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The map label for this gene is ribA [H]

Identifier: 238024080

GI number: 238024080

Start: 769891

End: 770649

Strand: Direct

Name: ribA [H]

Synonym: bglu_2g06410

Alternate gene names: 238024080

Gene position: 769891-770649 (Clockwise)

Preceding gene: 238024079

Following gene: 238024081

Centisome position: 27.23

GC content: 63.24

Gene sequence:

>759_bases
ATGCCAGGGGCGGTTCGATCCGCCCCATTCGTCCAGACTCTGCGCAAATCGCCAGGGCATACCAGCCCGTTAGCGTGTCT
ATCGATGCGCGCGTATCTCCCGAACCTGAGAGGCCGAGCCATGAATCAATCCGATGATCATTCCGGTGTGAGCATCCGCA
CACGCATCAAGGTGCCGATTCGTCCGCGTTCGAGCGCGACGGCATTTGAAACCGAGATGGTGACCTTCAACGGTCTTTGC
GACAGCGCCGAACATATCGCGCTGGTGTTCGGCAAGATCGGCGAGGCGCCGCTGGTGCGCCTGCATTCCGAGTGCCTGAC
GGGCGACGTGTTCGGCTCCGCGCGCTGCGACTGCGGCGAGCAGCTCGACGAGTCGATCGCGCTGTTCGGCGAGCGCGGCG
GCATCCTGCTCTACCTGCGCCAGGAAGGGCGCGGCATCGGGCTCTACAACAAGCTCGACGCCTATCGCCTGCAGATCTCG
CAGGGACTCGACACCTTCGCTGCCAATCGCGCGCTCAACTTCCCCGACGACCTGCGCGACTTCCGCGTGGCGGCCCAGAT
GCTCAAGGCGCTCGGCGTCGGCGAGGTCTCGCTGGTCACCAACAACCCCGACAAGACCGCGCAACTGACCCGTCACGGCA
TCAAGGTGCGCCAGGTGAAGTCGACCGGCGTGTTCGCCAACAGCGTCAACTTTGGTTATCTGCATGCGAAGGCGACCCAG
CACCGGCATGCCATCAAGCTCAACGGAGAAATGCAATGA

Upstream 100 bases:

>100_bases
CCGCTGCTCGAGGCCGACGACATCGCCACCCATCCGCCCGGCTTCTGGGACGTGTTCCAGAACAACTGCCTGCAGACCGG
CCTGGTCTGCAAGCCTTGAT

Downstream 100 bases:

>100_bases
TTGCCCATCGCAGCCCGATCAGCGGCATCGCCGCTCACCGCGACCAGTACGTGCTGACGGCCGGCTACGACAATCAGGTG
ATCCTGTGGGACGCGAAGAC

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: GTP cyclohydrolase II [H]

Number of amino acids: Translated: 252; Mature: 251

Protein sequence:

>252_residues
MPGAVRSAPFVQTLRKSPGHTSPLACLSMRAYLPNLRGRAMNQSDDHSGVSIRTRIKVPIRPRSSATAFETEMVTFNGLC
DSAEHIALVFGKIGEAPLVRLHSECLTGDVFGSARCDCGEQLDESIALFGERGGILLYLRQEGRGIGLYNKLDAYRLQIS
QGLDTFAANRALNFPDDLRDFRVAAQMLKALGVGEVSLVTNNPDKTAQLTRHGIKVRQVKSTGVFANSVNFGYLHAKATQ
HRHAIKLNGEMQ

Sequences:

>Translated_252_residues
MPGAVRSAPFVQTLRKSPGHTSPLACLSMRAYLPNLRGRAMNQSDDHSGVSIRTRIKVPIRPRSSATAFETEMVTFNGLC
DSAEHIALVFGKIGEAPLVRLHSECLTGDVFGSARCDCGEQLDESIALFGERGGILLYLRQEGRGIGLYNKLDAYRLQIS
QGLDTFAANRALNFPDDLRDFRVAAQMLKALGVGEVSLVTNNPDKTAQLTRHGIKVRQVKSTGVFANSVNFGYLHAKATQ
HRHAIKLNGEMQ
>Mature_251_residues
PGAVRSAPFVQTLRKSPGHTSPLACLSMRAYLPNLRGRAMNQSDDHSGVSIRTRIKVPIRPRSSATAFETEMVTFNGLCD
SAEHIALVFGKIGEAPLVRLHSECLTGDVFGSARCDCGEQLDESIALFGERGGILLYLRQEGRGIGLYNKLDAYRLQISQ
GLDTFAANRALNFPDDLRDFRVAAQMLKALGVGEVSLVTNNPDKTAQLTRHGIKVRQVKSTGVFANSVNFGYLHAKATQH
RHAIKLNGEMQ

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=176, Percent_Identity=50.5681818181818, Blast_Score=149, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6319438, Length=124, Percent_Identity=50, Blast_Score=111, Evalue=8e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000926 [H]

Pfam domain/function: PF00925 GTP_cyclohydro2 [H]

EC number: =3.5.4.25 [H]

Molecular weight: Translated: 27551; Mature: 27420

Theoretical pI: Translated: 9.74; Mature: 9.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGAVRSAPFVQTLRKSPGHTSPLACLSMRAYLPNLRGRAMNQSDDHSGVSIRTRIKVPI
CCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEEEC
RPRSSATAFETEMVTFNGLCDSAEHIALVFGKIGEAPLVRLHSECLTGDVFGSARCDCGE
CCCCCCCEEEEEEEEECCCCCCCHHEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCHHH
QLDESIALFGERGGILLYLRQEGRGIGLYNKLDAYRLQISQGLDTFAANRALNFPDDLRD
HHHHHHHEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCHHHHHCCCCCCCHHHHH
FRVAAQMLKALGVGEVSLVTNNPDKTAQLTRHGIKVRQVKSTGVFANSVNFGYLHAKATQ
HHHHHHHHHHCCCCEEEEEECCCCHHHHHHHCCCEEEEEECCCEEECCCCEEEEEEECCC
HRHAIKLNGEMQ
CCEEEEECCCCC
>Mature Secondary Structure 
PGAVRSAPFVQTLRKSPGHTSPLACLSMRAYLPNLRGRAMNQSDDHSGVSIRTRIKVPI
CCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEEEC
RPRSSATAFETEMVTFNGLCDSAEHIALVFGKIGEAPLVRLHSECLTGDVFGSARCDCGE
CCCCCCCEEEEEEEEECCCCCCCHHEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCHHH
QLDESIALFGERGGILLYLRQEGRGIGLYNKLDAYRLQISQGLDTFAANRALNFPDDLRD
HHHHHHHEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCHHHHHCCCCCCCHHHHH
FRVAAQMLKALGVGEVSLVTNNPDKTAQLTRHGIKVRQVKSTGVFANSVNFGYLHAKATQ
HHHHHHHHHHCCCCEEEEEECCCCHHHHHHHCCCEEEEEECCCEEECCCCEEEEEEECCC
HRHAIKLNGEMQ
CCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]