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The map label for this gene is fkpA [H]

Identifier: 238024146

GI number: 238024146

Start: 855871

End: 856269

Strand: Reverse

Name: fkpA [H]

Synonym: bglu_2g07230

Alternate gene names: 238024146

Gene position: 856269-855871 (Counterclockwise)

Preceding gene: 238024147

Following gene: 238024145

Centisome position: 30.29

GC content: 68.92

Gene sequence:

>399_bases
ATGAAATCAGTGATCGCTTTGCTCGCCGCTGGCGCCTTCGCCTCCACCGCGTTCGCCGCCAACCCGGTCGAGAAGCTGCC
CTCGGGCGTGATCGTCGAGCAGTTGAAGGCCGGCACCGGCCCGCAGCCGAGCGCGAACGACGTGGTGCGCGTGAACTATC
GCGGCACGCTCGCCAACGGCACCGAATTCGACAGCTCGGCGCAGCACGGCGGCCCCGCCACGTTCCCGCTCAACCAGGTG
ATCCCGTGCTGGACGCAGGGCGTGCAGAAGATGAAGGTGGGCGGCAAGGCGAAGCTGACCTGCCCGGCCGCGACCGCCTA
CGGCAGCCGCGCCGTCGGCACGATCCCGCCGAACAGCGACCTGACCTTCGAGGTCGAACTGGTGGGCATCGGGCGGTAA

Upstream 100 bases:

>100_bases
GTCCCGAGCCGCGCGGCATCCCGCATCGCGCGCGGCGCGCCGGCACGAAGCCGGGCAACGCTGCGGCTATAATCGGTGCG
CCATCCAACCAGGACCTCGC

Downstream 100 bases:

>100_bases
CGCCGCCAGCGGCGCGTGCCGGCCTGGCCGACCGCCGGGCCGGGCACGGTCGCGCGCGCGCCGGCACGTCCCCGTCAGCG
GCCGGCGCCGGCACGGCAAG

Product: FKBP-type peptidylprolyl isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 132; Mature: 132

Protein sequence:

>132_residues
MKSVIALLAAGAFASTAFAANPVEKLPSGVIVEQLKAGTGPQPSANDVVRVNYRGTLANGTEFDSSAQHGGPATFPLNQV
IPCWTQGVQKMKVGGKAKLTCPAATAYGSRAVGTIPPNSDLTFEVELVGIGR

Sequences:

>Translated_132_residues
MKSVIALLAAGAFASTAFAANPVEKLPSGVIVEQLKAGTGPQPSANDVVRVNYRGTLANGTEFDSSAQHGGPATFPLNQV
IPCWTQGVQKMKVGGKAKLTCPAATAYGSRAVGTIPPNSDLTFEVELVGIGR
>Mature_132_residues
MKSVIALLAAGAFASTAFAANPVEKLPSGVIVEQLKAGTGPQPSANDVVRVNYRGTLANGTEFDSSAQHGGPATFPLNQV
IPCWTQGVQKMKVGGKAKLTCPAATAYGSRAVGTIPPNSDLTFEVELVGIGR

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FkpA probably acts in the folding of extracytoplasmic proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI4758380, Length=106, Percent_Identity=38.6792452830189, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI17149836, Length=106, Percent_Identity=40.5660377358491, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI4503725, Length=106, Percent_Identity=40.5660377358491, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI224809331, Length=108, Percent_Identity=40.7407407407407, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI206725530, Length=89, Percent_Identity=46.0674157303371, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI17149844, Length=89, Percent_Identity=46.0674157303371, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI17149842, Length=89, Percent_Identity=46.0674157303371, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI224809329, Length=123, Percent_Identity=39.0243902439024, Blast_Score=68, Evalue=2e-12,
Organism=Homo sapiens, GI224809327, Length=123, Percent_Identity=39.0243902439024, Blast_Score=68, Evalue=2e-12,
Organism=Homo sapiens, GI4758384, Length=123, Percent_Identity=39.0243902439024, Blast_Score=68, Evalue=2e-12,
Organism=Homo sapiens, GI4503729, Length=107, Percent_Identity=41.1214953271028, Blast_Score=66, Evalue=8e-12,
Organism=Escherichia coli, GI87082390, Length=104, Percent_Identity=49.0384615384615, Blast_Score=96, Evalue=6e-22,
Organism=Escherichia coli, GI1789745, Length=103, Percent_Identity=47.5728155339806, Blast_Score=92, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17540882, Length=133, Percent_Identity=40.6015037593985, Blast_Score=73, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI71993519, Length=92, Percent_Identity=44.5652173913043, Blast_Score=70, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324194, Length=111, Percent_Identity=42.3423423423423, Blast_Score=84, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320727, Length=88, Percent_Identity=51.1363636363636, Blast_Score=80, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6323482, Length=107, Percent_Identity=42.0560747663551, Blast_Score=77, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323566, Length=107, Percent_Identity=41.1214953271028, Blast_Score=74, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24655568, Length=91, Percent_Identity=47.2527472527472, Blast_Score=79, Evalue=9e-16,
Organism=Drosophila melanogaster, GI281363946, Length=95, Percent_Identity=47.3684210526316, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17352457, Length=95, Percent_Identity=47.3684210526316, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24583150, Length=107, Percent_Identity=42.9906542056075, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI21356629, Length=134, Percent_Identity=38.8059701492537, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24647110, Length=104, Percent_Identity=45.1923076923077, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 13526; Mature: 13526

Theoretical pI: Translated: 9.27; Mature: 9.27

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSVIALLAAGAFASTAFAANPVEKLPSGVIVEQLKAGTGPQPSANDVVRVNYRGTLANG
CHHHHHHHHHCHHHHHHHCCCCHHHCCCCHHHHHHHCCCCCCCCCCCEEEEEECCEECCC
TEFDSSAQHGGPATFPLNQVIPCWTQGVQKMKVGGKAKLTCPAATAYGSRAVGTIPPNSD
CCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHCCCCCEEEECCCCCCCCCCEEECCCCCCC
LTFEVELVGIGR
CEEEEEEEEECC
>Mature Secondary Structure
MKSVIALLAAGAFASTAFAANPVEKLPSGVIVEQLKAGTGPQPSANDVVRVNYRGTLANG
CHHHHHHHHHCHHHHHHHCCCCHHHCCCCHHHHHHHCCCCCCCCCCCEEEEEECCEECCC
TEFDSSAQHGGPATFPLNQVIPCWTQGVQKMKVGGKAKLTCPAATAYGSRAVGTIPPNSD
CCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHCCCCCEEEECCCCCCCCCCEEECCCCCCC
LTFEVELVGIGR
CEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9171380 [H]