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The map label for this gene is gcvT [H]

Identifier: 237814300

GI number: 237814300

Start: 3921473

End: 3922669

Strand: Direct

Name: gcvT [H]

Synonym: GBP346_A4098

Alternate gene names: 237814300

Gene position: 3921473-3922669 (Clockwise)

Preceding gene: 237814298

Following gene: 237814301

Centisome position: 95.68

GC content: 68.59

Gene sequence:

>1197_bases
ATGCGCCGGCGGTTCGCCGAGTTGCCATTTTGTTTTCGCGCCCGGGCTCAAGGCCCGGCCGCCTTGCCTGGGACCCCGAT
GACCGTTCTCAAAACCACCCCGCTTCATGCCGCGCATCGCGCCCTCAACGCCCGCATGGTCGATTTCGGCGGCTGGGACA
TGCCCGTCAACTACGGCTCGCAGATCGAAGAGCACCAGGCGGTGCGCACCGATGCCGGCATGTTCGACGTGTCGCACATG
TGCGTCGTCGATTTCACGGGCCCGCGCGTGCGCGCGTTCTTCGAACACGCGATCGCGAACAACGTCGCGAAGCTGCAAAC
GCCCGGCAAGGCGCTCTACTCGTGCCTGCTGAACCCGCAAGGCGGCGTGATCGACGATCTGATCGTCTACTACTTCACCG
AGGAATTCTTCCGCGTCGTCGTCAACGCCGGCACTGCGGAGAAGGACATCGCGTGGTTCAACCAGCTCAACGAGCAAGGC
GGCTTCGGCCTCACGATCGCGCCGCGTCGCGACTTCGCGATCGTCGCCGCCCAAGGCCCGAACGCGCGCGCGAAGGTGTG
GGACACCGTCCCCTCCGCGCGCGCAGCGACGAGCGAGCTCAAGCCGTTCAACGCCGCGCAGGTCGCGGGCACGCCGTTCG
GCGATCTCACCGTCGCGCGCACCGGCTACACCGGCGAGGACGGCTTCGAGATCATCGTCCCGGCGACGCACGTGGAAGCG
CTGTGGAACGCGCTCGCCGAGCGCGGCGTGCGCCCGTGCGGGCTCGGCGCGCGCGACACGCTGCGGCTCGAGGCCGGCAT
GAACCTGTACGGCCAGGACATGGACGAAAGCGTTTCCCCGCTCGACGCGGGCCTCGCGTGGACGGTCGACCTGTCCGCGC
CGCGCGCGTTCGTCGGCCGCGACGCGCTCGAAGCGCACGGCTCGCGCGCGGCATTCGTCGGCCTGATCCTGCAGAAGGAG
AACGGCCGCGCGGGCGGCGTGCTGCGCGCGCACCAGAAGGTCGCCACGCCGCACGGCGAAGGCGAGATCACGAGCGGCAC
GTTCTCGCCGTCGATGCAGGAATCGATCGCCTTTGCGCGCGTGCCGAAGGACGTCGCGATCGGCGACACGGTGCACGTGC
AGATCCGCGACAAGCAACTTCCCGCGCGCGTGGTAAAACTGCCGTTCGTGCGCAACGGCAAGGTCCTCGCTGCGTAA

Upstream 100 bases:

>100_bases
GGCTGCCCACCGAAGGGGCGCGCGCGAGCCGGATCGAAACCGTCGCGCAATCTCTCAGGTATCGAGGACAGAGGGGCATG
CACGCATCGCAGGCGGCTTC

Downstream 100 bases:

>100_bases
CGGGCCGGGCGGCGCGCCGCCCGGCGATACCGTACCCGGCGCGCCGATTGCGCGCCAGAAAGAATCACACCCTTTTCCAT
TCAGGAGCATTCGATGAGCA

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MRRRFAELPFCFRARAQGPAALPGTPMTVLKTTPLHAAHRALNARMVDFGGWDMPVNYGSQIEEHQAVRTDAGMFDVSHM
CVVDFTGPRVRAFFEHAIANNVAKLQTPGKALYSCLLNPQGGVIDDLIVYYFTEEFFRVVVNAGTAEKDIAWFNQLNEQG
GFGLTIAPRRDFAIVAAQGPNARAKVWDTVPSARAATSELKPFNAAQVAGTPFGDLTVARTGYTGEDGFEIIVPATHVEA
LWNALAERGVRPCGLGARDTLRLEAGMNLYGQDMDESVSPLDAGLAWTVDLSAPRAFVGRDALEAHGSRAAFVGLILQKE
NGRAGGVLRAHQKVATPHGEGEITSGTFSPSMQESIAFARVPKDVAIGDTVHVQIRDKQLPARVVKLPFVRNGKVLAA

Sequences:

>Translated_398_residues
MRRRFAELPFCFRARAQGPAALPGTPMTVLKTTPLHAAHRALNARMVDFGGWDMPVNYGSQIEEHQAVRTDAGMFDVSHM
CVVDFTGPRVRAFFEHAIANNVAKLQTPGKALYSCLLNPQGGVIDDLIVYYFTEEFFRVVVNAGTAEKDIAWFNQLNEQG
GFGLTIAPRRDFAIVAAQGPNARAKVWDTVPSARAATSELKPFNAAQVAGTPFGDLTVARTGYTGEDGFEIIVPATHVEA
LWNALAERGVRPCGLGARDTLRLEAGMNLYGQDMDESVSPLDAGLAWTVDLSAPRAFVGRDALEAHGSRAAFVGLILQKE
NGRAGGVLRAHQKVATPHGEGEITSGTFSPSMQESIAFARVPKDVAIGDTVHVQIRDKQLPARVVKLPFVRNGKVLAA
>Mature_398_residues
MRRRFAELPFCFRARAQGPAALPGTPMTVLKTTPLHAAHRALNARMVDFGGWDMPVNYGSQIEEHQAVRTDAGMFDVSHM
CVVDFTGPRVRAFFEHAIANNVAKLQTPGKALYSCLLNPQGGVIDDLIVYYFTEEFFRVVVNAGTAEKDIAWFNQLNEQG
GFGLTIAPRRDFAIVAAQGPNARAKVWDTVPSARAATSELKPFNAAQVAGTPFGDLTVARTGYTGEDGFEIIVPATHVEA
LWNALAERGVRPCGLGARDTLRLEAGMNLYGQDMDESVSPLDAGLAWTVDLSAPRAFVGRDALEAHGSRAAFVGLILQKE
NGRAGGVLRAHQKVATPHGEGEITSGTFSPSMQESIAFARVPKDVAIGDTVHVQIRDKQLPARVVKLPFVRNGKVLAA

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=382, Percent_Identity=36.3874345549738, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI257796258, Length=357, Percent_Identity=35.8543417366947, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI257796256, Length=317, Percent_Identity=35.9621451104101, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI257796254, Length=377, Percent_Identity=31.8302387267904, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI24797151, Length=340, Percent_Identity=28.5294117647059, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI197927446, Length=347, Percent_Identity=24.4956772334294, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI21361378, Length=347, Percent_Identity=24.4956772334294, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI1789272, Length=378, Percent_Identity=54.2328042328042, Blast_Score=377, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI17560118, Length=399, Percent_Identity=34.0852130325814, Blast_Score=164, Evalue=9e-41,
Organism=Caenorhabditis elegans, GI71994045, Length=369, Percent_Identity=23.0352303523035, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71994052, Length=369, Percent_Identity=23.0352303523035, Blast_Score=86, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6320222, Length=388, Percent_Identity=35.0515463917526, Blast_Score=186, Evalue=4e-48,
Organism=Drosophila melanogaster, GI20129441, Length=406, Percent_Identity=33.743842364532, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI28571104, Length=273, Percent_Identity=23.4432234432234, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI20130091, Length=299, Percent_Identity=25.752508361204, Blast_Score=72, Evalue=7e-13,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 42976; Mature: 42976

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRRFAELPFCFRARAQGPAALPGTPMTVLKTTPLHAAHRALNARMVDFGGWDMPVNYGS
CCCCHHHCCHHHHHCCCCCCCCCCCCEEEEECCCHHHHHHHHCCEEEECCCCCCCCCCCC
QIEEHQAVRTDAGMFDVSHMCVVDFTGPRVRAFFEHAIANNVAKLQTPGKALYSCLLNPQ
HHHHHHHHHCCCCCEECCCEEEEECCCCHHHHHHHHHHHCCHHHHCCCHHHHHHHHCCCC
GGVIDDLIVYYFTEEFFRVVVNAGTAEKDIAWFNQLNEQGGFGLTIAPRRDFAIVAAQGP
CCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEECCCCEEEEEECCC
NARAKVWDTVPSARAATSELKPFNAAQVAGTPFGDLTVARTGYTGEDGFEIIVPATHVEA
CCCEEEEECCCCHHHHHHHCCCCCCHHCCCCCCCCEEEEECCCCCCCCCEEEEEHHHHHH
LWNALAERGVRPCGLGARDTLRLEAGMNLYGQDMDESVSPLDAGLAWTVDLSAPRAFVGR
HHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHCC
DALEAHGSRAAFVGLILQKENGRAGGVLRAHQKVATPHGEGEITSGTFSPSMQESIAFAR
HHHHHCCCCEEEEEEEEECCCCCCCCEEEHHHHHCCCCCCCCEECCCCCCCHHHHHHHHH
VPKDVAIGDTVHVQIRDKQLPARVVKLPFVRNGKVLAA
CCCCCCCCCEEEEEEECCCCCCEEEECCEEECCCEEEC
>Mature Secondary Structure
MRRRFAELPFCFRARAQGPAALPGTPMTVLKTTPLHAAHRALNARMVDFGGWDMPVNYGS
CCCCHHHCCHHHHHCCCCCCCCCCCCEEEEECCCHHHHHHHHCCEEEECCCCCCCCCCCC
QIEEHQAVRTDAGMFDVSHMCVVDFTGPRVRAFFEHAIANNVAKLQTPGKALYSCLLNPQ
HHHHHHHHHCCCCCEECCCEEEEECCCCHHHHHHHHHHHCCHHHHCCCHHHHHHHHCCCC
GGVIDDLIVYYFTEEFFRVVVNAGTAEKDIAWFNQLNEQGGFGLTIAPRRDFAIVAAQGP
CCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEECCCCEEEEEECCC
NARAKVWDTVPSARAATSELKPFNAAQVAGTPFGDLTVARTGYTGEDGFEIIVPATHVEA
CCCEEEEECCCCHHHHHHHCCCCCCHHCCCCCCCCEEEEECCCCCCCCCEEEEEHHHHHH
LWNALAERGVRPCGLGARDTLRLEAGMNLYGQDMDESVSPLDAGLAWTVDLSAPRAFVGR
HHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHCC
DALEAHGSRAAFVGLILQKENGRAGGVLRAHQKVATPHGEGEITSGTFSPSMQESIAFAR
HHHHHCCCCEEEEEEEEECCCCCCCCEEEHHHHHCCCCCCCCEECCCCCCCHHHHHHHHH
VPKDVAIGDTVHVQIRDKQLPARVVKLPFVRNGKVLAA
CCCCCCCCCEEEEEEECCCCCCEEEECCEEECCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA