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The map label for this gene is dnaA [H]

Identifier: 237814480

GI number: 237814480

Start: 4097137

End: 4098516

Strand: Reverse

Name: dnaA [H]

Synonym: GBP346_A4278

Alternate gene names: 237814480

Gene position: 4098516-4097137 (Counterclockwise)

Preceding gene: NA

Following gene: 237814479

Centisome position: 100.0

GC content: 66.74

Gene sequence:

>1380_bases
GTGCAATTCGTGCTCGATCCGAAGGCGGGCCAACGCAGTCCCGCCGGCGCGACGCCGCTTGCGCCCCGCGCGCCGCTGCC
GAGCGCGAATCCCGCGCCGGTTGCGCCCGGCCCGGCGTGCGCGCCCGCCGTCGACGCGCACGCGCCCGCCCCCGCCGGCA
TGAACGCCGCCACCGCGGCCGCCGTCGCCGCCGCGCAGGCCGCGCAAGCGGCCCAGGCGAACGCCGCCGCGCTGAACGCG
GACGAGGCCGCCGACCTCGACCTGCCGAGCCTCACCGCGCACGAGGCGGCGGCAGGCCGCCGCACGTGGCGCCCGGGCGC
GGCGAACGCGAACAGCGAAGCCGCCGATTCGATGTACGAGCGCTCGAAGCTGAACCCGGTGCTCACGTTCGACAACTTCG
TCACCGGCAAGGCGAACCAGCTCGCACGCGCGGCGGCGATCCAGGTGGCCGATAATCCGGGGATTTCGTACAACCCGCTG
TTCCTGTACGGCGGTGTCGGCCTCGGCAAGACCCACCTGATCCACGCGATCGGCAACCAGTTGCTGCTCGACAAACCCGG
CGCGCGCATCCGCTACATCCACGCGGAACAGTACGTGTCCGACGTCGTGAAGGCGTACCAGCGCAAGGCGTTCGACGATT
TCAAGCGCTACTATCATTCGCTCGACCTGCTGCTCATCGACGACATCCAATTCTTCTCGGGCAAGTCGCGCACGCAGGAA
GAGTTCTTCTACGCGTTCGAAGCGCTCGTCGCGAACAAGGCGCAGGTGATCATCACGAGCGATACGTATCCGAAGGAAAT
CTCCGGCATCGACGATCGCCTGATCTCGCGCTTCGATTCGGGCCTCACTGTCGCGATCGAGCCGCCCGAGCTGGAGATGC
GCGTCGCGATCCTGATGCGCAAGGCGCAATCGGAAGGCGTGAGCCTGTCGGAGGACGTCGCGTTCTTCGTCGCGAAGCAC
CTGCGCTCGAACGTGCGCGAGCTCGAAGGCGCGCTGCGCAAGATCCTCGCGTACTCGAAGTTCCACGGCCGGGAGATCAC
GATCGAGCTGACGAAGGAAGCGCTGAAGGATCTGCTCACCGTGCAGAACCGGCAGATCTCGGTCGAGAACATCCAGAAGA
CGGTGGCCGACTTCTACAACATCAAGGTCGCCGACATGTATTCGAAGAAGCGCCCCGCGAACATCGCGCGGCCTCGGCAG
ATCGCGATGTATCTCGCGAAGGAGCTCACGCAGAAGAGCCTGCCCGAAATCGGCGAGCTGTTCGGCGGGCGCGACCACAC
CACCGTGCTGCACGCGGTGCGCAAGATCGCCGACGAACGCGGCAAGGACGCGCAGCTCAATCACGAGCTGCACGTGCTCG
AACAGACGCTCAAGGGCTGA

Upstream 100 bases:

>60_bases
AGCCAGTTCTCGGGCCGGATCTCCGATCTGGCCCGCGATTTCTGGAACGCGCCGATCGAA

Downstream 100 bases:

>100_bases
TGCGCGCGAGCGCTTGAGAATGGCGGAACCGCCCCAATTTAAAAGGGGCGGTTCGGTTTTGAGGCACAATACTGGTTTGA
CCGCCTGGCCGGGCGGGCCG

Product: chromosomal replication initiator protein DnaA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MQFVLDPKAGQRSPAGATPLAPRAPLPSANPAPVAPGPACAPAVDAHAPAPAGMNAATAAAVAAAQAAQAAQANAAALNA
DEAADLDLPSLTAHEAAAGRRTWRPGAANANSEAADSMYERSKLNPVLTFDNFVTGKANQLARAAAIQVADNPGISYNPL
FLYGGVGLGKTHLIHAIGNQLLLDKPGARIRYIHAEQYVSDVVKAYQRKAFDDFKRYYHSLDLLLIDDIQFFSGKSRTQE
EFFYAFEALVANKAQVIITSDTYPKEISGIDDRLISRFDSGLTVAIEPPELEMRVAILMRKAQSEGVSLSEDVAFFVAKH
LRSNVRELEGALRKILAYSKFHGREITIELTKEALKDLLTVQNRQISVENIQKTVADFYNIKVADMYSKKRPANIARPRQ
IAMYLAKELTQKSLPEIGELFGGRDHTTVLHAVRKIADERGKDAQLNHELHVLEQTLKG

Sequences:

>Translated_459_residues
MQFVLDPKAGQRSPAGATPLAPRAPLPSANPAPVAPGPACAPAVDAHAPAPAGMNAATAAAVAAAQAAQAAQANAAALNA
DEAADLDLPSLTAHEAAAGRRTWRPGAANANSEAADSMYERSKLNPVLTFDNFVTGKANQLARAAAIQVADNPGISYNPL
FLYGGVGLGKTHLIHAIGNQLLLDKPGARIRYIHAEQYVSDVVKAYQRKAFDDFKRYYHSLDLLLIDDIQFFSGKSRTQE
EFFYAFEALVANKAQVIITSDTYPKEISGIDDRLISRFDSGLTVAIEPPELEMRVAILMRKAQSEGVSLSEDVAFFVAKH
LRSNVRELEGALRKILAYSKFHGREITIELTKEALKDLLTVQNRQISVENIQKTVADFYNIKVADMYSKKRPANIARPRQ
IAMYLAKELTQKSLPEIGELFGGRDHTTVLHAVRKIADERGKDAQLNHELHVLEQTLKG
>Mature_459_residues
MQFVLDPKAGQRSPAGATPLAPRAPLPSANPAPVAPGPACAPAVDAHAPAPAGMNAATAAAVAAAQAAQAAQANAAALNA
DEAADLDLPSLTAHEAAAGRRTWRPGAANANSEAADSMYERSKLNPVLTFDNFVTGKANQLARAAAIQVADNPGISYNPL
FLYGGVGLGKTHLIHAIGNQLLLDKPGARIRYIHAEQYVSDVVKAYQRKAFDDFKRYYHSLDLLLIDDIQFFSGKSRTQE
EFFYAFEALVANKAQVIITSDTYPKEISGIDDRLISRFDSGLTVAIEPPELEMRVAILMRKAQSEGVSLSEDVAFFVAKH
LRSNVRELEGALRKILAYSKFHGREITIELTKEALKDLLTVQNRQISVENIQKTVADFYNIKVADMYSKKRPANIARPRQ
IAMYLAKELTQKSLPEIGELFGGRDHTTVLHAVRKIADERGKDAQLNHELHVLEQTLKG

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family [H]

Homologues:

Organism=Escherichia coli, GI2367267, Length=337, Percent_Identity=62.0178041543027, Blast_Score=441, Evalue=1e-125,
Organism=Escherichia coli, GI226510964, Length=233, Percent_Identity=27.0386266094421, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921 [H]

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C [H]

EC number: NA

Molecular weight: Translated: 49910; Mature: 49910

Theoretical pI: Translated: 8.37; Mature: 8.37

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFVLDPKAGQRSPAGATPLAPRAPLPSANPAPVAPGPACAPAVDAHAPAPAGMNAATAA
CCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
AVAAAQAAQAAQANAAALNADEAADLDLPSLTAHEAAAGRRTWRPGAANANSEAADSMYE
HHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHH
RSKLNPVLTFDNFVTGKANQLARAAAIQVADNPGISYNPLFLYGGVGLGKTHLIHAIGNQ
HHCCCEEEEECCCCCCCHHHHHHHHHEEEECCCCCCCCCEEEECCCCCCHHHHHHHHCCC
LLLDKPGARIRYIHAEQYVSDVVKAYQRKAFDDFKRYYHSLDLLLIDDIQFFSGKSRTQE
EEECCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECHHHHCCCCCHHH
EFFYAFEALVANKAQVIITSDTYPKEISGIDDRLISRFDSGLTVAIEPPELEMRVAILMR
HHHHHHHHHHCCCCEEEEECCCCCHHHCCHHHHHHHHHCCCCEEEECCCCHHHHHHHHHH
KAQSEGVSLSEDVAFFVAKHLRSNVRELEGALRKILAYSKFHGREITIELTKEALKDLLT
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHH
VQNRQISVENIQKTVADFYNIKVADMYSKKRPANIARPRQIAMYLAKELTQKSLPEIGEL
HCCCCCCHHHHHHHHHHHHCCEEHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHH
FGGRDHTTVLHAVRKIADERGKDAQLNHELHVLEQTLKG
HCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MQFVLDPKAGQRSPAGATPLAPRAPLPSANPAPVAPGPACAPAVDAHAPAPAGMNAATAA
CCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
AVAAAQAAQAAQANAAALNADEAADLDLPSLTAHEAAAGRRTWRPGAANANSEAADSMYE
HHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHH
RSKLNPVLTFDNFVTGKANQLARAAAIQVADNPGISYNPLFLYGGVGLGKTHLIHAIGNQ
HHCCCEEEEECCCCCCCHHHHHHHHHEEEECCCCCCCCCEEEECCCCCCHHHHHHHHCCC
LLLDKPGARIRYIHAEQYVSDVVKAYQRKAFDDFKRYYHSLDLLLIDDIQFFSGKSRTQE
EEECCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECHHHHCCCCCHHH
EFFYAFEALVANKAQVIITSDTYPKEISGIDDRLISRFDSGLTVAIEPPELEMRVAILMR
HHHHHHHHHHCCCCEEEEECCCCCHHHCCHHHHHHHHHCCCCEEEECCCCHHHHHHHHHH
KAQSEGVSLSEDVAFFVAKHLRSNVRELEGALRKILAYSKFHGREITIELTKEALKDLLT
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHH
VQNRQISVENIQKTVADFYNIKVADMYSKKRPANIARPRQIAMYLAKELTQKSLPEIGEL
HCCCCCCHHHHHHHHHHHHCCEEHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHH
FGGRDHTTVLHAVRKIADERGKDAQLNHELHVLEQTLKG
HCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA