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The map label for this gene is tdcB [H]

Identifier: 238024001

GI number: 238024001

Start: 664887

End: 665861

Strand: Direct

Name: tdcB [H]

Synonym: bglu_2g05550

Alternate gene names: 238024001

Gene position: 664887-665861 (Clockwise)

Preceding gene: 238024000

Following gene: 238024011

Centisome position: 23.52

GC content: 70.77

Gene sequence:

>975_bases
ATGAGCCAGCCGAATCCTCCGACCTACGACGACGTCGCCGCCGCCGCCGAACGCCTCGCCGGCCACGCCCACCGCACGCC
CGTGCTGACGTCGCGCACGGTCGACGAGGCGCTGGGCGCGCAGGTGTTCTTCAAGTGCGAGAACTTCCAGCGCATGGGCG
CGTTCAAGTTCCGTGGCGCGTTCAACGCGCTCTCGCAGTTCAGCGCGGCGCAGCGCAAGGCCGGCGTGGTCGCGTTCTCG
TCGGGCAACCACGCGCAGGCGATCGCGCTGTCGGCCAAGCTGCTCGGCATGCCGGCCACGATCGTGATGCCGCACGACGC
GCCGGCCGCGAAGGTCGCGGCCACGCGCGGCTACGGCGGCCAGGTGGTGATCTACGACCGCTACACCGAGGACCGCGAGC
AGATCGGCCGCGAGCTTGCCGAGCAGCAGGGCCTTACGCTGATCCCGCCGTATGACCACCCGCACGTGATCGCCGGGCAG
GGCACCGCGGCGGCCGAACTGTTCGATGAGGTCGGCCCGCTCGAGGCGGTGTTCGCGCCGCTCGGCGGCGGCGGGCTGCT
GTCGGGCACCGCGCTCGCCACGCGCGCGCTGGCGCCGGGCGCCGAACTCTACGGCGTCGAACCCGAGGCCGGCAACGACG
GCCAGCAGTCGTTCGCCTCGGGCTCGATCGTCCATATCGAGACGCCGAAGACGATTGCCGACGGCGCGCAGACGCAGCAT
CTGGGCACGCTCACGTTCCCGATCATCCGCCGCGACGTCAACGCGATCCTGACCGCGAGCGATGCCGAACTGGTCGACTG
CATGCGCTTTTTCGCCTCGCGCATGAAGATGCTGGTCGAGCCCACCGGCTGCCTCGCGTTTGCCGCGGCGCGCCGCATGA
AGGCGCAGTTGAAGGGGCGCCGCGTCGGCGTGGTGGTGAGCGGCGGCAACATCGATCTCGAGAAGTTCTGCCAGCTGGTG
TCGGCGGCCGGCTGA

Upstream 100 bases:

>100_bases
CCGTGCCGGCGACCGGCTCGCCGGCACGGCGATCGAGCATCCGCCCTTGCGCGCCGCGCCCCATCGATCCTTCCCACCGA
TCCGTTCCAGCCCAGCCACG

Downstream 100 bases:

>100_bases
GCGTTCGCCCGGCAGGGCGCGGTCTTCGCGAAGGCCCGCCTGCATCGCGCCCGCAAAGCGCGTGACGCGTCATGCGGCAC
GCGTCTTTCTTTTCATGGTT

Product: serine/threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 324; Mature: 323

Protein sequence:

>324_residues
MSQPNPPTYDDVAAAAERLAGHAHRTPVLTSRTVDEALGAQVFFKCENFQRMGAFKFRGAFNALSQFSAAQRKAGVVAFS
SGNHAQAIALSAKLLGMPATIVMPHDAPAAKVAATRGYGGQVVIYDRYTEDREQIGRELAEQQGLTLIPPYDHPHVIAGQ
GTAAAELFDEVGPLEAVFAPLGGGGLLSGTALATRALAPGAELYGVEPEAGNDGQQSFASGSIVHIETPKTIADGAQTQH
LGTLTFPIIRRDVNAILTASDAELVDCMRFFASRMKMLVEPTGCLAFAAARRMKAQLKGRRVGVVVSGGNIDLEKFCQLV
SAAG

Sequences:

>Translated_324_residues
MSQPNPPTYDDVAAAAERLAGHAHRTPVLTSRTVDEALGAQVFFKCENFQRMGAFKFRGAFNALSQFSAAQRKAGVVAFS
SGNHAQAIALSAKLLGMPATIVMPHDAPAAKVAATRGYGGQVVIYDRYTEDREQIGRELAEQQGLTLIPPYDHPHVIAGQ
GTAAAELFDEVGPLEAVFAPLGGGGLLSGTALATRALAPGAELYGVEPEAGNDGQQSFASGSIVHIETPKTIADGAQTQH
LGTLTFPIIRRDVNAILTASDAELVDCMRFFASRMKMLVEPTGCLAFAAARRMKAQLKGRRVGVVVSGGNIDLEKFCQLV
SAAG
>Mature_323_residues
SQPNPPTYDDVAAAAERLAGHAHRTPVLTSRTVDEALGAQVFFKCENFQRMGAFKFRGAFNALSQFSAAQRKAGVVAFSS
GNHAQAIALSAKLLGMPATIVMPHDAPAAKVAATRGYGGQVVIYDRYTEDREQIGRELAEQQGLTLIPPYDHPHVIAGQG
TAAAELFDEVGPLEAVFAPLGGGGLLSGTALATRALAPGAELYGVEPEAGNDGQQSFASGSIVHIETPKTIADGAQTQHL
GTLTFPIIRRDVNAILTASDAELVDCMRFFASRMKMLVEPTGCLAFAAARRMKAQLKGRRVGVVVSGGNIDLEKFCQLVS
AAG

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=323, Percent_Identity=38.390092879257, Blast_Score=224, Evalue=7e-59,
Organism=Homo sapiens, GI19923959, Length=145, Percent_Identity=35.1724137931034, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI33469958, Length=311, Percent_Identity=26.3665594855305, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI1789505, Length=317, Percent_Identity=37.8548895899054, Blast_Score=207, Evalue=9e-55,
Organism=Escherichia coli, GI1790207, Length=293, Percent_Identity=33.1058020477816, Blast_Score=154, Evalue=7e-39,
Organism=Caenorhabditis elegans, GI17508781, Length=311, Percent_Identity=35.3697749196142, Blast_Score=189, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI71991565, Length=311, Percent_Identity=30.8681672025724, Blast_Score=145, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17537387, Length=311, Percent_Identity=30.8681672025724, Blast_Score=127, Evalue=9e-30,
Organism=Saccharomyces cerevisiae, GI6322631, Length=315, Percent_Identity=66.984126984127, Blast_Score=424, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6320930, Length=289, Percent_Identity=33.5640138408304, Blast_Score=150, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6319788, Length=282, Percent_Identity=24.822695035461, Blast_Score=76, Evalue=8e-15,
Organism=Drosophila melanogaster, GI21355833, Length=327, Percent_Identity=32.7217125382263, Blast_Score=143, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24645328, Length=227, Percent_Identity=31.2775330396476, Blast_Score=82, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 34106; Mature: 33975

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQPNPPTYDDVAAAAERLAGHAHRTPVLTSRTVDEALGAQVFFKCENFQRMGAFKFRGA
CCCCCCCCHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHCCEEEEEECCHHHCCCCHHHHH
FNALSQFSAAQRKAGVVAFSSGNHAQAIALSAKLLGMPATIVMPHDAPAAKVAATRGYGG
HHHHHHHHHHHHHCCEEEECCCCCCEEEEEHHHHHCCCEEEEECCCCCHHHHEEECCCCC
QVVIYDRYTEDREQIGRELAEQQGLTLIPPYDHPHVIAGQGTAAAELFDEVGPLEAVFAP
EEEEEECCCHHHHHHHHHHHHHCCCEEECCCCCCEEEECCCCHHHHHHHHHCCHHHHHHC
LGGGGLLSGTALATRALAPGAELYGVEPEAGNDGQQSFASGSIVHIETPKTIADGAQTQH
CCCCCCCCHHHHHHHHCCCCCCEEECCCCCCCCHHHHHCCCCEEEEECCCHHHCCCCCCC
LGTLTFPIIRRDVNAILTASDAELVDCMRFFASRMKMLVEPTGCLAFAAARRMKAQLKGR
CCCHHHHHHHHCHHHEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCC
RVGVVVSGGNIDLEKFCQLVSAAG
EEEEEEECCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
SQPNPPTYDDVAAAAERLAGHAHRTPVLTSRTVDEALGAQVFFKCENFQRMGAFKFRGA
CCCCCCCHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHCCEEEEEECCHHHCCCCHHHHH
FNALSQFSAAQRKAGVVAFSSGNHAQAIALSAKLLGMPATIVMPHDAPAAKVAATRGYGG
HHHHHHHHHHHHHCCEEEECCCCCCEEEEEHHHHHCCCEEEEECCCCCHHHHEEECCCCC
QVVIYDRYTEDREQIGRELAEQQGLTLIPPYDHPHVIAGQGTAAAELFDEVGPLEAVFAP
EEEEEECCCHHHHHHHHHHHHHCCCEEECCCCCCEEEECCCCHHHHHHHHHCCHHHHHHC
LGGGGLLSGTALATRALAPGAELYGVEPEAGNDGQQSFASGSIVHIETPKTIADGAQTQH
CCCCCCCCHHHHHHHHCCCCCCEEECCCCCCCCHHHHHCCCCEEEEECCCHHHCCCCCCC
LGTLTFPIIRRDVNAILTASDAELVDCMRFFASRMKMLVEPTGCLAFAAARRMKAQLKGR
CCCHHHHHHHHCHHHEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCC
RVGVVVSGGNIDLEKFCQLVSAAG
EEEEEEECCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]