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The map label for this gene is hisD [H]

Identifier: 237814066

GI number: 237814066

Start: 3702620

End: 3703957

Strand: Reverse

Name: hisD [H]

Synonym: GBP346_A3851

Alternate gene names: 237814066

Gene position: 3703957-3702620 (Counterclockwise)

Preceding gene: 237814067

Following gene: 237814065

Centisome position: 90.37

GC content: 69.73

Gene sequence:

>1338_bases
ATGGCTATCAAGATACGCAAACTCGATTCGGCAGGCGAAGGCTTCGCGGCCGAATTGCGCGCGGTGCTCGCGTTCGAGGC
GAGCGAAGACGACGCGATCGAGCGCGCGGTCGCGCAGATTCTCGCCGACGTGAAGGCGCGCGGCGACGCCGCGGTGCTCG
ACTACACGAATCGCTTCGACCGGCTGAACGCGGCGAGCGTCGCGGCGCTCGAGCTGCCGCAAAGCGAGCTGGAAGCGGCG
CTCGAGGGCCTCGAGCCGAAGCGCCGCGCGGCGCTCGAAGCGGCGGCCGCGCGCGTGCGCGGCTACCACGAGAAGCAGAA
GATCGAGTGCGGCAGCCATAGCTGGCAGTACACCGAGGCCGACGGCACCGTGCTCGGCCAGAAGGTGACGCCGCTCGACC
GCGTCGGCCTGTACGTGCCGGGCGGCAAGGCCGCGTATCCGTCGTCGGTGCTGATGAACGCGATTCCGGCGCGCGTCGCG
GGCGTCGGCGAGATCGTGATGGTCGTGCCGACGCCGGACGGCCTGAAGAACGATCTCGTGCTCGCCGCGGCGCTGTTGGG
CGGCGTCGATCGCGTGCTCACGATCGGCGGCGCGCAGGCGGTGGCCGCGCTCGCGTACGGCACGCAAACGGTGCCCGCCG
TCGACAAGATCTGCGGGCCGGGCAACGCGTACGTCGCGTCGGCCAAGCGCCGCGTGTTCGGCACGGTCGGCATCGACATG
ATCGCCGGGCCGTCGGAGATCCTCGTGCTGTGCGACGGCACGACCGATCCGTCGTGGGTCGCGATGGACCTGTTCTCGCA
GGCCGAGCACGACGAGCTCGCGCAATCGATCCTGCTGTGCCCGGACGAAGCGTTCATCGAGCGCGTCGAGAAGGCGATCG
GCGAGCTGCTGCCGACGATGCCGCGCCAGGACGTGATCCGCGCGTCGCTCGAGGGGCGCGGCGCGCTCGTCAAGGTGCGC
GACATGGCCGAGGCGTGCAGGATCGCGAACGACATCGCGCCCGAGCACCTGGAGATCTCCGCGCTCGAGCCGCACCAATG
GGGCAAGCAGATCCGCCACGCGGGCGCGATCTTCCTCGGCCGCTACACGAGCGAGAGCCTGGGCGATTACTGCGCGGGCC
CGAATCACGTGCTGCCGACGTCGCGCACCGCGCGCTTTTCGTCGCCGCTCGGCGTGTACGATTTCTTCAAGCGCTCGAGC
CTGATCGAGGTGAGCGCCGAAGGCGCGCACACGCTCGGCGAGATCGCGTCCGAGCTCGCGTACGGCGAAGGTTTGCAGGC
GCACGCGAAGAGCGCCGAGTACCGGATGAAAGGAGCGGGCGACCGCCAGAAAGGCTAA

Upstream 100 bases:

>100_bases
CCGCGCTGAAGCCGTTCCTCGACGCGTTCGAACGCGCGTCGCTGGGGAGCGGCGCCTGACCCTCCGCGGCTCTCGGCGCA
TTACCGGAACGGATGACAGC

Downstream 100 bases:

>100_bases
GGGTAAGCCCAGCCGCGCCGGTTGCGCGAGACGAGACCAGCCCAAAAAGACGATAACCCGAGACCGCCCGGCGAGGCGTC
TCGCGCGGCGCGACCGGTGC

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 445; Mature: 444

Protein sequence:

>445_residues
MAIKIRKLDSAGEGFAAELRAVLAFEASEDDAIERAVAQILADVKARGDAAVLDYTNRFDRLNAASVAALELPQSELEAA
LEGLEPKRRAALEAAAARVRGYHEKQKIECGSHSWQYTEADGTVLGQKVTPLDRVGLYVPGGKAAYPSSVLMNAIPARVA
GVGEIVMVVPTPDGLKNDLVLAAALLGGVDRVLTIGGAQAVAALAYGTQTVPAVDKICGPGNAYVASAKRRVFGTVGIDM
IAGPSEILVLCDGTTDPSWVAMDLFSQAEHDELAQSILLCPDEAFIERVEKAIGELLPTMPRQDVIRASLEGRGALVKVR
DMAEACRIANDIAPEHLEISALEPHQWGKQIRHAGAIFLGRYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYDFFKRSS
LIEVSAEGAHTLGEIASELAYGEGLQAHAKSAEYRMKGAGDRQKG

Sequences:

>Translated_445_residues
MAIKIRKLDSAGEGFAAELRAVLAFEASEDDAIERAVAQILADVKARGDAAVLDYTNRFDRLNAASVAALELPQSELEAA
LEGLEPKRRAALEAAAARVRGYHEKQKIECGSHSWQYTEADGTVLGQKVTPLDRVGLYVPGGKAAYPSSVLMNAIPARVA
GVGEIVMVVPTPDGLKNDLVLAAALLGGVDRVLTIGGAQAVAALAYGTQTVPAVDKICGPGNAYVASAKRRVFGTVGIDM
IAGPSEILVLCDGTTDPSWVAMDLFSQAEHDELAQSILLCPDEAFIERVEKAIGELLPTMPRQDVIRASLEGRGALVKVR
DMAEACRIANDIAPEHLEISALEPHQWGKQIRHAGAIFLGRYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYDFFKRSS
LIEVSAEGAHTLGEIASELAYGEGLQAHAKSAEYRMKGAGDRQKG
>Mature_444_residues
AIKIRKLDSAGEGFAAELRAVLAFEASEDDAIERAVAQILADVKARGDAAVLDYTNRFDRLNAASVAALELPQSELEAAL
EGLEPKRRAALEAAAARVRGYHEKQKIECGSHSWQYTEADGTVLGQKVTPLDRVGLYVPGGKAAYPSSVLMNAIPARVAG
VGEIVMVVPTPDGLKNDLVLAAALLGGVDRVLTIGGAQAVAALAYGTQTVPAVDKICGPGNAYVASAKRRVFGTVGIDMI
AGPSEILVLCDGTTDPSWVAMDLFSQAEHDELAQSILLCPDEAFIERVEKAIGELLPTMPRQDVIRASLEGRGALVKVRD
MAEACRIANDIAPEHLEISALEPHQWGKQIRHAGAIFLGRYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYDFFKRSSL
IEVSAEGAHTLGEIASELAYGEGLQAHAKSAEYRMKGAGDRQKG

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=415, Percent_Identity=41.2048192771084, Blast_Score=280, Evalue=1e-76,
Organism=Saccharomyces cerevisiae, GI6319819, Length=417, Percent_Identity=35.9712230215827, Blast_Score=237, Evalue=3e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 47269; Mature: 47138

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIKIRKLDSAGEGFAAELRAVLAFEASEDDAIERAVAQILADVKARGDAAVLDYTNRFD
CEEEEEECCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHC
RLNAASVAALELPQSELEAALEGLEPKRRAALEAAAARVRGYHEKQKIECGSHSWQYTEA
CCCHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCEEECC
DGTVLGQKVTPLDRVGLYVPGGKAAYPSSVLMNAIPARVAGVGEIVMVVPTPDGLKNDLV
CCCEECCCCCCHHHCCEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHH
LAAALLGGVDRVLTIGGAQAVAALAYGTQTVPAVDKICGPGNAYVASAKRRVFGTVGIDM
HHHHHHCCHHHHEEECCHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHEECCHHE
IAGPSEILVLCDGTTDPSWVAMDLFSQAEHDELAQSILLCPDEAFIERVEKAIGELLPTM
ECCCCEEEEEECCCCCCCHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC
PRQDVIRASLEGRGALVKVRDMAEACRIANDIAPEHLEISALEPHQWGKQIRHAGAIFLG
CHHHHHHHHCCCCCCEEEHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHCCCEEEE
RYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYDFFKRSSLIEVSAEGAHTLGEIASELA
CCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCEEEEECCCCHHHHHHHHHHH
YGEGLQAHAKSAEYRMKGAGDRQKG
HCCCHHHHHCCCCEEECCCCCCCCC
>Mature Secondary Structure 
AIKIRKLDSAGEGFAAELRAVLAFEASEDDAIERAVAQILADVKARGDAAVLDYTNRFD
EEEEEECCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHC
RLNAASVAALELPQSELEAALEGLEPKRRAALEAAAARVRGYHEKQKIECGSHSWQYTEA
CCCHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCEEECC
DGTVLGQKVTPLDRVGLYVPGGKAAYPSSVLMNAIPARVAGVGEIVMVVPTPDGLKNDLV
CCCEECCCCCCHHHCCEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHH
LAAALLGGVDRVLTIGGAQAVAALAYGTQTVPAVDKICGPGNAYVASAKRRVFGTVGIDM
HHHHHHCCHHHHEEECCHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHEECCHHE
IAGPSEILVLCDGTTDPSWVAMDLFSQAEHDELAQSILLCPDEAFIERVEKAIGELLPTM
ECCCCEEEEEECCCCCCCHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC
PRQDVIRASLEGRGALVKVRDMAEACRIANDIAPEHLEISALEPHQWGKQIRHAGAIFLG
CHHHHHHHHCCCCCCEEEHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHCCCEEEE
RYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYDFFKRSSLIEVSAEGAHTLGEIASELA
CCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCEEEEECCCCHHHHHHHHHHH
YGEGLQAHAKSAEYRMKGAGDRQKG
HCCCHHHHHCCCCEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA