Click here to switch to the map view.

The map label for this gene is hisA [H]

Identifier: 237814061

GI number: 237814061

Start: 3698506

End: 3699261

Strand: Reverse

Name: hisA [H]

Synonym: GBP346_A3846

Alternate gene names: 237814061

Gene position: 3699261-3698506 (Counterclockwise)

Preceding gene: 237814062

Following gene: 237814060

Centisome position: 90.26

GC content: 64.02

Gene sequence:

>756_bases
ATGCTGCTGATTCCGGCCATCGATCTTAAAGACGGTCAGTGTGTGCGCCTCAAACAAGGCGATATGGACCAGGCGACGAT
TTTTTCCGAGGATCCTGCGGCGATGGCCCGTAAATGGGTCGATCTCGGGGCGCGGCGTCTGCATCTCGTCGATCTGAACG
GCGCGTTCGCCGGCAAGCCGAAGAATCTCGAGGCGATCGAGGCGATCCTCGGCGAGGTCGGCGACGAGATCCCCGTGCAG
CTCGGCGGCGGCATCCGCAGCCTCGAGACAATCGAGAAATATCTCGACGCGGGCCTGTCGTACGTGATCATCGGCACGGC
GGCGGTGAAGGACCCGGGCTTCCTGCAGGACGCGTGCAGCGCGTTCGCGGGCAACATCATCGTCGGCCTCGACGCGAAGG
ACGGCAAGGTCGCCACCGACGGTTGGAGCAAGCTCACGGGCCACGAAGTGATCGATCTCGCGCGCAAGTTCGAGGACTAC
GGCGTCGAATCGATCGTCTACACGGACATCGGCCGCGACGGGATGTTGCAGGGCATCAACATCGAGGCGACCGTGAAGCT
CGCGCAGGCGGTCGGCATTCCGGTGATCGCGAGCGGCGGCCTGTCGAACATCGTCGACATCGAGAAGCTCTGCGAGGTGG
AAGACGAGGGCATCGAAGGCGTGATCTGCGGCCGGGCGATCTACTCGGGCGACCTCGATTTCGCCGCCGCGCAAAAGCGC
GCGGACGAACTGAACGGCGAGCTCGACGACGCCTGA

Upstream 100 bases:

>100_bases
CAGAAAGAGTTGTACTAAACTAGCGAGACGGCATCGCGCCGGATGGGCCGGCGCGCGTCTTTTCGATCTCTTCATTTTTC
CCTGACAACACCCGATTGCT

Downstream 100 bases:

>100_bases
CGCGCCGTCTCGGCACGACGCCTTTTCGCCAAGCCGTCCGCCTCGCGCGGGCGGCATTACCCGCGGCATGCCGCGCAACA
TCATGGCTCTAGCTAAACGC

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [H]

Number of amino acids: Translated: 251; Mature: 251

Protein sequence:

>251_residues
MLLIPAIDLKDGQCVRLKQGDMDQATIFSEDPAAMARKWVDLGARRLHLVDLNGAFAGKPKNLEAIEAILGEVGDEIPVQ
LGGGIRSLETIEKYLDAGLSYVIIGTAAVKDPGFLQDACSAFAGNIIVGLDAKDGKVATDGWSKLTGHEVIDLARKFEDY
GVESIVYTDIGRDGMLQGINIEATVKLAQAVGIPVIASGGLSNIVDIEKLCEVEDEGIEGVICGRAIYSGDLDFAAAQKR
ADELNGELDDA

Sequences:

>Translated_251_residues
MLLIPAIDLKDGQCVRLKQGDMDQATIFSEDPAAMARKWVDLGARRLHLVDLNGAFAGKPKNLEAIEAILGEVGDEIPVQ
LGGGIRSLETIEKYLDAGLSYVIIGTAAVKDPGFLQDACSAFAGNIIVGLDAKDGKVATDGWSKLTGHEVIDLARKFEDY
GVESIVYTDIGRDGMLQGINIEATVKLAQAVGIPVIASGGLSNIVDIEKLCEVEDEGIEGVICGRAIYSGDLDFAAAQKR
ADELNGELDDA
>Mature_251_residues
MLLIPAIDLKDGQCVRLKQGDMDQATIFSEDPAAMARKWVDLGARRLHLVDLNGAFAGKPKNLEAIEAILGEVGDEIPVQ
LGGGIRSLETIEKYLDAGLSYVIIGTAAVKDPGFLQDACSAFAGNIIVGLDAKDGKVATDGWSKLTGHEVIDLARKFEDY
GVESIVYTDIGRDGMLQGINIEATVKLAQAVGIPVIASGGLSNIVDIEKLCEVEDEGIEGVICGRAIYSGDLDFAAAQKR
ADELNGELDDA

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family [H]

Homologues:

Organism=Escherichia coli, GI87082028, Length=243, Percent_Identity=32.5102880658436, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1788336, Length=209, Percent_Identity=27.7511961722488, Blast_Score=73, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00977 His_biosynth [H]

EC number: =5.3.1.16 [H]

Molecular weight: Translated: 26589; Mature: 26589

Theoretical pI: Translated: 4.14; Mature: 4.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLIPAIDLKDGQCVRLKQGDMDQATIFSEDPAAMARKWVDLGARRLHLVDLNGAFAGKP
CEEEEEEECCCCCEEEECCCCCCCEEEECCCHHHHHHHHHHCCCCEEEEEEECCCCCCCC
KNLEAIEAILGEVGDEIPVQLGGGIRSLETIEKYLDAGLSYVIIGTAAVKDPGFLQDACS
CCHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHCCCEEEEEEEEECCCCCHHHHHHH
AFAGNIIVGLDAKDGKVATDGWSKLTGHEVIDLARKFEDYGVESIVYTDIGRDGMLQGIN
HHCCCEEEEEECCCCEEECCCCHHCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCEECCC
IEATVKLAQAVGIPVIASGGLSNIVDIEKLCEVEDEGIEGVICGRAIYSGDLDFAAAQKR
HHHHHHHHHHCCCCEEECCCCCHHHHHHHHHCCCCCCCCEEEECCEEECCCCCHHHHHHH
ADELNGELDDA
HHHCCCCCCCC
>Mature Secondary Structure
MLLIPAIDLKDGQCVRLKQGDMDQATIFSEDPAAMARKWVDLGARRLHLVDLNGAFAGKP
CEEEEEEECCCCCEEEECCCCCCCEEEECCCHHHHHHHHHHCCCCEEEEEEECCCCCCCC
KNLEAIEAILGEVGDEIPVQLGGGIRSLETIEKYLDAGLSYVIIGTAAVKDPGFLQDACS
CCHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHCCCEEEEEEEEECCCCCHHHHHHH
AFAGNIIVGLDAKDGKVATDGWSKLTGHEVIDLARKFEDYGVESIVYTDIGRDGMLQGIN
HHCCCEEEEEECCCCEEECCCCHHCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCEECCC
IEATVKLAQAVGIPVIASGGLSNIVDIEKLCEVEDEGIEGVICGRAIYSGDLDFAAAQKR
HHHHHHHHHHCCCCEEECCCCCHHHHHHHHHCCCCCCCCEEEECCEEECCCCCHHHHHHH
ADELNGELDDA
HHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA