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The map label for this gene is metR [H]

Identifier: 238023945

GI number: 238023945

Start: 591073

End: 591981

Strand: Direct

Name: metR [H]

Synonym: bglu_2g04940

Alternate gene names: 238023945

Gene position: 591073-591981 (Clockwise)

Preceding gene: 238023935

Following gene: 238023946

Centisome position: 20.91

GC content: 67.88

Gene sequence:

>909_bases
ATGCTCGAACGCATCCATCTCGTCATCATTCGCGAAGTCGCCCGGCAGGGCTCGCTGACGGCCGCCGCCGACGTGCTGTG
CCTGACCCAGTCGGCGCTGAGCCACACCGTCAAGAAGATCGAGCAGCAGCTCGGCACGCCGATCTGGGATCGTGAAGGGC
GCAGCCTGCGGCTCACGCAGGCCGGGCAATACCTGCTGTCGCTGGCCGAGCGGCTGCTGCCGCAGTTCGAGCATGCCGAG
GCGCGCATGAAGCAGTACGCCGACGGCGAGCGCGGCACGCTGCGCATCGGCATGGAGTGCCACCCGTGCTATCAGTGGCT
GCTGAAGGTGGTGTCGCCTTACCTCGCGCGCTGGCCCGACGTGGACGTGGACGTCAAGCAGCGCTTCCAGTTCGGCGGCA
TCGGCGCGCTGTTCGGCTATGACATCGACGTGCTGGTTACCCCCGATCCCCTCGCGCGCCCGGGGCTGCGTTTCGAGCCG
GTGTTCGACTACGAGCAGGTGCTGGTGGTGGCCGACCGGCACCCGCTGGCCGGCGTGCGCTACGTGAAGCCCGCGCAACT
GGCGGACGAGACCCTCATCACCTATCCCGTCGAAACCGACCGGCTCGACATCTACAACCACTTCCTGCGCCCGGCCAACA
TCGCGCCGCGCCGCCACAAGACCATCGAGACCACCGACATCATGCTGCAGATGGTGGCCAGCAATCGCGGCGTGGCCGCG
CTGCCGCGCTGGCTTGCCGAGGAATACGTCCAGCGCATGCCGGTTGCCGCCGTGAAGCTCGGCAAGCACGGCATCGCCAA
GCAGATCTTCCTCGGCATGCGCGAGGCGGACGAATCGGTCGATTATCTGCGCTCGTTCGTCGAGCTCGCGCGCGGGTCGA
ACCTGCCGCCGCCGCGCATGCGCCGGTGA

Upstream 100 bases:

>100_bases
TAGGGGCCGCCGCTCATGAAGAAAAATGGATTGTTTTCATTGATCGATTAGAATTCTTCATGCTCGAATTCCATCCCGGC
CCCGCCGCCGGGCGCCCTTC

Downstream 100 bases:

>100_bases
ACACGCAGCGCGTGCCGGCCTGCCCGTCCCGGCGGCGGTGCGGGGCCGCCGGGACGGACCACGGCCCGCGGCCATGCGTG
CTACGATCGCCTCGGCCCGC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MLERIHLVIIREVARQGSLTAAADVLCLTQSALSHTVKKIEQQLGTPIWDREGRSLRLTQAGQYLLSLAERLLPQFEHAE
ARMKQYADGERGTLRIGMECHPCYQWLLKVVSPYLARWPDVDVDVKQRFQFGGIGALFGYDIDVLVTPDPLARPGLRFEP
VFDYEQVLVVADRHPLAGVRYVKPAQLADETLITYPVETDRLDIYNHFLRPANIAPRRHKTIETTDIMLQMVASNRGVAA
LPRWLAEEYVQRMPVAAVKLGKHGIAKQIFLGMREADESVDYLRSFVELARGSNLPPPRMRR

Sequences:

>Translated_302_residues
MLERIHLVIIREVARQGSLTAAADVLCLTQSALSHTVKKIEQQLGTPIWDREGRSLRLTQAGQYLLSLAERLLPQFEHAE
ARMKQYADGERGTLRIGMECHPCYQWLLKVVSPYLARWPDVDVDVKQRFQFGGIGALFGYDIDVLVTPDPLARPGLRFEP
VFDYEQVLVVADRHPLAGVRYVKPAQLADETLITYPVETDRLDIYNHFLRPANIAPRRHKTIETTDIMLQMVASNRGVAA
LPRWLAEEYVQRMPVAAVKLGKHGIAKQIFLGMREADESVDYLRSFVELARGSNLPPPRMRR
>Mature_302_residues
MLERIHLVIIREVARQGSLTAAADVLCLTQSALSHTVKKIEQQLGTPIWDREGRSLRLTQAGQYLLSLAERLLPQFEHAE
ARMKQYADGERGTLRIGMECHPCYQWLLKVVSPYLARWPDVDVDVKQRFQFGGIGALFGYDIDVLVTPDPLARPGLRFEP
VFDYEQVLVVADRHPLAGVRYVKPAQLADETLITYPVETDRLDIYNHFLRPANIAPRRHKTIETTDIMLQMVASNRGVAA
LPRWLAEEYVQRMPVAAVKLGKHGIAKQIFLGMREADESVDYLRSFVELARGSNLPPPRMRR

Specific function: Control of the last step in methionine biosynthesis; metR is a positive activator of the metA, metE and metH genes. It is also a negative regulator of its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790262, Length=292, Percent_Identity=38.013698630137, Blast_Score=206, Evalue=1e-54,
Organism=Escherichia coli, GI157672245, Length=249, Percent_Identity=28.5140562248996, Blast_Score=104, Evalue=6e-24,
Organism=Escherichia coli, GI1786401, Length=315, Percent_Identity=23.8095238095238, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI2367136, Length=245, Percent_Identity=26.1224489795918, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1787879, Length=249, Percent_Identity=26.1044176706827, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1789173, Length=251, Percent_Identity=28.2868525896414, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1788887, Length=246, Percent_Identity=26.0162601626016, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1787530, Length=288, Percent_Identity=23.6111111111111, Blast_Score=68, Evalue=9e-13,
Organism=Escherichia coli, GI1787589, Length=156, Percent_Identity=32.6923076923077, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788296, Length=193, Percent_Identity=29.0155440414508, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1787949, Length=198, Percent_Identity=27.2727272727273, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI145693105, Length=181, Percent_Identity=22.6519337016575, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1787128, Length=116, Percent_Identity=33.6206896551724, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1786508, Length=200, Percent_Identity=27, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1786713, Length=172, Percent_Identity=27.3255813953488, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789639, Length=257, Percent_Identity=25.6809338521401, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI87082024, Length=277, Percent_Identity=24.187725631769, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34363; Mature: 34363

Theoretical pI: Translated: 8.74; Mature: 8.74

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLERIHLVIIREVARQGSLTAAADVLCLTQSALSHTVKKIEQQLGTPIWDREGRSLRLTQ
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEHHH
AGQYLLSLAERLLPQFEHAEARMKQYADGERGTLRIGMECHPCYQWLLKVVSPYLARWPD
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCC
VDVDVKQRFQFGGIGALFGYDIDVLVTPDPLARPGLRFEPVFDYEQVLVVADRHPLAGVR
CCCCHHHHHHHCCEEEHHCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCC
YVKPAQLADETLITYPVETDRLDIYNHFLRPANIAPRRHKTIETTDIMLQMVASNRGVAA
CCCCHHHCCCCEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHH
LPRWLAEEYVQRMPVAAVKLGKHGIAKQIFLGMREADESVDYLRSFVELARGSNLPPPRM
HHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
RR
CC
>Mature Secondary Structure
MLERIHLVIIREVARQGSLTAAADVLCLTQSALSHTVKKIEQQLGTPIWDREGRSLRLTQ
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEHHH
AGQYLLSLAERLLPQFEHAEARMKQYADGERGTLRIGMECHPCYQWLLKVVSPYLARWPD
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCC
VDVDVKQRFQFGGIGALFGYDIDVLVTPDPLARPGLRFEPVFDYEQVLVVADRHPLAGVR
CCCCHHHHHHHCCEEEHHCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCC
YVKPAQLADETLITYPVETDRLDIYNHFLRPANIAPRRHKTIETTDIMLQMVASNRGVAA
CCCCHHHCCCCEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHH
LPRWLAEEYVQRMPVAAVKLGKHGIAKQIFLGMREADESVDYLRSFVELARGSNLPPPRM
HHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
RR
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]