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The map label for this gene is fdhA [H]

Identifier: 238024026

GI number: 238024026

Start: 696408

End: 697604

Strand: Direct

Name: fdhA [H]

Synonym: bglu_2g05800

Alternate gene names: 238024026

Gene position: 696408-697604 (Clockwise)

Preceding gene: 238024024

Following gene: 238024029

Centisome position: 24.63

GC content: 69.26

Gene sequence:

>1197_bases
ATGAGCAGCAATCGAGGAGTCGTGTATCAGGGGCCGGGCAAGGTCGAGGTGCAGAAGATCGATTACCCGCGGATGGTGGA
CCCGAGCGGGCGCAAGATCGGCCACGGCGTGATCCTGAAGGTGGTCAGCACCAACATCTGCGGCTCCGATCAGCACATGG
TGCGCGGCCGGACCACGGCGCCCGTCGGCCTCGTGCTCGGCCACGAGATCACCGGCGAGGTGATCGAGCTCGGCAGCGAC
GTCGAGACGCTGAAGATCGGCGACATCGTCACGGTGCCGTTCAACGTGGCCTGCGGGCGCTGCCCGATGTGCCGCGAGCA
GAGCACCGGCGTGTGCCTGAACGTGAACCCGGCGCGCGCCGGCGGCGCCTACGGCTACGTGGACATGGGCGGCTGGATCG
GCGGGCAGGCCGAGTACGTGCTGGTGCCGTATGCCGACTTCAATCTGATCAAGTTCCCGGACCGCGACCAGGCGATGGCC
AAGATCCGCGACCTGACCTGCCTGTCCGACATCCTGCCCACCGGCTACCACGGCGCCGTCACGGCCGGCGTGAAGCCGGG
CTCGACCGTCTACATCGCGGGCGCGGGCCCGGTGGGGATGGCCGCGGCCGCCTCGGCGCGGCTGCTCGGCGCGGCGGTGA
CGATCGTCGGCGACATGAACGCCGAGCGCCTCGCGCACGCGCGCAAGGTCGGCTTCGAGACGGTTGACCTCTCGCAGGAC
ACGCCGCTCGGCGAGCAGATCGCGCGCATCGTCGGGCGCCCCGAGATCGACTGCGCCGTCGATTGCGTCGGCTTCGAGGC
ACACGGCCACGGCTCCTCGGGCCATGCCGAGGAGGCGCCCGCCACGGTGCTGAACTCGTTGATGGAAATCACGCGCCCGG
CCGGCGCGATCGGCATCCCGGGCCTGTACGTGACCGACGATCCGGGCGCGAAGGATGCCGCCGCGCAGCACGGCAGCCTC
AGCATCCGCTTCGGCCTGGGCTGGGCCAAGTCGCATACCTTCCATACCGGCCAGACGCCGGTGCTGAAGTACAACCGCAA
CCTGATGCAGGCGATCCTGTTCGACCGCCTGCCGATCGCCGAGATCGTCAACGTCACCGTGATCTCGCTCGATCAGGCGC
CGGAGGGCTACCGCAAGTTCGATGGCGGCGCGCCGCGCAAGTTCGTGATCGATCCGCACGGGCTGATCGCGGCCTGA

Upstream 100 bases:

>100_bases
CCCGCTTCGCAGACTACCCTCTGAGGGTTCGCTGCCCGACCCGCGCGCGGCCGCGCCGGGCGACGCGCAGCACGAAGCCA
GACAGACAGGAGACGAAGCG

Downstream 100 bases:

>100_bases
GCGTGATTCGGGCGGCCCGGAGCGGCCGCGCGGCAAGGCCGACGGCCCGCGTGCGCGCGGGCCGTCGTCATTTTGTTGCG
GATGCAACCAGGCGGGGCCG

Product: Threonine dehydrogenase

Products: NA

Alternate protein names: FALDH; FDH [H]

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MSSNRGVVYQGPGKVEVQKIDYPRMVDPSGRKIGHGVILKVVSTNICGSDQHMVRGRTTAPVGLVLGHEITGEVIELGSD
VETLKIGDIVTVPFNVACGRCPMCREQSTGVCLNVNPARAGGAYGYVDMGGWIGGQAEYVLVPYADFNLIKFPDRDQAMA
KIRDLTCLSDILPTGYHGAVTAGVKPGSTVYIAGAGPVGMAAAASARLLGAAVTIVGDMNAERLAHARKVGFETVDLSQD
TPLGEQIARIVGRPEIDCAVDCVGFEAHGHGSSGHAEEAPATVLNSLMEITRPAGAIGIPGLYVTDDPGAKDAAAQHGSL
SIRFGLGWAKSHTFHTGQTPVLKYNRNLMQAILFDRLPIAEIVNVTVISLDQAPEGYRKFDGGAPRKFVIDPHGLIAA

Sequences:

>Translated_398_residues
MSSNRGVVYQGPGKVEVQKIDYPRMVDPSGRKIGHGVILKVVSTNICGSDQHMVRGRTTAPVGLVLGHEITGEVIELGSD
VETLKIGDIVTVPFNVACGRCPMCREQSTGVCLNVNPARAGGAYGYVDMGGWIGGQAEYVLVPYADFNLIKFPDRDQAMA
KIRDLTCLSDILPTGYHGAVTAGVKPGSTVYIAGAGPVGMAAAASARLLGAAVTIVGDMNAERLAHARKVGFETVDLSQD
TPLGEQIARIVGRPEIDCAVDCVGFEAHGHGSSGHAEEAPATVLNSLMEITRPAGAIGIPGLYVTDDPGAKDAAAQHGSL
SIRFGLGWAKSHTFHTGQTPVLKYNRNLMQAILFDRLPIAEIVNVTVISLDQAPEGYRKFDGGAPRKFVIDPHGLIAA
>Mature_397_residues
SSNRGVVYQGPGKVEVQKIDYPRMVDPSGRKIGHGVILKVVSTNICGSDQHMVRGRTTAPVGLVLGHEITGEVIELGSDV
ETLKIGDIVTVPFNVACGRCPMCREQSTGVCLNVNPARAGGAYGYVDMGGWIGGQAEYVLVPYADFNLIKFPDRDQAMAK
IRDLTCLSDILPTGYHGAVTAGVKPGSTVYIAGAGPVGMAAAASARLLGAAVTIVGDMNAERLAHARKVGFETVDLSQDT
PLGEQIARIVGRPEIDCAVDCVGFEAHGHGSSGHAEEAPATVLNSLMEITRPAGAIGIPGLYVTDDPGAKDAAAQHGSLS
IRFGLGWAKSHTFHTGQTPVLKYNRNLMQAILFDRLPIAEIVNVTVISLDQAPEGYRKFDGGAPRKFVIDPHGLIAA

Specific function: Catalyzes the oxidation of long-chain alcohols but is inactive against ethanol [H]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=204, Percent_Identity=32.3529411764706, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI34577061, Length=213, Percent_Identity=30.9859154929577, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI4501929, Length=214, Percent_Identity=31.3084112149533, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI156627571, Length=282, Percent_Identity=29.0780141843972, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI71743840, Length=227, Percent_Identity=29.5154185022026, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI262073058, Length=226, Percent_Identity=29.646017699115, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI71565154, Length=247, Percent_Identity=27.1255060728745, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI4501939, Length=204, Percent_Identity=28.921568627451, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI156523966, Length=204, Percent_Identity=28.921568627451, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1786825, Length=407, Percent_Identity=33.9066339066339, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI1790045, Length=215, Percent_Identity=34.4186046511628, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI87082125, Length=240, Percent_Identity=33.3333333333333, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1790718, Length=269, Percent_Identity=26.0223048327138, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1788073, Length=238, Percent_Identity=29.4117647058824, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1787863, Length=245, Percent_Identity=29.3877551020408, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI226510992, Length=227, Percent_Identity=30.8370044052863, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI87081918, Length=225, Percent_Identity=33.3333333333333, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1786552, Length=276, Percent_Identity=28.6231884057971, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17562878, Length=241, Percent_Identity=26.5560165975104, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17562876, Length=235, Percent_Identity=26.3829787234043, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6319955, Length=273, Percent_Identity=30.7692307692308, Blast_Score=96, Evalue=9e-21,
Organism=Saccharomyces cerevisiae, GI6322619, Length=273, Percent_Identity=30.4029304029304, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6319258, Length=259, Percent_Identity=25.8687258687259, Blast_Score=77, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6320033, Length=278, Percent_Identity=28.4172661870504, Blast_Score=76, Evalue=9e-15,
Organism=Drosophila melanogaster, GI17737897, Length=279, Percent_Identity=28.673835125448, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI17137530, Length=281, Percent_Identity=28.4697508896797, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI17737895, Length=213, Percent_Identity=30.0469483568075, Blast_Score=72, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR014184
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.2.1.46 [H]

Molecular weight: Translated: 41888; Mature: 41757

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSNRGVVYQGPGKVEVQKIDYPRMVDPSGRKIGHGVILKVVSTNICGSDQHMVRGRTTA
CCCCCCEEEECCCEEEEEECCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCEECCCCCC
PVGLVLGHEITGEVIELGSDVETLKIGDIVTVPFNVACGRCPMCREQSTGVCLNVNPARA
CEEEEECCCCCCHHHHCCCCCCEEEECCEEEECCCCCCCCCCCCCCCCCCEEEECCCCCC
GGAYGYVDMGGWIGGQAEYVLVPYADFNLIKFPDRDQAMAKIRDLTCLSDILPTGYHGAV
CCCEEEEECCCCCCCCCCEEEEEECCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCEE
TAGVKPGSTVYIAGAGPVGMAAAASARLLGAAVTIVGDMNAERLAHARKVGFETVDLSQD
EECCCCCCEEEEEECCCCCHHHHHHHHHHEEEEEEEECCCHHHHHHHHHCCCEEEECCCC
TPLGEQIARIVGRPEIDCAVDCVGFEAHGHGSSGHAEEAPATVLNSLMEITRPAGAIGIP
CCHHHHHHHHHCCCCCCEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCC
GLYVTDDPGAKDAAAQHGSLSIRFGLGWAKSHTFHTGQTPVLKYNRNLMQAILFDRLPIA
EEEEECCCCCCHHHCCCCCEEEEEECCCCCCCCEECCCCCEEEHHHHHHHHHHHCCCCHH
EIVNVTVISLDQAPEGYRKFDGGAPRKFVIDPHGLIAA
HHCEEEEEEECCCCCHHHHCCCCCCEEEEECCCCCCCC
>Mature Secondary Structure 
SSNRGVVYQGPGKVEVQKIDYPRMVDPSGRKIGHGVILKVVSTNICGSDQHMVRGRTTA
CCCCCEEEECCCEEEEEECCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCEECCCCCC
PVGLVLGHEITGEVIELGSDVETLKIGDIVTVPFNVACGRCPMCREQSTGVCLNVNPARA
CEEEEECCCCCCHHHHCCCCCCEEEECCEEEECCCCCCCCCCCCCCCCCCEEEECCCCCC
GGAYGYVDMGGWIGGQAEYVLVPYADFNLIKFPDRDQAMAKIRDLTCLSDILPTGYHGAV
CCCEEEEECCCCCCCCCCEEEEEECCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCEE
TAGVKPGSTVYIAGAGPVGMAAAASARLLGAAVTIVGDMNAERLAHARKVGFETVDLSQD
EECCCCCCEEEEEECCCCCHHHHHHHHHHEEEEEEEECCCHHHHHHHHHCCCEEEECCCC
TPLGEQIARIVGRPEIDCAVDCVGFEAHGHGSSGHAEEAPATVLNSLMEITRPAGAIGIP
CCHHHHHHHHHCCCCCCEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCC
GLYVTDDPGAKDAAAQHGSLSIRFGLGWAKSHTFHTGQTPVLKYNRNLMQAILFDRLPIA
EEEEECCCCCCHHHCCCCCEEEEEECCCCCCCCEECCCCCEEEHHHHHHHHHHHCCCCHH
EIVNVTVISLDQAPEGYRKFDGGAPRKFVIDPHGLIAA
HHCEEEEEEECCCCCHHHHCCCCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]