BacMap

Definition	Burkholderia glumae BGR1 chromosome chromosome 2, complete sequence.
Accession	NC_012721
Length	2,827,333

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The map label for this gene is ywfH [H]

Identifier: 238023568

GI number: 238023568

Start: 72344

End: 73156

Strand: Direct

Name: ywfH [H]

Synonym: bglu_2g00700

Alternate gene names: 238023568

Gene position: 72344-73156 (Clockwise)

Preceding gene: 238023567

Following gene: 238023569

Centisome position: 2.56

GC content: 68.63

Gene sequence:

>813_bases
ATGGATCTGCAACTGCACGGAAAAGCCGCGTTCATCACCGGCGGCAGCATGGGCATCGGCAAGGCGGTCGCGCTCGAACT
GGCGCGCGAAGGCGTCGACGTCACGATCGCCGCGCGGCGCATGGAGCACCTCGAAGCGGCGGCTGCCGAGATTGGCGCGG
CGCTCGCGCCGCTGGGCAGCGCGGCCGGCGCCATCCTGCCCGTCACGATGGACACGACCGACATGGCGTCGGTCGAGGCG
GCGATGGCCGCGAGCGTCGAGCGCTTCGGCCGGCTCGACATCCTGCTGAACGGCGCCGCGCACCCGGGCGGGCTGGTGCG
GACGGAGCTGGAGCAAGCGGACCCGCAGGGGCTGCTGCAGGACATCGATATCAAGGTGGTCGGCTACCTGCGCTGCGCGA
AAGCGGCCGCGCCGCACATGCGGCGCAACGGCTTCGGCCGCATCGTGAACATCGGCGGCCTGACGGGGCGCGGCAGCAAG
CAGCTGTCCGGCATGCGCAACGTGGCGATCGTACACCTGACCAAGACGCTGTCCGACCAGCTCGGCCCGTTCGGCATCAC
GGTCAACACGATTCATCCGGGCGTGGTCGAGACGCCGCACATTCACGAACTCTACGAGAAAGAAGCGCAGAAGCAGGGGC
TCACGGCCGCGGCGGTCGAGGCCGACTACGTGAAGCTCACGCCGATCCGCCGCGTGCTGCAGCCGGAAGAAATGGGGTGG
ATCGTCGCGTTTCTCGCATCGCCGAAGTCCGGCGCAATCACCGGCGAGTCGATCGGCTGCGACGGCGGACTCACGCGCGG
AATTTTTCTCTGA

Upstream 100 bases:

>100_bases
GCGCTCGCTCATGCCGACGGGCCGACACTCATCGAAATGCAGTTGTCCTGATCGCGCCGCGCGATCGTTTCCTCAATCCC
GACTCTCACCTCTCATCGAC

Downstream 100 bases:

>100_bases
CACAAGGAGCACTTCATGACCGCAACCGTACTGGTCGCCACCGCGGGGCAGGGCATCCTGCGCTCGAACGACGAGGGCAA
GACCTGGCATCGTCTCGGGC

Product: Short-chain dehydrogenase/reductase SDR

Products: 3-oxoacyl-[acyl-carrier protein]; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MDLQLHGKAAFITGGSMGIGKAVALELAREGVDVTIAARRMEHLEAAAAEIGAALAPLGSAAGAILPVTMDTTDMASVEA
AMAASVERFGRLDILLNGAAHPGGLVRTELEQADPQGLLQDIDIKVVGYLRCAKAAAPHMRRNGFGRIVNIGGLTGRGSK
QLSGMRNVAIVHLTKTLSDQLGPFGITVNTIHPGVVETPHIHELYEKEAQKQGLTAAAVEADYVKLTPIRRVLQPEEMGW
IVAFLASPKSGAITGESIGCDGGLTRGIFL

Sequences:

>Translated_270_residues
MDLQLHGKAAFITGGSMGIGKAVALELAREGVDVTIAARRMEHLEAAAAEIGAALAPLGSAAGAILPVTMDTTDMASVEA
AMAASVERFGRLDILLNGAAHPGGLVRTELEQADPQGLLQDIDIKVVGYLRCAKAAAPHMRRNGFGRIVNIGGLTGRGSK
QLSGMRNVAIVHLTKTLSDQLGPFGITVNTIHPGVVETPHIHELYEKEAQKQGLTAAAVEADYVKLTPIRRVLQPEEMGW
IVAFLASPKSGAITGESIGCDGGLTRGIFL
>Mature_270_residues
MDLQLHGKAAFITGGSMGIGKAVALELAREGVDVTIAARRMEHLEAAAAEIGAALAPLGSAAGAILPVTMDTTDMASVEA
AMAASVERFGRLDILLNGAAHPGGLVRTELEQADPQGLLQDIDIKVVGYLRCAKAAAPHMRRNGFGRIVNIGGLTGRGSK
QLSGMRNVAIVHLTKTLSDQLGPFGITVNTIHPGVVETPHIHELYEKEAQKQGLTAAAVEADYVKLTPIRRVLQPEEMGW
IVAFLASPKSGAITGESIGCDGGLTRGIFL

Specific function: Along with the bacABCDE operon is involved in bacilysin biosynthesis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI19923817, Length=262, Percent_Identity=31.2977099236641, Blast_Score=117, Evalue=8e-27,
Organism=Homo sapiens, GI32483357, Length=266, Percent_Identity=28.1954887218045, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI10190704, Length=263, Percent_Identity=28.8973384030418, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI40254992, Length=262, Percent_Identity=28.2442748091603, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI126723750, Length=264, Percent_Identity=25.7575757575758, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI225579078, Length=209, Percent_Identity=30.1435406698565, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI59889578, Length=194, Percent_Identity=30.4123711340206, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI7706318, Length=202, Percent_Identity=29.7029702970297, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI40254986, Length=148, Percent_Identity=29.7297297297297, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI15277342, Length=274, Percent_Identity=30.2919708029197, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI5031737, Length=269, Percent_Identity=26.7657992565056, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI109715829, Length=250, Percent_Identity=27.2, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI4503817, Length=206, Percent_Identity=26.6990291262136, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI209862901, Length=214, Percent_Identity=27.5700934579439, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI19923983, Length=214, Percent_Identity=27.5700934579439, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI87082100, Length=268, Percent_Identity=34.7014925373134, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1787335, Length=266, Percent_Identity=30.4511278195489, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1789057, Length=262, Percent_Identity=30.1526717557252, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1787905, Length=265, Percent_Identity=26.7924528301887, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI1789208, Length=269, Percent_Identity=26.3940520446097, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI87082160, Length=274, Percent_Identity=27.007299270073, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788459, Length=261, Percent_Identity=26.8199233716475, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI2367175, Length=264, Percent_Identity=30.3030303030303, Blast_Score=67, Evalue=9e-13,
Organism=Escherichia coli, GI1790717, Length=271, Percent_Identity=26.1992619926199, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17560676, Length=266, Percent_Identity=28.1954887218045, Blast_Score=97, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17562910, Length=273, Percent_Identity=28.9377289377289, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17560332, Length=271, Percent_Identity=30.9963099630996, Blast_Score=94, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17559104, Length=264, Percent_Identity=32.1969696969697, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17531453, Length=277, Percent_Identity=31.0469314079422, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17562908, Length=276, Percent_Identity=29.3478260869565, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71994604, Length=266, Percent_Identity=29.6992481203008, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17562906, Length=280, Percent_Identity=28.9285714285714, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI193204405, Length=282, Percent_Identity=30.1418439716312, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17538480, Length=284, Percent_Identity=30.6338028169014, Blast_Score=87, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17562904, Length=270, Percent_Identity=28.1481481481481, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17551412, Length=278, Percent_Identity=28.4172661870504, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17536025, Length=268, Percent_Identity=29.8507462686567, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI71994600, Length=266, Percent_Identity=28.5714285714286, Blast_Score=84, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17565030, Length=287, Percent_Identity=28.2229965156794, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17544670, Length=279, Percent_Identity=27.2401433691756, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17560150, Length=277, Percent_Identity=28.5198555956679, Blast_Score=80, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17536651, Length=267, Percent_Identity=29.5880149812734, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17560220, Length=270, Percent_Identity=27.4074074074074, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17562990, Length=275, Percent_Identity=26.5454545454545, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17563726, Length=271, Percent_Identity=27.6752767527675, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71982365, Length=192, Percent_Identity=27.0833333333333, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17561272, Length=271, Percent_Identity=30.6273062730627, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17558628, Length=192, Percent_Identity=29.6875, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17538486, Length=271, Percent_Identity=26.9372693726937, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17561402, Length=267, Percent_Identity=26.2172284644195, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI72000259, Length=274, Percent_Identity=25.9124087591241, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17538182, Length=271, Percent_Identity=28.0442804428044, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17568967, Length=197, Percent_Identity=25.3807106598985, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=265, Percent_Identity=26.7924528301887, Blast_Score=82, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6322861, Length=208, Percent_Identity=25.4807692307692, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21355319, Length=268, Percent_Identity=33.2089552238806, Blast_Score=107, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24639444, Length=269, Percent_Identity=29.368029739777, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI23397609, Length=266, Percent_Identity=29.3233082706767, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21357041, Length=262, Percent_Identity=29.3893129770992, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28571526, Length=264, Percent_Identity=28.7878787878788, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24644339, Length=273, Percent_Identity=27.1062271062271, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI21357673, Length=148, Percent_Identity=31.0810810810811, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24580925, Length=127, Percent_Identity=36.2204724409449, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI116007236, Length=206, Percent_Identity=30.0970873786408, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24643142, Length=268, Percent_Identity=25.3731343283582, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100

Molecular weight: Translated: 28213; Mature: 28213

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLQLHGKAAFITGGSMGIGKAVALELAREGVDVTIAARRMEHLEAAAAEIGAALAPLGS
CCEEECCCEEEEECCCCCCHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCC
AAGAILPVTMDTTDMASVEAAMAASVERFGRLDILLNGAAHPGGLVRTELEQADPQGLLQ
CCCEEEEEEECCCHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCEEHHHHHCCHHHHHH
DIDIKVVGYLRCAKAAAPHMRRNGFGRIVNIGGLTGRGSKQLSGMRNVAIVHLTKTLSDQ
HCCEEEEHHHHHHHHHCCHHHHCCCCEEEEECCCCCCCCHHHHCCCCEEEEEEEHHHHHC
LGPFGITVNTIHPGVVETPHIHELYEKEAQKQGLTAAAVEADYVKLTPIRRVLQPEEMGW
CCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCEEEEHHHHHHCCCCCCCE
IVAFLASPKSGAITGESIGCDGGLTRGIFL
EEEEEECCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDLQLHGKAAFITGGSMGIGKAVALELAREGVDVTIAARRMEHLEAAAAEIGAALAPLGS
CCEEECCCEEEEECCCCCCHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCC
AAGAILPVTMDTTDMASVEAAMAASVERFGRLDILLNGAAHPGGLVRTELEQADPQGLLQ
CCCEEEEEEECCCHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCEEHHHHHCCHHHHHH
DIDIKVVGYLRCAKAAAPHMRRNGFGRIVNIGGLTGRGSKQLSGMRNVAIVHLTKTLSDQ
HCCEEEEHHHHHHHHHCCHHHHCCCCEEEEECCCCCCCCHHHHCCCCEEEEEEEHHHHHC
LGPFGITVNTIHPGVVETPHIHELYEKEAQKQGLTAAAVEADYVKLTPIRRVLQPEEMGW
CCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCEEEEHHHHHHCCCCCCCE
IVAFLASPKSGAITGESIGCDGGLTRGIFL
EEEEEECCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (3R)-3-hydroxyacyl-[acyl-carrier protein]; NADP+

Specific reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7934828; 9384377 [H]