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The map label for this gene is ggt [H]

Identifier: 238023946

GI number: 238023946

Start: 592188

End: 593945

Strand: Direct

Name: ggt [H]

Synonym: bglu_2g04950

Alternate gene names: 238023946

Gene position: 592188-593945 (Clockwise)

Preceding gene: 238023945

Following gene: 339717968

Centisome position: 20.95

GC content: 69.62

Gene sequence:

>1758_bases
ATGAGGCGCTTCCTTCCCGCCGCCAGCGTACTGGCCGTCTGCCTTGCCCCGATCGCCCATGCGGCCTCCGAGCCAGCGGT
GGAGGCGCGGCACGGCATGGTGGTGTCGTCGCAGCATTTGGCCTCCGAGATCGGCGTGCAGATCCTCAAGCAGGGCGGCA
ACGCCGTGGACGCGGCGGTGGCCGTGGGCTACGCGCAGGCCGTCACGAACCCCTGTTGCGGCAACATCGGCGGCGGCGGA
TTCATGACGCTGCATCTGGCCGACGGGCGCGACCGCTTCATCGATTTCCGCGAGAAGGCGCCGGCCGGCGCTTCGGCGAA
CATGTACCTCGACGAGGCCGGCAACGTGCGCAAGGGCGCGAGCCTGTACGGCTATCTGGCCGTCGGCGTGCCCGGCACGG
TGGCCGGCCTGAACCTCGCCGAGCGCAAGTACGGCAGGCTCACGCTGCGCCAGGTGATGGCGCCTGCGATCCGGCTCGCG
CGCGACGGCTTCGTCCTCACGCGCGGCGACACCGACATCCTCGACACCACCACCGACCGCTTGCGCGACGATCCCGACGC
GGCCCGCGTGTTCCTGCGCAAGGACGGCACGCCGCTGCAGCCCGGCGACCGCCTGGTGCAGAAGGATCTGGCCGCGACGC
TCGAGGGCATTGCGCAGCACGGCGACGACGCGTTCTACCACGGCAGGATTGCGCAGGCCGTGGAAGCCGCCTCGAGGCGC
GGCGGCGGCGTGATCACGGCGGCCGATTTCGCGGCCTACCGCGCCGAGGACACCGAGCCGCTCAAATGCAGCTATCGCGG
CTACACCTTCATCTCGGCGCCGCCGCCGAGCTCGGGCGGCGTCACGCTCTGCGAGACGCTGAACATCCTCGAGGGCTACG
ACATGCGCGCGCTCGGCTATCACTCGGCCGCGGCGGTCCACTACATGACCGAGGCGATGCGCCATGCCTATCTCGACCGC
AACACGCTGCTCGGCGATCCGGCATTCGTCGACAATCCGGTCGAGCGCCTGACGAGCAAGGCCTATGCGGACCAGATCCG
CCAGACCATCAGCGACGATCGGGCCGCCTCGTCGAAGCAGGTCGTGCCGGGCTTCGGCGTCCACGAAAAGCCCGAGACGA
CGCATTACTCGATCATCGACGCCGACGGCAACGCGGTATCGACCACCTACACGGTGAACGGCCGGTTCGGCGCCGTGGTG
ATCGCGCCGGGCACCGGCTTCTTCCTCAACGACGAGATGGACGACTTCACCACCAAGATCGGCGCGCAGAACCTGTTCGG
CCTCGTGCAGGGCTCGCGCAACGCGATCGCGCCGGGCAAGCGGCCGCTCTCGTCGATGGCGCCGACGGTGGTCACGAAGG
ACGGCAAGGTGTTCATGGTGATCGGCTCGCCGGGCGGCTCGCGCATCATCACGATCACGCTCGAGACCGCGCTGAACGTG
ATCGACTACGCGATGCCGCCGCAGGATGCCGTGGATGCGCCGCGCGTCCATCACCAGTGGCTGCCCGACGAGGTCTATTA
CGAAACGCGCGGCCTGTCGCCCGACACGCTCGCGATCCTGCGCAGGATGGGCTACAAGATGGTCGAGCAGACGCCCTGGG
GCGCCGCCGAGCTGGTGCTGGTCGGGCTGCCCGGCACCGAGGTGGCGAGCCGCGCCAGCTCGGGCAACGATGCGTCGGTG
TCGGACATCGTGCGGCCCGGCTTCATCTACGGCGCGAACGATCCGCGCCGGCCGGCCGGCGCGGCGGTGGGCTACTGA

Upstream 100 bases:

>100_bases
CCGCGGGCCCGGCTTCGGGCCGGCTTCCAGCGCGCTTCAGGCGCGCCACCGGCCGCCGCGGGCCGCCTTCCTTCCACTGC
CCATCCAGGAGTTTCGCGAC

Downstream 100 bases:

>100_bases
GCCGCCGCCATCCGTGAGGGCGTGTGGCGCGACGACGATCGGAGGCTTCCCGTTTGTCGGGCCGCGCTCAATTTTCAGCG
CCGGCCGCCGATAACCCGAA

Product: Gamma-glutamyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 585; Mature: 585

Protein sequence:

>585_residues
MRRFLPAASVLAVCLAPIAHAASEPAVEARHGMVVSSQHLASEIGVQILKQGGNAVDAAVAVGYAQAVTNPCCGNIGGGG
FMTLHLADGRDRFIDFREKAPAGASANMYLDEAGNVRKGASLYGYLAVGVPGTVAGLNLAERKYGRLTLRQVMAPAIRLA
RDGFVLTRGDTDILDTTTDRLRDDPDAARVFLRKDGTPLQPGDRLVQKDLAATLEGIAQHGDDAFYHGRIAQAVEAASRR
GGGVITAADFAAYRAEDTEPLKCSYRGYTFISAPPPSSGGVTLCETLNILEGYDMRALGYHSAAAVHYMTEAMRHAYLDR
NTLLGDPAFVDNPVERLTSKAYADQIRQTISDDRAASSKQVVPGFGVHEKPETTHYSIIDADGNAVSTTYTVNGRFGAVV
IAPGTGFFLNDEMDDFTTKIGAQNLFGLVQGSRNAIAPGKRPLSSMAPTVVTKDGKVFMVIGSPGGSRIITITLETALNV
IDYAMPPQDAVDAPRVHHQWLPDEVYYETRGLSPDTLAILRRMGYKMVEQTPWGAAELVLVGLPGTEVASRASSGNDASV
SDIVRPGFIYGANDPRRPAGAAVGY

Sequences:

>Translated_585_residues
MRRFLPAASVLAVCLAPIAHAASEPAVEARHGMVVSSQHLASEIGVQILKQGGNAVDAAVAVGYAQAVTNPCCGNIGGGG
FMTLHLADGRDRFIDFREKAPAGASANMYLDEAGNVRKGASLYGYLAVGVPGTVAGLNLAERKYGRLTLRQVMAPAIRLA
RDGFVLTRGDTDILDTTTDRLRDDPDAARVFLRKDGTPLQPGDRLVQKDLAATLEGIAQHGDDAFYHGRIAQAVEAASRR
GGGVITAADFAAYRAEDTEPLKCSYRGYTFISAPPPSSGGVTLCETLNILEGYDMRALGYHSAAAVHYMTEAMRHAYLDR
NTLLGDPAFVDNPVERLTSKAYADQIRQTISDDRAASSKQVVPGFGVHEKPETTHYSIIDADGNAVSTTYTVNGRFGAVV
IAPGTGFFLNDEMDDFTTKIGAQNLFGLVQGSRNAIAPGKRPLSSMAPTVVTKDGKVFMVIGSPGGSRIITITLETALNV
IDYAMPPQDAVDAPRVHHQWLPDEVYYETRGLSPDTLAILRRMGYKMVEQTPWGAAELVLVGLPGTEVASRASSGNDASV
SDIVRPGFIYGANDPRRPAGAAVGY
>Mature_585_residues
MRRFLPAASVLAVCLAPIAHAASEPAVEARHGMVVSSQHLASEIGVQILKQGGNAVDAAVAVGYAQAVTNPCCGNIGGGG
FMTLHLADGRDRFIDFREKAPAGASANMYLDEAGNVRKGASLYGYLAVGVPGTVAGLNLAERKYGRLTLRQVMAPAIRLA
RDGFVLTRGDTDILDTTTDRLRDDPDAARVFLRKDGTPLQPGDRLVQKDLAATLEGIAQHGDDAFYHGRIAQAVEAASRR
GGGVITAADFAAYRAEDTEPLKCSYRGYTFISAPPPSSGGVTLCETLNILEGYDMRALGYHSAAAVHYMTEAMRHAYLDR
NTLLGDPAFVDNPVERLTSKAYADQIRQTISDDRAASSKQVVPGFGVHEKPETTHYSIIDADGNAVSTTYTVNGRFGAVV
IAPGTGFFLNDEMDDFTTKIGAQNLFGLVQGSRNAIAPGKRPLSSMAPTVVTKDGKVFMVIGSPGGSRIITITLETALNV
IDYAMPPQDAVDAPRVHHQWLPDEVYYETRGLSPDTLAILRRMGYKMVEQTPWGAAELVLVGLPGTEVASRASSGNDASV
SDIVRPGFIYGANDPRRPAGAAVGY

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=526, Percent_Identity=35.7414448669202, Blast_Score=263, Evalue=4e-70,
Organism=Homo sapiens, GI73915090, Length=526, Percent_Identity=35.7414448669202, Blast_Score=263, Evalue=4e-70,
Organism=Homo sapiens, GI73915096, Length=526, Percent_Identity=35.7414448669202, Blast_Score=263, Evalue=4e-70,
Organism=Homo sapiens, GI73915094, Length=526, Percent_Identity=35.7414448669202, Blast_Score=263, Evalue=4e-70,
Organism=Homo sapiens, GI113429324, Length=502, Percent_Identity=35.4581673306773, Blast_Score=236, Evalue=3e-62,
Organism=Homo sapiens, GI113429326, Length=561, Percent_Identity=33.1550802139037, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI153266885, Length=479, Percent_Identity=30.6889352818372, Blast_Score=181, Evalue=2e-45,
Organism=Homo sapiens, GI109148539, Length=479, Percent_Identity=31.9415448851775, Blast_Score=181, Evalue=2e-45,
Organism=Homo sapiens, GI153266901, Length=480, Percent_Identity=30.4166666666667, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI153266907, Length=478, Percent_Identity=29.7071129707113, Blast_Score=166, Evalue=7e-41,
Organism=Homo sapiens, GI30581157, Length=189, Percent_Identity=39.6825396825397, Blast_Score=119, Evalue=1e-26,
Organism=Homo sapiens, GI30581155, Length=189, Percent_Identity=39.6825396825397, Blast_Score=119, Evalue=1e-26,
Organism=Homo sapiens, GI218505805, Length=196, Percent_Identity=33.6734693877551, Blast_Score=93, Evalue=8e-19,
Organism=Homo sapiens, GI310124095, Length=197, Percent_Identity=30.4568527918782, Blast_Score=74, Evalue=5e-13,
Organism=Escherichia coli, GI1789856, Length=560, Percent_Identity=46.9642857142857, Blast_Score=511, Evalue=1e-146,
Organism=Caenorhabditis elegans, GI17506189, Length=494, Percent_Identity=33.8056680161943, Blast_Score=254, Evalue=9e-68,
Organism=Caenorhabditis elegans, GI72000294, Length=489, Percent_Identity=35.5828220858896, Blast_Score=249, Evalue=4e-66,
Organism=Caenorhabditis elegans, GI212646519, Length=489, Percent_Identity=35.5828220858896, Blast_Score=248, Evalue=5e-66,
Organism=Caenorhabditis elegans, GI193208247, Length=495, Percent_Identity=33.1313131313131, Blast_Score=224, Evalue=8e-59,
Organism=Caenorhabditis elegans, GI193208245, Length=495, Percent_Identity=33.1313131313131, Blast_Score=224, Evalue=9e-59,
Organism=Caenorhabditis elegans, GI17542894, Length=506, Percent_Identity=31.8181818181818, Blast_Score=215, Evalue=4e-56,
Organism=Caenorhabditis elegans, GI17564448, Length=436, Percent_Identity=26.1467889908257, Blast_Score=110, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6323330, Length=535, Percent_Identity=30.0934579439252, Blast_Score=193, Evalue=7e-50,
Organism=Drosophila melanogaster, GI45551474, Length=517, Percent_Identity=32.495164410058, Blast_Score=238, Evalue=9e-63,
Organism=Drosophila melanogaster, GI161077880, Length=517, Percent_Identity=32.495164410058, Blast_Score=238, Evalue=9e-63,
Organism=Drosophila melanogaster, GI161077878, Length=517, Percent_Identity=32.495164410058, Blast_Score=238, Evalue=1e-62,
Organism=Drosophila melanogaster, GI24642670, Length=517, Percent_Identity=32.495164410058, Blast_Score=238, Evalue=1e-62,
Organism=Drosophila melanogaster, GI24642666, Length=517, Percent_Identity=32.495164410058, Blast_Score=238, Evalue=1e-62,
Organism=Drosophila melanogaster, GI18859893, Length=518, Percent_Identity=33.2046332046332, Blast_Score=229, Evalue=5e-60,
Organism=Drosophila melanogaster, GI161077496, Length=539, Percent_Identity=32.6530612244898, Blast_Score=229, Evalue=6e-60,
Organism=Drosophila melanogaster, GI18859741, Length=490, Percent_Identity=29.3877551020408, Blast_Score=191, Evalue=1e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 62230; Mature: 62230

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS00462 G_GLU_TRANSPEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRFLPAASVLAVCLAPIAHAASEPAVEARHGMVVSSQHLASEIGVQILKQGGNAVDAAV
CCCCCCHHHHHHHHHHHHHHHCCCCCHHHHCCEEEEHHHHHHHHHHHHHHCCCCHHHHHH
AVGYAQAVTNPCCGNIGGGGFMTLHLADGRDRFIDFREKAPAGASANMYLDEAGNVRKGA
HHHHHHHHCCCCCCCCCCCCEEEEEEECCCCHHEEHHHCCCCCCCCCEEECCCCCCCCCC
SLYGYLAVGVPGTVAGLNLAERKYGRLTLRQVMAPAIRLARDGFVLTRGDTDILDTTTDR
CEEEEEEECCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHCCCHHH
LRDDPDAARVFLRKDGTPLQPGDRLVQKDLAATLEGIAQHGDDAFYHGRIAQAVEAASRR
HCCCCHHHEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHC
GGGVITAADFAAYRAEDTEPLKCSYRGYTFISAPPPSSGGVTLCETLNILEGYDMRALGY
CCCEEEEHHHHHHCCCCCCCCEEEECCEEEEECCCCCCCCEEHHHHHHHHCCCCCEECCC
HSAAAVHYMTEAMRHAYLDRNTLLGDPAFVDNPVERLTSKAYADQIRQTISDDRAASSKQ
CHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
VVPGFGVHEKPETTHYSIIDADGNAVSTTYTVNGRFGAVVIAPGTGFFLNDEMDDFTTKI
CCCCCCCCCCCCCCEEEEEECCCCEEEEEEEECCCEEEEEEECCCCEEECCCHHHHHHHH
GAQNLFGLVQGSRNAIAPGKRPLSSMAPTVVTKDGKVFMVIGSPGGSRIITITLETALNV
HHHHHHHHHCCCCCCCCCCCCCHHHCCCEEEECCCEEEEEEECCCCCEEEEEEHHHHHHH
IDYAMPPQDAVDAPRVHHQWLPDEVYYETRGLSPDTLAILRRMGYKMVEQTPWGAAELVL
HHHCCCCCCCCCCCCHHHCCCCHHHHHHHCCCCHHHHHHHHHHCHHHHHCCCCCCEEEEE
VGLPGTEVASRASSGNDASVSDIVRPGFIYGANDPRRPAGAAVGY
EECCCHHHHHHCCCCCCCCHHHHCCCCEEECCCCCCCCCCCCCCC
>Mature Secondary Structure
MRRFLPAASVLAVCLAPIAHAASEPAVEARHGMVVSSQHLASEIGVQILKQGGNAVDAAV
CCCCCCHHHHHHHHHHHHHHHCCCCCHHHHCCEEEEHHHHHHHHHHHHHHCCCCHHHHHH
AVGYAQAVTNPCCGNIGGGGFMTLHLADGRDRFIDFREKAPAGASANMYLDEAGNVRKGA
HHHHHHHHCCCCCCCCCCCCEEEEEEECCCCHHEEHHHCCCCCCCCCEEECCCCCCCCCC
SLYGYLAVGVPGTVAGLNLAERKYGRLTLRQVMAPAIRLARDGFVLTRGDTDILDTTTDR
CEEEEEEECCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHCCCHHH
LRDDPDAARVFLRKDGTPLQPGDRLVQKDLAATLEGIAQHGDDAFYHGRIAQAVEAASRR
HCCCCHHHEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHC
GGGVITAADFAAYRAEDTEPLKCSYRGYTFISAPPPSSGGVTLCETLNILEGYDMRALGY
CCCEEEEHHHHHHCCCCCCCCEEEECCEEEEECCCCCCCCEEHHHHHHHHCCCCCEECCC
HSAAAVHYMTEAMRHAYLDRNTLLGDPAFVDNPVERLTSKAYADQIRQTISDDRAASSKQ
CHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
VVPGFGVHEKPETTHYSIIDADGNAVSTTYTVNGRFGAVVIAPGTGFFLNDEMDDFTTKI
CCCCCCCCCCCCCCEEEEEECCCCEEEEEEEECCCEEEEEEECCCCEEECCCHHHHHHHH
GAQNLFGLVQGSRNAIAPGKRPLSSMAPTVVTKDGKVFMVIGSPGGSRIITITLETALNV
HHHHHHHHHCCCCCCCCCCCCCHHHCCCEEEECCCEEEEEEECCCCCEEEEEEHHHHHHH
IDYAMPPQDAVDAPRVHHQWLPDEVYYETRGLSPDTLAILRRMGYKMVEQTPWGAAELVL
HHHCCCCCCCCCCCCHHHCCCCHHHHHHHCCCCHHHHHHHHHHCHHHHHCCCCCCEEEEE
VGLPGTEVASRASSGNDASVSDIVRPGFIYGANDPRRPAGAAVGY
EECCCHHHHHHCCCCCCCCHHHHCCCCEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7765305 [H]