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The map label for this gene is trpE [H]

Identifier: 237813946

GI number: 237813946

Start: 3601990

End: 3603558

Strand: Direct

Name: trpE [H]

Synonym: GBP346_A3730

Alternate gene names: 237813946

Gene position: 3601990-3603558 (Clockwise)

Preceding gene: 237813945

Following gene: 237813947

Centisome position: 87.88

GC content: 65.97

Gene sequence:

>1569_bases
GTGCTGCGGGCGCGAGCGCAGCGCCACGCGAAACCCGGCGCGCTGCGCCGATCGTCCCGACGACAGGACCGGAACATGAC
TGAACTCGAATTCCAATCGCTTGCCAACGAGGGCTACAACCGCATTCCGCTCATCGCCGAAGCGCTGGCCGACCTCGAAA
CGCCGCTTTCACTGTATCTGAAGCTCGCGCAGCCCGAACGCGGCGGCGCCAACTCGTTCCTGCTCGAATCGGTGGTGGGC
GGCGAGCGCTTCGGACGCTATTCGTTCATCGGCCTGCCCGCGCATACGCTGGTGCGCACGAAGAACGGCGTGTCGGAGGT
CGTGACGGACGGCCAGGTCACCGAGACCCACGACGGCGACCCGTTCGCGTTCATCGCGACATTCCAGAGCCGCTTCAAGG
TCGCGCAGCGCCCCGGCCTGCCGCGCTTCTGCGGCGGCCTCGCCGGCTATTTCGGCTACGACGCGGTGCGCTACATCGAG
AAGAAGCTCGCGCACACCGCGCCGCGCGACGATCTCGGCCTGCCCGACATCCAGTTGCTGCTGACCGAGGAAGTCGCCGT
GATCGACAACCTCGCCGGCAAGCTCTACCTGATCGTCTATGCCGATCCGACGAAGCCCGAGGCGTACACGAAAGCCAAGC
AACGGCTGCGCGAGCTCAAGCAGCGGCTGCGCGCGAGCGTCGTGCCGCCCGTCACGTCGGCGAGCGTGCGCACCGAGATC
TATCGCGAATTCAAGAAGGATGACTATCTGGCCGCCGTGCGCACGGCGAAGGAATACATCGCGGCGGGCGAGCTGATGCA
GATCCAGGTCGGCCAGCGCCTGACGAAGCCGTATCGCGACAATCCGCTGTCGCTGTACCGCGCGCTGCGCTCGCTGAACC
CGTCGCCATACATGTATTACTACAATTTCGGCGAATTCCATGTCGTCGGCGCTTCGCCGGAGATTCTCGTGCGTCAGGAG
AAGCGCGGCGACGACCAGATCGTGACGATCCGCCCGCTTGCCGGCACGCGGCCGCGGGGCAACACGCCCGAGCGCGACGC
CGAGCTCGCGACCGAACTGCTTAACGATCCGAAGGAAATCGCCGAGCACGTGATGCTGATCGACCTCGCGCGCAACGACG
TCGGCCGCATCGCGGAAATCGGCTCGGTCCACGTGACCGACAAGATGGTGATCGAGAAATACTCGCACGTGCAGCACATC
GTGAGTTCGGTCGAGGGCAAGCTGAAGCCCGGCGTGACGAACTACGACGTGCTGCGCGCGACGTTCCCGGCGGGCACGCT
GTCCGGCGCGCCGAAAGTCCGCGCGATGGAGCTGATCGACGAGCTCGAGCCGATCAAGCGCGGGCTGTACGGCGGCGCGG
TCGGCTACCTGTCGTTCTCGGGCGAGATGGATCTCGCGATCGCGATCCGCACGGGCCTCATCCACAACGGCAATCTGTAC
GTGCAGGCGGCGGCGGGCATCGTCGCCGACTCGGTGCCCGAATCCGAATGGCAGGAGACCGAGAACAAGGCGCGCGCGGT
GCTGCGCGCGGCCGAACAGGTGCAAGACGGCCTCGATTCCGATTTCTGA

Upstream 100 bases:

>100_bases
GCTGTCGAACGTTTTTCGCGTTCGGGCTGCCCGCCGGCGCGCGACGCACGATCGCCAGGCACAGCATCCGCCGGTTCGTC
CGATCCACCCCGCGAGGGGC

Downstream 100 bases:

>100_bases
CCGGAGACTGACCATGCTGCTCATGATCGACAACTACGATTCGTTCACCTACAACCTGGTCCAGTACTTCGGCGAGCTCG
GCGAGGCCGTGCGCACCTAT

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 522; Mature: 522

Protein sequence:

>522_residues
MLRARAQRHAKPGALRRSSRRQDRNMTELEFQSLANEGYNRIPLIAEALADLETPLSLYLKLAQPERGGANSFLLESVVG
GERFGRYSFIGLPAHTLVRTKNGVSEVVTDGQVTETHDGDPFAFIATFQSRFKVAQRPGLPRFCGGLAGYFGYDAVRYIE
KKLAHTAPRDDLGLPDIQLLLTEEVAVIDNLAGKLYLIVYADPTKPEAYTKAKQRLRELKQRLRASVVPPVTSASVRTEI
YREFKKDDYLAAVRTAKEYIAAGELMQIQVGQRLTKPYRDNPLSLYRALRSLNPSPYMYYYNFGEFHVVGASPEILVRQE
KRGDDQIVTIRPLAGTRPRGNTPERDAELATELLNDPKEIAEHVMLIDLARNDVGRIAEIGSVHVTDKMVIEKYSHVQHI
VSSVEGKLKPGVTNYDVLRATFPAGTLSGAPKVRAMELIDELEPIKRGLYGGAVGYLSFSGEMDLAIAIRTGLIHNGNLY
VQAAAGIVADSVPESEWQETENKARAVLRAAEQVQDGLDSDF

Sequences:

>Translated_522_residues
MLRARAQRHAKPGALRRSSRRQDRNMTELEFQSLANEGYNRIPLIAEALADLETPLSLYLKLAQPERGGANSFLLESVVG
GERFGRYSFIGLPAHTLVRTKNGVSEVVTDGQVTETHDGDPFAFIATFQSRFKVAQRPGLPRFCGGLAGYFGYDAVRYIE
KKLAHTAPRDDLGLPDIQLLLTEEVAVIDNLAGKLYLIVYADPTKPEAYTKAKQRLRELKQRLRASVVPPVTSASVRTEI
YREFKKDDYLAAVRTAKEYIAAGELMQIQVGQRLTKPYRDNPLSLYRALRSLNPSPYMYYYNFGEFHVVGASPEILVRQE
KRGDDQIVTIRPLAGTRPRGNTPERDAELATELLNDPKEIAEHVMLIDLARNDVGRIAEIGSVHVTDKMVIEKYSHVQHI
VSSVEGKLKPGVTNYDVLRATFPAGTLSGAPKVRAMELIDELEPIKRGLYGGAVGYLSFSGEMDLAIAIRTGLIHNGNLY
VQAAAGIVADSVPESEWQETENKARAVLRAAEQVQDGLDSDF
>Mature_522_residues
MLRARAQRHAKPGALRRSSRRQDRNMTELEFQSLANEGYNRIPLIAEALADLETPLSLYLKLAQPERGGANSFLLESVVG
GERFGRYSFIGLPAHTLVRTKNGVSEVVTDGQVTETHDGDPFAFIATFQSRFKVAQRPGLPRFCGGLAGYFGYDAVRYIE
KKLAHTAPRDDLGLPDIQLLLTEEVAVIDNLAGKLYLIVYADPTKPEAYTKAKQRLRELKQRLRASVVPPVTSASVRTEI
YREFKKDDYLAAVRTAKEYIAAGELMQIQVGQRLTKPYRDNPLSLYRALRSLNPSPYMYYYNFGEFHVVGASPEILVRQE
KRGDDQIVTIRPLAGTRPRGNTPERDAELATELLNDPKEIAEHVMLIDLARNDVGRIAEIGSVHVTDKMVIEKYSHVQHI
VSSVEGKLKPGVTNYDVLRATFPAGTLSGAPKVRAMELIDELEPIKRGLYGGAVGYLSFSGEMDLAIAIRTGLIHNGNLY
VQAAAGIVADSVPESEWQETENKARAVLRAAEQVQDGLDSDF

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=376, Percent_Identity=40.4255319148936, Blast_Score=244, Evalue=1e-65,
Organism=Escherichia coli, GI1788114, Length=445, Percent_Identity=31.9101123595506, Blast_Score=232, Evalue=5e-62,
Organism=Escherichia coli, GI87082077, Length=275, Percent_Identity=28.7272727272727, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1786809, Length=225, Percent_Identity=30.6666666666667, Blast_Score=86, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6320935, Length=465, Percent_Identity=40.2150537634409, Blast_Score=309, Evalue=8e-85,
Organism=Saccharomyces cerevisiae, GI6324361, Length=496, Percent_Identity=26.008064516129, Blast_Score=128, Evalue=2e-30,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 57969; Mature: 57969

Theoretical pI: Translated: 7.82; Mature: 7.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRARAQRHAKPGALRRSSRRQDRNMTELEFQSLANEGYNRIPLIAEALADLETPLSLYL
CCCCCHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHE
KLAQPERGGANSFLLESVVGGERFGRYSFIGLPAHTLVRTKNGVSEVVTDGQVTETHDGD
EECCCCCCCCHHHHHHHHHCCHHCCCEEEECCCHHHHHHCCCCHHHHHCCCCEEECCCCC
PFAFIATFQSRFKVAQRPGLPRFCGGLAGYFGYDAVRYIEKKLAHTAPRDDLGLPDIQLL
CEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
LTEEVAVIDNLAGKLYLIVYADPTKPEAYTKAKQRLRELKQRLRASVVPPVTSASVRTEI
HHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
YREFKKDDYLAAVRTAKEYIAAGELMQIQVGQRLTKPYRDNPLSLYRALRSLNPSPYMYY
HHHHCCCHHHHHHHHHHHHHHCCCCEEEHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEE
YNFGEFHVVGASPEILVRQEKRGDDQIVTIRPLAGTRPRGNTPERDAELATELLNDPKEI
EECCEEEEECCCCCEEEEECCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHCCHHHH
AEHVMLIDLARNDVGRIAEIGSVHVTDKMVIEKYSHVQHIVSSVEGKLKPGVTNYDVLRA
HHHHHHHHHHHCCHHHHHHCCCEECHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHEE
TFPAGTLSGAPKVRAMELIDELEPIKRGLYGGAVGYLSFSGEMDLAIAIRTGLIHNGNLY
ECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEEEECEEECCCEE
VQAAAGIVADSVPESEWQETENKARAVLRAAEQVQDGLDSDF
EEECCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MLRARAQRHAKPGALRRSSRRQDRNMTELEFQSLANEGYNRIPLIAEALADLETPLSLYL
CCCCCHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHE
KLAQPERGGANSFLLESVVGGERFGRYSFIGLPAHTLVRTKNGVSEVVTDGQVTETHDGD
EECCCCCCCCHHHHHHHHHCCHHCCCEEEECCCHHHHHHCCCCHHHHHCCCCEEECCCCC
PFAFIATFQSRFKVAQRPGLPRFCGGLAGYFGYDAVRYIEKKLAHTAPRDDLGLPDIQLL
CEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
LTEEVAVIDNLAGKLYLIVYADPTKPEAYTKAKQRLRELKQRLRASVVPPVTSASVRTEI
HHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
YREFKKDDYLAAVRTAKEYIAAGELMQIQVGQRLTKPYRDNPLSLYRALRSLNPSPYMYY
HHHHCCCHHHHHHHHHHHHHHCCCCEEEHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEE
YNFGEFHVVGASPEILVRQEKRGDDQIVTIRPLAGTRPRGNTPERDAELATELLNDPKEI
EECCEEEEECCCCCEEEEECCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHCCHHHH
AEHVMLIDLARNDVGRIAEIGSVHVTDKMVIEKYSHVQHIVSSVEGKLKPGVTNYDVLRA
HHHHHHHHHHHCCHHHHHHCCCEECHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHEE
TFPAGTLSGAPKVRAMELIDELEPIKRGLYGGAVGYLSFSGEMDLAIAIRTGLIHNGNLY
ECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEEEECEEECCCEE
VQAAAGIVADSVPESEWQETENKARAVLRAAEQVQDGLDSDF
EEECCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10417653 [H]