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The map label for this gene is mro [H]

Identifier: 238023675

GI number: 238023675

Start: 223588

End: 224799

Strand: Direct

Name: mro [H]

Synonym: bglu_2g01960

Alternate gene names: 238023675

Gene position: 223588-224799 (Clockwise)

Preceding gene: 238023671

Following gene: 238023677

Centisome position: 7.91

GC content: 68.15

Gene sequence:

>1212_bases
ATGAGAGCGCTTTCCCTGCCCATGTGCCGCCCGGCTTCTCGCCGCGCAGCCTGTCCCGCCCGCCGCGGTCTTCTTCCCGG
TCTGAAGCTGGCCGCCCGCGCGCTCGCCGCTTCGGGCTGGCTGGCGGCGTCGTCAGTGTGGGCGGCAACGCTGTCCGAGG
CGCCCTACGGCACGACCAGCGACGGCAAGCCGGTGACCGAGTACACGCTGAAGAACGCGCGCGGCACCACCGTCAGGCTG
ATCGACTACGGCGGCTGCATCACCGCCATCGAGGTGCCCGACCGTCGCGGCCGGTTTGCCAACATCGTGCTCGGCTTCGC
GTCACTGAAGGACTACGAGGCCTACAACGGCAACATCCATTTCGGCGCCCTGATCGGCCGCTACGCGAACCGCATCGCAG
GCGGCAAGTTCGAACTCGACGGCAAGACCTACCAGTTGCCGATCAACAACGCGCCGAACACGCTGCATGGCGGACCCGGC
AGCTTCGACTCGAAGGTCTGGCGCGCAAAGCCCGTGAGCGGCAAGGACGGCGCCGGCGTGGAGCTCACCTACGTGAGCCC
CGACGGCGAGAACGGCTTTCCCGGCACGCTGACGACGCACGTCACCTACCTGCTGACCGACGACAACGCGCTGCACATCC
GCTACGAGGCCACCACCGACCGGGACACCGTGGTCAATCTGACCAACCACACCTATTTCAATCTGGCCGGCGAGGGCAGC
GGCAGCGTGGAGCAGCAGGAGATCCGGATTGCCGCCTCGCGCTACACGCCCACCGATCGCACCTCGATTCCCACCGGCGA
GCTGGCACCCGTGGAGGGAACGCCGCTCGACCTGCGCCGGCTCACGCCGATCGGCAAGTATTTGCGCTCGAACTTCGAGC
AGATGGTCTACGCGCGCGGCTACGACCACAACTGGGTGCTCGACCACGGCGGCCAGCGCGTGCCGGCCTTTGCGGCCAGC
GTGCGCGACCCGCACAGCGGGCGCGTGCTGACCGTCGACACCACGCAGCCGGGCCTGCAGTTCTACTCGGCGAATTCGCT
CGACGGCGGCGTGGTGGGTGCGAGCGGCCATACCTACCGGCAGACCGACGCGTTCGCGCTCGAGGCCGAGCACTTCCCCG
ATTCGCCTAACCATCCGGCGTTCCCGACCACGGTGCTCAAGCCCGGCGACACGCTGCGCGAGGAAACCGTGCTGCGTTTC
TCGGTACGCTGA

Upstream 100 bases:

>100_bases
TTGCCGCATGCCAGAACGCGTCCCGCCCGGCCGGTGTGGCAGTGCCATGCCGCGCCGGCCAGCGGCCCTCCCCGCCTCGC
CAGAAAGGAACCGGTATCCG

Downstream 100 bases:

>100_bases
GCGCACCGCGTGTCGGCGTCGGCCTTCGAGATGGATGCTGGATGGCTTGCGCCTTGCCGGGCGAGGGCGACGAGCACGAA
AGGGGCTGCATGCGAAGCCG

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MRALSLPMCRPASRRAACPARRGLLPGLKLAARALAASGWLAASSVWAATLSEAPYGTTSDGKPVTEYTLKNARGTTVRL
IDYGGCITAIEVPDRRGRFANIVLGFASLKDYEAYNGNIHFGALIGRYANRIAGGKFELDGKTYQLPINNAPNTLHGGPG
SFDSKVWRAKPVSGKDGAGVELTYVSPDGENGFPGTLTTHVTYLLTDDNALHIRYEATTDRDTVVNLTNHTYFNLAGEGS
GSVEQQEIRIAASRYTPTDRTSIPTGELAPVEGTPLDLRRLTPIGKYLRSNFEQMVYARGYDHNWVLDHGGQRVPAFAAS
VRDPHSGRVLTVDTTQPGLQFYSANSLDGGVVGASGHTYRQTDAFALEAEHFPDSPNHPAFPTTVLKPGDTLREETVLRF
SVR

Sequences:

>Translated_403_residues
MRALSLPMCRPASRRAACPARRGLLPGLKLAARALAASGWLAASSVWAATLSEAPYGTTSDGKPVTEYTLKNARGTTVRL
IDYGGCITAIEVPDRRGRFANIVLGFASLKDYEAYNGNIHFGALIGRYANRIAGGKFELDGKTYQLPINNAPNTLHGGPG
SFDSKVWRAKPVSGKDGAGVELTYVSPDGENGFPGTLTTHVTYLLTDDNALHIRYEATTDRDTVVNLTNHTYFNLAGEGS
GSVEQQEIRIAASRYTPTDRTSIPTGELAPVEGTPLDLRRLTPIGKYLRSNFEQMVYARGYDHNWVLDHGGQRVPAFAAS
VRDPHSGRVLTVDTTQPGLQFYSANSLDGGVVGASGHTYRQTDAFALEAEHFPDSPNHPAFPTTVLKPGDTLREETVLRF
SVR
>Mature_403_residues
MRALSLPMCRPASRRAACPARRGLLPGLKLAARALAASGWLAASSVWAATLSEAPYGTTSDGKPVTEYTLKNARGTTVRL
IDYGGCITAIEVPDRRGRFANIVLGFASLKDYEAYNGNIHFGALIGRYANRIAGGKFELDGKTYQLPINNAPNTLHGGPG
SFDSKVWRAKPVSGKDGAGVELTYVSPDGENGFPGTLTTHVTYLLTDDNALHIRYEATTDRDTVVNLTNHTYFNLAGEGS
GSVEQQEIRIAASRYTPTDRTSIPTGELAPVEGTPLDLRRLTPIGKYLRSNFEQMVYARGYDHNWVLDHGGQRVPAFAAS
VRDPHSGRVLTVDTTQPGLQFYSANSLDGGVVGASGHTYRQTDAFALEAEHFPDSPNHPAFPTTVLKPGDTLREETVLRF
SVR

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=359, Percent_Identity=44.8467966573816, Blast_Score=286, Evalue=3e-77,
Organism=Escherichia coli, GI1786971, Length=352, Percent_Identity=38.3522727272727, Blast_Score=209, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI17557428, Length=336, Percent_Identity=30.6547619047619, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI115533334, Length=336, Percent_Identity=30.6547619047619, Blast_Score=156, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6319493, Length=319, Percent_Identity=29.7805642633229, Blast_Score=112, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6322004, Length=360, Percent_Identity=30, Blast_Score=106, Evalue=7e-24,
Organism=Saccharomyces cerevisiae, GI6324399, Length=329, Percent_Identity=28.8753799392097, Blast_Score=101, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24659048, Length=347, Percent_Identity=40.9221902017291, Blast_Score=248, Evalue=4e-66,
Organism=Drosophila melanogaster, GI24668278, Length=365, Percent_Identity=38.9041095890411, Blast_Score=238, Evalue=4e-63,
Organism=Drosophila melanogaster, GI24583720, Length=368, Percent_Identity=38.8586956521739, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24668282, Length=345, Percent_Identity=37.9710144927536, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI24641876, Length=356, Percent_Identity=30.8988764044944, Blast_Score=172, Evalue=3e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 43597; Mature: 43597

Theoretical pI: Translated: 8.41; Mature: 8.41

Prosite motif: PS00545 ALDOSE_1_EPIMERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRALSLPMCRPASRRAACPARRGLLPGLKLAARALAASGWLAASSVWAATLSEAPYGTTS
CCCCCCCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCC
DGKPVTEYTLKNARGTTVRLIDYGGCITAIEVPDRRGRFANIVLGFASLKDYEAYNGNIH
CCCCCHHEEECCCCCCEEEEEECCCEEEEEECCCCCCCEEEEEEEEHHHCCCCCCCCCEE
FGALIGRYANRIAGGKFELDGKTYQLPINNAPNTLHGGPGSFDSKVWRAKPVSGKDGAGV
EHHHHHHHHHHHCCCEEEECCEEEEEECCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCE
ELTYVSPDGENGFPGTLTTHVTYLLTDDNALHIRYEATTDRDTVVNLTNHTYFNLAGEGS
EEEEECCCCCCCCCCEEEEEEEEEEECCCEEEEEEECCCCCCEEEEEECCEEEEEECCCC
GSVEQQEIRIAASRYTPTDRTSIPTGELAPVEGTPLDLRRLTPIGKYLRSNFEQMVYARG
CCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHCC
YDHNWVLDHGGQRVPAFAASVRDPHSGRVLTVDTTQPGLQFYSANSLDGGVVGASGHTYR
CCCCEEECCCCCCCCHHHHHCCCCCCCEEEEEECCCCCEEEEECCCCCCCEEECCCCCEE
QTDAFALEAEHFPDSPNHPAFPTTVLKPGDTLREETVLRFSVR
CCCEEEEEHHCCCCCCCCCCCCEEEECCCCCCCCCEEEEEECC
>Mature Secondary Structure
MRALSLPMCRPASRRAACPARRGLLPGLKLAARALAASGWLAASSVWAATLSEAPYGTTS
CCCCCCCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCC
DGKPVTEYTLKNARGTTVRLIDYGGCITAIEVPDRRGRFANIVLGFASLKDYEAYNGNIH
CCCCCHHEEECCCCCCEEEEEECCCEEEEEECCCCCCCEEEEEEEEHHHCCCCCCCCCEE
FGALIGRYANRIAGGKFELDGKTYQLPINNAPNTLHGGPGSFDSKVWRAKPVSGKDGAGV
EHHHHHHHHHHHCCCEEEECCEEEEEECCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCE
ELTYVSPDGENGFPGTLTTHVTYLLTDDNALHIRYEATTDRDTVVNLTNHTYFNLAGEGS
EEEEECCCCCCCCCCEEEEEEEEEEECCCEEEEEEECCCCCCEEEEEECCEEEEEECCCC
GSVEQQEIRIAASRYTPTDRTSIPTGELAPVEGTPLDLRRLTPIGKYLRSNFEQMVYARG
CCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHCC
YDHNWVLDHGGQRVPAFAASVRDPHSGRVLTVDTTQPGLQFYSANSLDGGVVGASGHTYR
CCCCEEECCCCCCCCHHHHHCCCCCCCEEEEEECCCCCEEEEECCCCCCCEEECCCCCEE
QTDAFALEAEHFPDSPNHPAFPTTVLKPGDTLREETVLRFSVR
CCCEEEEEHHCCCCCCCCCCCCEEEECCCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3012466; 3531172 [H]