Click here to switch to the map view.

The map label for this gene is dsbD [H]

Identifier: 237814116

GI number: 237814116

Start: 3755062

End: 3756945

Strand: Reverse

Name: dsbD [H]

Synonym: GBP346_A3902

Alternate gene names: 237814116

Gene position: 3756945-3755062 (Counterclockwise)

Preceding gene: 237814117

Following gene: 237814113

Centisome position: 91.66

GC content: 68.95

Gene sequence:

>1884_bases
ATGTTTAACCGTATTCCGCGTCACGCGCAGCCCCGCTTTCGCTTCCTGATCGCTGTCGTCGCGATGCTCGGCGTGCTGTT
CGGCACGTCGCTCGCGGCGCGCGCGGCGGACGACTTCCTCGATCCCGCGGTTGCGTTCAAATTCAGCGCGAGCGAGGCGC
CGGGCCAGGTCGACGTTCATTTCAAGATCGCCGACGGCTATTACATGTATCGCGAGCGCTTCGCGTTCGCGGTGAAAAGC
GGCTCGGCCACGCTTGGCGAGCCGCAACTGCCGGCCGGGCACGTCAAGTTCGATCCGACGTTCCAGAAGAACGTCGAAAC
CTACCGAGGCGATTTGACGATCCATCTGCCGATCAAGCAGGCATCGGGACCGTTCGAGCTCGCCGTGACATCGCAGGGGT
GCGCGGACGAAGGGATCTGCTATCCGCCCGCCGAGCACGTCGCGCGCATCGAGGGCGCGGCGCTCGGCGCCGCCGGCACC
GCGCCCGCCGCGGCGGGCGCCGGTGCGGATACGTCCGCGGCCGACGGCGGCAGTTGGTACGAGCGCGTGACGAGCGCCGA
CTACGCGCGCTCGCTGCTCGAAGGCCACGGATTCCTGACGATCGTCGCCCTTTATTTCGTGGCCGGCATGGTGCTGAGCC
TGTTGCCGTGTTCGTATCCGATGATTCCGATCCTGTCGGCCATCATCGTCGGCGAAGGCGCGCGGGCGACACGTGCGCGC
GCCTTCGCGCTGTCGCTCACCTATGTGATCGGCATGGCGCTCGTCTATACGGCGCTTGGCGTCGCAGCCGCGCTCGTCGG
GCAGAGCCTCGGCGCGTGGTTGCAGAATCCGTGGGTGCTCGGCGCGTTTGCGTTGCTGCTCACCGTGTTCGCGCTGCTGC
TGATCGGCGGCGTCGACATCACGCTGCCGCAGCGCTGGCAGAACGGTGCCGCGCAGACGAGCGGGCCGCGCAAGGGCGGC
CGCTTCGCAGCCGTCGCAACGATGGGGGCGCTGTCCGCGCTCGTCGTCGGCGCCTGCATGACCGCTCCGCTTTTCGCCGT
GCTCGCGTTCATCGCGCATACCGGCAACGCACTTCTCGGCGGCGCCGCGCTCTTCTCGATGGGGATCGGCCTCGGCGTGC
CGCTGCTCGTCATCGGAATCGGCGCCGGGACGTTGCTGCCCCGCGCCGGCGCATGGATGGACGGCGTGAAGGTGTTTTTC
GGCGTCCTGTTGCTTGCCGCCGCGCTATGGATCGTCTGGCCGGTGCTGAACGCCGCGTCGCAGCTTGGCCTGGGGGCGTT
GTGGCTACTGATCGCCGCCGCCGCGCTCGGGCTCTTCACGCCGCATTCGGGCTCTTCGTCGGTCTGGCGCCGCCTTGGGC
GCGGGCTTGGCGCCGCGCTCGCGATCTGGGCGGCGACGCTCCTCGTCGGTCTCGCGGCGGGGTCCACCGATCCGTTGCGT
CCGCTTGCCGTACTCGCGGCGCGCGCGGCGCCGAGCAACGGCGCCGCCGGTGCGGGTGCCGGCGCGCACGAAGGGCCGGC
GTTCGCGCCGGTGCGCTCGATCGCGGAGCTCGACGAGATCGTGAAGACGTCGACCCGGCCGGTGATGCTCGATTTCTATG
CGGACTGGTGCGTGAGCTGCAAGGAGATGGAGCATCTGACGTTCACCGATGCGCGCGTCGGCGCGCGGCTTTCGCAGATG
CATCTCGTGCGTGCGGACGTCACGGCGAATTCGCCGGACGACCAGGCGCTGCTGAAGCGTTTCGGCCTGTTCGGGCCGCC
CGGCATCATCGTGTTCGATGCAAACGGGCAGGAGCGGGGGCGCGTCGTCGGTTATCAGTCGGCCGATCGTTTCCTGCGCA
GCCTCGACCGGATGTCGTTGCCGGCCGCATGGTCGGCTTCGTGA

Upstream 100 bases:

>100_bases
TCGCATCATCCGTACGATGTGCCGGAGATCGTCTCGTGGCAGGCGACGGCGTCCGCCGCGTACGGCCAGTGGGTCGCCAC
CGAAACTCAGCGTCTATTTC

Downstream 100 bases:

>100_bases
CGCGTCGCCCGATGCTGGCTTGATGCGGCGCGATGCGGAAGCGATGCCGACACCGCCGACGTCGCGGATGCAGGGCGCGC
GAACGCGCGGCGCCGTGCCC

Product: thiol:disulfide interchange protein DsbD (Protein-disulfide reductase) (Disulfide reductase)

Products: NA

Alternate protein names: Protein-disulfide reductase; Disulfide reductase [H]

Number of amino acids: Translated: 627; Mature: 627

Protein sequence:

>627_residues
MFNRIPRHAQPRFRFLIAVVAMLGVLFGTSLAARAADDFLDPAVAFKFSASEAPGQVDVHFKIADGYYMYRERFAFAVKS
GSATLGEPQLPAGHVKFDPTFQKNVETYRGDLTIHLPIKQASGPFELAVTSQGCADEGICYPPAEHVARIEGAALGAAGT
APAAAGAGADTSAADGGSWYERVTSADYARSLLEGHGFLTIVALYFVAGMVLSLLPCSYPMIPILSAIIVGEGARATRAR
AFALSLTYVIGMALVYTALGVAAALVGQSLGAWLQNPWVLGAFALLLTVFALLLIGGVDITLPQRWQNGAAQTSGPRKGG
RFAAVATMGALSALVVGACMTAPLFAVLAFIAHTGNALLGGAALFSMGIGLGVPLLVIGIGAGTLLPRAGAWMDGVKVFF
GVLLLAAALWIVWPVLNAASQLGLGALWLLIAAAALGLFTPHSGSSSVWRRLGRGLGAALAIWAATLLVGLAAGSTDPLR
PLAVLAARAAPSNGAAGAGAGAHEGPAFAPVRSIAELDEIVKTSTRPVMLDFYADWCVSCKEMEHLTFTDARVGARLSQM
HLVRADVTANSPDDQALLKRFGLFGPPGIIVFDANGQERGRVVGYQSADRFLRSLDRMSLPAAWSAS

Sequences:

>Translated_627_residues
MFNRIPRHAQPRFRFLIAVVAMLGVLFGTSLAARAADDFLDPAVAFKFSASEAPGQVDVHFKIADGYYMYRERFAFAVKS
GSATLGEPQLPAGHVKFDPTFQKNVETYRGDLTIHLPIKQASGPFELAVTSQGCADEGICYPPAEHVARIEGAALGAAGT
APAAAGAGADTSAADGGSWYERVTSADYARSLLEGHGFLTIVALYFVAGMVLSLLPCSYPMIPILSAIIVGEGARATRAR
AFALSLTYVIGMALVYTALGVAAALVGQSLGAWLQNPWVLGAFALLLTVFALLLIGGVDITLPQRWQNGAAQTSGPRKGG
RFAAVATMGALSALVVGACMTAPLFAVLAFIAHTGNALLGGAALFSMGIGLGVPLLVIGIGAGTLLPRAGAWMDGVKVFF
GVLLLAAALWIVWPVLNAASQLGLGALWLLIAAAALGLFTPHSGSSSVWRRLGRGLGAALAIWAATLLVGLAAGSTDPLR
PLAVLAARAAPSNGAAGAGAGAHEGPAFAPVRSIAELDEIVKTSTRPVMLDFYADWCVSCKEMEHLTFTDARVGARLSQM
HLVRADVTANSPDDQALLKRFGLFGPPGIIVFDANGQERGRVVGYQSADRFLRSLDRMSLPAAWSAS
>Mature_627_residues
MFNRIPRHAQPRFRFLIAVVAMLGVLFGTSLAARAADDFLDPAVAFKFSASEAPGQVDVHFKIADGYYMYRERFAFAVKS
GSATLGEPQLPAGHVKFDPTFQKNVETYRGDLTIHLPIKQASGPFELAVTSQGCADEGICYPPAEHVARIEGAALGAAGT
APAAAGAGADTSAADGGSWYERVTSADYARSLLEGHGFLTIVALYFVAGMVLSLLPCSYPMIPILSAIIVGEGARATRAR
AFALSLTYVIGMALVYTALGVAAALVGQSLGAWLQNPWVLGAFALLLTVFALLLIGGVDITLPQRWQNGAAQTSGPRKGG
RFAAVATMGALSALVVGACMTAPLFAVLAFIAHTGNALLGGAALFSMGIGLGVPLLVIGIGAGTLLPRAGAWMDGVKVFF
GVLLLAAALWIVWPVLNAASQLGLGALWLLIAAAALGLFTPHSGSSSVWRRLGRGLGAALAIWAATLLVGLAAGSTDPLR
PLAVLAARAAPSNGAAGAGAGAHEGPAFAPVRSIAELDEIVKTSTRPVMLDFYADWCVSCKEMEHLTFTDARVGARLSQM
HLVRADVTANSPDDQALLKRFGLFGPPGIIVFDANGQERGRVVGYQSADRFLRSLDRMSLPAAWSAS

Specific function: Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a

COG id: COG4232

COG function: function code OC; Thiol:disulfide interchange protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1790578, Length=581, Percent_Identity=33.2185886402754, Blast_Score=295, Evalue=7e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003834
- InterPro:   IPR022910
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF02683 DsbD; PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 65227; Mature: 65227

Theoretical pI: Translated: 8.56; Mature: 8.56

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNRIPRHAQPRFRFLIAVVAMLGVLFGTSLAARAADDFLDPAVAFKFSASEAPGQVDVH
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEECCCCCCCEEEEE
FKIADGYYMYRERFAFAVKSGSATLGEPQLPAGHVKFDPTFQKNVETYRGDLTIHLPIKQ
EEECCCHHHHHHHHHHHEECCCCCCCCCCCCCCCEEECCCHHHCHHHHCCCEEEEEEECC
ASGPFELAVTSQGCADEGICYPPAEHVARIEGAALGAAGTAPAAAGAGADTSAADGGSWY
CCCCEEEEEECCCCCCCCCCCCCHHHHHHHHCHHCCCCCCCCCCCCCCCCCCCCCCCHHH
ERVTSADYARSLLEGHGFLTIVALYFVAGMVLSLLPCSYPMIPILSAIIVGEGARATRAR
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHH
AFALSLTYVIGMALVYTALGVAAALVGQSLGAWLQNPWVLGAFALLLTVFALLLIGGVDI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCE
TLPQRWQNGAAQTSGPRKGGRFAAVATMGALSALVVGACMTAPLFAVLAFIAHTGNALLG
ECCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
GAALFSMGIGLGVPLLVIGIGAGTLLPRAGAWMDGVKVFFGVLLLAAALWIVWPVLNAAS
HHHHHHHHHCCCCHHHHHCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLGLGALWLLIAAAALGLFTPHSGSSSVWRRLGRGLGAALAIWAATLLVGLAAGSTDPLR
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
PLAVLAARAAPSNGAAGAGAGAHEGPAFAPVRSIAELDEIVKTSTRPVMLDFYADWCVSC
HHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHH
KEMEHLTFTDARVGARLSQMHLVRADVTANSPDDQALLKRFGLFGPPGIIVFDANGQERG
HHHCCCEECHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHCCCCCCCCEEEECCCCCCCC
RVVGYQSADRFLRSLDRMSLPAAWSAS
CEECHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MFNRIPRHAQPRFRFLIAVVAMLGVLFGTSLAARAADDFLDPAVAFKFSASEAPGQVDVH
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEECCCCCCCEEEEE
FKIADGYYMYRERFAFAVKSGSATLGEPQLPAGHVKFDPTFQKNVETYRGDLTIHLPIKQ
EEECCCHHHHHHHHHHHEECCCCCCCCCCCCCCCEEECCCHHHCHHHHCCCEEEEEEECC
ASGPFELAVTSQGCADEGICYPPAEHVARIEGAALGAAGTAPAAAGAGADTSAADGGSWY
CCCCEEEEEECCCCCCCCCCCCCHHHHHHHHCHHCCCCCCCCCCCCCCCCCCCCCCCHHH
ERVTSADYARSLLEGHGFLTIVALYFVAGMVLSLLPCSYPMIPILSAIIVGEGARATRAR
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHH
AFALSLTYVIGMALVYTALGVAAALVGQSLGAWLQNPWVLGAFALLLTVFALLLIGGVDI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCE
TLPQRWQNGAAQTSGPRKGGRFAAVATMGALSALVVGACMTAPLFAVLAFIAHTGNALLG
ECCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
GAALFSMGIGLGVPLLVIGIGAGTLLPRAGAWMDGVKVFFGVLLLAAALWIVWPVLNAAS
HHHHHHHHHCCCCHHHHHCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLGLGALWLLIAAAALGLFTPHSGSSSVWRRLGRGLGAALAIWAATLLVGLAAGSTDPLR
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
PLAVLAARAAPSNGAAGAGAGAHEGPAFAPVRSIAELDEIVKTSTRPVMLDFYADWCVSC
HHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHH
KEMEHLTFTDARVGARLSQMHLVRADVTANSPDDQALLKRFGLFGPPGIIVFDANGQERG
HHHCCCEECHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHCCCCCCCCEEEECCCCCCCC
RVVGYQSADRFLRSLDRMSLPAAWSAS
CEECHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]