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The map label for this gene is hisG

Identifier: 237814067

GI number: 237814067

Start: 3703999

End: 3704655

Strand: Reverse

Name: hisG

Synonym: GBP346_A3852

Alternate gene names: 237814067

Gene position: 3704655-3703999 (Counterclockwise)

Preceding gene: 237814068

Following gene: 237814066

Centisome position: 90.39

GC content: 68.19

Gene sequence:

>657_bases
ATGAGCGCACCGCTGACGCTGGCGTTGTCGAAAGGGCGTATCTTCGAGGAAACCGTGCCGCTTCTCGCGGCGGCGGGCGT
GACGGTCGCCGAGGACCCGGAGACTTCGCGCAAGCTGATCTTGCCGACCACCGATCCGAACCTGCGTGTGATCGTCGTGC
GCGCGACCGACGTGCCGACCTACGTCGAGTACGGCGCGGCGGATTTCGGCGTCGCCGGCAAGGACGTGCTGCTCGAGCAC
GGCGGCGGCGGGCTGTATCAGCCGATCGATCTGAACATCGCGCGCTGCCGGATGTCGGTTGCCGTGCCGGCGGGCTTCGA
TTACGCAAACGCGGTGCGCCAGGGCGCGCGGCTGCGCGTCGCGACGAAGTACGTCGAAACGGCGCGCGAGCACTTCGCCG
CGAAGGGCGTGCACGTCGATCTGATCAAGCTGTACGGCTCGATGGAGCTCGCGCCGCTCGTCGGCCTCGCCGACGCGATC
GTCGACCTCGTCAGCTCGGGCGGCACGCTGAAGGCGAACAATCTGGTCGAGGTCGAGGAGATCATGCCGATCTCCTCGCG
CCTCGTCGTGAACCAGGCCGCGCTGAAACTGAAGCGCGCCGCGCTGAAGCCGTTCCTCGACGCGTTCGAACGCGCGTCGC
TGGGGAGCGGCGCCTGA

Upstream 100 bases:

>100_bases
TCGTCGAGCGCATCTATCACTTGGACCGCGGCTACGACCGGATGGAAACGAAGCTGACGGCCGTCGGCGCGAACGTGCGC
CGCATTTCGGGGAGCGAAGC

Downstream 100 bases:

>100_bases
CCCTCCGCGGCTCTCGGCGCATTACCGGAACGGATGACAGCATGGCTATCAAGATACGCAAACTCGATTCGGCAGGCGAA
GGCTTCGCGGCCGAATTGCG

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 218; Mature: 217

Protein sequence:

>218_residues
MSAPLTLALSKGRIFEETVPLLAAAGVTVAEDPETSRKLILPTTDPNLRVIVVRATDVPTYVEYGAADFGVAGKDVLLEH
GGGGLYQPIDLNIARCRMSVAVPAGFDYANAVRQGARLRVATKYVETAREHFAAKGVHVDLIKLYGSMELAPLVGLADAI
VDLVSSGGTLKANNLVEVEEIMPISSRLVVNQAALKLKRAALKPFLDAFERASLGSGA

Sequences:

>Translated_218_residues
MSAPLTLALSKGRIFEETVPLLAAAGVTVAEDPETSRKLILPTTDPNLRVIVVRATDVPTYVEYGAADFGVAGKDVLLEH
GGGGLYQPIDLNIARCRMSVAVPAGFDYANAVRQGARLRVATKYVETAREHFAAKGVHVDLIKLYGSMELAPLVGLADAI
VDLVSSGGTLKANNLVEVEEIMPISSRLVVNQAALKLKRAALKPFLDAFERASLGSGA
>Mature_217_residues
SAPLTLALSKGRIFEETVPLLAAAGVTVAEDPETSRKLILPTTDPNLRVIVVRATDVPTYVEYGAADFGVAGKDVLLEHG
GGGLYQPIDLNIARCRMSVAVPAGFDYANAVRQGARLRVATKYVETAREHFAAKGVHVDLIKLYGSMELAPLVGLADAIV
DLVSSGGTLKANNLVEVEEIMPISSRLVVNQAALKLKRAALKPFLDAFERASLGSGA

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=186, Percent_Identity=34.4086021505376, Blast_Score=89, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320896, Length=185, Percent_Identity=30.2702702702703, Blast_Score=78, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_BURM7 (A3MPV1)

Other databases:

- EMBL:   CP000548
- RefSeq:   YP_001082287.1
- ProteinModelPortal:   A3MPV1
- SMR:   A3MPV1
- GeneID:   4894285
- GenomeReviews:   CP000548_GR
- KEGG:   bmn:BMA10247_2766
- TIGR:   BMA10247_2766
- HOGENOM:   HBG391868
- OMA:   QVDIIKL
- ProtClustDB:   PRK01686
- BioCyc:   BMAL320389:BMA10247_2766-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01018
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070

Pfam domain/function: PF01634 HisG

EC number: =2.4.2.17

Molecular weight: Translated: 23067; Mature: 22936

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPLTLALSKGRIFEETVPLLAAAGVTVAEDPETSRKLILPTTDPNLRVIVVRATDVPT
CCCCEEEEECCCCHHHHHHHHHHHCCCEEECCCCCCCEEEEECCCCCEEEEEEEECCCCH
YVEYGAADFGVAGKDVLLEHGGGGLYQPIDLNIARCRMSVAVPAGFDYANAVRQGARLRV
HHHCCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHEEEEEECCCCCCHHHHHHCCCEEEH
ATKYVETAREHFAAKGVHVDLIKLYGSMELAPLVGLADAIVDLVSSGGTLKANNLVEVEE
HHHHHHHHHHHHHHCCCEEEEEHHHCCCCHHHHHHHHHHHHHHHHCCCEEECCCEEEHHH
IMPISSRLVVNQAALKLKRAALKPFLDAFERASLGSGA
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SAPLTLALSKGRIFEETVPLLAAAGVTVAEDPETSRKLILPTTDPNLRVIVVRATDVPT
CCCEEEEECCCCHHHHHHHHHHHCCCEEECCCCCCCEEEEECCCCCEEEEEEEECCCCH
YVEYGAADFGVAGKDVLLEHGGGGLYQPIDLNIARCRMSVAVPAGFDYANAVRQGARLRV
HHHCCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHEEEEEECCCCCCHHHHHHCCCEEEH
ATKYVETAREHFAAKGVHVDLIKLYGSMELAPLVGLADAIVDLVSSGGTLKANNLVEVEE
HHHHHHHHHHHHHHCCCEEEEEHHHCCCCHHHHHHHHHHHHHHHHCCCEEECCCEEEHHH
IMPISSRLVVNQAALKLKRAALKPFLDAFERASLGSGA
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA