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The map label for this gene is leuE [H]

Identifier: 237813542

GI number: 237813542

Start: 3200878

End: 3201501

Strand: Direct

Name: leuE [H]

Synonym: GBP346_A3318

Alternate gene names: 237813542

Gene position: 3200878-3201501 (Clockwise)

Preceding gene: 237813541

Following gene: 237813543

Centisome position: 78.1

GC content: 68.11

Gene sequence:

>624_bases
ATGACGGTCAACCCCACTCTCGCCTTCATCGCGACGTGCATCGGCTTCGGCTTCATTCCGGGCCCGGCGCTGCTGCAAAC
CGTTTCGCTGACGTTGCAGCACGGCCGGCGCGCGGGCGTGCTTTCGGCGCTCGGCATCCACCTCGGCGCGTTCTTCCAGA
TCTGCGCGGTCGCGATCGGCGCGGTGGTCGTGCTCGACACGTCGCCGTGGCTCTATCACGCGCTGCGCATCGCGGGCGGC
GGGTATCTGATCTGGCTCGGCATCCAACGCATCCGCACGCGCGAGGCGAACGACGGCGGCGACGGCGCGCCGTCGACGGT
GCCGAAGAACGTGATCTCGTCGAGCGCGCTCATCGAGGCGTCGAATCCGAAATCGGCGCTGTTCTATCTGTCGTTCCTGC
TGCAGTTCGTCGATCCGTCCGCTTCGCTCGATGTCGGCTGGCAGCTCTTCCTGCTCGGCGCGGGTGCAAACCTGCTGTTC
TCGCTCGCCGATCTGACCTGCATCGCGCTCGCGCATCCGCTGTGCAAGCGCGCGGCGCCGGGCGGCGCGGCGATGATCAT
TGGGCGCTATCTCGCGGGCGGGCTGTTCATCGCGCTCGGCGTCGCCGCGATCGTCGAGCGCTGA

Upstream 100 bases:

>100_bases
CCGCCGGCGTCGACGCATCACCGCCGACGCGAGCCAATGCCGTTTCCGGCCATCGCTCAGCGACGGCGGCCGGCCGCGTT
TCCTCGACGAGCGATTCCCC

Downstream 100 bases:

>100_bases
CGCGCAGCCGGGCGGGCGATCAGGCCGCGCCGAGCACCTCGCGGCCGACGTCGCGGCGCTGCCGCGCCGGTCGGCATGCT
TCGCACGTCCGCTTGCGGAC

Product: translocator protein, LysE family

Products: homoserine lactone [Periplasm]; Proton [Cytoplasm]; homoserine [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 207; Mature: 206

Protein sequence:

>207_residues
MTVNPTLAFIATCIGFGFIPGPALLQTVSLTLQHGRRAGVLSALGIHLGAFFQICAVAIGAVVVLDTSPWLYHALRIAGG
GYLIWLGIQRIRTREANDGGDGAPSTVPKNVISSSALIEASNPKSALFYLSFLLQFVDPSASLDVGWQLFLLGAGANLLF
SLADLTCIALAHPLCKRAAPGGAAMIIGRYLAGGLFIALGVAAIVER

Sequences:

>Translated_207_residues
MTVNPTLAFIATCIGFGFIPGPALLQTVSLTLQHGRRAGVLSALGIHLGAFFQICAVAIGAVVVLDTSPWLYHALRIAGG
GYLIWLGIQRIRTREANDGGDGAPSTVPKNVISSSALIEASNPKSALFYLSFLLQFVDPSASLDVGWQLFLLGAGANLLF
SLADLTCIALAHPLCKRAAPGGAAMIIGRYLAGGLFIALGVAAIVER
>Mature_206_residues
TVNPTLAFIATCIGFGFIPGPALLQTVSLTLQHGRRAGVLSALGIHLGAFFQICAVAIGAVVVLDTSPWLYHALRIAGGG
YLIWLGIQRIRTREANDGGDGAPSTVPKNVISSSALIEASNPKSALFYLSFLLQFVDPSASLDVGWQLFLLGAGANLLFS
LADLTCIALAHPLCKRAAPGGAAMIIGRYLAGGLFIALGVAAIVER

Specific function: Exporter of leucine [H]

COG id: COG1280

COG function: function code E; Putative threonine efflux protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the rht family [H]

Homologues:

Organism=Escherichia coli, GI48994979, Length=140, Percent_Identity=30.7142857142857, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1788099, Length=143, Percent_Identity=28.6713286713287, Blast_Score=65, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001123 [H]

Pfam domain/function: PF01810 LysE [H]

EC number: NA

Molecular weight: Translated: 21515; Mature: 21383

Theoretical pI: Translated: 8.65; Mature: 8.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVNPTLAFIATCIGFGFIPGPALLQTVSLTLQHGRRAGVLSALGIHLGAFFQICAVAIG
CCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
AVVVLDTSPWLYHALRIAGGGYLIWLGIQRIRTREANDGGDGAPSTVPKNVISSSALIEA
HEEEEECCHHHHHHHHHCCCCEEEEEEHHHHHHCCCCCCCCCCCCCCHHHHHCCHHEEEC
SNPKSALFYLSFLLQFVDPSASLDVGWQLFLLGAGANLLFSLADLTCIALAHPLCKRAAP
CCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCC
GGAAMIIGRYLAGGLFIALGVAAIVER
CCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TVNPTLAFIATCIGFGFIPGPALLQTVSLTLQHGRRAGVLSALGIHLGAFFQICAVAIG
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
AVVVLDTSPWLYHALRIAGGGYLIWLGIQRIRTREANDGGDGAPSTVPKNVISSSALIEA
HEEEEECCHHHHHHHHHCCCCEEEEEEHHHHHHCCCCCCCCCCCCCCHHHHHCCHHEEEC
SNPKSALFYLSFLLQFVDPSASLDVGWQLFLLGAGANLLFSLADLTCIALAHPLCKRAAP
CCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCC
GGAAMIIGRYLAGGLFIALGVAAIVER
CCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; homoserine [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + homoserine lactone [Cytoplasm] = Proton [Cytoplasm] + homoserine lactone [Periplasm] Proton [Periplasm] + homoserine [Cytoplasm] = Proton [Cytoplasm] + homoserine [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA