecarboxylate, 4- fluorobenzoate, 4-chlorobenzoate and 2-methoxybenzoate [H]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Partially Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family. Benzoate-CoA ligase subfamily [H]

Homologues:

Organism=Homo sapiens, GI38505220, Length=525, Percent_Identity=25.3333333333333, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI42544132, Length=528, Percent_Identity=23.6742424242424, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI122937307, Length=513, Percent_Identity=25.1461988304094, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI187761345, Length=516, Percent_Identity=27.1317829457364, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI187761343, Length=516, Percent_Identity=27.1317829457364, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI58082049, Length=348, Percent_Identity=27.2988505747126, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI157311624, Length=348, Percent_Identity=26.7241379310345, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI157311622, Length=348, Percent_Identity=26.7241379310345, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI156151445, Length=364, Percent_Identity=26.0989010989011, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI115511026, Length=354, Percent_Identity=26.271186440678, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI8923896, Length=558, Percent_Identity=23.6559139784946, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI195947378, Length=455, Percent_Identity=23.7362637362637, Blast_Score=83, Evalue=7e-16,
Organism=Homo sapiens, GI253970489, Length=571, Percent_Identity=23.1173380035026, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI13325057, Length=292, Percent_Identity=29.4520547945205, Blast_Score=79, Evalue=2e-14,
Organism=Escherichia coli, GI1788107, Length=527, Percent_Identity=26.1859582542694, Blast_Score=132, Evalue=8e-32,
Organism=Escherichia coli, GI145693145, Length=517, Percent_Identity=28.8201160541586, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1789201, Length=365, Percent_Identity=27.9452054794521, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1790505, Length=582, Percent_Identity=26.4604810996564, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1786810, Length=523, Percent_Identity=26.1950286806883, Blast_Score=102, Evalue=8e-23,
Organism=Escherichia coli, GI221142682, Length=500, Percent_Identity=23.8, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786529, Length=547, Percent_Identity=23.400365630713, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786801, Length=293, Percent_Identity=26.6211604095563, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1788595, Length=343, Percent_Identity=26.8221574344023, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17558820, Length=516, Percent_Identity=24.8062015503876, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI32563687, Length=534, Percent_Identity=23.0337078651685, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17531443, Length=354, Percent_Identity=26.5536723163842, Blast_Score=96, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI71985884, Length=353, Percent_Identity=28.6118980169972, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17538037, Length=384, Percent_Identity=25.78125, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17557194, Length=383, Percent_Identity=25.5874673629243, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71982997, Length=551, Percent_Identity=24.6823956442831, Blast_Score=82, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI71983001, Length=551, Percent_Identity=24.6823956442831, Blast_Score=82, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI71994690, Length=359, Percent_Identity=25.3481894150418, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17560140, Length=201, Percent_Identity=32.8358208955224, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71994694, Length=359, Percent_Identity=25.3481894150418, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71994703, Length=359, Percent_Identity=25.3481894150418, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17559526, Length=294, Percent_Identity=26.8707482993197, Blast_Score=79, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17560308, Length=395, Percent_Identity=26.0759493670886, Blast_Score=73, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6323182, Length=564, Percent_Identity=25.177304964539, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6319699, Length=360, Percent_Identity=24.1666666666667, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI18859661, Length=350, Percent_Identity=29.1428571428571, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24667959, Length=405, Percent_Identity=27.4074074074074, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI62472339, Length=553, Percent_Identity=24.2314647377938, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24667955, Length=405, Percent_Identity=27.4074074074074, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI21356441, Length=369, Percent_Identity=25.7452574525745, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21355181, Length=525, Percent_Identity=22.4761904761905, Blast_Score=93, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24648260, Length=391, Percent_Identity=25.8312020460358, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI20130353, Length=554, Percent_Identity=25.0902527075812, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI28573631, Length=554, Percent_Identity=25.0902527075812, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24581924, Length=380, Percent_Identity=26.0526315789474, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24648253, Length=366, Percent_Identity=24.5901639344262, Blast_Score=76, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24648255, Length=366, Percent_Identity=24.3169398907104, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21356947, Length=199, Percent_Identity=28.643216080402, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000873
- InterPro:   IPR011957 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.25; =6.2.1.27 [H]

Molecular weight: Translated: 58392; Mature: 58261

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00455 AMP_BINDING ; PS00213 LIPOCALIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDVNLAAALLFNKRHLDKPAYIGPDFALSYAELDRAVRRQAAWMTMQEVAPGERIVIAL
CCCHHHHHHHHHHHHCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
DDGPDLAVIFFASLAVGALPVVVSSKLDTAPLRHILGDAEPLMVYGKAVQADTIRAAIDG
CCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHH
LATRPQAFLLEAGWYRTLLARRVGAPRAPAAALAGDAFDESSDEALEEAAEQEWDAAVLR
HCCCCHHEEECCCHHHHHHHHHCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
DRHAPALIQYTSGTTGLAKGVTHSAASVLACCAAVTGQLGLSADDVLYSVPKSFFGFGMG
CCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCC
NSLFFPLHLGASAVLDAAWPNAAQVEANLRRFRPTVLFAVPTLYRMLLDNGFGPDDSPLR
CCEEEEEECCHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCEE
LAFSAGAPLAGNTGARWRERFGFDLHDGIGATELCHVFATSYPDSLRRGSLGRLLAGCEA
EEEECCCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHCCCHHHHCCCHHHHHHCCHH
RIVDEAGHEVRPGETGVLVVKSPAVSPGYWRRPQDDAARFHGGWYRTGDLFSRDADGFLY
HHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHCCCEEECCCCCCCCCCCEEE
FHGREDDRFKVFGRWVVPAEIEALLVAHAPQLGDCFVVPGREPNGEDRPVLCLHGQHGGH
EECCCCCCEEEEEEEECCHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCEEEEECCCCCH
AARQVLAVLHRLDGYKRPVRLLPVDELPLTPNGKPNRRALAQLASRALQDGTGINLVEES
HHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEECCC
TC
CC
>Mature Secondary Structure 
SDVNLAAALLFNKRHLDKPAYIGPDFALSYAELDRAVRRQAAWMTMQEVAPGERIVIAL
CCHHHHHHHHHHHHCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
DDGPDLAVIFFASLAVGALPVVVSSKLDTAPLRHILGDAEPLMVYGKAVQADTIRAAIDG
CCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHH
LATRPQAFLLEAGWYRTLLARRVGAPRAPAAALAGDAFDESSDEALEEAAEQEWDAAVLR
HCCCCHHEEECCCHHHHHHHHHCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
DRHAPALIQYTSGTTGLAKGVTHSAASVLACCAAVTGQLGLSADDVLYSVPKSFFGFGMG
CCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCC
NSLFFPLHLGASAVLDAAWPNAAQVEANLRRFRPTVLFAVPTLYRMLLDNGFGPDDSPLR
CCEEEEEECCHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCEE
LAFSAGAPLAGNTGARWRERFGFDLHDGIGATELCHVFATSYPDSLRRGSLGRLLAGCEA
EEEECCCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHCCCHHHHCCCHHHHHHCCHH
RIVDEAGHEVRPGETGVLVVKSPAVSPGYWRRPQDDAARFHGGWYRTGDLFSRDADGFLY
HHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHCCCEEECCCCCCCCCCCEEE
FHGREDDRFKVFGRWVVPAEIEALLVAHAPQLGDCFVVPGREPNGEDRPVLCLHGQHGGH
EECCCCCCEEEEEEEECCHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCEEEEECCCCCH
AARQVLAVLHRLDGYKRPVRLLPVDELPLTPNGKPNRRALAQLASRALQDGTGINLVEES
HHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEECCC
TC
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8300518 [H]