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The map label for this gene is hsrA [H]

Identifier: 238023858

GI number: 238023858

Start: 474243

End: 475667

Strand: Direct

Name: hsrA [H]

Synonym: bglu_2g03970

Alternate gene names: 238023858

Gene position: 474243-475667 (Clockwise)

Preceding gene: 238023857

Following gene: 238023862

Centisome position: 16.77

GC content: 67.51

Gene sequence:

>1425_bases
ATGACCGACACGCACGTCGATCGTCGTCCGACGACAGATTTTCTCCCCTATCTCGTGGCCGCGACGTTCTTCATGGAATA
TCTCGACACGACGGTCATCGCGACCGCACTGCCGCAGATGGCGAAATCGTTCGGCGTCGGTCCGAACGCGCTGAGCCTTG
GCATGACCGCCTACATGCTCGCGCTCGCGGTGTTCATCCCGATCAGCGGCTGGATCGCCGATCGCTTCGGCTCGCGCACC
GTGTTCGCTTCGGCGATCGCGATCTTCACGATCGCCTCCGTGCTGTGCGGGCTGTCGAACGGCACCGAAACGTTTACCGC
CGCGCGACTGCTGCAGGGCGTGGGTGGCGCGATGATGGTGCCGGTCGGCCGGATGATCGTGGTGCGCAGCACCGACAAGG
CGAAGCTGATGCGCGCCATCGCGACGATCACCTGGCCCGGCATCGTGGCGCCGGTGGTCGGGCCGCCCGTCGGCGGCTTC
ATCACCACCTACGCGTCGTGGCGCTGGATCTTCCTGCTCAACGTGCCGCTCGGCATTGCCGCGTTTGCCTGCGTGCTGCT
GCTGGTGCGCAACGAGCGCGCCGAGCAGGCGCGCCCGCTCGACTGGCTCGGCTTCGTGCTGTCGGGCGCGACGCTGACCT
GCATGCTCTGCGGCACCGAGGCGGCAGGGCAGCAGGACGCGCATTTCATGGCCGCGTTCGGCCTGATCGCCGCCGCGATC
GGGTTCGGCGCCGCGGCGCTCTGGCATGCACGCCGCACGCCGCATCCGCTGCTCGATTTCACCACGCTGAAGGTGCCGAC
GTTCTCGGTCACGGTGCTGACCGGCTCGGTCACGCGCGTGGCGATCAATGCAGTACCGTATCTGCAGCCGCTGCTGTTCC
AAGTCGGCTTCGGCATGTCGCCGTTCCAGTCCGGGCTGCTGCTGCTCGCGAGCGCGACCGGCAACCTCGGGATGAAGGCG
CTGACTTCGTGGATTCTCGATCGCTTCGGATTCCGCCGCGTGGCGCTCGTCGACGTGACAATCGCAGGCGCGGCGACGAT
CGCGTGCGGCTGGCTCACCGCCTCGACACCGCTCGTCATCACCTTGTTCGTCGTGTTCGTCTACGGGCTGTCGCGCTCGA
TGCAGTTCTCGACGCTGGCGACGCTCGCGTTCGCCGACATCCCGCCGGCGCAGACCAGTGCCGCCAGCACGCTGTCGAGC
GCGGCGCAGCAAATGACGATCGGCATGGGCATCGCGTTCGGCGCGATGTCGCTGCGGCTCGCATCGATGCTGCGCGGCGA
CGCGGTCGGCACGCACTATGTGCTTGCCGATTTCCGCTGGGCGTTTCTCGCGGCCGGCGTGCTCGCCTTGCTGACGCTGC
CCGGTTATGCACGGCTCGCGGCGAATGCCGGTGACCGGCTGCGCACCAGCGTATCGAAGGGTTGA

Upstream 100 bases:

>100_bases
CAGCGACGATCAATCGGCGTACCATCGACGCCTCGGCCAACCGGCGCCGGTTGGCCTGTTGTCTTGACGTCCCACCGACT
CCTTTCGCCCGCCATTGCGT

Downstream 100 bases:

>100_bases
GCGGCCCGGCTCCCTGGCGGTACGCGCATCGAATCGAGGCCGCCGCACCAGGTGCTGCCTGGCATCGAGCGCAGTCGCTC
CCTCACTGCGCGTCGTGAAA

Product: EmrB/QacA family drug resistance transporter

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: High-copy suppressor of rspA [H]

Number of amino acids: Translated: 474; Mature: 473

Protein sequence:

>474_residues
MTDTHVDRRPTTDFLPYLVAATFFMEYLDTTVIATALPQMAKSFGVGPNALSLGMTAYMLALAVFIPISGWIADRFGSRT
VFASAIAIFTIASVLCGLSNGTETFTAARLLQGVGGAMMVPVGRMIVVRSTDKAKLMRAIATITWPGIVAPVVGPPVGGF
ITTYASWRWIFLLNVPLGIAAFACVLLLVRNERAEQARPLDWLGFVLSGATLTCMLCGTEAAGQQDAHFMAAFGLIAAAI
GFGAAALWHARRTPHPLLDFTTLKVPTFSVTVLTGSVTRVAINAVPYLQPLLFQVGFGMSPFQSGLLLLASATGNLGMKA
LTSWILDRFGFRRVALVDVTIAGAATIACGWLTASTPLVITLFVVFVYGLSRSMQFSTLATLAFADIPPAQTSAASTLSS
AAQQMTIGMGIAFGAMSLRLASMLRGDAVGTHYVLADFRWAFLAAGVLALLTLPGYARLAANAGDRLRTSVSKG

Sequences:

>Translated_474_residues
MTDTHVDRRPTTDFLPYLVAATFFMEYLDTTVIATALPQMAKSFGVGPNALSLGMTAYMLALAVFIPISGWIADRFGSRT
VFASAIAIFTIASVLCGLSNGTETFTAARLLQGVGGAMMVPVGRMIVVRSTDKAKLMRAIATITWPGIVAPVVGPPVGGF
ITTYASWRWIFLLNVPLGIAAFACVLLLVRNERAEQARPLDWLGFVLSGATLTCMLCGTEAAGQQDAHFMAAFGLIAAAI
GFGAAALWHARRTPHPLLDFTTLKVPTFSVTVLTGSVTRVAINAVPYLQPLLFQVGFGMSPFQSGLLLLASATGNLGMKA
LTSWILDRFGFRRVALVDVTIAGAATIACGWLTASTPLVITLFVVFVYGLSRSMQFSTLATLAFADIPPAQTSAASTLSS
AAQQMTIGMGIAFGAMSLRLASMLRGDAVGTHYVLADFRWAFLAAGVLALLTLPGYARLAANAGDRLRTSVSKG
>Mature_473_residues
TDTHVDRRPTTDFLPYLVAATFFMEYLDTTVIATALPQMAKSFGVGPNALSLGMTAYMLALAVFIPISGWIADRFGSRTV
FASAIAIFTIASVLCGLSNGTETFTAARLLQGVGGAMMVPVGRMIVVRSTDKAKLMRAIATITWPGIVAPVVGPPVGGFI
TTYASWRWIFLLNVPLGIAAFACVLLLVRNERAEQARPLDWLGFVLSGATLTCMLCGTEAAGQQDAHFMAAFGLIAAAIG
FGAAALWHARRTPHPLLDFTTLKVPTFSVTVLTGSVTRVAINAVPYLQPLLFQVGFGMSPFQSGLLLLASATGNLGMKAL
TSWILDRFGFRRVALVDVTIAGAATIACGWLTASTPLVITLFVVFVYGLSRSMQFSTLATLAFADIPPAQTSAASTLSSA
AQQMTIGMGIAFGAMSLRLASMLRGDAVGTHYVLADFRWAFLAAGVLALLTLPGYARLAANAGDRLRTSVSKG

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=465, Percent_Identity=33.7634408602151, Blast_Score=276, Evalue=2e-75,
Organism=Escherichia coli, GI1788392, Length=423, Percent_Identity=36.1702127659575, Blast_Score=238, Evalue=8e-64,
Organism=Escherichia coli, GI1789042, Length=389, Percent_Identity=27.7634961439589, Blast_Score=108, Evalue=8e-25,
Organism=Escherichia coli, GI87081983, Length=309, Percent_Identity=25.8899676375405, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1788710, Length=390, Percent_Identity=24.3589743589744, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1790146, Length=157, Percent_Identity=26.7515923566879, Blast_Score=67, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6325455, Length=152, Percent_Identity=30.9210526315789, Blast_Score=77, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6321663, Length=150, Percent_Identity=30.6666666666667, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6322958, Length=202, Percent_Identity=27.7227722772277, Blast_Score=64, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 50057; Mature: 49925

Theoretical pI: Translated: 10.11; Mature: 10.11

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTHVDRRPTTDFLPYLVAATFFMEYLDTTVIATALPQMAKSFGVGPNALSLGMTAYML
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
ALAVFIPISGWIADRFGSRTVFASAIAIFTIASVLCGLSNGTETFTAARLLQGVGGAMMV
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEE
PVGRMIVVRSTDKAKLMRAIATITWPGIVAPVVGPPVGGFITTYASWRWIFLLNVPLGIA
CCCCEEEEECCCHHHHHHHHHHHCCCCHHHCCCCCCCCHHHHHHCCEEEEEEEECCHHHH
AFACVLLLVRNERAEQARPLDWLGFVLSGATLTCMLCGTEAAGQQDAHFMAAFGLIAAAI
HHHHHHHHHHCCHHHHCCCHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHH
GFGAAALWHARRTPHPLLDFTTLKVPTFSVTVLTGSVTRVAINAVPYLQPLLFQVGFGMS
HHHHHHHHHHCCCCCCCCCEEEEECCEEEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCC
PFQSGLLLLASATGNLGMKALTSWILDRFGFRRVALVDVTIAGAATIACGWLTASTPLVI
CHHCCEEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEEEEECCHHHHHHHHHHCCCHHHH
TLFVVFVYGLSRSMQFSTLATLAFADIPPAQTSAASTLSSAAQQMTIGMGIAFGAMSLRL
HHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASMLRGDAVGTHYVLADFRWAFLAAGVLALLTLPGYARLAANAGDRLRTSVSKG
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHCCCC
>Mature Secondary Structure 
TDTHVDRRPTTDFLPYLVAATFFMEYLDTTVIATALPQMAKSFGVGPNALSLGMTAYML
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
ALAVFIPISGWIADRFGSRTVFASAIAIFTIASVLCGLSNGTETFTAARLLQGVGGAMMV
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEE
PVGRMIVVRSTDKAKLMRAIATITWPGIVAPVVGPPVGGFITTYASWRWIFLLNVPLGIA
CCCCEEEEECCCHHHHHHHHHHHCCCCHHHCCCCCCCCHHHHHHCCEEEEEEEECCHHHH
AFACVLLLVRNERAEQARPLDWLGFVLSGATLTCMLCGTEAAGQQDAHFMAAFGLIAAAI
HHHHHHHHHHCCHHHHCCCHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHH
GFGAAALWHARRTPHPLLDFTTLKVPTFSVTVLTGSVTRVAINAVPYLQPLLFQVGFGMS
HHHHHHHHHHCCCCCCCCCEEEEECCEEEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCC
PFQSGLLLLASATGNLGMKALTSWILDRFGFRRVALVDVTIAGAATIACGWLTASTPLVI
CHHCCEEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEEEEECCHHHHHHHHHHCCCHHHH
TLFVVFVYGLSRSMQFSTLATLAFADIPPAQTSAASTLSSAAQQMTIGMGIAFGAMSLRL
HHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASMLRGDAVGTHYVLADFRWAFLAAGVLALLTLPGYARLAANAGDRLRTSVSKG
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7686882; 9278503 [H]