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The map label for this gene is ytcI [H]

Identifier: 238024066

GI number: 238024066

Start: 752132

End: 753826

Strand: Direct

Name: ytcI [H]

Synonym: bglu_2g06270

Alternate gene names: 238024066

Gene position: 752132-753826 (Clockwise)

Preceding gene: 238024065

Following gene: 238024067

Centisome position: 26.6

GC content: 70.03

Gene sequence:

>1695_bases
ATGACGGCGCAGGCTTTTCTCGAGGCACGCGATTTTCTGTTGCGGCACCGCACCGATTACGACACGGCGTACCGCGAATT
CCGCTGGCCGCAACTGGACGCGTTCAACTGGGCGCTCGATTACTTCGACGTGATGGCGCGCGACAACGCGAGCCCCGCGC
TGTGGATCGTCGACGCGGTCACGGGCGAGGGCGAGCCGGTATCGTTCGCGCGCATCTCGGCGCAGTCCTCGCGGATCGCG
AACCACCTGCGCGCGCTCGGCGTGGGCCGTGGCGAGCGCATCCTGCTGATGCTGCCGAACCGCGTCGAGCTGTGGGAAAC
CATGCTCGCCGCGATGAAGCTCGGCGCGGTCGTGCTGCCGGCCACCACGCAGCTGTCGGCCGACGACATCCGCGACCGCG
TGATGATCGGCGAGGCCCGCTTCGCCGTGGTCGACGCGGCCGAGGCCGAGAAGTTCGACCAGGCCGGCGTCGATCTGACC
CGGCTGATCGTGGGCGGCGAGCGTGCCGGCTGGCTGCGCTTCGAGGATGGCTACGCGGCCGATGCCGCGTTCACGCCCGA
CGCGCCCACCCACGCTCACGACCCGCTGCTGCTCTACTTCACGTCGGGCACCACCTCGAAGCCGAAGCTCGTCGAGCATA
CCCACTTCACCTACCCGGTGGGCAGCCTCTCGACCCTGTACTGGATCGGGCTGCAGCCCGGCGACATCCATTGGAACATC
AGCTCGCCCGGTTGGGCCAAGCACGCCTGGAGCTGCTTGTTCGCGCCCTGGAACGCCGGGGCCTGCGTGTTCGCGTTCAA
CTACCCGCGCTTCGATCCGCAGCAGGCGCTCGAGGCGCTGGTGCGCTACGGCGTGACCACGCTGTGCGCGCCGCCCACGG
TCTGGCGCATGCTGGTGCAGCAGCCGCTCGCGTCCTACCCGGTGAAGCTGCGCGAGATCATCGGCGCCGGCGAGCCGCTG
AACCCCGAGATCATCGAGCGCGTGCGGCGCGCCTGGGGCGTGACGATCCGCGACGGCTACGGCCAGACCGAAACCACCTG
CCTGATCGGCAACTCGCCGGGCCAGCCGGTGGTGGCGGGCTCGATGGGGCGGCCGATGCCGGGCTACCGGATCGCGCTGC
TCGATCCCGACGGCGCGCCGGTGACGGAGGGCGAGATCGCGCTGCCGCTCGACGGCGAGCGCCCCGGCGGGCTGATGACA
GGCTACGCGAATCACCCCGACGCCACCGCCTGGGCGATGCGCGACGGCCATTACCGCACCTCGGACATCGCGCTGCGCCG
CGACGACGGTTACTACCTCTACATCGGCCGCGCCGACGACGTCTTCAAGTCGTCCGACTATCGCCTGAGCCCGTTCGAGC
TCGAGAGCGTGCTGATCGAGCACGAGGCCGTCGCCGAGGCGGCCGTGGTGCCGAGCCCCGACCCGCTGCGGCTCGCGGTG
CCCAAGACCTTCATCACGCTGCGCGCCGGCTTCGAGCCGGGCGAGGCGCTCGCGCGCGACATCTTCCGCTTCTCGCGCGA
GAAGCTCGCGCCGTACAAGCGCATCCGCCGCCTGCAGTTCACGGAGCTGCCGAAGACCATCTCGGGGAAGATCCGCCGCG
TCGAGCTGCGGCGCCGCGAGATCGAGCGCGATGCCGATCCGGCCGCGCGCATGCCCCACGAGTACTGGGAAGAGGATTTC
CCGAGCCAGTCGTAA

Upstream 100 bases:

>100_bases
CAGCTGCTGGCCTGACGCGCCGTGCGCATTCCCACGGCGGTATGATCACCCTCACACGACGCACGATCACACGCTGCGCG
AGACGGAAGGAGACGAGACG

Downstream 100 bases:

>100_bases
TCGATCGCCGCGCGCCGCGGCGCGCGGTTCCGTGTTACCGGCCGGCCGCGCGCGGCGCGGCGGCCTTCAAGGAGAGCCGA
ACCATGAATGCAACGCCGAT

Product: acyl-coenzyme A synthetase

Products: Acetyl-CoA; AMP; Diphosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 564; Mature: 563

Protein sequence:

>564_residues
MTAQAFLEARDFLLRHRTDYDTAYREFRWPQLDAFNWALDYFDVMARDNASPALWIVDAVTGEGEPVSFARISAQSSRIA
NHLRALGVGRGERILLMLPNRVELWETMLAAMKLGAVVLPATTQLSADDIRDRVMIGEARFAVVDAAEAEKFDQAGVDLT
RLIVGGERAGWLRFEDGYAADAAFTPDAPTHAHDPLLLYFTSGTTSKPKLVEHTHFTYPVGSLSTLYWIGLQPGDIHWNI
SSPGWAKHAWSCLFAPWNAGACVFAFNYPRFDPQQALEALVRYGVTTLCAPPTVWRMLVQQPLASYPVKLREIIGAGEPL
NPEIIERVRRAWGVTIRDGYGQTETTCLIGNSPGQPVVAGSMGRPMPGYRIALLDPDGAPVTEGEIALPLDGERPGGLMT
GYANHPDATAWAMRDGHYRTSDIALRRDDGYYLYIGRADDVFKSSDYRLSPFELESVLIEHEAVAEAAVVPSPDPLRLAV
PKTFITLRAGFEPGEALARDIFRFSREKLAPYKRIRRLQFTELPKTISGKIRRVELRRREIERDADPAARMPHEYWEEDF
PSQS

Sequences:

>Translated_564_residues
MTAQAFLEARDFLLRHRTDYDTAYREFRWPQLDAFNWALDYFDVMARDNASPALWIVDAVTGEGEPVSFARISAQSSRIA
NHLRALGVGRGERILLMLPNRVELWETMLAAMKLGAVVLPATTQLSADDIRDRVMIGEARFAVVDAAEAEKFDQAGVDLT
RLIVGGERAGWLRFEDGYAADAAFTPDAPTHAHDPLLLYFTSGTTSKPKLVEHTHFTYPVGSLSTLYWIGLQPGDIHWNI
SSPGWAKHAWSCLFAPWNAGACVFAFNYPRFDPQQALEALVRYGVTTLCAPPTVWRMLVQQPLASYPVKLREIIGAGEPL
NPEIIERVRRAWGVTIRDGYGQTETTCLIGNSPGQPVVAGSMGRPMPGYRIALLDPDGAPVTEGEIALPLDGERPGGLMT
GYANHPDATAWAMRDGHYRTSDIALRRDDGYYLYIGRADDVFKSSDYRLSPFELESVLIEHEAVAEAAVVPSPDPLRLAV
PKTFITLRAGFEPGEALARDIFRFSREKLAPYKRIRRLQFTELPKTISGKIRRVELRRREIERDADPAARMPHEYWEEDF
PSQS
>Mature_563_residues
TAQAFLEARDFLLRHRTDYDTAYREFRWPQLDAFNWALDYFDVMARDNASPALWIVDAVTGEGEPVSFARISAQSSRIAN
HLRALGVGRGERILLMLPNRVELWETMLAAMKLGAVVLPATTQLSADDIRDRVMIGEARFAVVDAAEAEKFDQAGVDLTR
LIVGGERAGWLRFEDGYAADAAFTPDAPTHAHDPLLLYFTSGTTSKPKLVEHTHFTYPVGSLSTLYWIGLQPGDIHWNIS
SPGWAKHAWSCLFAPWNAGACVFAFNYPRFDPQQALEALVRYGVTTLCAPPTVWRMLVQQPLASYPVKLREIIGAGEPLN
PEIIERVRRAWGVTIRDGYGQTETTCLIGNSPGQPVVAGSMGRPMPGYRIALLDPDGAPVTEGEIALPLDGERPGGLMTG
YANHPDATAWAMRDGHYRTSDIALRRDDGYYLYIGRADDVFKSSDYRLSPFELESVLIEHEAVAEAAVVPSPDPLRLAVP
KTFITLRAGFEPGEALARDIFRFSREKLAPYKRIRRLQFTELPKTISGKIRRVELRRREIERDADPAARMPHEYWEEDFP
SQS

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI42544132, Length=545, Percent_Identity=37.7981651376147, Blast_Score=375, Evalue=1e-104,
Organism=Homo sapiens, GI122937307, Length=544, Percent_Identity=38.9705882352941, Blast_Score=344, Evalue=1e-94,
Organism=Homo sapiens, GI38505220, Length=526, Percent_Identity=38.212927756654, Blast_Score=343, Evalue=2e-94,
Organism=Homo sapiens, GI58082049, Length=530, Percent_Identity=35.2830188679245, Blast_Score=312, Evalue=6e-85,
Organism=Homo sapiens, GI157311624, Length=530, Percent_Identity=35.0943396226415, Blast_Score=307, Evalue=1e-83,
Organism=Homo sapiens, GI157311622, Length=530, Percent_Identity=35.0943396226415, Blast_Score=307, Evalue=1e-83,
Organism=Homo sapiens, GI115511026, Length=535, Percent_Identity=33.2710280373832, Blast_Score=274, Evalue=2e-73,
Organism=Homo sapiens, GI42544134, Length=373, Percent_Identity=34.8525469168901, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI195947378, Length=438, Percent_Identity=31.9634703196347, Blast_Score=202, Evalue=5e-52,
Organism=Homo sapiens, GI8923896, Length=366, Percent_Identity=34.4262295081967, Blast_Score=146, Evalue=6e-35,
Organism=Homo sapiens, GI253970489, Length=366, Percent_Identity=34.4262295081967, Blast_Score=145, Evalue=7e-35,
Organism=Homo sapiens, GI13375727, Length=564, Percent_Identity=26.5957446808511, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI28416953, Length=561, Percent_Identity=25.1336898395722, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI156151445, Length=531, Percent_Identity=24.8587570621469, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI187761345, Length=390, Percent_Identity=24.8717948717949, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI187761343, Length=390, Percent_Identity=24.8717948717949, Blast_Score=90, Evalue=5e-18,
Organism=Escherichia coli, GI1790505, Length=556, Percent_Identity=28.7769784172662, Blast_Score=176, Evalue=5e-45,
Organism=Escherichia coli, GI221142682, Length=502, Percent_Identity=23.7051792828685, Blast_Score=123, Evalue=4e-29,
Organism=Escherichia coli, GI1788107, Length=521, Percent_Identity=25.5278310940499, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1786529, Length=530, Percent_Identity=26.0377358490566, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI145693145, Length=509, Percent_Identity=24.3614931237721, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1786810, Length=538, Percent_Identity=23.9776951672862, Blast_Score=89, Evalue=9e-19,
Organism=Escherichia coli, GI1788595, Length=474, Percent_Identity=22.5738396624473, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71982997, Length=526, Percent_Identity=30.7984790874525, Blast_Score=155, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI71983001, Length=526, Percent_Identity=30.7984790874525, Blast_Score=155, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI17559526, Length=398, Percent_Identity=27.8894472361809, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17531443, Length=509, Percent_Identity=24.950884086444, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI71994690, Length=369, Percent_Identity=27.9132791327913, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI71994694, Length=369, Percent_Identity=27.9132791327913, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI71994703, Length=369, Percent_Identity=27.9132791327913, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17560308, Length=404, Percent_Identity=28.2178217821782, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71996755, Length=492, Percent_Identity=24.5934959349593, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17560140, Length=492, Percent_Identity=23.9837398373984, Blast_Score=89, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17558820, Length=506, Percent_Identity=21.9367588932806, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI32563687, Length=472, Percent_Identity=22.8813559322034, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17538037, Length=527, Percent_Identity=23.719165085389, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17557194, Length=540, Percent_Identity=25.5555555555556, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI115534440, Length=479, Percent_Identity=21.294363256785, Blast_Score=80, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71985884, Length=370, Percent_Identity=24.3243243243243, Blast_Score=79, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6323182, Length=532, Percent_Identity=28.5714285714286, Blast_Score=155, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6319264, Length=535, Percent_Identity=25.2336448598131, Blast_Score=132, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6319699, Length=349, Percent_Identity=24.0687679083095, Blast_Score=101, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24667955, Length=587, Percent_Identity=27.7683134582624, Blast_Score=172, Evalue=4e-43,
Organism=Drosophila melanogaster, GI62472339, Length=527, Percent_Identity=29.6015180265655, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24667959, Length=496, Percent_Identity=30.0403225806452, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI21355225, Length=549, Percent_Identity=26.4116575591985, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI21355181, Length=505, Percent_Identity=26.3366336633663, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI18859661, Length=512, Percent_Identity=23.6328125, Blast_Score=109, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24581924, Length=527, Percent_Identity=24.8576850094877, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24648260, Length=505, Percent_Identity=24.1584158415842, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI21356947, Length=489, Percent_Identity=23.3128834355828, Blast_Score=84, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: 6.2.1.1 [C]

Molecular weight: Translated: 63106; Mature: 62975

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAQAFLEARDFLLRHRTDYDTAYREFRWPQLDAFNWALDYFDVMARDNASPALWIVDAV
CCHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEEE
TGEGEPVSFARISAQSSRIANHLRALGVGRGERILLMLPNRVELWETMLAAMKLGAVVLP
CCCCCCEEEEEECHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHCEEEEC
ATTQLSADDIRDRVMIGEARFAVVDAAEAEKFDQAGVDLTRLIVGGERAGWLRFEDGYAA
CCCCCCHHHHHHHEEECCCEEEEEECHHHHHHHHCCCCEEEEEECCCCCCEEEECCCCCC
DAAFTPDAPTHAHDPLLLYFTSGTTSKPKLVEHTHFTYPVGSLSTLYWIGLQPGDIHWNI
CCCCCCCCCCCCCCCEEEEEECCCCCCCCEECCCEEECCCCCCCEEEEEECCCCCEEEEC
SSPGWAKHAWSCLFAPWNAGACVFAFNYPRFDPQQALEALVRYGVTTLCAPPTVWRMLVQ
CCCCCHHHHHEEEECCCCCCEEEEEECCCCCCHHHHHHHHHHCCCHHHCCCHHHHHHHHH
QPLASYPVKLREIIGAGEPLNPEIIERVRRAWGVTIRDGYGQTETTCLIGNSPGQPVVAG
HHHHHCCHHHHHHHCCCCCCCHHHHHHHHHHHCCEEECCCCCCCEEEEEECCCCCCEEEC
SMGRPMPGYRIALLDPDGAPVTEGEIALPLDGERPGGLMTGYANHPDATAWAMRDGHYRT
CCCCCCCCCEEEEECCCCCCCCCCCEEEECCCCCCCCEEECCCCCCCCEEEEEECCCEEC
SDIALRRDDGYYLYIGRADDVFKSSDYRLSPFELESVLIEHEAVAEAAVVPSPDPLRLAV
CCEEEEECCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEC
PKTFITLRAGFEPGEALARDIFRFSREKLAPYKRIRRLQFTELPKTISGKIRRVELRRRE
CCEEEEEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHCCCCEEHHHHHHH
IERDADPAARMPHEYWEEDFPSQS
HHCCCCHHHCCCHHHHHHCCCCCC
>Mature Secondary Structure 
TAQAFLEARDFLLRHRTDYDTAYREFRWPQLDAFNWALDYFDVMARDNASPALWIVDAV
CHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEEE
TGEGEPVSFARISAQSSRIANHLRALGVGRGERILLMLPNRVELWETMLAAMKLGAVVLP
CCCCCCEEEEEECHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHCEEEEC
ATTQLSADDIRDRVMIGEARFAVVDAAEAEKFDQAGVDLTRLIVGGERAGWLRFEDGYAA
CCCCCCHHHHHHHEEECCCEEEEEECHHHHHHHHCCCCEEEEEECCCCCCEEEECCCCCC
DAAFTPDAPTHAHDPLLLYFTSGTTSKPKLVEHTHFTYPVGSLSTLYWIGLQPGDIHWNI
CCCCCCCCCCCCCCCEEEEEECCCCCCCCEECCCEEECCCCCCCEEEEEECCCCCEEEEC
SSPGWAKHAWSCLFAPWNAGACVFAFNYPRFDPQQALEALVRYGVTTLCAPPTVWRMLVQ
CCCCCHHHHHEEEECCCCCCEEEEEECCCCCCHHHHHHHHHHCCCHHHCCCHHHHHHHHH
QPLASYPVKLREIIGAGEPLNPEIIERVRRAWGVTIRDGYGQTETTCLIGNSPGQPVVAG
HHHHHCCHHHHHHHCCCCCCCHHHHHHHHHHHCCEEECCCCCCCEEEEEECCCCCCEEEC
SMGRPMPGYRIALLDPDGAPVTEGEIALPLDGERPGGLMTGYANHPDATAWAMRDGHYRT
CCCCCCCCCEEEEECCCCCCCCCCCEEEECCCCCCCCEEECCCCCCCCEEEEEECCCEEC
SDIALRRDDGYYLYIGRADDVFKSSDYRLSPFELESVLIEHEAVAEAAVVPSPDPLRLAV
CCEEEEECCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEC
PKTFITLRAGFEPGEALARDIFRFSREKLAPYKRIRRLQFTELPKTISGKIRRVELRRRE
CCEEEEEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHCCCCEEHHHHHHH
IERDADPAARMPHEYWEEDFPSQS
HHCCCCHHHCCCHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Acetate; ATP; Coenzyme A [C]

Specific reaction: Acetate + ATP + Coenzyme A --> Acetyl-CoA + AMP + Diphosphate [C]

General reaction: Acid-thiol ligation [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]